Flavonoids extracted from the roots of Petasites japonicus were evaluated for their cytoprotective, antioxidant, and anti-aging effects. The MTT assay confirmed that cell viability remained above 95% across concentrations up to 12 μg/mL, indicating no cytotoxicity. The extract demonstrated strong DPPH radical scavenging activity in a concentration-dependent manner, reaching 86.7% at 12 μg/mL, which is comparable to vitamin C. ROS scavenging activity also increased with dosage, showing significant suppression at concentrations of 6 μg/mL and above, thus effectively mitigating oxidative stress. Collagen synthesis assays revealed an initial decrease at low concentrations, followed by a clear recovery and significant enhancement at higher doses (10–12 μg/mL). Additionally, the extract inhibited collagenase activity, with notable suppression occurring at concentrations above 10 μg/mL, suggesting protective effects against collagen degradation. Elastase activity was reduced in a dose-dependent manner, achieving over 60% inhibition at 10–12 μg/mL. These results imply that flavonoids have dual functions: they stimulate collagen production while suppressing the enzymes that degrade collagen and elastin. The strong antioxidant and anti-inflammatory potential of these flavonoids likely contributes to their protective effects on dermal structure and function. Collectively, these findings highlight the potential of flavonoids as promising natural ingredients for anti-aging cosmetics and skin health applications.

Area-selective atomic layer deposition (AS-ALD) is a bottom-up process that selectively deposits thin films onto specific areas of a wafer surface. The surface reactions of AS-ALD are controlled by blocking the adsorption of precursors using inhibitors such as self-assembled monolayers (SAMs) or small molecule inhibitors. To increase selectivity during the AS-ALD process, the design of both the inhibitor and the precursor is crucial. Both inhibitors and precursors vary in reactivity and size, and surface reactions are blocked through interactions between precursor molecules and surface functional groups. However, challenges in the conventional SAM-based AS-ALD method include thermal instability and potential damage to substrates during the removal of residual SAMs after the process. To address these issues, recent studies have proposed alternative inhibitors and process design strategies.

The Republic of Korea has implemented an obligatory vaccination on major livestock breeds to prevent and eradicate nationwide foot and mouth disease (FMD) since the end of 2010. The government has executed massive serological survey to check the immune level of various herds after vaccination, and seropositive rates against FMD virus (FMDV) structural proteins can be measured to assess FMD immunity level. The purpose of this study is to investigate the FMDV serological level of every cattle breeding farm in the country and to determine whether there is a significant difference between groups classified by time, age, and management authority. A total of 5,781 serum samples was collected in 18 cattle breeding farms from 2020 to 2021, and the seropositive rates were measured using PrioCHECK FMDV Type O ELISA kit. Firstly, the cattle breeding farms were classified by which they are managed: the central government, the local government, and the private agency. Every management authority had a seropositive rate of 99.5% or higher. Secondly, the samples were divided into 6 to 12 months old, 12 to 24 months old, and 24 months or more. The 6 to 12 months old group in 2020 showed a significantly low seropositive rate of 98.1%, but it was improved by implementing the enhanced vaccination policy from 2021 to 100%. In summary, there are considerably high seropositive rates including all groups with time, age, and by which they are managed, which means the FMD vaccination in cattle breeding farms is well-managed.