목적 : 본 연구의 목적은 시각장애 청소년의 일상생활활동에 대한 경험과 어려움을 탐색하여 작업치료가 필요한 주요 영역을 파악하고, 작업치료에 대한 인식 수준을 확인함으로써 향후 작업치료 서비스 제공을 위한 기초자료를 마련하는 데 있다. 방법 : 2023년 8월 15일부터 10월 31일까지 계통추출방식을 통해 선정된 시각장애 청소년 6명을 대상으로 반 구조화된 심층면담을 실시하였다. 면담은 작업치료 실행체계 4판에 근거한 기본적 일상생활활동, 수단적 일상생활 활동, 작업치료 인식으로 구성하여 총 4회기, 회기당 60분씩 진행하였다. 수집된 자료는 현상학적 연구방법인 콜라 이지(Colaizzi)의 분석 방법을 적용하였으며, 질적 연구의 신뢰도와 엄밀성을 확보하기 위해 질적 연구 보고 지침 (COREQ: Consolidated Criteria for Reporting Qualitative Research)을 준수하였다. 결과 : 시각장애 청소년은 기본적 일상생활활동에서 시각 보상과 환경수정을 통해 수행이 가능하였으나, 타인의 인식으로 인해 심리적 위축을 경험하였다. 수단적 일상생활활동에서는 대부분의 영역에서 어려움을 보고하였으나, 전자기기와 소프트웨어를 활용해 일부 활동의 어려움을 보완하고 있었다. 작업치료에 대한 인식은 전반적으로 낮았 으며, 재활서비스는 중증 장애인을 위한 것이라는 인식이 나타났다. 결론 : 시각장애 청소년은 일상생활활동 전반에서 다양한 어려움을 경험함에도 불구하고 작업치료에 대한 인식 은 낮은 수준이었다. 작업치료 서비스 접근성 향상과 적극적인 정보 제공을 통해 시각장애 청소년을 위한 작업치료 서비스의 확대가 필요함을 시사한다.

In canine solid tumors, genetic alterations are crucial for initiating and advancing tumor growth, leading to modifications in the originating tissue and shaping the tumor’s developmental course. Structural variants, including inversions, deletions, and translocations, are hallmarks of most cancer genomes and are causatively linked to tumorigenesis. Histopathology was used to confirm tumor type, while structural genomic alterations were identified through whole-genome sequencing. The examination of 4 tumors and 52 normal whole-genome sequences enabled a precise exploration of the genetic foundations of solid tumor biology, particularly the pattern of somatic structural variation. Structural variants in tumor samples were predominantly found in genes involved in the RTK–Ras–MEK–ERK signaling pathway, as well as in those regulating apoptosis and cell survival. Among the structural variants discovered, the detection of STARD4 in the solid tumor group, which is related to cholesterol regulation, indicates a potential common pathway in tumorigenesis. This research highlights the genetic intricacy of tumors and underscores the importance of personalized strategies for diagnosis and prognosis, employing comprehensive genetic profiling.

This study evaluated the fit of a one-piece dress using a 3D-printed dress form designed to reflect the body shape of middle-aged women and examined its potential for practical application by comparing the results with those from a 3D virtual fitting program. Therefore, a dress form was created based on the body measurements of middle-aged women using 3D body scanning and 3D printing, and an actual one-piece dress was fitted onto it. The same pattern was then simulated in a 3D virtual fitting program. A subsequent visual assessment was performed to compare and analyze the similarity between the 3D virtual fitting and actual fitting results. The analysis revealed that the 3D-printed dress form more accurately replicated the body characteristics of middle-aged women, making it advantageous for evaluating actual wearing comfort and garment fit. In contrast, the virtual fitting program demonstrated limitations in detailed expressions of elements such as wrinkles in specific body areas and fabric properties, resulting in lower consistency with real-world fitting outcomes compared to the dress form. This study confirmed that the 3D-printed dress form for middle-aged women can enhance accuracy in both fit evaluation and garment production processes. Future studies should focus on developing dress forms that accommodate diverse body types and refining virtual fitting technologies to enable more precise garment simulation and evaluation.

Valerianella radiata (L.) Dufr., which is native to North America, was newly found in Gyeonggi-do and Gyeongsangnam-do, Korea. This species can be distinguished from other Valerianella species in Korea by its white flowers, and the fertile fruit locule lacks a corky mass on the abaxial surface. V. radiata grows on slopes and roadsides, suggesting that it is likely to have been introduced when green sites were installed and during road construction. Its introduction into Japan has been reported, but the associated ecological risk is unknown. Here, we provide a detailed morphological description, taxonomic key to related taxa, voucher specimens, photographs, and distribution maps of its habitat.

한국 분포가 확인되지 않았던 니토베은주둥이벌 Ectemnius nitobei (Matsumura, 1912)을 경기도 포천시 광릉숲에서 처음으로 확인하였다. 국립수목원 내 휴게광장의 가래나무과(Juglandaceae) 목재 벤치 구멍에서 암컷의 둥지 짓기 행동을 관찰하였으며, 유충의 먹이로 사용하기 위해 나방류 성충을 운반하는 행동을 확인하였다. 본 연구에서는 니토베은주둥이벌 암컷의 전신 사진, 주요 형태학적 진단 형질, 그리고 DNA 바코드 (COI) 서열을 함께 제시하여 향후 국내 분류학적 및 생태학적 연구의 기초 자료로 제공하고자 한다.

It is challenging to treat canine brucellosis due to the immune evading and stealthy characteristic of the causative bacteria, Brucella (B.) canis. Gold nanoparticle aptamer (AuNP-Apt) conjugated antimicrobial peptide (AMP) is a promising alternative to antibiotics for various bacterial infections. However, the toxicity of AuNP-Apt has been variable throughout research, and the in vivo toxic mechanism has not been fully elucidated. This study evaluated the therapeutic potential against B. canis, and the toxicity of AuNP-Apt conjugated antimicrobial peptide, RW-BP100 (AuNP-AptHis-RW-BP100His), in a mouse model. Intravenous (IV) treatment with AuNP-AptHis-RW-BP100His reduced the bacteria burden and histopathologic lesions. The IV treatment also induced CD4+ T cell differentiation and modulated serum cytokine levels. However, high-dose AuNP-Apt was lethal, resulting in tissue accumulation and vessel embolism. Therefore, AuNP-AptHis-RW-BP100His is a promising therapeutic agent for B. canis treatment, but due to its toxicity, further studies are needed for its utilization in clinical practice.