Wolfiporia cocos is an edible fungus commercially cultivated in Asia. To investigate metabolic changes of W. cocos mycelia under both light and dark culture conditions, gas chromatography mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) analyses were performed. In terms of the total amount of sugars, alcohols, amino acids, organic acids, fatty acids, and purines, there no significant differences between the W. cocos mycelia cultivated under light (L) or dark (D) conditions (p < 0.05). However, there were some differences with respect to the production of particular sugars and proteins. The levels of trehalose (L: 17.2 ± 0.3% vs. D: 13.9 ± 1.6%), maltose (L: 0.9 ± 0.1% vs. D: 0.3 ± 0.1%), turanose (L: 0.7 ± 0.2% vs. D: 0.1 ± 0.1%), glutamine (L: 1.6 ± 0.3% vs. D: 0.7 ± 0.2%), and proline (L: 0.3 ± 0% vs. D: 0.1 ± 0%) were all significantly higher under light condition (p < 0.05). In contrast, the levels of galactose (L: 13.7 ± 1.2% vs. D: 17.6 ± 2.0%), aspartic acid (L: 0.6 ± 0.1 % vs. D: 0.9 ± 0.1%), cystathionine (L: 0.6 ± 0.1% vs. D: 0.8 ± 0 %), and malic acid (L: 0.7 ± 0.1% vs. D: 1.2 ± 0.1%) were higher under the dark condition. It is worth noting that the amount of pachymic acid, a pharmaceutically active compound of W. cocos, was 1.68 times greater under the light condition (p < 0.05).

Following the previous study, the toxicity of a single subcutaneous administration of the Thyrokitty injection (I-131) and the side effects that may occur at therapeutic doses were confirmed. The Thyrokitty injection (I-131) was administered subcutaneously once at a dose of 0, 2.0, 6.0, and 18.0 mCi/kg, 5 male and female rats per group, and mortality, general symptom observation, and weight measurement were performed for 2 weeks, followed by observation of autopsy findings. There were no deaths, and no statistically significant weight change was observed. Mild hair loss, fissures, and crusting were observed by general symptom observation, but it was not a toxic change related to the Thyrokitty injection (I-131). Gastric atrophy and a decrease in the size of the spleen were observed by the autopsy. As a results of single subcutaneous administration of the Thyrokitty Injection (I-131) to rats at a maximum dose of 18.0 mCi/kg, a decrease in the size of the spleen and gastric atrophy were observed as the dose of the Thyrokitty Injection (I-131) increased, which may be related to the test substance. No abnormal findings related to the Thyrokitty injection (I-131) were observed. Therefore, the approximate lethal dose of the Thyrokitty injection (I-131) was 18.0 mCi/kg or more. In addition, as reported for the treatment of feline hyperthyroidism with radioiodine (131I), side effects of the Thyrokitty injection (I-131) are expected to be extremely rare. Temporary dysphagia and fever may occur, but it will recover naturally. It should be administered with caution in cats with diseases such as urinary system, cardiovascular system, gastrointestinal system and endocrine system, especially with kidney disease. And it should not be used in cats who are pregnant, lactating, or likely. It is expected that the Thyrokitty injection (I-131) can be used for clinical treatment in Korea as a veterinary drug.

Radioiodine (131I) has been used for the treatment of feline hyperthyroidism since the 1990s in the USA and Europe, and it is recommended as the most effective treatment for feline hyperthyroidism because it has a high therapeutic effect, small side effects, and does not require anesthesia. In this study, the pharmacological properties of the Thyrokitty injection (I-131), which is being developed as a treatment for feline hyperthyroidism, using radioiodine (131I) as an active ingredient, was tested. The %cell uptake of the Thyrokitty injection (I-131) in FRTL- 5 thyroid cells was 0.410 ± 0.016%, which was about 18 times higher compared to Clone 9 hepatocytes, and it was decreased by 30.7% due to the competitive reaction with iodine (sodium iodide). In addition, the %cell growth of the FRTL-5 thyroid cells was reduced by 25.0% by treatment with the Thyrokitty injection (I-131). As a result of the tissue distribution test, the Thyrokitty injection (I-131) was distributed at the highest concentration at 0.083 hours (5 minutes) after subcutaneous administration to animals in most organs except the stomach, small intestine, large intestine, muscle and thyroid gland, and it was excreted mainly through the kidneys. The stomach and thyroid gland showed a typical distribution pattern observed when radioiodine (131I) was administered. In addition, about 78.45% of the total amount of excretion was excreted within 48 hours, of which more than 85% was excreted in urine. In conclusion, the Thyrokitty injection (I-131) has the same mechanism of action, potency, absorption, distribution, metabolism and excretion characteristics as radioiodine (131I) reported in connection with the treatment of feline hyperthyroidism. In the future, using the results of this study, it is expected that the Thyrokitty (I-131) could be safely used in the clinical treatment of feline hyperthyroidism.

Ticks and tick-borne pathogens are among the main sources of interest in veterinary medicine and public health. This review aimed to cover published data on tick species and their geographical distribution in Korea. Over 143 articles regarding ticks were published between 1966 and 2022, and reporting at least 29 species belonging to the family Ixodidae and five belonging to the family Argasidae. Among these, Haemaphysalis longicornis, H. flava, and Ixodes nipponensis were the main genera distributed nationwide, whereas Amblyomma was mostly identified in the southern region. Conversely, only a limited number of Argasidae ticks were present, including the genera Argas and Ornithodoros. Considering the changes in tick distribution patterns due to global warming, continuous nationwide monitoring of ticks is required.

Diabetic encephalopathy is a major complication with cognitive impairment and neurodegeneration in patients with type 1 or type 2 diabetes mellitus (DM). DM-induced glucolipotoxicity is a risk factor for Alzheimer’s disease–like phenotype, including amyloidogenesis, tau hyperphosphorylation, and neuronal apoptosis. Although the detailed mechanism underlying the pathogenesis of diabetic encephalopathy remains unclear, mitochondrial oxidative stress is emerging as a key factor for diabetic complications and neurodegeneration. A deeper understanding of the regulatory mechanism of mitochondrial oxidative stress under hyperglycemic conditions will provide insights into the development of therapeutic strategies for diabetic encephalopathy. Here, we review the role of mitochondrial oxidative stress in diabetic encephalopathy and the regulatory mechanisms by which high glucose induces the generation of mitochondrial reactive species oxygen species in neuronal cells. This review also summarizes the mitochondrial-dependent and -independent pathways (O-linked-N-acetylglucosaminylation, calcium, and glycogen synthase kinase 3β signaling) that regulate mitochondrial oxidative stress in a DM model.

Automatic question-answering is a classical problem in natural language processing, which aims at designing systems that can automatically answer a question, in the same way as human does. The need to query information content available in various formats including structured and unstructured data has become increasingly important. Thus, Question Answering Systems (QAS) are essential to satisfy this need. QAS aim at satisfying users who are looking to answer a specific question in natural language.Moreover, it is a representative of open domain QA systems, where the answer selection process leans on syntactic and semantic similarities between the question and the answering text snippets. Such approach is specifically oriented to languages with fine grained syntactic and morphologic features that help to guide the correct QA match. Furthermore, word and sentence embedding have become an essential part of any Deep-Learning-based natural language processing systems as they encode words and sentences in fixed-length dense vectors to drastically improve the processing of textual data. The paper will concentrate on incorporating the sentence embedding with its various techniques like Infersent, ElMo and BERT in the construction of Question Answering systems, and also it can be used in game play.

James S. Gale (1863-1937), a Protestant missionary to Korea (1888~1927), was well-known for his extensive and profound influence on Korean studies and for his translation of the Cloud Dream of Nine (九雲夢), which was the first Korean classical novel translated into English by a Westerner. However, it is not well-known that Gale published a translation of the Great Learning (Daxue, 1924) and arranged for the publication of the Mean of the Doctrine, the Analects and Mencius. This is because it was known that Gale regarded Chinese characters and Confucian scriptures as obstacles to establishing the Christianity during his early period of mission in Korea. This paper examined the change of Gale’s perspective of Chinese characters and the characteristics of Gale’s Daxue. The analysis compares Gale and James Legg in their translations of the Chinese characters ‘命,’ ‘天,’ ‘明’ and ‘君子’ He employed the pure Korean word ‘Hananim’ for ‘God’ from a traditional Korean religion and its Korean etymology, while he rejected the use of Sino-Korean ‘Sangje上帝’, or ‘Chunju天主’ in the Korean Bible. Gale subsequently translated Daxue from a Korean point of view. However, his Korean perspective is mingled with Christianized concepts, which are illustrated in his translation of ‘命’ as ‘God’s command’ ‘天’ as ‘God’ ‘明’ as ‘glory,’ and ‘君子’ as ‘good man’ and ‘godly man.’

This study addresses the lack of comprehension data in second language acquisition research by focusing on English existential there-constructions (ETCs) with a locative extension (e.g., there is an X on the Y). The post-copular noun X used in the present study consisted of two types: actual and nonsense. Participants included 40 native speakers, as well as 40 advanced and 40 intermediate Korean learners of English, who completed an online picture selection task. In one picture, X was placed on the nearby Y; in another picture, X was placed on the far Y. The choice of both pictures was the correct response because ETCs are used to describe the existence of something regardless of its distance. There was a statistically significant relationship between English proficiency and the interpretation of ETCs. However, there was no relationship between the noun type and the interpretation of ETCs. In the Korean English curriculum, the distinction between expletive there and locative there must be emphasized.

Nearpod, an online teaching cloud-based platform, offers great potential to generate pedagogical tasks and yield better results in teaching communication skills. This study thus examined the effects of Nearpod-based English-speaking classes. To this end, one-on-one speaking tests were conducted twice in a semester, and a questionnaire was administered to assess university students’ perceptions of the usefulness of Nearpod in offline classroom. The participants comprised 39 university students who took a mandatory English class titled Communication in English. The paired samples t-test results indicated that the students’ overall speaking performance has improved over time. Specifically, compared to the high-level students, the low-level students showed a significant increase in speaking performance. The questionnaire analysis demonstrated that most students were satisfied with Nearpod-based English speaking classes because of enhanced interest, active participation in class, and increased interaction with class content and peers. The pedagogical implications are suggested and the limitations of the study are further discussed.

PURPOSES : The aim of this study is to evaluate the effects of air voids, binder content, and aggregate gradation on the indirect tensile strength (IDT) and cracking tolerance index (CTindex) of cored asphalt pavements. METHODS : Cored samples were obtained from roads in Incheon city, and several laboratory experiments were performed. First, the cored samples were first to cut into a size appropriate for the IDT test. Subsequently, the air voids of the samples were measured. The damaged sample from the IDT test was loose mixed at 150 ℃ before the binder content was determined, which was conducted via an asphalt extraction test. Finally, the clean aggregates obtained from asphalt extraction process were analyzed in the aggregate gradation test. RESULTS : The result shows that an increase in air voids from 4% to 8% decreases the IDT and cracking tolerance index (CTindex) by 30% and 28%, respectively. Incorporating a binder enhances the ductile behavior of the asphalt mixture, resulting in a higher CTindex. Finally, the contribution of the aggregate grade on the IDT and CTindex is negligible. CONCLUSIONS : The IDT and CTindex are primarily affected by the air voids and binder content. A higher percentage of air voids results in a lower IDT. In addition, a higher amount of binder increases the IDT and CTindex of the cored samples. Meanwhile, the aggregate grade does not affect the IDT.

본 연구에서 Tetraneura triangula 를 국내에서 처음으로 보고한다. 이 종의 분포지역, 기주식물, 형태학적 정보를 제공하였다.

본 연구에서 Kaltenbachiella japonica를 국내에서 처음으로 보고한다. 이 종의 분포지역, 기주식물, 형태학적 정보를 제공하였다.

선박의 운항이 유인(有人)으로부터 무인(無人)상태로 변화함에 관한 새로운 기술의 등장은, 사람의 탑승을 전제로 하여 마련되었던 전통적인 법적 패러다 임의 근본적인 변화를 가져오게 될 것이다. 본 논문은 자율운항 선박의 AI 및 사이버보안과 같은 신기술이 영국 법제하에서 책임 및 해상보험에 어떠한 영향 을 미칠지에 특히 관심을 기울이고자 하였다. 자율운항선박의 개념에 관하여 간단히 소개를 한 뒤, 영국 법과 법원이 자율주행차량 및 자율운항기체에 관해 어떠한 입장을 가지고 있는지와 자율주행차량의 보험제도 등을 다루기 위해 새 로이 입법된 영국 Automated and Electric Vehicles Act 2018을 소개한다. 영국법제하에서의 AI 책임 문제에 관하여서는 AI의 법적 지위에 기반하여, 패러다 임 시프트가 일어나는 동안의 현실과 법제의 괴리를 해소하기 위한 제안을 하 고자 노력하였다. 마지막으로, 해상보험 관련법의 해석 관련, AI 및 사이버보안 등은 자율운항선박 감항성의 요인으로서 묵시적 보증의 요소가 될 수 있으며 나아가 예측가능하지 않은 수준의 사이버보안 문제 등도 부보가능한 위험으로 해석하여야 함을 밝히고자 하였다. 다시 말해, 본 논문의 목적은 신기술이 영국 법제하에서 자율운항선박 관련 영향을 미칠 수 있는 분야를 개괄적으로 제시하 고 그에 관하여 발생할 수 있는 법적 문제를 포괄적으로 정리하는 데에 있다고 하겠다.