In this study, vibrational characteristics of upright breakwater under wave condition is numerically analyzed. Firstly, finite element model of upright breakwater which composed by structure-foundation system is established. Dynamic behavior of the upright breakwater’s structure-foundation system is analyzed. Secondly, numerical model for wave field is created. Wave pressure is extracted to apply for the upright breakwater model as the excitation force. Both of design wave and small wave are considered. Thirdly, the vibrational responses are extracted from the upright breakwater model and there model parameters are extracted. Finally, the effect of the wave condition on vibration characteristics of upright breakwater is examined.

The motivation of this paper is to identify the variation of stress filed in multi-strand tendon anchorage system using electromechanical impedance measurement. To achieve the objective, the following approaches are implemented. Firstly, stress variation in multi-strand anchorage system due to strand breakage is analyzed to determine the location of impedance acquisition. Secondly, a piezoelectric-based interface technique is designed to localize the damage strand. Lastly, the conceptual design of the PZT-interface is preliminarily verified by an experimental test. Impedance signatures obtained from PZT-interface are quantified by using RMSD index (root-mean-square-deviation). The result shows that the PZT-interface technique is promisingly to identify damage strands.

In this paper, a soft robotic arm which can prevent impact injury during human-robot interaction is introduced. Two degrees of freedom joint are required to realize free movement of the robotic arm. A robotic joint concept with a single degree of freedom is presented using simple inflatable elements, and then extended to form a robotic joint with two degrees of freedom joint using similar manufacturing methods. The robotic joint with a single degree of freedom has a joint angle of 0° bending angle when both chamber are inflated at equal pressures and maximum bending angles of 28.4° and 27.1° when a single chamber if inflated. The robotic joint with two degrees of freedom also has a bending angle of 0° in both direction when all three chambers are inflated at equal pressures. When either one or two chambers were pressurized, the robotic joint performed bending towards the uninflated chambers.

Background : Obesity, a global health problem and a chronic diseases, is associated with increased risk of developing type 2 diabetes and coronary heart diseases. A wide variety of natural remedies have been explored for their obesity treatment potential. To elucidate the anti-obesity effect of ginsenoside Rg5 : Rk1 (Rg5 : Rk1), a mixture of protopanaxadiol type ginsenosides isolated from Panax ginseng Meyer in a 3T3-L1 adipocytes. Methods and Results : In order to determinate the anti-obesity effect of Rg5 : Rk1, Oil Red O staining and triglyceride (TG) content was assessed. Furthermore, to elucidate the possible mechanism whether Rg5:Rk1 affects lipid accumulation, mRNA and protein expression analyses of adipocyte markers such as STAT3, PPARγ, CBEPα and ap2 were carried out. Rg5:Rk1 treatment showed an inhibition of lipid droplet accumulation and decrease on TG content. In addition, expression of STAT3, PPARγ, CEBPα and ap2 were decreased in dose dependent manner. Similar to these results, Rg5:Rk1 treatment reduced PPARγ and CEBPα protein expression. Conclusion : Rg5 : Rk1 treatment exhibits anti-adipogenic activity by down-regulation of the STAT3PPARγ/CEBPα pathway in 3T3-L1 adipocyte cell line.

Background : Nowadays obesity has increased dramatically in developed countries which lead various metabolic disorders such as type 2 diabetes, hypertension, cancer, and the risk of stroke. Thus, looking forward a new chemical entity from natural sources which have a strong potential of anti-lipid regulation activity. Recently, protein based nanomedicine offers a new approach to treat a number of diseases including metabolic disorder such as obesity. In this study we evaluated the anti-lipid regulation effect of nano-carrier Bovine serum albumin and Mesoporous silica (MSNPs) conjugated ginsenoside F1 in 3T3-L1adipocytes and HepG2 hepatocytes. Methods and Results : BSA incorporated drugs has been shown to protect the drug degredation as well as improvement bioavalilability. To assess the anti- adipogenic effect of BSA-F1 and MSNPs-F1 cell viability was investigated in different time point of cell cycle growth and the intracellular lipid accumulation was evaluated in mature adipocytes and hepatocytes by Oil red staining assay. In addition, transcriptional gene regulation was quantified by the real time PCR for targeting adipogenic genes such as PPARγ, STAT3, CEBPα, ap2 and aP2 as well as hepatogenic genes such as ACC, AMPK, FAS and PPARα. Moreover, protein expression was evaluated by immunoblotting assay. Conclusion : Altogether, the above results were confirmed that BSA-F1 at dose 25 μM exhibited the anti-adipogenesis effect by downregulating the major transcriptional factors PPAR γ/STAT3 in signalling in 3T3-L1 mature adipocytes and upregulated the fatty acid oxidative AMPK signaling in fatty acid induced HepG2 hepatocytes.

Background : Anemarrhena asphodeloides has efficacy such as anti-fungal, anti-cancerous, anti-inflammatory, anti-diabetic, Anti-UV etc. Metal nanoparticles are used for photo imaging, cancer resection and drug delivery etc in medical field. Therefore A. asphodeloides nanoparticles will be expected better efficacy for therapeutic properties in medical field. Methods and Results : The water extract of A. asphodeloides mediated the synthesis of Aa-AgNPs and Aa-AuNPs. Their characterized by several physicochemical techniques such as UV-Vis spectrophotometry, FE-TEM, EDX spectroscopy, SAED pattern, DLS size analysis, XRD analysis, and FTIR analysis. Both Aa-Ag/AuNPs were evaluated for cytotoxicity towards 3T3-L1, A549, HT29 and MCF7. Aa-AgNPs and Aa-Au NPs were found to be spherical, face-centered cubic nanocrystals with hydrodynamic diameter of 190 and 258 ㎚. In vitro cytotoxic analysis revealed that up to 50 ㎍/㎖-1 concentration Aa-Au NPs did not exhibit any toxicity on 3T3-L1, HT29 and MCF7 cell lines, while being specifically cytotoxic to A549 cell line. On the contrary, Aa-Ag NPs displayed a significantly higher toxicity in all cell lines specially MCF7 cell line. ROS generation was not affected by Aa-Au NPs, but Aa-AgNPs has a higher potential to induce oxidative stress in A549 cells than HT29 and MCF7 cells. Aa-Au NPs have the potential for anticancer agent during lung cancer treatment. Aa-AgNPs is also exhibited to inhibit cell migration by induce oxidatie stress. Conclusion : The Aa-Au/AgNPs might have the anticancer potential and might be effective in the lung cancer therapy, however further evaluation is must needed.

The talking head (TH) indicates an utterance face animation generated based on text and voice input. In this paper, we propose the generation method of TH with facial expression and intonation by speech input only. The problem of generating TH from speech can be regarded as a regression problem from the acoustic feature sequence to the facial code sequence which is a low dimensional vector representation that can efficiently encode and decode a face image. This regression was modeled by bidirectional RNN and trained by using SAVEE database of the front utterance face animation database as training data. The proposed method is able to generate TH with facial expression and intonation TH by using acoustic features such as MFCC, dynamic elements of MFCC, energy, and F0. According to the experiments, the configuration of the BLSTM layer of the first and second layers of bidirectional RNN was able to predict the face code best. For the evaluation, a questionnaire survey was conducted for 62 persons who watched TH animations, generated by the proposed method and the previous method. As a result, 77% of the respondents answered that the proposed method generated TH, which matches well with the speech.

본 논문은 음악의 감성을 시각화하는 새로운 방법을 제안하는 논문으로 시각화를 위하여 감성 LED조명 제어 시스템을 고안하였으며 이 시스템은 청중들의 음악 경험을 더욱 풍요롭게 하기 위함에 목적이 있다. 이 시스템은 기존 연구의 음악 감성 분석 알고리즘을 이용하였는데 하나의 음악에서 하나의 감성을 추출하는 기존 연구의 한계를 보완하고자 음악의 1초당 세그먼트에서 감 성을 추출 하여 감성 변화를 감지하는 방법을 연구하였다. 또한 LED조명의 감성 컬러는 IRI컬러 모델과 Thayer의 감성 모델을 기초로 새로운 감성 컬러 36가지를 정의 하여 각 감성에 맞는 색 으로 연출 할 수 있도록 구성하고 애니메이션과 더불어 감성 LED 조명으로 표현 할 수 있도록 하였다. 이 시스템의 검증을 위한 실험 결과, 듣는이의 감성과 감성 LED 조명 시스템의 감성 일 치율이 60% 이상으로 향후 음악 감성 기반 서비스의 중요한 밑거름이 될 것으로 보인다.

This study suggests a plan to expand the rural experience program linked to natural disaster through the case analysis of the village of Garisan-ri, Inje-gun, Gangwon-do, Republic of Korea. This will help to establish the necessary improving and policies for Re-leap of rural villages in disaster areas and activation of rural experience villages. The local residents have created flood recovery stories, disaster response content, and disaster prevention camp sites, all of which have been hit by serious disaster damage. It has also contributed to the revitalization of the village by providing various experience programs such as disaster response training, crossing rapids, and evacuation experience. This is a way to get rid of the negative perception of disaster and utilize it. The conversion of idea through disaster experience content contributed to the activation of the area. By linking the disaster experience contents to the rural experience program in the future, it can be helpful to avoid the duplication of contents and limit the similar operation method, which is an existing problem of rural experience villages.

A new Rehmannia glutinosa cultivar ‘Tokang’ was derived from ‘Jihwang 1’ seedlings by medicinal crop breeding team of National Institute of Horticulture and Herbal Science, RDA in 2009. It has pink flower, dark brown seed coat, light yellow root cortex. The plant type was some rising from the ground. The content of catalpol and extract were higher than the ‘Jihwang 1’(check variety). The content of catalpol was 4.55% and the extract was 71.2%. It showed stronger resistance to root rot compare with the ‘Jihwang 1’. The regional yield trials were conducted at three different locations from 2007 to 2009. The average yield of ‘Tokang’ was 21.1ton/ha, which was 12% more than the ‘Jihwang 1’. This cultivar is adaptable to the whole of Korea except for mountain areas. (Registration No. 4725)

This study was investigated to develop mass evaluation system for the contents of crude protein, oil and fatty acid in soybean germplasm using NIRS. NIRS equations were created with 345 soybeans, multiple correlation coefficients of crude protein, oil, palmitic, stearic, oleic, linoleic and linolenic acid between data obtained from NIRS and quantitative analysis were 0.983, 0.969, 0.592, 0.514, 0.978, 0.961 and 0.957, respectively. Equation statistics indicated that contents of crude protein, oil and unsaturated fatty acid except palmitic and stearic acid in soybean seed were suitable for determination by NIRS. Those NIRS equations were applied to examine crude protein, oil and unsaturated fatty acid of 854 soybean landraces from Korea. The average contents and ranges of crude protein and oil were 39.2% with a range of 33.7-47.0% and 15.0% with a range of 9.8-20.3%, individually. In addition, those of oleic, linoleic and linolenic acid were 21.4% with a range of 12.1-30.2%, 55.6% with a 47.8-62.3% and 8.1% with a range of 5.9-10.7% respectively. We conducted quantitative analysis to reconfirm with IT154552 (45.1%) and IT023955(46.9%) above 45% of crude protein, the results were similar from NIRS (45.2%, 47.0%). NIRS data for protein from this study made no difference with lab data, which would be useful for mass evaluation. There was negative correlation (-0.203) between crude protein and oil, positive correlation (0.379) between crude oil and oleic acid, and significantly negative correlation (-0.879) between oleic and linoleic acid.

Demand for the development of non-antibiotic growth promoters (AGP) in animal production surged in recent years. However, elucidating the specific mechanisms and action of prebiotics, probiotics, and synbiotics as non-AGP in animals is still in progress. This work investigated and compared faecal microbiotas of weaned piglets under the administration of a basal diet (CON) and with prebiotic lactulose (LAC), probiotic Enterococcus faecium NCIMB 11181 (PRO), or their synbiotic combination (SYN). Although prebiotics and/or probiotics in the diet significantly increased alpha-diversity compared with CON values, no differences were detected in richness and diversity values among the treatment groups (LAC, PRO, and SYN). At phylum level, the Firmicutes to Bacteroidetes ratio increased in the treatment groups in comparison to the CON group, and the lowest abundance of Proteobacteria was found in LAC group. At family level, Enterobacteriaceae decreased in all treatments, especially more than 10-fold reduction in LAC group compared with CON group. At genus level, the highest abundance of Oscillibacter was detected in PRO group, the highest Clostridium in LAC group, and the highest Lactobacillus in SYN group; the abundance of Escherichia was lowest in LAC group. Clustering in the DAPC plots illustrated distinct separation of the feeding groups (CON, LAC, PRO, and SYN) from one another, showing that microbial communities had different compositions according to different feed additives. Effects of LAC and PRO treatments on the faecal microbiota suggest independent mechanisms; nonetheless, the impact of SYN might also be distinct from that when each are administered singly as LAC or PRO.

해상교량의 선박충돌 문제는 기본적으로 선박의 충격력에 의한 부가 하중의 빈도를 추정하는 것이므로 특정한 수용 기준을 만족하 도록 설계하는 것도 중요하지만 공용기간동안 이러한 충돌 위험의 증가분을 어떻게 유지관리 해야 하는지도 매우 중요하다. 본 논문에서는 인 천대교를 대상으로 선박충돌 문제에 대한 중간점검을 위하여 관련 계획, 주경간장, 형하고 및 충돌 위험도를 검토하였다. 특히, 충돌 위험의 증 가분에 대하여 근시적인 해결방안으로 관련 연구결과 및 운항관련 지침 등을 검토하여 최적화된 운항 속도를 8노트로 제시하였으며, 근본적인 해결방안으로 설계 단계에서 대상선박 및 통행량의 합리적인 예측을 위한 기본 절차를 수립하고 예측의 불확실성을 수용할 수 있는 확률론적 예측 기법을 제안하였다. 향후 선박충돌 관련 유지관리에 대한 추가적인 연구와 공용중인 다른 해상교량의 즉각적인 중간점검이 필요할 것으 로 판단된다.

Elemental mercury has a very high volatility allowing easy dissipation from water or soil into air. To better understand how the kinetics of diffusion of elemental mercury through a medium, which is soil in this study, a mercury diffusion column experiment was done. The correlation between temperature and equilibrium concentrations of mercury in standardized soil samples and a pure mercury standard were determined. Total mercury concentrations were analysed using CVAFS. The effect of time and soil depth to the kinetics of mercury diffusion were determined. Differences in mercury concentrations at different sampling probes were observed during the first few gas phase analyses. Equilibrium was reached through the column after 72 hours.

The probabilistic prediction method and procedure of ships traffic for reasonably considering the enlargement of ships and increase in the large vessels of the vessel were established in this paper. However the problem related on prediction method, confidence intervals and selecting the target tonnage considering the enlargement of ship for prediction of ships is lack of results such as design example and study case. Therefore it requires various methodological study.