A one-year-old, intact male Maltese was referred with dehydration, anorexia, and marked hyperglycemia. The dog had been managed due to meningoencephalitis of unknown etiology (MUE) for three months. The dog had been treated with long-term prednisolone administration. Diabetic ketoacidosis (DKA) was identified based on the blood chemistry and venous gas analyses, and intensive treatments including insulin administration were initiated. On further examinations, there was no any other disease that contributed to the occurrence of DKA. Insulin resistance resulted from the administration of prednisolone was highly suspected, but the agent could not be tapered due to managing MUE. Following resolution of DKA, the dog was discharged with life-long insulin and prednisolone therapy. Over the next two years, the dog continued to be routinely re-evaluated and was managed with permanent insulin therapy (0.8–1.4 units/kg SC 12 hourly) and medications including prednisolone (0.4–1.1 mg/kg PO 12 hourly). Because MUE severely progressed, the dog was euthanized by owner’s request. Histopathologic examination of pancreas obtained by post-mortem revealed that both endo- and exocrine pancreas was within normal limit. The case described herein showed the risk of ketoacidosis as well as hyperglycemia after long-term prednisolone administration in a dog without pancreatic islet pathology.

본 연구는 아유르베다와 중국전통의학에서 바라보는 질병에 대한 병리적 이해를 비교하였다. 두 전통의학은 고대로부터 내려온 의학체계로 수많은 유형의 질병을 극복하여 온 역사적 기록들로 이루어져 있다. 아유르베다에서는 질병의 원인으로 심신의 잘못된 사용과 감각기관의 과잉 사용 혹은 부족한 사용과 자연을 거스르는 행동으로 꼽았다. 중국전통의 학에서는 질병의 원인을 외인으로 외부 사기의 침범, 내인으로 칠정의 손상, 불내인으로 외상과 음식 및 과로라고 보았다. 질병의 발현을 보는 관점도 차이가 있다. 아유르베다에서는 도샤의 불균형을 질병 발현의 핵심으로 본다. 반면에 중국전통의학에서는 음양의 평형이 파괴되는 것을 주요인으로 본다. 질병의 발전과 변화단계를 보면, 아유르베다에서는 6단계로 나눈다. 도샤의 불균형, 자극단계, 분산, 재배치, 출현단계이며 마지막으로 분화단계는 합병증이 발생하는 단계이다. 중국전통의학에서 질병의 발전과 변화단계를 살펴보면, 사기와 정기의 변화단계를 거쳐 음양 평형의 파괴 단계, 기혈의 병리 변화단계, 생리 장애단계 이며 마지막으로 장부의 병기 발생단계로 나눈다. 두 전통의학에서는 건강한 삶을 위해서는 질병의 원인이 되는 행동이나 환경으로부터 주의가 필요하며, 질병 발현의 초기 단계에서 불균형을 인식하고 더이상 진행이 되지 못하게 하는 것에 주력해야 함을 강조하고 있다.

The longhorned tick, Haemaphysalis longicornis, is one of the vectors of severe fever with thrombocytopenia syndrome virus (SFTSV) in human. The use of pyrethroid insecticides induced pest resistance and environmental residual toxicity. Here in this work, our interest was given to the selection of highly virulent fungi against longhorned tick. A total of 101 fungal pathogens were assayed by dipping the nymph stage of ticks into a conidial suspension. Interestingly of the several species, one species showed high virulence and mycosis were observed in 7-15 days. Highly virulent strains were selected, and semi-field experiments were conducted. As a result, the control efficacy of the isolate was over 80% at 30 days of treatment. This work suggests that entomopathogenic fungi could be used to effectively control longhorend ticks.

Japanese pine sawyer, Monochamus alternatus HOPE (Coleoptera: Cerambycidae) are considered as important pine forestinsect pests in several countries which transmits the pine wood nematode, Bursaphelenchus xylophylus. In this study, wetried to control Japanese pine sawyer using entomopathogenic fungi to prevent the spread of pine wilt disease in Korea.Several entomopathogenic fungi were exposed to the adults of Japanese pine sawyer and mycosis was observed in themembranous cuticles after 6 days. In particular, two isolates showed high virulence against the adults. The selected 2isolates were sprayed to the adults at 1×105, 1×106 and 1×107 conidia/ml. In the concentration of 1×107 conidia/ml, thesurvival rates of insects were 40% and 47%, respectively. Based on these results, the possibility of controlling the Japanesepine sawyer was confirmed.

The hard tick, Haemaphysalis longicornis (Ixodida: Ixodidae) is one of the vectors of severe fever with thrombocytopeniasyndrome virus (SFTSV) causing in humans, however little consideration was given to the biological control of the pest.We evaluated three bioassay methods, such as spray, dipping and dropping. As a result, the dipping method was themost efficient way to measure the fungal virulence. Finally, we constructed a Haemaphysalis longicornis pathogenic fungallibrary to further facilitate the resources to be used as potential biological control agents. A conidial suspension of 1×107conidia/ml was exposed to the ticks by dipping. We confirmed that some isolates were highly virulent to the ticks. Thisresults indicated that some fungi could be used to effectively control the Haemaphysalis longicornis.

The purpose of this study was to examine the state of the articles in the Korean Journal of Oral and Maxillofacial Pathology and overall research trends in this field in an effort to grasp the reality of the Journal and suggest some of the right directions for the development of research in this field. 332 articles that were printed in the Korean Journal of Oral and Maxillofacial Pathology over the past decade (2003-2012) were selected for the purpose of analysis. As a result of analysing the 332 articles in 52 issues of the Journal, it's found that a mean of 6.3 articles were contained in each issue. As for the form of article, original articles was more common than case reports, which were respectively used in 275 articles (82.8%) and 57 articles (17.2%). Concerning research methods by year, cell culture was most prevailing (124 articles, 37.3%), followed by clinicopathologic study (68, 20.5%), case report (62, 18.8%), animal experiments (28, 8.4%), clinical trial study (28, 8.4%) and others (22, 6.6%). As to the number of researchers, the majority of the articles were written by two or more researchers. The most common number of researchers was three (66 articles, 19.9%), and the number of the articles written by two (49, 14.8%) was similar to that of the articles written by four (47, 14.2%). 38 articles (11.4%) were written by eight researchers or more. Regarding the language of the articles, Korean was used in 213 articles (64.2%), and English was used in 119 articles (35.8%). As for the number of references, this number ranged from a low of zero(in the articles related to the history of pathology) to a high of 71, and the average number of references was 27.91. In relation to the themes of research, the largest number of the articles (47, 32.6%) dealt with oral squamous cell carcinoma, followed by diseases related to odontogenic carcinoma (21, 14.5%), diseases related to odontogenic cyst (17, 11.7%), salivary gland tumor (seven, 4.8%) and granuloma (five, 3.5%). The efforts by this study to explore the shifts of articles and recent research trends are expected to provide useful information on how to accelerate the identity building of this journal and the development of research in oral and maxillofacial pathology.

Purpose: Yin-Yan(陰陽) is often seen with the mean of ascending and descending force in the Sasang Constitutional Medicine. In the PI(脾) and Shen(腎), oppositive interacting forces existe and causes the change that ascending and descending of Yin-Yan(陰陽). The purpose of this study is understand the mean of Pi-Yan(脾陽), Pi-Yin(脾陰), Shen-Yan(腎陽), Shen-Yin(腎陰) and their inter action in the pathology of Soyangin(少陽人) and Soumin(少陰人). Method: It was depended on the sentence that recorded in the Dongyi-Soose-Bowon(東醫壽世保元) Result: The following results have been obtained 1. The origen of Soumin's outer disease is ascending obstruction of Shen-Yan(腎陽), caused by deficiency of Pi-Yan(脾陽) 2. The origen of Soumin's interior disease is being cold of Shen-Yin(腎陰), caused by deficiency of Pi-Yin(脾陰) 3. The origen of Soyangin's outer disease is descending obstruction of Pi-Yin(脾陰), caused by deficiency of Shen-Yin(腎陰) 4. The origen of Soyangin's interior disease is being heat of Pi-Yan(脾陽), caused by deficiency of Shen-Yan(腎陽)