베어링은 많은 회전체에서 사용되는 핵심부품으로, 예기치 않은 고장을 방지하기 위해 많은 연구가 집중되고 있다. 이때 중요한 것은 되도록 초기에 건전성 상태를 잘 나타내는 적절한 특징신호를 추출하는 것이다. 그러나 기존의 연구들은 주로 진단관점에서 특징신호를 추출하여 고장예지에는 적합하지 않은 측면이 있었다. 본 논문에서는 이러한 문제를 극복하기 위 해 베어링 고장 주파수의 에너지와 시간 사이의 상관계수 가중 합을 이용하여 베어링 수명 예측에 용이한 특징신호를 추출 하는 방법을 개발하였다. 그 결과 일반적으로 고장진단에서 많이 사용되고 있는 특징신호인 RMS에 비해서 결함 초기부터 단조로운 증가 경향의 특징신호를 추출함을 알 수 있었다. 이를 입증하기 위해서 NASA Ames에서 제공한 IMS bearing 진 동 데이터를 이용하였고 제시한 특징신호와 일반적인 RMS와 의 거동을 비교하여 유효성을 검증하였다.

Muscle atrophy is characterized by a decrease in the mass of the muscle. With an increase in life expectancy and chronic illnesses, the incidence of muscle atrophy is increasing and the quality of life of patients is decreasing. Thus, reducing muscle atrophy is of high clinical and socio-economic importance. Mistletoe is a semi-parasitic plant that has been used as a traditional medicine in many countries to treat various human illnesses. It has been reported that Korean mistletoe extract (KME) has diverse biological functions including anti-tumor, anti-oxidant, anti-diabetic, anti-obesity properties, and extension of lifespan. Especially, we have recently reported that KME improves exercise endurance in mice, indicating its beneficial roles in enhancing the capacity of skeletal muscle. In this study, we investigated whether KME could activate the signaling pathway related to protein synthesis in a mouse model of muscle atrophy. Interestingly, KME efficiently activated the Akt/mTOR pathway, and Akt and mTOR are important signaling hub molecules for the acceleration of protein synthesis in muscle cells. In addition, KME also increased the activity of S6 kinase which is involved in the regulation of muscle cell size. Moreover, the ERK activity, required for transcription of ribosomal RNA for protein synthesis, was also enhanced in KME-treated mouse muscle. These data support the idea that KME increases muscle mass via increased protein synthesis. Our findings also suggest that Korean mistletoe might be a promising candidate for the development of functional foods that are beneficial for preventing muscle atrophy.

This paper described the effect of subjective approach in case of the human sensibility experiments. The procedure is proceeded subjectively. Human faces are selected as the image presentation media. Pleasant and unpleasant images are selected directly by examiner, And also the image presentation system, which is executed with a computer and has the square-type black box monitor equipment, is manufactured. Images are presented with the step-variation time interval technique. questionnaire test and EEG signal detection data are analyzed. The analysis parameters are a “frequency band integral value” and a “band differential variation ratio”. he results show the high sensibility and fast response. The fact that image presenting repetition alleviates is verified.

본 연구에서 상동나무 가지 추출물(STB-E100)은 대장암 세포에서 세포사멸을 유도하여 세포생육을 억제하였다. 또한 Iκ B-α 인산화를 통한 IκB-α 단백질 분해를 유도하며 이로 인해 P65 핵내 전이를 유도하여 NF-κB 신호전달을 활성화시킨다. NF-κB 신호전달 활성화는 GSK3β 활성화를 통해 P65 핵내 전 이를 유도에 의한 것이지만 IκB-α분해는 GSK3β 의존성이 아니다. 상동나무 가지 추출물은 이러한 신호전달 활성화를 통해 세포사멸을 유도하여 대장암의 세포생육을 억제한다. 본 결과를 바탕으로 상동나무 가지가 암 예방 및 치료를 목적으로한 표적 요법에서 항암제 개발의 잠재적 활용 소재로서 이용 가능하다고 사료된다. 그러나 대장암 세포에서 상동나무 가지 추출물에 의해 유도된 NF-κB 신호전달 작용기전을 좀 더 구체적으로 구명할 필요가 있고 대장암에 대한 세포사멸과 작용기전의 정확한 관련성을 조사하기 위해 추가적인 연구가 필요하다.

Background : This study aimed to determine the anti-osteoclastogenic effects of extracts from CK berry’s and identify the underlying mechanisms in vitro. Methods and Results : Reactive oxygen species (ROS) are signal mediators in osteoclast differentiation. AM extracts inhibited ROS production in RAW264.7 cells in a dose-dependent manner and exhibited strong radical scavenging activity. The extracts also attenuated the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated osteoclasts. To attain molecular insights, the effect of the extracts on the signaling pathways induced by receptor activator of nuclear factor kappa B ligand (RANKL) were also investigated. RANKL triggers many transcription factors through the activation of mitogen-activated protein kinase (MAPK) and ROS, leading to the induction of osteoclast-specific genes. The extracts significantly suppressed RANKL-induced activation of MAPKs, such as extracellular signal-regulated kinase (ERK), c-Jun-N-terminal kinase (JNK), and p38, and consequently led to the downregulation of c-Fos and nuclear factor of activated T cells 1 (NFATc1) protein expression which ultimately suppress the activation of the osteoclast-specific genes, cathepsin K, TRAP, calcitonin receptor, and integrin β3. Conclusion : In conclusion, our findings suggest that AM extracts inhibited RANKL-induced osteoclast differentiation by downregulating ROS generation and inactivating JNK/ERK/p38, nuclear factor kappa B (NF-κB)-mediated c-Fos and NFATc1 signaling pathway.

The Wnt/β-catenin signaling pathway is mandatory in adipogenesis. In this study, we investigated the applicability of functional materials for the treatment of obesity by examining Wnt/β-catenin pathway reporter activity related to adipocyte differentiation inhibiting with korean native plant extracts. The luciferase activity of HEK 293-TOP cells increased the reporter activity approximately 152% and 130% by treatment with Sanguisorba officinalis and Thuja orientalis, respectively. Ricinus communis were represented about 90% higher activity, two samples(Rosa rugosa and Sophorae Flos) showed 80% higher activity than the control. Three samples of plant extracts (Zanthoxylum piperitum, Pueraria thunbergiana, Solanum nigrum) were about 70% higher activity compared with the non-treated control. Cytotoxicity of plant extracts was not detected in the rat neural stem cells. These results suggest that the selected eight plant extracts are safe compounds. Our findings indicate that Wnt/β-catenin pathway reporter activity could be used for high throughput screening system. In addition, the plant extracts selected as candidates for adipocyte differentiation inhibiting may be potential therapeutic agents for obesity, it will be exploring the possibility of developing an anti-obesity materials through further experiments with selected plant extracts.

초장대교량의 건설로 인해 메인 거더의 공기역학적 거동이 주요 이슈가 되었다. 특히 연성 구조를 갖는 장대교량의 안정성에 대한 주요 관점은 플러터의 발현에 있다. 플러터의 예측은 2차원 단면 실험을 통해 가능하다. 플러터계수 추출을 위해 변위를 주변수로 하여 속도와 가속도를 구현하였다. 이때 플러터계수의 정확한 예측이 매우 중요하게 된다. 측정데이터를 통해 구조물의 유효강성과 댐핑을 역계산하는 SI기법에서 측정치 해석의 정확성에 따라 교량파괴에 해당하는 임계속도의 정확성이 결정된다. 본 연구에서는 오차가 포함된 측정치의 데이터를 신호처리방법을 이용해 정확도를 개선하는 것을 목적으로 한다. 측정치의 오차정도를 구현하기 위해 white gaussian noise를 적용하였고 수치 검증을 통해 zero phase filtering과 stacking방법 그리고 moving average방법을 적용하여 좀 더 정확성 있는 교량의 구조물성치가 산출됨을 확인 할 수 있다.