Background: Pulmonary fibrosis (PF) is a progressive lung disease marked by excessive fibrosis and declining respiratory function. While pharmacological treatments help manage symptoms, they offer limited reversal of fibrosis and often have side effects. As a result, interest in rehabilitation approaches such as breathing exercises combined with self-myofascial release (SMR) has increased. These techniques may enhance trunk stability and thoracic flexibility, contributing to improved respiratory function. Objectives: This study investigated the effects of thoracic expansion exercises using SMR techniques on pulmonary function and chest mobility in a patient with PF, and assessed their clinical applicability. Design: Single-subject A-B-A′ design. Methods: A 60s male with idiopathic PF underwent 20 days of intervention. Standard rehabilitation was applied during baseline (A) and follow-up (A′) phases. During the intervention (B), SMR-based breathing exercises were added. Outcomes included Functional Reach Test (FRT), chest expansion, and pulmonary function tests (FVC, FEV₁, PEF, FEV₁/FVC). Data were analyzed using the 2SD band method. Results: FRT improved from 23.4 cm (A) to 31.3 cm (B) and 34.2 cm (A′). Chest expansion increased from 1.7 cm to 2.8 cm, and FVC rose from 1.70 L to 2.08 L before dropping to 0.94 L. FEV₁/FVC improved from 80.8% to 86.7% during intervention but decreased at follow-up. Conclusion: SMR-based thoracic expansion exercises may enhance trunk stability, thoracic mobility, and certain pulmonary function indicators in PF patients. These findings suggest potential clinical benefits, warranting further studies to confirm long-term effectiveness.

본 연구는 DNVGL-CG-0127 및 통합공통구조규칙(H-CSR)이 적용된 유한요소해석(FEA)을 통해 검증된, 기존 드라이도킹의 지 속 가능한 대안으로서 안벽 부유식 구조 보수의 타당성을 연구하였다. 정수압 하중을 받는 75K 제품 운반선의 전역 및 국소 거동을 시뮬레이션하여, 보수가 필요한 무시할 수 있는 변위 변화(<1%, 12.3mm~12.4mm)와 von-Mises 응력(26.4MPa, 허용 한계값 188MPa의 14%) 에서, 구조적 무결성을 확인했다. 최적화된 보수 설계는 고강도 해양 등급 강재(예: AH36)와 하위 모델링 기법을 활용하여 Saint-Venant 의 원리와 선형 탄성 가정을 준수하면서 기하학적 불연속점의 응력 집중을 해결하였다. 선급 지침을 준수하면 유체역학적 안정성과 하 중 경로 충실도가 보장되어 선박 운항 중단을 최소화할 수 있습니다. 본 연구 결과는 비용 효율적이고 시간 효율적인 유지보수로의 패 러다임 전환을 보여주며, 기존 방식 대비 가동 중단 시간을 최대 30% 단축합니다. 향후 추진 방향에는 동적 하중 하의 피로 분석, AI 기반 최적화, 그리고 실시간 구조 건전성 모니터링을 위한 디지털 트윈 통합이 포함되며, 이는 해양 탈탄소화 및 운영 민첩성 목표 달 성에 부합한다. 본 연구는 노후화된 선박의 성능 개선을 위한 확장 가능한 프레임워크를 제공하며, 계산 정밀도와 지속가능성에 대한 업계의 요구를 충족한다.

남방큰무당벌레(신칭)를 한국 미기록종으로 보고한다. 본 종은 국내 Harmornia속의 3종과는 둥글고 볼록한 체형, 앞가슴등판의 갈라진 점 모양, 각 딱지날개에 7개의 검은점이 1-3-2-1 배열로 나타나는 특징으로 쉽게 구별할 수 있다. 본 연구에서는 Harmonia속의 종 검색표, 진단형질과 DNA바코드 정보를 제공하고자 한다.

This case report describes a 40-year-old captive male hippopotamus exhibiting systemic clinical signs, including anorexia and coughing, prior to death. Despite comprehensive medical treatments, the animal died due to age-related immunodepression, which led to severe pneumonia. Necropsy and subsequent histopathological examination revealed severe acute diffuse seropurulent bronchopneumonia, right ventricular hypertrophy, hepatic congestion, and glomerulonephritis. These findings highlight the vulnerability of geriatric large animals to systemic infections and emphasize the need for improved pathological understanding and the development of evidence-based treatment protocols for these less-studied species like the hippopotamus. To enhance disease management and veterinary care for aging zoo animals, future research should prioritize gut microbiome analysis and antimicrobial resistance profiling.

Emerging RNA viruses continue to pose serious threats to animal and human health, necessitating the development of broad-spectrum antiviral agents within a One Health framework. In this study, we evaluated the antiviral potential of Desmodesmus multivariabilis extracts against three representative RNA viruses: influenza A virus (IAV), porcine epidemic diarrhea virus (PEDV), and hepatitis A virus (HAV). Extracts derived from four closely related microalgal isolates were tested using pre- and post-treatment protocols in vitro. Among them, strain ME749 demonstrated the most potent and consistent antiviral activity, with low cytotoxicity and high selectivity index (SI), particularly against IAV (SI = 23.8), followed by PEDV (SI = 10.7) and HAV (SI = 6.2). ME752 also showed moderate antiviral efficacy. RT-qPCR confirmed significant reductions in viral RNA levels for all three viruses, with ME749 achieving up to 3-log₁₀ reduction in IAV and 2.4-log₁₀ reduction in HAV. These results suggest that the antiviral effect may be mediated through mechanisms beyond direct virucidal activity, potentially involving host immune modulation. Although the active compounds remain unidentified, carotenoids are hypothesized as key bioactive components. This study highlights Desmodesmus multivariabilis, particularly ME749, as a promising source of novel, natural antiviral agents with applications in both veterinary and zoonotic disease control. Future studies including metabolomic profiling, mechanism-of-action analyses, and in vivo validation are warranted to further explore its potential in combating current and emerging RNA virus threats.

Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, leading to a deficiency in α-Galactosidase A activity and subsequent accumulation of globotriaosylceramide (Gb3). This accumulation contributes to progressive multiorgan dysfunction, with cardiovascular complications, particularly endothelial dysfunction and left ventricular hypertrophy being major drivers of disease morbidity and mortality. Although enzyme replacement therapy is currently the standard treatment, its effectiveness is limited in addressing advanced cardiovascular pathology. To better understand Fabry-associated vascular and cardiac phenotypes, an isogenic human induced pluripotent stem cell (hiPSC) model in which GLA was knocked out was developed using CRISPR/ Cas9. GLA-knockout (GLA-KO) hiPSCs were differentiated into endothelial cells (ECs) and cardiomyocytes (CMs) to evaluate disease-relevant phenotypes in vitro . GLA-KO ECs exhibited normal morphology and differentiation capacity but showed markedly impaired tube formation, high expression of inflammatory genes ICAM1, VCAM1, and SELE, and increased mitochondrial and cytoplasmic reactive oxygen species levels. GLA-KO CMs demonstrated enlarged cell size and nuclear translocation of NFATC4, consistent with hypertrophic remodeling. Together, these findings recapitulate key features of Fabry vasculopathy and cardiomyopathy in a genetically defined, human-derived system. This platform enables direct investigation of Gb3-induced oxidative and inflammatory mechanisms and provides a valuable model for the preclinical evaluation of therapeutic strategies targeting the cardiovascular manifestations of Fabry disease.

본 연구는 기업공개(IPO) 과정에서 최고경영자(CEO)의 해외 경험이 IPO의 성공에 미치는 영 향을 탐구하고, CEO가 경험한 국가와 주관사 국적 간 문화적 거리가 이 관계에 미치는 조절효과 를 분석한다. 또한 IPO 기업과 외부 투자자 간의 정보 비대칭성 정도가 CEO 해외 경험의 신호 효 과에 미치는 영향을 살펴본다. 2014년부터 2019년 사이 코스피와 코스닥 시장에 상장한 368개 기업을 대상으로 실증 분석을 진행한 결과, CEO의 해외 경험은 IPO 성공에 긍정적 영향을 미쳤다. 하지만 이러한 긍정적 영향은 CEO가 경험한 국가와 주관사의 국적 간 문화적 거리가 클수록 약화 되었다. 반면 IPO 기업과 외부 투자자 간 정보 비대칭성이 높을수록 CEO의 해외 경험이 IPO 성 공에 미치는 긍정적 효과는 더욱 강화되었다. 본 연구는 도구변수를 사용하여 내생성 문제를 통제 하였으며, 도구변수 사용 시에도 주요 가설은 대체로 지지되었다. 본 연구는 CEO의 해외 경험이 IPO 과정에서 중요한 신호(signal)로 작용할 수 있음을 제시하며, 특히 문화적 거리와 정보 비대 칭성이라는 맥락적 요인이 CEO 특성의 신호 효과를 조절할 수 있음을 밝힘으로써, 기업공개 및 신호 이론 연구에 기여한다. 실무적으로는 IPO를 준비하는 기업들이 해외 경험이 있는 CEO를 선 임하면 도움이 될 수 있음을 시사하고, 주관사를 선택할 때는 문화적으로 유사한 국가의 주관사를 전략적으로 고려할 필요가 있음을 시사한다.

As digital transformation accelerates, platform business has become a core business model in modern society. Platform business has a network effect where the winner takes all. For this reason, it is crucial for a company's pricing policy to attract as many customers as possible in the early stages of business. Telecommunication service companies are experiencing stagnant growth due to the saturation of the smartphone market and intensifying competition in rates, but the burden of maintaining communication networks is increasing due to the rapid increase in traffic caused by domestic and foreign CSPs. This study aims to understand the dynamic characteristics of the telecommunications market by focusing on pricing policy. To this end, we analyzed how ISPs, CSPs, and consumers react to changes in pricing policy based on the prisoner's dilemma theory. The analysis of the dynamic characteristics of the market was conducted through simulation using the Agent-Based Model.

As social media becomes increasingly integrated into daily life, it has reshaped how people communicate and consume advertising. Instagram, a visually-oriented platform, uses advanced targeting and shopping features to deliver personalized advertising, particularly in the fashion retail sector. Grounded in the cognitive-affective-behavioral model and human information processing theory, this study investigates how Instagram’s personalized fashion advertising influences consumer perception and behavior, focusing on recommendation system quality (accuracy, novelty, diversity) and content quality (vividness, diagnosticity). A survey of 403 Korean adults aged 20–69 was conducted to assess causal relationships among these variables. The findings reveal that accuracy and diversity in recommendation systems, along with diagnosticity of content quality, positively influence user satisfaction, which, in turn, influences their click-through and purchase intentions. However, novelty and vividness exhibited no significant effects. Academically, the study contributes to a deeper understanding of the mechanisms underlying personalized advertising on visuallyoriented platforms like Instagram. Practically, it underscores the importance of creating high-quality, personalized content that aligns with user preferences and provides clear product information. Brands can enhance user engagement by designing visually appealing advertisements and optimizing linked web pages to foster emotional bonds with consumers. These strategies can cultivate long-term customer relationships and enhance brand loyalty while maximizing advertising effectiveness on Instagram.