As space missions extend in duration, the impact of spaceflight on human reproduction poses serious biomedical challenges. The reproductive system is susceptible to microgravity, ionizing radiation, and circadian disruption. This review summarizes current evidence on how space environments affect reproductive function, focusing on gametogenesis, hormonal regulation, pregnancy, and embryonic development. We reviewed data from rodent models, parabolic flight experiments, and space-exposed cellular systems to assess the effect of space-relevant stressors on reproductive health. Findings show that microgravity impairs sperm motility and hormonal balance, while radiation increases DNA fragmentation and induces heritable epigenetic changes. Female reproductive health is similarly affected, with radiation accelerating follicular loss and hormonal disruption impairing ovulation. Early pregnancy stages, including implantation and placental development, are especially vulnerable to space conditions. Rodent studies indicate that while basic fertility may persist, the long-term effect on offspring health and multi-generational outcomes remains unclear. These findings highlight the need for targeted countermeasures and continued research to ensure reproductive success in future space missions.

세네갈은 농촌진흥청의 아프리카 국제협력사업의 일환으로 수행되는 「아프리카 다수성 벼 품종개발 ·보급」사업의 주요 회원국으로 본 사업의 효율적 추진을 위해 세네갈의 쌀의 중요성, 쌀 생산 및 육종 현황에 대한 기초정보를 얻고자 조사하였다. 1. 현재 세네갈의 일인당 연간 쌀 소비량은 85kg로서 인구 증가, 도시화 및 쌀의 편의성으로 쌀 수요가 급격히 증가하고 있으나 쌀 생산 부족으로 국내 쌀 전체 수요량의 44%를 해외 수입쌀에 의존하고 있어 쌀 자급자족은 세네갈의 국가정책의 가장 중요한 목표이다. 2. 세네갈에서 쌀 생산은 세네갈 북부에 있는 관개농업과 이기작이 가능한 ‘Senegal River Valley’와 남부세네갈의 까자망스 지역의 천수답지대에서 이루어지고 있으나, 가뭄, 냉해, 염 해, 철분독성 불량토양, 비료 및 제초제 부족, 조류 및 잡초 피해 등 생물학적 제한 요인과 수확후 관리 기반시설 부족, 쌀 운송, 시장형성 등 제도적 제한요인 등으로 쌀 생산이 저해되고 있는 실정이다. 3. 세네갈의 벼 품종개발은 UN산하 농업연구기관인 AfricaRice, IRRI 등과 인도, 스리랑카, 중국, 한국 등 국가 협력과 지원으로 이루어져 왔으며, 1994년 이래 60개의 품종이 개발· 보급 되었다. 그러나 2017년 이후 세네갈 국가육종기관에 의한 품종개발도 이루어지고 있으며 조생종, 수량성, 향을 보유한 품종개발이 주된 육종 목표이다. 4. 현재 세네갈 국내 쌀의 품질과 밥맛에서 수입쌀에 비해 열악하여 소비자로부터 외면당하고 있는 실정으로 향후 세네 갈의 품종육성 목표는 쌀의 품질, 밥맛 및 수량을 동시에 올리기 위한 전략이 최우선시 되었다. 이를 위해 역사적으로 한국의 통일형 품종개발 및 아시아 녹색혁명을 창생시킨 IRRI 의 IR8에서 증명된 바와 같이 자포니카와 아프리카 품종과의 교배를 통한 아프리카 적응 통일형 품종을 육성하는 육종전략이 필요하다.

This study aimed to examine the effect of a mild elevation in serum cholesterol level in a porcine coronary overstretch restenosis model using a balloon angioplasty catheter or drug-eluting coronary stent. Pigs were divided into two groups and were fed a commercial normal diet (CND, n = 4) or a high-fat diet (HFD, n = 4) for 5 weeks. Coronary overstretch injury by balloon angioplasty or stent implantation was induced in the left anterior descending and left circumflex artery after 1 week of feeding. Histopathological analysis was performed at 4 weeks after coronary injury. During the experiment, the total cholesterol level in the HFD group increased by approximately 44.9% (from 65.9 ± 3.21 mg/dL at baseline to 95.5 ± 9.94 mg/dL at 5 weeks). The lumen area in the CND group was reduced in comparison with that in the HFD group after balloon angioplasty. After stent implantation, the injury score showed no significant difference. There were significant differences in the neointimal area (2.7 ± 0.33 mm2 in the CND group vs. 3.3 ± 0.34 mm2 in the HFD group, p<0.05), lumen area (2.6 ± 0.54 mm2 in the CND group vs. 2.0 ± 0.33 mm2 in the HFD group, p<0.05), and percent area stenosis (52.0 ± 7.96% in the CND group vs. 62.4 ± 5.15% in the HFD group, p<0.05). Body weight change was not different between the two groups. Increased serum cholesterol level activated vascular smooth muscle cell proliferation in the porcine coronary overstretch model.

This study examined the factors affecting the bubble generation of a motor driven bubble generator to develop a heating unit using hydrodynamic cavitation. This study also investigated the heat production and thermal efficiency by changing operating conditions. Bubble generation using the 25 ℓ-capacity motor is driven bubble generator was confirmed visually in various experimental conditions: three levels of motor powers(1, 3, 5 HP), two levels of revolutions(1800, 3200 rpm), and two levels of internal pressures of the bubble generator(the atmospheric pressure, pressurized air). After constructing the heating unit, heat production, and thermal efficiency were measured in the following experimental conditions: two levels of motor powers(3, 5 HP) and three levels of water quantities(102, 152, 230 kg). And then specifically temperature increasing rate and specific consumed energy required for the heating unit design were calculated. Bubbles were generated stably at 1,800 rpm and pressure from 0~0.8 bar. When heating water around 30℃, specific temperature increasing rate was maximized at 0.247℃/min and 0.002422℃/min-kg. Thermal efficiencies were 121% with only motor driving power as input energy and 98% with both motors driving power and water circulating pump driving power as input energy. This showed that the heating unit using hydrodynamic cavitation had higher thermal efficiency than the existing combustion boiler. Maximum specific consumed energy was 0.0270 KJ/min-kg-℃. This study confirmed that water can be heated with the heat caused by the explosion of the bubbles generated by hydrodynamic cavitation. And the results of this study could be utilized for commercial use because it showed much higher thermal efficiency than the existing combustion boiler.

The recent development in genetic assisted selection (combining traditional- and genome assisted selection method) and reproduction technologies will allow multiplying elite cow in Hanwoo small farm. This review describes the new context and corresponding needs for genome assisted selection schemes and how reproductive technologies can be incorporated to get more genetic gain for cow genetic improvement in Hanwoo. New improved massive phenotypes and pedigree information are being generated from commercial farm sector and these are allowing to do genetic evaluation using BLUP to get elite cows in Korea. Moreover cattle genome information can now be incorporated into breeding program. In this context, this review will discuss about combining the reproductive techniques (Multiple Ovulation Embryo Transfer; MOET) and genome assisted selection method to get more genetic gain in Hanwoo breeding program. Finally, how these technologies can be used for multiplication of elite cow in small farm was discussed.

Smart phones have drastically changed the life of today’s competitive world. Smart phone application (App) developers are trying their best to meet the customer requirements in the most efficient way while considering all its attributes. However smart phone service quality has been given less consideration comparatively during the last few years. This paper proposes a measurement method for improving service quality of smart phone application. This method combines the service quality performance model and process capability index. The service quality performance model is used to identify service items that require improvement. Process capability index is used to prioritize these items for improvement. We collected data on satisfaction level of customers who have used application service. By the proposed method, we found five significant service items from three categories - execution, security and resilience and prioritized those items for improvement.

This paper describes the initial operations and preliminary results of the Instrument for the study of Stable/Storm-time Space (ISSS) onboard the microsatellite Next Generation Small Satellite-1 (NEXTSat-1), which was launched on December 4, 2018 into a sun-synchronous orbit at an altitude of 575 km with an orbital inclination angle of 97.7°. The spacecraft and the instruments have been working normally, and the results from the observations are in agreement with those from other satellites. Nevertheless, improvement in both the spacecraft/instrument operation and the analysis is suggested to produce more fruitful scientific results from the satellite operations. It is expected that the ISSS observations will become the main mission of the NEXTSat-1 at the end of 2020, when the technological experiments and astronomical observations terminate after two years of operation.

Background : The study about cultured wild ginseng root (Panax ginseng C. A. Meyer) have been reported mainly ginsenosides in saponins family. However metabolites of fermented wild ginseng roots by microorganisms was not reported yet. Methods and Results : Cultured wild ginseng roots were used for fermentation of ginseng roots using Pediococcus pentosaceus and other bacterial strains. We analyzed different types of ginsenoside contents, metabolite and enzyme contents, and gene expression by using microorganisms. Results showed considerable differences in ginseonoside contents specially Rk1 and Rg5. The highest enzyme activity level was by Glutathione reductase (GR) and Glutathione S transferase (GST) in fermented ginseng roots than control (non-fermented), whereas Glutathione peroxidase (GPX) and Peroxidase (POD) contents were reduced. Score plots and loading plots of principal components 1 of the PCA result obtained from the data on 43 metabolites in fermented wild ginseng root of five conditions. The concentration of metabolite such as β-alanin and 4-aminobutyric acid (GABA), which is used to improve memory were increased in fermented ginseng roots than control. We found functional gene in wild ginseng root related with metabolic process. The APX gene expression gradually increased in fermented ginseng root with respect to fermentation times. Conclusion : In this study, accumulation of functional metabolite in cultured ginseng r

Background : Perilla frutescens L. is valuable as a medicinal plant as well as a natural medicine and functional food. Limonene perilla collected from various places showed 60% limonene compounds. However biological activity of these accession has not been reported before. Therefore, this study was conducted to investigate the biological activity of limonene perilla. Methods and Results : Fractional solvent extracts were obtained by using organic solvents such as n-hexane, chloroform, ethyl acetate, n-BuOH, and aqueous solvent from different parts of limonene perilla extracted initially in 70% EtOH. We investigated the effects of limonene perilla on total phenol and flavonoid contents, FRAP (Ferric Reducing Antioxidant Power), total saponin contents and tyrosinase inhibition activity. Leaves of limonene perilla produced the highest total phenolic contents (29.88 mg·CAE/g), flavonoid (8.39 mg·QE/g) and saponin contents (47.77 mg·GIE/g) than stems and roots of limonene perilla. FRAP of leaves was 823.00±3.58 μM·FeSO4·E/mg. Tyrosinase inhibition activity rate was 40.31% in 70% ethanol extracts from leaves of limonene perilla. Conclusion : This results suggest that leaf of limonene perilla fractions has significant antioxidant activity. Also, limonene perilla could be used as a functional biomaterial in developing cosmetics and functional foods.

Background : This study, the fraction for testing the efficacy of the Astragalus extract was concentrated active ingredient. The concentrated fraction was applied to a cosmetic material that Astragalus testing results confirmed that the improved efficacy. Methods and Results : The fractions were performed using an n-butanol solvent for increasing the efficacy of the Astragalus extract, by using the material fractions collected to compare and ultimately an increase in whitening and wrinkle efficacy. The solvent to be used in the fractions was used for the n-butanol good dissolution to the effective substance(Astragaloside, Isoflavonoid). It increased approximately 6.5 times the sample extract and the n-butanol fraction of the Astragalus as a result Astragaloside 15 ppm, 97 ppm respectively analyzed by HPLC equipment, isoflavonoid content was confirmed by an increase in the content of the fractions increased 4.5 times to 280 ppm, 1,260 ppm. Tyrosinase inhibitory effect, respectively IC50 5.70 mg/mL, IC50 1.02 mg/mL to, Collagenase producing ability is IC50 4.88 mg/mL, IC50 0.93 mg/mL with n-butanol fraction was good whitening, anti-wrinkle efficacy than the extract. Sensory evaluation was conducted in the same amount of sample, using a purified Astragalus cosmetics received high marks. Stability evaluation(MTT assay) was checked for more than 100% cell viability at the concentration 2,000 ppm. Conclusion : n-butanol fraction of Astragalus was subjected to a component analysis and In vitro test, it was confirmed an increase active ingredient content. The results of sensory evaluation and stability evaluation, it was confirmed been made to improve qualities as a cosmetic materials.

Background : Plants are the rich source of antioxidants, which plays a very important role in maintaining human health. Their antioxidant property protects cells of different organs of human beings against free radicals and free radical mediated diseases. Even though, there is lack of knowledge on the antioxidant effect of lutein present in plants. In the present study, lutein was isolated from the GreenTea leaves (Camellia sinensis) which is used as a dietary source. Methods and Results : The procedure adopted for the isolation and purification of lutein using acetone extraction and preparative high performance liquid chromatography (HPLC) is simple and less time consuming. Free radicals scavenging activity of isolated lutein from acetone extract of GreenTea was assessed by DPPH radical scavenging assay and reducing power. The isolated lutein scavenged 79% of DPPH radicals at 20 ㎍/㎖ and two fold lower concentration compared to the standard antioxidants (α-tocopherol). No significant differences were found between the reducing power of the lutein and BHT when their concentrations were high. However, significant differences were observed at relatively low concentrations, the reducing power of lutein was isolated from the GreenTea leaves was stronger than those of their acetone extract and standard antioxidants (BHA). Both electron spin resonance (ESR) and in vitro assay confirmed that lutein was isolated from the GreenTea leaves, exhibited a greater capacity for scavenging superoxide (O2 •－) and hydroxyl (OH •) radicals than standard antioxidants β-carotene and α-tocopherol respectively. Conclusion : The results proven that lutein isolated from GreenTea leaves has an efficient antioxidant ability, it could serve as an antioxidant to scavenge reactive oxygen species.

Background : Lutein, a xanthophyll, consists of chains with 8 conjugated double bounds containing closed rings on each end of the chain. This carotenoid is found in fruits and vegetables, especially dark green leafy vegetables such as green tea. In this study, we investigated the anticancer effects of purified lutein from green tea on human cancer cell lines containing prostate carcinoma cancer cells (LNCaP). Methods and Results : Prostate carcinoma cancer cells (LNCaP) were cultured and evaluated the inhibitory effect of lutein isolated from green tea compared other carotenoids (β-carotene and lycopene) on cell proliferation. Cyclin D1 and PCNA were evaluated as cell differentiation. In results, PCNA/cyclin regulates the initiation of cell proliferation by mediating DNA polymerase. Under cultural conditions, lycopene remarkably suppressed the PCNA expression prostate cancer cell line LNCaP in higher doses (20 μM - 100 μM) statistically. However, β-carotene and lutein presented the less inhibitory effects on PCNA expression. Determination of PCNA expression in control and treated cells demonstrates that lycopene did affect proliferation in LNCaP cancer cells in dose-dependent manner. However, β-carotene and lutein suppressed the cyclin D1 expression in dose-dependent manner but no in lycopene group. These results indicate that differ carotenoids presented the various suppressive ability of PCNA and cyclin D1 expression in cell proliferation. Conclusion : In conclusion, lutein suppressed the carcinogenesis of induced prostate cancer cell line by acting as a suppressor for inhibiting the expression of cyclin D.