Melanoplus differentialis (Thomas, 1865) is a widely distributed Orthopteran species in North America, including the United States and Mexico. Known for causing damage to various crops such as vegetables and grains throughout its lifecycle. In South Korea, it has been observed concentratedly in the vicinity of the Onsan National Industrial Park in Ulsan and was designated as “Ecosystem Disturbing Species” by Ministy of Environment in 2020. This study aims to present foundational data on pest management strategies for Melanoplus differentialis identified within the Onsan National Industrial Park. Through collaborative efforts between the National Institute of Ecology, related agencies, and tenant private companies from 2020 to 2023, we will demonstrate the reduction in habitat area as a result of proactive pest control measures.

As climate changes and global trade volume increases, the spread of invasive alien species accelerates. Early prevention before occurrence is crucial for invasive pest control. Therefore, this study modeled the current and future potential distribution of the tomato leafminer(Tuta absoluta) (Meyrick) (Lepidoptera: Gelechiidae), the most significant pest affecting tomatoes, in Korea. This pest primarily feeds on Solanaceae crops and can cause extensive damage, resulting in 50-100% loss of crops in greenhouses or fields. While previously unreported in Korea, it invaded China in 2017, indicating a potential threat to Korea. The potential distribution of the tomato leafminer in Korea under current and three future climate scenarios (SSP1-26, SSP3-70, SSP5-85) was predicted using the MaxEnt model. Additionally, elevation and land cover were incorporated as abiotic factors considering the ecological characteristics of the pest.

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, and it has been steadily increasing in worldwide. Pituitary tumor transforming gene 1 (PTTG1) has been known as oncogene in a verity of cancers. Nevertheless, the expression and role of PTTG1 in OSCC progression remains largely unexplored. In this study, clinical datasets were analyzed to assess the genetic impact of PTTG1 on OSCC progression and to identify its functional roles in OSCC cell lines. We analyzed the expression of PTTG1 in head and neck squamous cell carcinoma (HNSC) and OSCC using databases form the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). To investigate the effect of PTTG1 on proliferation and migration abilities in OSCC cell lines, following the knockdown of PTTG1 in HSC-2 and SCC-9 cell lines, we analyzed the proliferation and metastatic abilities of OSCC cells using EdU and Boyden chamber assays. Our database analysis revealed that PTTG1 was significantly overexpressed in tumor tissues compared to normal tissues. Moreover, its expression correlated with clinical parameters of OSCC. In vitro experiments demonstrated that depletion of PTTG1 suppressed the ability of cell proliferation and migration in both HSC-2 and SCC-9 cell lines. In conclusion, our study suggests that PTTG1 may act as an oncogene in OSCC. These findings provide new insights into the mechanisms and clinical implications of PTTG1 expression in OSCC patients.

Climate change and biological invasions are the greatest threats to biodiversity, agriculture, health and the global economy. Tomato leafminer(Tuta absoluta) (Meyrick) (Lepidoptera: Gelechiidae) is one of the most important threats to agriculture worldwide. This pest is characterized by rapid reproduction, strong dispersal ability, and highly overlapping of generations. Plants are damaged by direct feeding on leaves, stems, buds, calyces, young ripe fruits and by the invasion of secondary pathogens which enter through the wounds made by the pest. Since it invaded Spain in 2006, it has spread to Europe, the Mediterranean region, and, in 2010, to some countries in Central Asia and Southeast Asia. In East Asia, Tomato leafminer was first detected in China in Yili, Xinjiang Uygur Autonomous Region, in 2017. There is a possibility that this pest will invade South Korea as well. This study provides this by the use of MaxEnt algorithm for modelling the potential geographical distribution of Tomato Leafminer in South Korea Using presence-only data.

The process of biological invasion is led by the dynamics of a population as a demographic and evolutionary unit. Spatial structure can affect the population dynamics, and it is worth being considered in research on biological invasion which is always accompanied by dispersal. Metapopulation theory is a representative approach to spatially structured populations, which is chiefly applied in the field of ecology and evolutionary biology despite the controversy about its definition. In this study, metapopulation was considered as a spatially structured population that includes at least one subpopulation with significant extinction probability. The early phase of the invasion is suitable to be analyzed in aspects of the metapopulation concept because the introduced population usually has a high extinction probability, and their ecological·genetic traits determining the invasiveness can be affected by the metapopulation structure. Although it is important in the explanation of the prediction of the invasion probability, the metapopulation concept is rarely used in ecological research about biological invasion in Korea. It is expected that applying the metapopulation theory can supply a more detailed investigation of the invasion process at the population level, which is relatively inadequate in Korea. In this study, a framework dividing the invasive metapopulation into long- and middle-distance scales by the relative distance of movement to the natural dispersal range of species is proposed to easily analyze the effect of a metapopulation in real cases. Increased understanding of the mechanisms underlying invasions and improved prediction of future invasion risk are expected with the metapopulation concept and this framework.

러시아의 우크라이나 무력 침공이 계속되면서 갈등은 더욱 복잡해지고 있다. 러시아의 '특수군사작전 Z'에 맞서 우크라이나의 저항과 미국과 북 대서양조약기구(NATO)를 중심으로 한 국제사회의 지지에 고전하고 있 다. 전쟁 초기 러시아와 우크라이나 간의 평화 협상은 성과가 없고 러시 아에 대한 경제제재와 나토 회원국들의 각종 무기 지원, 러시아의 핵무 기나 화학무기 사용 가능성 등이 제기되면서 군사적 긴장감은 고조되고 있다. 문제를 제기하면: 우리는 어떻게 그러한 침략적인 전쟁을 정의할 수 있습니까? 러시아의 우크라이나 침공에 대한 합법적이고 규범적인 논 의가 유용한가? 본 논문의 목적은 국제사회의 비난과 제재에도 불구하고 푸틴이 우크라이나에 대한 침공의 요인을 분석하는 데 있다. 이는 케네 스 왈츠가 제안한 "개인적 성향, 국내 정치, 국제 체제"라는 삼자적 이론 적 틀을 통해 이루어질 것이다. 또한 분단된 한반도에 제공된 전쟁의 교 훈과 시사점을 분석한다. 현대전에서 글로벌 안보위협의 변화 양상과 리 더십, 군 통수권자의 전략적 선택이 중요하다. 기술력 육성, 예비군 강 화, 하이브리드 전쟁과 정보기술이 평화를 위한 도구로서 중요해지고 있 다. 여기에 사이버전과 국제적 연대와 지원, 반전 여론 등이 포함된다.

13세기 몽골침략은 페르시아의 사상, 종교, 문화에 전반적인 영향을 주었다. 그 중 몽골지배 이 전과 대비하여 가장 극명한 차이를 보이는 것은 이슬람 신비 주의 종교철학인 수피즘에 대한 인식 변화이다. 이슬람 왕조의 세속주의와 향락 에 대한 반작용으로 태동한 수피즘은 12세기 페르시아에서 종단이 세워지면서 하나의 기득권층이 되었으며, 몽골침략 이 후 몽골지배층과 결탁하여 이민족의 정권을 선전하는 수단이 되었다. 이러한 과정에서 금욕과 청빈이 미덕인 수피들 은 부패하기 시작하였고, 14세기 몽골족 지배하에 활동했던 하페즈와 같은 시 인들은 자신들의 시에서 이러한 수피들을 비판하였다. 본 연구에서는 페르시아 의 시성인 하페즈의 작품에 나타난 수피 상징 연구를 통하여 몽골 침략 이 후 수피에 대한 인식 변화를 보여주고자 한다.

Salivary gland adenocarcinoma(AdCa NOS) is one of the major causes of mortality among malignant salivary gland tumors. New therapeutic measure are needed to improve the outcome for patients with AdCa NOS because current therapy does not significantly improve survival rates. Transglutaminase 2(TGase 2) was implicated in forming cross-linked protein polymer, apoptosis and matrix interaction. And also TGase 2 expression is up-regulated in proliferation, migration, invasion, and metastasis of cancer cells. shRNA which has emerged as an effective method to target specific genes for silencing has provided new opportunities for cancer therapy. But there has been rarely reported using shRNA-TGase 2 transfection in AdCa NOS. The purpose of this study were to examine the specific inhibition of TGase 2 mRNA and protein expression by siRNA transfection of TGase 2 through RT-PCR and immunoslot blotting, and to study proliferation, migration and invasion assay of SGT cell line from AdCa NOS. Cell cycle analysis showed that the downregulation of shRNA-TGase 2 caused the accumulation of cells in the sub-G0/G1 phase. In migration assay, suppressing shRNA-TGase 2 inhibited the capacity of the cells to migrate compared to parental cells. In invasion assay, cells transfected with shRNA-TGase 2 decreased in invasion when compared to SGT and vector transfected cells. shRNA-TGase 2 expressing plasmids efficiently downregulated TGase 2 mRNA and TGase 2 protein expression. It suggested that the shRNA-TGase 2 targeting system against TGase 2 could have a therapeutic potentiality for malignant salivary gland tumors, especially in inhibiting and/or preventing cancer cell proliferation, migration and invasion.

Human melatonin receptors consist of melatonin receptor 1A (MT1) and melatonin receptor 1B (MT2), and possess various biological activations, which include the control of circadian rhythm and immune regulation. Recently, it have been found that melatonin receptors inhibit cell proliferation and have oncostatic properties, which is being researched in the treatment strategies of breast cancer, prostate cancer, and Non-Small Cell Lung Cancer. Also, interest in the effect of melatonin receptor’s correlation to head and neck carcinogenesis and application possibilities on head and neck cancer has been found. However, in head and neck cancer, how melatonin receptor relates and functions with epithelial-mesenchymal transition (EMT), which plays a major role in human carcinogenesis, is yet unknown. In this research, in HSC5 cell and YD15 cell, the head and neck cancer cell lines, a selective melatonin receptor antagonist, Luzindole, was utilized to examine the effect of melatonin receptors on EMT. After treating Luzindole on HSC5 cells and YD15 cells, the authors evaluated cell viability rate with CCK 8 assay, and performing colony forming assay, invasion assay and western blot analysis, to confirm melatonin receptor’s effect on EMT. When Luzindole was treated on HSC5 cells and YD15 cells in low concentration of 100nM, no significant difference in cell viability was found, whereas Luzindole-treated cells had a significantly increase in the invasion assay. As a result of colony forming assay, in YD15 cells, the number of colony formation decreased slightly, whereas in HSC3 cells, the number of colony formation increased. According to the western blotting, no difference in E-cadherin, Slug, and vimentin protein expression was shown. This result of research indicates the possibility of melatonin receptor being related to EMT and new chemotherapeutic target in the carcinogenesis of head and neck cancer.

최근 연안지역의 대규모 개발로 인해 고파랑 내습과 강한 태풍으로 발생된 월파는 연안지역의 많은 인명 및 재산피해를 발생시켰으나 연안지역의 특성을 고려한 침수·범람 연구는 미비한 실정이다. 본 연구는 ADCSWAN(ADCIRC+SWAN) 모델과 FLOW-3D 모델을 적용하여 해일 및 파랑의 복합요소에 대한 침수범람을 재현하기 위한 방법론에 대한 연구이다. 본 연구에서는 ADCSWAN(ADCIRC+SWAN) 모델을 이용하여 FLOW-3D 모델의 경계자료(해수위, 파랑)를 추출하고, FLOW-3D 모델 입력값으로 적용하여 태풍 차바 통과시 부산 마린시 티를 대상으로 해일과 월파에 의한 침수범람을 재현하였다. 또한 기존 월파량 경험식과 FLOW-3D 모델로 계산된 월파량을 비교하였으며, 침수범람은 한국국토정보공사의 침수흔적도를 활용하여 정성적인 검증을 수행하여, 본 연구의 유효성을 검토하였다.

선박과 물체의 충돌위험을 파악하는 것은 항해안전에 중요하다. 본 연구의 목적은 선박이 방파제 사이를 통과할 때 선박 도메인이 방파제에 의해서 침범당하는 현상을 분석하는 것이다. 연구방법은 먼저, 방파제가 주어진 조건으로 설계된 선박 도메인을 침범하는 영역을 평가하기 위한 방법을 제안하였다. 그런 후, 부산항 방파제 부근을 항해하는 선박들의 AIS(Automatic Identification System)로부터 실 험 데이터를 획득하고 처리하여 방파제 사이에서 형성될 수 있는 선박 도메인을 구축하였다. 이 때 선박 도메인은 Fujii의 Domain을 이용 해 구축하였다. 마지막으로, 구축한 선박 도메인이 방파제에 의해서 침범당하는 현상을 분석하였다. 실험결과, 방파제에 의해서 침범당하는 선박 도메인이 확인되었다.

Perineural invasion (PNI) is the underestimated metastatic pathway and has been widely recognized as a negative prognostic factor in many human cancers. L1CAM is one of members of the immunoglobulin-like cell adhesion molecule (CAM) family, which play a role in neural development. Moreover, a new role of L1CAM outside the nervous system has been revealed. Overexpression of L1CAM was involved in the tumor progression and LN metastasis in various malignancies. In the present study, presence of PNI and L1CAM expression were examined to define their prognostic values in OSCC. In addition, association of L1CAM expression with presence of PNI was assessed to define the value as a candidate molecule supporting the diagnosis of PNI. We found that presence of PNI significantly correlated with LN metastasis and advanced clinical stage. L1CAM expression also significantly correlated with differentiation, lymph node metastasis, advanced clinical stage, as well as presence of PNI. Our results suggest that L1CAM seems to play a role in tumor progression, possibly through the PNI-related mechanism and could be a molecular marker for supporting the presence of PNI and predicting clinical outcome in OSCC.

자갈해빈에 대한 태풍의 영향력을 조사하기 위하여 태종대 감지 자갈해빈에서 2018년 10월에 내습한 태풍 ‘콩레이’와 2019년 7월의 태풍 ‘다나스’에 대하여 VRS-GPS, 드론 측량을 수행하였다. 감지해빈의 전반적인 퇴적물 분포를 파악하기 위해서 입도분석을 하였으며, 자갈해빈의 회복력을 확인하기 위해 주기적으로 감지해빈의 지형측량을 수행 하였다. 감지해빈의 자갈퇴적물은 서쪽에서 동쪽으로 갈수록 평균 −6.2Φ에서 −5.4Φ로 세립해지며, 해안선의 수직방향으로는 포말대(swash zone)에서 상대적으로 세립한 구형의 퇴적물(−4.5Φ)이, 범(berm)에서는 상대적으로 조립하고 편평한 퇴적물(−5Φ - −6Φ)이 나타난다. 감지 자갈해빈은 특징적으로 2열의 범을 갖는데, 해빈의 전방에 정상조건에서 형성되는 하부 범(lower berm)과 약 10 m 후방에 상부 범(upper berm)이 존재한다. 태풍 콩레이 내습 후 감지해빈은 육지쪽에 위치한 상부 범에서 약 1.4 m의 침식이 발생하여 상부 범이 사라졌고, 상부 범의 배후지에서는 평균 약 50 cm 침식되어 그 고도가 낮아졌으나, 하부 범에서의 침식은 관찰되지 않았다. 한편 상대적으로 위력이 약한 태풍 다나스의 경우, 내습 직후 감지해빈은 하부 범과 상부 범에서 침식이 발생하여 평균 80 cm 높이의 퇴적물이 침식되었으나, 반면 배후지에서는 50 cm 높이의 퇴적이 확인되었다. 하지만 내습 후 하부 범에서 빠른 속도로 퇴적이 발생하여 내습 약 3일 내에 소실되었던 하부 범이 생성되었다. 이러한 결과는 감지 자갈해빈이 태풍에 의한 지형변화가 일시적으로 발생하지만, 이후 정상조건에서 태풍 이전의 지형으로 매우 빠르게 회복됨을 시사한다. 따라서 자갈해빈의 경우 태풍침식에 대한 복원력이 매우 뛰어나다고 평가된다.