Artemisia annua (AA) is a well-known as a source of antimalarial drug (artemisinin), which also has been traditionally used as an antipyretic and hemostatic agent in Korea and China. In preclinical effective study, a water extract of Artemisia annua (WEAA) ameliorated weight gain and hepatic lipid accumulation in high-fat diet-fed mice. The plasma levels of triglyceride, AST, and ALT were reduced in the WEAA-treated group. Based on these results, the safety of WEAA as a functional ingredient for liver health was evaluated in this repeated dose oral toxicity study before the clinical trial. Sprague- Dawley (SD) rats were treated by gavage with 20 times (1,000 mg/kg) more than the effective dose for 13 weeks. All rats had survived at the end of the study, and there were no changes indicating obviously abnormal clinical sign and behavior. The treatment of WEAA were also observed no obvious toxicities in the body weights, urine, hematological, serum biochemical, ophthalmic and histopathological examinations. Based on the results of this study, the NOAEL (no-observed-adverse-effect level) of WEAA in SD rats was estimated to be 1,000 mg/kg. In conclusion, WEAA could be used as a safe functional ingredient for the improvement of liver health in individuals with hepatic diseases including nonalcoholic steatohepatitis.

4 mol% Yttria-stabilized zirconia (4YSZ) coatings with 200 μm thick are fabricated by Electron Beam Physical Vapor Deposition (EB-PVD) for thermal barrier coating (TBC). 150 μm of NiCrAlY based bond coat is prepared by conventional APS (Air Plasma Spray) method on the NiCrCoAl alloy substrate before deposition of top coating. 4 mol% YSZ top coating shows typical tetragonal phase and columnar structure due to vapor phase deposition process. The adhesion strength of coating is measured about 40 MPa. There is no delamination or cracking of coatings after thermal cyclic fatigue and shock test at 850oC.

목적: 본 연구는 Anaglyph방식의 3D 입체영상물 시청 전·후에 나타나는 입체시와 사위 및 자각증상을 평가하고자 하였다. 방법: 일부대학 재학생 56명을 대상으로 입체시검사결과에 따라 입체시 안정그룹 A군과 입체시 불안정 그룹 B군으로 나누었다. 30분 동안 적록안경방식의 Anaglyph방식의 3D입체영상 시청 전·후 입체시를 평 가하였다. 사위는 von Graefe 기법을 측정하였고, 입체시는 Titmus fly 검사를 이용하였다. 결과: 난시는 안정그룹(평균±표준편차: 0.52±0.40)보다 불안정그룹(평균±표준편차: -1.05±0.73) 이 높은 난시도를 가지고 있는 것으로 나타났다(p < 0.005). 눈의 편위는 외사위가 안정그룹(36%)에 비해 불 안정그룹에서 (64%)에서 유의하게 높은 분포를 보였다(p < 0.01). 3D영상 시청과 관련하여 불안정그룹의 입 체시각이 113.6초에서 10.3.2초로 떨어짐으로써 시청전보다 시청후의 입체시 능력이 유의하게 향상되는 것으로 나타났다(p < 0.05). 시각적 증상과 비시각적 증상에서는 안정그룹과 불안정그룹 모두 비슷한 증상을 보여 유의한 차이를 보이지 않았다. 결론: 본 연구결과를 통해, Anaglyph방식의 3D 입체영상물 시청 후 입체시 능력이 어려운 사람일수록 난시도수가 높고 외사위 경향이 있음을 알 수 있었다.