Background : Panax ginseng the king of Oriental medicines, has enormous potential against many of the disease symptoms and ailments. Panax quinquefolius is an another important member of Panax family which has similar benefits and medicinal properties. Both the species contains ginsenosides a pharmacologically active component abundant in their roots. In an effort to establish the new ginseng cultivars with improved agronomical characters such as root shape, stress tolerant and higher ginsenoside contents, the reciprocal interspecific hybrids were generated Methods and Results : Four elite cultivars and two new lines of ginseng were chosen to produce interspecies reciprocal hybrids with P. quinquefolius, by pollen dusting on the emasculated flowers. Among the F1 populations, the reciprocal hybrids generated by using new line 0837 both as maternal and paternal parent showed better properties and hybrid vigor. They showed strong root phenotypes with many lateral and fine roots thus having 10% to 20% higher ginsenoside contents compared to the parental populations. Among the major ginsenosides, the pharmacologically active ginsenosides such as Re, Rb1, Rb2 and F1 were enriched and accounted for the 70% of the PPD ginsenosides in 0837/Pq and Pq/0837 crosses, displaying strong dominance. Conclusion : Thus, based on our result we could conclude that P. ginseng line 0837 is the superior variety compared to the already existing lines for performing the interspecific hybrids with promising outcome in their root quality and ginsenoside content.

Various treatment modalities for vocal process granuloma include simple observation, antireflux therapy, voice therapy, botulinum injection, and steroid inhalation, but recurrence rates are high. Surgical excision can be considered in refractory and recurrent cases. In this study, the authors report the effectiveness of surgical excision using a carbon-dioxide laser with topical Mitomycin-C for the treatment of recurrent vocal process granuloma. The study included 28 patients with recurrent vocal process granuloma despite various treatments. The vocal process granuloma was excised using a carbon-dioxide laser and 1 cc of 0.4 mg/mL topical Mitomycin-C was applied for 4 minutes. Follow-up duration was 13-33 months (mean, 21.8 months). Of 28 patients, 19 (67.9%) were cured. Two who received surgical excision as a first-line treatment, 2 who used a steroid inhaler as a first-line treatment, and 5 who previously took antireflux medication as initial treatment showed recurrence. Surgical excision using a carbon-dioxide laser with topical application of Mitomycin-C is considered effective for recurrent vocal process granuloma.