목적: 간헐외사시의 비수술처치 효과에 관한 국내외 개별연구들을 대상으로 메타분석을 이용하여 현재까 지 연구 동향을 파악하고, 간헐외사시에 대한 비수술처치 효과의 방향과 크기를 바탕으로 임상적 및 이론적 의미를 제시하고자 하였다. 방법: 간헐외사시의 비수술처치 효과에 대한 논문들을 메타분석하기 위하여 1990년부터 2015년까지 발 표된 국내외 학위논문과 학술지를 대상으로 포함 및 배제 기준을 적용하여 15편을 선정하였다. 개별연구들 로부터 연구별 효과크기와 변량, 전체 효과크기를 산출하고 동질성을 검증한 후 처치변인별 하위요인의 효 과크기 차이를 검증하였다. 비수술처치에서 고려할 항목으로 치료 방법, 사시 유형, 연령 수준 등을 선정하 였으며, 각 항목이 간헐외사시의 치료에 미치는 효과를 구분하여 분석하였다. 결과: 간헐외사시의 치료를 위한 비수술처치 방법의 전체 효과크기는 -0.715이었다. 치료 방법의 효과크 기는 시기능훈련; -1.753, 혼합치료; -1.747, 굴절이상교정; -1.295, 마이너스렌즈 과교정; -0.500, 가림 치료; -0.281 순이었다. 사시 유형별 효과크기는 개산과다; -2.111, 폭주부족; -1.171, 기본형; -1.220 순 이었다. 연령별 효과크기는 13~19세; -2.029, 7~13세; -1.057, 4세 미만; -0.751, 및 4~7세; -0.379 순 이었다. 결론: 본 연구에서 제시된 효과크기들은 간헐외사시의 비수술처치에 의한 사시각 감소나 입체시 향상 등의 개선효과를 정량적으로 분석한 것이며, 이로부터 비수술처치의 객관적 타당성이 제시된 것으로 생각된다.

A 2-year-old female Maltese dog was presented with a history of anemia and vaginal hemorrhagic discharge. Physical examination revealed severe vaginal hemorrhagic discharge, abdominal pain, pale mucous membranes, low blood pressure and dehydration. Results of serum biochemistry, hematology, venous blood gas, and electrolyte canine C-reactive protein (CRP) test revealed severe normocytic normochromic anemia, severe neutropenia, a high level of CRP, hypoglycemia, and imbalanced electrolytes. Abdominal ultrasound examination showed focal hypoechoic defect with loss of layering in uterine horn wall. A laparotomy revealed a clear reddish fluid in the abdomen, the fistula of left and right uterine horn, the purulent discharge from fistula, and symptoms of septic peritonitis near by the fistula site. The bitch underwent ovariohysterectomy and recovered without complication. Histopathological diagnosis of the uterine fistula site was adenocarcinoma.

Cryopreservation of oocytes by vitrification technique may contribute a lot in the field of reproductive biotechnology. The objectives of the present study were to evaluate the effectiveness of two cryo-devices for vitrification of immature oocytes of indigenous zebu cows. Slaughter house derived immature cumulus-oocyte-complexes (COCs) of cows were vitrified using 15% dimethyl sulphoxide (DMSO) as cryoprotective agent (CPA) with 0.5 mol sucrose in TCM 199 supplemented with 20% FBS. Vitrification of COCs was completed after immediate plunging of COCs loaded cryotop or French mini straw into the liquid nitrogen (LN2). Then the COCs containing cryotop or French mini straws were warmed in 0.25 mol sucrose and 20% FBS supplemented TCM 199 followed by in vitro culture in 50 μl droplets of bicarbonate buffered TCM 199 supplemented with 10% FBS, pyruvate, FSH and oestradiol for 24 hrs at 39°C with 5% CO2 in humidified air. After maturation culture, oocytes were denuded and examined under inverted microscope for presence of polar body as the indication of maturation. Denuded oocytes were also stained by whole mount technique using 1% orcein to examine the maturation by presence of MII chromosomes. The in vitro maturation rate was significantly (p<0.05) higher in oocytes vitrified and warmed using crytop (47.1±6.9%) than that of French mini straw (15.9±12.5%). Moreover, in vitro maturation rate was significantly (p<0.05) highe r in control oocytes (not vitrified) (84.5±14.2%) than that of vitrified oocytes. In conclusion, cryotop is better than French mini straw as cryo-device for vitrification of bovine immature oocytes

방울토마토의 수경재배 중 붕소+칼슘+규소 및 칼슘+규소의 복합 엽면시비가 수확 후 품질과 MAP 저장 중 저장성에 미치는 영향을 알아보고자 본 연구를 실시하였다. 엽면시비한 방울 토마토(‘Unicorn’)는 반숙 과상태에서 수확하여 산소투과성 필름으로 포장한 5oC, 11oC, 그리고 24oC에서 25일, 15일, 10일간 저장하였다. 붕소+칼슘+규소 복합처리한 방울토마토가 3가지 저장온도 모두에서 호흡과 에틸렌 발생이 억제되어 MAP 저장중 가장 낮은 생체중 감소와 가장 높은 외관상 품질을 보였다. 수확 후 조사한 방울토마토의 경도, 산도, 비타민 C 함량은 붕소+칼슘+규소 복합처리에서 가장 높았으며, 3가지 온도 모두에서 MAP 저장 후에도 모두 높게 유지되었다. 그러나 과피색, 라이코펜 함량과 당도는 수확 후에는 엽면시비 처리로 차이가 없었으나, 3가지 온도 모두 붕소+칼슘+규소 복합처리에서 가장 낮은 수치를 보였다. 이상의 결과로 볼 때 붕소+칼슘+규소 복합처리는 방울토마토의 수확후 생리 작용을 억제하고 경도, 산도, 비타민 C 함량을 높여 저장성을 향상시키는 것으로 판단되었다

This study was designed to determine the effect of monosodium glutamate (MSG) on in vitro maturation (IVM) of oocytes and early development of parthenogenesis (PA) embryos in pigs. Each IVM and IVC medium was supplemented with various concentrations (0, 0.1, 0.5 and 5 mM) of MSG and non-essential amino acids (NEAA) depending on the experimental design. Immature pig oocytes were matured for 44 h and then oocytes reached metaphase II (MII) stage were electrically activated to induce parthenogenesis (PA). When immature oocytes were treated with MSG in the absence of NEAA during IVM, nuclear maturation (83.1-87.1%), intra-oocyte glutathione content, cumulus expansion, and cleavage (91.4-93.4%) of PA embryos were not influenced by MSG treatment at all concentrations. However, blastocyst formation of PA embryos was significantly increased by 5.0 mM MSG (45.3 ± 6.2%) compared to control (25.6 ± 3.4%). MSG treatment during IVM in the presence of NEAA did not show significant effect on nuclear maturation of oocytes and blastocyst formation after PA while 0.5 mM MSG (89.3 ± 1.9%) decreased (P < 0.05) cleavage of PA embryos compared to 0.1 mM MSG (94.6 ± 1.1%). When PA embryos were treated for 7 days with MSG during IVC, 5.0 mM MSG significantly decreased blastocyst formation (27.8 ± 4.9%) compared to no treatment (41.4 ± 1.9%) while no decrease in blastocyst formation was observed in 0.1 and 0.5 mM (37.4 ± 3.4% and 34.4 ± 2.6%, respectively). Our results demonstrated that 5 mM MSG in a NEAA-free chemically defined maturation medium showed positive effect on PA embryonic development while 5 mM MSG treatment during IVC was deleterious to PA embryonic development in pigs.

Mitochondrial dysfunction is found in oocytes and transmitted to offspring due to maternal obesity. Treatment of obese mothers with endoplasmic reticulum (ER) stress inhibitors such as salubrinal (SAL) can reverse the mitochondrial dysfunction and result in normal embryonic development. Pig oocytes have also shown ER stress mostly in metaphase II stage. ER stress in oocytes may hinder the in vitro production of pig embryos. This study investigated the effect of ER stress inhibition by SAL treatment during in vitro maturation (IVM) of porcine oocytes at 1, 10, 50 and 100 nM concentrations. Firstly, we tested various concentrations of SAL. SAL at 10 nM showed higher (P < 0.05) developmental competence to the blastocyst stage (55.6%) after parthenogenesis (PA) than control (44.2%) while not different from other concentrations (49.2, 51.6, and 50.8% for 1, 50, and 100 nM, respectively). Secondly, we performed time-dependent treatment at 10 nM of SAL for IVM of oocytes. It revealed that treatment with SAL during 22 to 44 h of IVM significantly improved PA embryonic development to the blastocyst stage compared to control (40.5, 46.3, 51.7 and 60.2% for control, 0 to 22 h, 22 to 44 h and 0 to 44 h of IVM, respectively, P < 0.05). Glutathione (GSH) content is an indicator of cytoplasmic maturation of oocytes. Reactive oxygen species (ROS) have a harmful effect on developmental competence of oocytes. For this, we determined the intraoocyte levels of GSH and ROS after 44 h of IVM. It was found that SAL increased intraoocyte GSH level and also decreased ROS level (P < 0.05). Finally, we performed somatic cell nuclear transfer (SCNT) after treating oocytes with 10 nM SAL during IVM. SAL treatment significantly improved blastocyst formation of SCNT embryos compared to control (39.6% vs. 24.7%, P < 0.05). Our results indicate that treatment of pig oocytes with ER stress inhibitor SAL during IVM improves preimplantation development PA and cloned pig embryos by influencing cytoplasmic maturation in terms of increased GSH content and decreased ROS level in IVM pig oocytes.

Shading is a key element in the control of light intensity and is usually used during the summer when sunlight is at its most intense. Succulents are ornamental crops that have beextremely popular because of their leaf structure and other characteristics. A study was conducted to determine the effects of shading on the growth and development as well as the anthocyanin content of two Echeveria species: Echeveria agavoides and E. marcus. Three levels of shading were used, namely no shading/full light treatment, partially shaded conditions, and well-shaded conditions, which were achieved by placement inside controlled growing chambers for 4 weeks. The results revealed the bolting of growth in both height and diameter for both species when grown under shaded and partially shaded conditions, which were abnormal compared withthe typical development. CIELAB color results also showed thata* was significantly affected by shading levels, exhibiting a higher positive value for succulents under full light or no shading. These results were consistent with the anthocyanin analysis, where the highest contents were identifiedinthe species grown under full light. The image analysis also confirmed a higher percentage area based on the smart segmentation for red pigments compared withthat for green pigments.

This study was conducted to determine the effects of light intensity on the growth and development as well as the anthocyanin content of two Echeveria species, namely Echeveria agavoides and E. marcus. Three light intensity levels (high, 150 μmol･m-2s-1; intermediate, 75 μmol･m-2s-1; and low, 35 μmol･m-2s-1) served as the treatments, which were replicated four times. The results revealed that the tallest and largest plants were those under low light conditions. It was observed that there was a decline as the light intensity increased, which is attributed to the coping mechanisms of plants to search for light sources, which has a similar effect to bolting or an increase in the node-to-node distance. CIELAB color values of L* and a* for both species were significantly affected by the light intensity, indicating changes in the lightness of hue and green-to-red color pigmentation in plants. These results were strongly reflected in those of the anthocyanin content analysis, where a direct increase in the concentration was observed with increasing light intensity. The results of the anthocyanin analysis were also supported by the histogram, smart segmentation images, as well as the ratio of red and green pigments found in the images. Thus, a high light intensity should be used to increase the quality and provide conducive growing conditions for both succulent species.

We present a study of the inexplicit connection between radio jet activity and γ-ray emission of BL Lacertae (BL Lac; 2200+420). We analyze the long-term millimeter activity of BL Lac via interferometric observations with the Korean VLBI Network (KVN) obtained at 22, 43, 86, and 129 GHz simultaneously over three years (from January 2013 to March 2016); during this time, two γ-ray outbursts (in November 2013 and March 2015) can be seen in γ-ray light curves obtained from Fermi observations. The KVN radio core is optically thick at least up to 86 GHz; there is indication that it might be optically thin at higher frequencies. To first order, the radio light curves decay exponentially over the time span covered by our observations, with decay timescales of 41185 days, 352±79 days, 310±57 days, and 283±55 days at 22, 43, 86, and 129 GHz, respectively. Assuming synchrotron cooling, a cooling time of around one year is consistent with magnetic field strengths B ∼ 2 μT and electron Lorentz factors γ ∼ 10 000. Taking into account that our formal measurement errors include intrinsic variability and thus over-estimate the statistical uncertainties, we nd that the decay timescale  scales with frequency τ ν - 0.2. This relation is much shallower than the one expected from opacity effects (core shift), but in agreement with the (sub-)mm radio core being a standing recollimation shock. We do not find convincing radio flux counterparts to the γ-ray outbursts. The spectral evolution is consistent with the `generalized shock model' of Valtaoja et al. (1992). A temporary increase in the core opacity and the emergence of a knot around the time of the second -ray event indicate that this γ-ray outburst might be an `orphan' are powered by the `ring of fire' mechanism.

Chlorine dioxide gas is a relatively new sanitizer in the food industry that has more accessibility than its aqueous form. Depending on the method by which ClO2 gas is generated, there can be byproducts like chlorite and chlorate ions, which can decrease its disinfectant effect and purity. Recently, new technology that generates chlorine dioxide without using chlorine gas has been developed to remove those defects. This new electrochemical method generates gaseous chlorine dioxide from aqueous sodium chlorite (NaClO2). The present study was conducted to evaluate the effects of ClO2 gas generated by an electrochemical method against foodborne microorganisms. To accomplish this, ClO2 gas at different concentrations (1, 5, 10 and 20 ppm) was applied to E. coli and S. Typhimurium for different exposure times (1, 5, 10, 15 and 20 min) under room temperature conditions at <40% relative humidity. The results revealed ClO2 gas was highly effective for the inactivation of E. coli and S. Typhimurium and showed a reduction in populations of over 5 log CFU/ml under ambient conditions with low relative humidity (30–40%). In conclusion, ClO2 gas treatment is highly applicable to control of foodborne pathogens.

Teeth and bones are highly mineralized tissues containing inorganic minerals such as calcium phosphate, and a growing number of evidences show that their mineral content is associated with many diseases. Although the quantification of mineral contents by micro-computed tomography(micro- CT) has been used in diagnosis and evaluation for treating bone diseases, its application for teeth diseases has not been well established. In this study, we attempted to estimate a usefulness of a high-resolution micro-CT in analysis of human teeth. The teeth were scanned by using the Skyscan 1172 micro-CT. In order to measure tooth mineral content, beam hardening effect of the machine was corrected with a radiopaque iodinecontaining substance, iodoacetamide. Under the maximum resolution of 6.6 μm, X-ray densities in teeth and hydroxyapatite standards were obtained with Hounsfield unit (HU), and they were then converted to an absolute mineral concentration by a CT Analyzer software. In enamel layer of cusp area, the mean mineral concentration was about 2.14 mg/mm3 and there was a constant mineral concentration gradient from the enamel surface to the dentinoenamel junction. In the dentin of middle 1/3 of tooth, the mean mineral concentration was approximately 1.27 mg/mm3 and there was a constant mineral concentration gradient from the outer of root to the pulp side, ranging from 1.3 to 1.06 mg/mm3. In decay region of dentin, the mineral content was gradually decreased from the intact inner side to the decayed surface. These results suggest that high-resolution micro-CT can be as a useful tool for non-invasive measurement of mineral concentration in teeth.

The purpose of the study was to find grey matter (GM) and white matter (WM) volume reduction in the brain reward system among patients with alcohol dependency. This study investigated regional GM and WM in chronic alcoholic patients, focusing primarily on the reward system, including principal components of the mesocorticolimbic reward circuit as well as cortical areas with modulating and oversight functions. Sixteen abstinent long-term chronic alcoholic men and demographically matched 16 healthy control men participated in the study. Morphometric analysis was performed on magnetic resonance brain scans using voxel-based morphometry (VBM)-diffeomorphic Anatomical Registration through Exponentiated Liealgebra (DARTEL). We derived GM and WM volumes from total brain and cortical and subcortical reward-related structures. Morphometric analyses that revealed the total volume of GM and WM was reduced and cerebrospinal fluid (CSF) was increased in the alcohol group compared to control group. The pronounced volume reduction in the reward system was observed in the GM and WM of the nucleus accumbens (NAc), GM of the amygdala, GM and WM of the hippocampus, WM of the thalamus, GM and WM of the insula, GM of the dorsolateral prefrontal cortex (DLPFC), GM of the orbitofrontal cortex (OFC), GM of the cingulate cortex (CC), GM and WM of the parahippocampal gyrus in the alcohol group. We identified volume reductions in WM as well as GM of reward system in the patients with alcohol dependency. These structural deficits in the reward system elucidate underlying impairment in the emotional and cognitive processing in alcoholism.

Naegleria fowleri is pathogenic free-living amoeba leading to primary amoebic meningoencephalitis(PAM) in human and animals. The nfa1 gene cloned from N. fowleri is located on food-cup structure called pseudopodia and function an adherence of host target cells. To evaluate the effect of nfa1 vaccination against N. fowleri infection, we constructed retroviral vector(pQCXIN) expressing nfa1 gene. To determine the effect of vaccination and protective immunity in in vivo models, we measured the immunoglobulin levels, cytokine induction, and survival rate in mice infected with N. fowleri. Both levels of IgG and IgG subclass in DNA vaccinated mice were significantly elevated. The cytokine analysis show that DNA vaccinated mice induces production of IL-4 and IFN-γcytokines suggesting a Th1/Th2 mixed type immune response. The levels of nfa1 specific IgG antibody were maintained highly until 12 weeks post-vaccination in vaccinted mice. The nfa1 vaccinated mice using retroviral vector increased significantly survival rate(60%) after N. fowleri infection. Consequently, the nfa1 vaccination effectively induces protective immunity by upregulation of immune response in mice infected with N. fowleri. These results suggest that DNA vaccination using retroviral vector may be proper trial for treatment and prevention of PAM.

While topics such as the use of English in the Korean workplace and specific industries have been studied widely, there is paucity of research that focus on the voices of various classes within a workplace that influence learners' English needs. In order to fill this gap, interviews and surveys were conducted at a major technology firm in Korea to examine the role of standardized English test, potential discrepancies between learner's perspective of their English needs and the language skills demanded or expected by thier employer. The study also attemped to analyze the needs of the learners to identify the target situations and tasks that can be incorporated into an EBP (English for Business Purposes) curriculum for the target learners. The findings from the interviews and the survey revealed that standardized tests are no longer used inthe hiring process, and there were diffrences between the employer and employees on how English skilss are perceived to influence one's chances of getting a job and being promoted. Based on the results of the needs analysis of the target group studied, examples of contexts and tasks that can be included in an EBP course are suggested. Finally, a renewed role of corporations and universities in meeting the needs of job seeking youths is proposed.

The current study examined the influence of individual trait such as Need-For-Touch level (NFT; high vs. low) and swiping orientation (vertical vs. horizontal) on product evaluation and preference when using touch-screen interface like a smart phone and a tablet. Swiping is one of the most common interaction techniques for changing pages or searching some aligned pictures on touch-screen interface and it can be used in vertical and horizontal orientations. The experiment revealed a significant interaction between swiping orientation and NFT on preference, however the interaction on change-in-price of given products was only marginally significant. To be specific, high NFT participants reported higher preference for horizontal-swipe than vertical-swipe products, but such difference did not occur with low NFT participants. The current study illustrates the influence of swiping orientation and NFT on product preference and it provides a new perspective of design principles especially for online shopping websites.

The purpose of the study is to investigate whether critical thinking skills can be fostered through a college English course. Approximately eighty female Korean students taking a basic freshman mandatory reading course participated in the study. The researcher taught them critical reading skills along with other reading comprehension skills and provided them with Korean local context in the given topic. The students critically read two units of the required textbook and attended presentations of high school students with minority cultural backgrounds. The students submitted four online reports about multiculturalism, and they were analyzed using a thematic analysis. The results revealed that even students with relatively low English proficiency could enhance their critical thinking skills by practicing critical reading. Also, additional information about local contexts not only compensated for a culturally limited text but also facilitated the development of critical thinking. The findings indicate that teaching critical thinking is feasible in an English language course despite limited environments. Yet, more studies are required to generalize the findings.

Recently, the migration of refugees has been drastically increasing and became a global issue which indirectly affects the shipmasters, authorities and shipowners during rescue operations. The objective of this paper is to study the challenges or difficulties in rescuing refugees at sea from the perspectives of shipmasters, authorities and shipowners in Malaysia. In this study, the key challenges faced by these three groups of individuals are collected and classified based on the primary data reviewed. The interview sessions were conducted with selected expertise and the data collected are analyzed based on the Analytical Hierarchy Process (AHP) or precisely the pair-wise comparison methods. Through the calculations, the challenges are ranked from the most important challenges to the least important challenges. Furthermore, the data is analyzed by using expert judgments focusing on the relatively most important challenges faced by the three groups of individuals. Finally, the most important challenge faced by shipmasters is the safety of ships and crews, while for authorities, the most important challenge faced is delays in the initiation of rescue operations. For ship-owners, the most important challenge faced is time sensitive cargo loss. Ultimately, two suggestions have been proposed to encounter the most important challenge faced by these groups.

The punctuality of containerships has become the prevalent issue in container liner shipping operations, as the on-time arrival of a containership at the next port of call is paramount. When a delay occurs at the previous port of call, it may also cause a delay at the next port of call. This paper proposes a departure punctuality model of analysis. This model employs a Fuzzy Rule-Based Bayesian Belief Network (FRBBN) for predicting the departure punctuality of a containership. To ensure the reliability of the model, two containerships were tested. The results show that the prediction values from the model are between 95.6% and 99% accurate provided that no tactical strategy is implemented during the voyage. In addition, the most significant factors that determine the punctuality of departure were found to be punctuality of arrival at the same (base) port prior to departure, dangerous events and other unexpected delays during the port stay. It is expected that this model is capable of helping researchers and practitioners to understand the influence of the dynamic environment and to make predictions on the departure punctuality of containerships.

The purpose of this study is to investigate the possibility of using the simulation landscape image by analyzing the landscape characteristics of the Landscape image and the simulation landscape image among the methods to grasp the quantitative relationship between the physical change of the user and the human response. The research subjects were set as Cheongnyang-ri station square, and the research method is as follows. A survey was conducted based on the extracted landscape adjectives for comparison of actual landscape image and simulated landscape images. In addition, image analysis, preference and complexity analysis, and decision factor of landscape preference were analyzed to Comparison analysis the characteristics of actual landscape image and simulated landscape images. The results of comparative analysis are as follows. First, it can be seen that there is no difference in the factors that affect the specificity and openness in using the simulation landscape image. Second, preference analysis shows that both the Landscape image and the simulation landscape image are the most preferred at 10% of users. Third, the complexity is low at 0% in both the Landscape image and the simulation landscape image, and 35% is high in complexity. Fourth, the comparative analysis of the decision factor of landscape preference by 'visual complexity and preference', 'User fluctuation and preference', 'User fluctuation and visual complexity' were analyzed. Therefore, it can be seen that the method using the simulation landscape image rather than the actual landscape image is more efficient when analyzing the visual cognitive characteristics.

Linguistic features that are indicative of higher writing proficiency levels can inform many aspects of lanauage assesment such as scoring rubrics, test items, and automated essay scoring(AES). The recent advancement of computer algorithms that automatically calculate indicates based on various linguistic features has made it possible to examine the relationship between linguistic features and writing proficiency on a larger scale. While the ability to use appropriate n-grams - recurring sequences of contiguous words - has been identified as a characteristic differentiating between proficiency levels in the literature, few studies have examined this relationship using computational indices. To this end, this study utilized the Tool for the Automatic Analysis of Lexical Sophistication(TAALES;Kyle&Crossley, 2015) to calcualte eight indices based on n-grams from a stratified corpus consisting of 360 argumentative essays written by Korean college-level learners. First, the indices from the training set of 240 essays were used to design a multinomial logistic regression model in order to identify indices that are significant predictors of writing proficiency levels. Subsequently, the regression model was applied to a test set of 120 essays to examine whether the model could be used to predict the proficiency levels of unseen essays. The results revealed that the mean bigram T, mean bigram Delta P, mean bigram-to-unigram Delta P, and proportion of 30,000 most frequent trigrams indices were significant predictors of proficiency levels. Furthermore, the regression model based on eight indices correctly classfied 52.5% of essays in the test set, demonstrating above-chance level accuarcy.