Jellyfish envenomation is a world-wide health problem, which often seriously affect the fishery and bathing activities. To date, few individual jellyfish venoms proteins have been thoroughly characterized yet. In this work, four species of scyphozoan jellyfish (Nemopilema nomurai, Cyanea nozakii, Aurellia aurita and Rhopilema esculentum) are compared according to their, cytotoxicity, hemolytic potency, brine shrimp toxicity and protein components. Jellyfish venoms showed higher cytotoxicity in H9C2 heart myoblast than in C2C12 skeletal myoblast, with the exception of C. nozakii venom. This result suggests that the selective cytotoxic effects may be possibly related to their in vivo effects of cardiac tissue dysfunction. On the other hand, hemolytic activity could be also observed from all tested jellyfish venoms. N. nomurai jellyfish venom displaying the greatest hemolytic activity. As an alternative method of evaluating the toxicities of jellyfish venoms, the toxicity on brine shrimp was examined with the four jellyfish venoms. From this, the venom of N. nomurai showed higher toxicity against brine shrimp than the other jellyfish venoms, which is consistent with the results of cytotoxicity assay as well as hemolysis assay of the present study. SDS-PAGE analysis of four jellyfish venoms showed the similar pattern with molecular weight of around 40 kDa, and appeared to be the major protein components. These results provided that N. nomurai jellyfish venom was potently toxic than other scyphozoan jellyfish venoms and may explain to some extent the deleterious effects associated with human envenoming.

The long term objective should be to achieve a high degree of self-financing for the WEU. However, initial funding of at least US$5 million will be needed to develop the University through the launching of its initial programs. This will have to come primarily from Korean sources. Korea will need to take a lead in mobilizing the funds required for the ongoing operation of the University until the WEU has progressed to the point where it can command attention and support of international funding sources and significant fee income. The process to establish the University will be initiated as soon as the final decision of the Government of South Korea is confirmed.

Objective: The Modified Barthel Index (MBI) measures individuals’ level of independence in performing activities of daily living. The purpose of this study was to examine the internal consistency and construct validity of the MBI for children with rare disorders. Methods: The study participants are children with rare disorders who have muscle weakness including Barth syndrome and congenital muscular dystrophy (N = 113). The MBI was completed by participants in either an online format utilizing the UF Qualtrics system or a pencil-and-paper format. Statistical analysis was conducted to examine the psychometric properties of the MBI. Results: The MBI showed excellent internal consistency for children with Barth syndrome (Cronbach’s α = .91) and congenital muscular dystrophy (Cronbach’s α = .93). Construct validity was supported by a significant difference in MBI scores among participants grouped by diagnoses. MBI score was significantly different between the unaffected group and congenital muscular dystrophy (p < .0001) as well as between the unaffected group and Barth syndrome (p < .0001). Conclusion: The psychometric properties of the MBI present good reliability and construct validity suggesting suitability for use as an outcome measure for children with rare disorders.

Seaports are under high-speed developing and booming with the extend of the facilities and equipment to support the port activities and industry’s needs. It may bring environment destruction due to the change of the environmental conditions, likes forests, soils, water, and air. Therefore, this paper aimed to analyze the negative environmental impact due to seaport activities in Malaysia. The priority dominant factors are determined through analytic hierarchy process (AHP). Malaysia Port is selected as case study and 20 respondents are selected from virous department based on their expertise. Pari-wise comparison survey is used to collect data. The results shown that the negative environmental impact’s main elements are water (0.451), noise (0.262), organism (0.181), and air (0.106). Meanwhile, the toxicity is the prominent negative environmental impact’s sub-element of port activities, which scored 0.241, followed by interfering communication (0.142), and smell (0.134). The CR values are less than 0.1 and are considered acceptable. Hence, the outcome of the paper stimulated public awareness toward environmental protection. The development and expansion of seaports must consider environment conservation and preservation, and it cannot bring irreparable sequelae to the earth.

As Alex Schuessler (2009, 34–39) has articulated, it is difficult to know the real reason for the choice of a particular graphic element within a composite graph. This is often due to “mental or cultural associations” that tend to interfere with the choice. Even with a simple graph it is not easy to discern what we call “graphic design” that must have guided the original scribes to create the graphs to express words. These are important issues in Chinese paleography. We will use terms like “pure phonetic”, “quasi-phonetic”, “quasi-phonosignific”, “etymonic”, “quasi-etymonic” that are not commonly used in the literature (we will define them in the paper). The Old Chinese (OC) rimes comprised of a relatively few words such as *-əp, *-en, and *-ui suffer a shortage of graphs to write the words with such rimes. This implies the existence of graphs with only a segment or segments of an OC syllable that suggest its entire phonological form with a meaning or function. For example, the top portion of (=羊 *jaŋ~*laŋ, i.e., ) seems to serve as quasi-phonosignific in (=羌 *khaŋ~*khiaŋ—cf. 西戎, 牧羊人也, 羊亦聲—SW). That is, 羌 were “sheep herders”, and the grapheme can be taken as partial phonetic, not really “亦聲” it would seem, because only the rime of 羊 agrees (“quasi-phonetic”). When we pay attention not only to the rimes but also to the initials, we may, if cogent analysis can be made, come to understand why a word was written in a certain specific way. This interfaces between paleography and historical phonology, further involving historical lexicology. We shall also assess some traditional paleographical interpretations of nǚ 女= ‘woman’ and mín 民= ‘people’ and try to descry “graphic designs” by the original scribes. Here, however, we first need to figure out the underlying meanings of the words nǚ and mín in their early history. Their semantic fields could range from synonymy, near/quasi-synonymy, antonyms, and near/quasi-antonyms to members of some large word-family. In this paper, we limit our analysis to some “graphic minimal pairs” and the words represented by them. For example, “ (女 ‘woman’) and (卩 ‘joint’)”; “ (如 ‘follow, go’) and (訊 ‘interrogate’)”; “ (目 ‘eye’) and (臣 ‘servant’)”; “ (民 ‘people’) and (見 ‘see’)”; and a few related graphs.

The Korea Atomic Energy Research Institute (KAERI) has developed geological repository systems for the disposal of high-level wastes and spent nuclear fuels (SNFs) in South Korea. The purpose of the most recently developed system, the improved KAERI Reference Disposal System Plus (KRS+), is to dispose of all SNFs in Korea with improved disposal area efficiency. In this paper, a system-level safety assessment model for the KRS+ is presented with long-term assessment results. A system-level model is used to evaluate the overall performance of the disposal system rather than simulating a single component. Because a repository site in Korea has yet to be selected, a conceptual model is used to describe the proposed disposal system. Some uncertain parameters are incorporated into the model for the future site selection process. These parameters include options for a fractured pathway in a geosphere, parameters for radionuclide migration, and repository design dimensions. Two types of SNF, PULS7 from a pressurized water reactor and Canada Deuterium Uranium from a heavy water reactor, were selected as a reference inventory considering the future cumulative stock of SNFs in Korea. The highest peak radiological dose to a representative public was estimated to be 8.19×10-4 mSv‧yr-1, primarily from 129I. The proposed KRS+ design is expected to have a high safety margin that is on the order of two times lower than the dose limit criterion of 0.1 mSv‧yr-1.

The operational safety assessment is an important part of a safety case for the deep geological repository of spent fuels. It consists of different stages such as the identification of initiating events, event tree analysis, fault tree analysis, and evaluation of exposure doses to the public and radiation workers. This study develops a probabilistic safety assessment method for the operational safety assessment and establishes an assessment framework. For the event and fault tree analyses, we propose the advanced information management system for probabilistic safety assessment (AIMS-PSA Manager). In addition, we propose the Radiological Safety Analysis Computer (RSAC) program to evaluate exposure doses to the public and radiation workers. Furthermore, we check the applicability of the assessment framework with respect to drop accidents of a spent fuel assembly arising out of crane failure, at the surface facility of the KRS+ (KAERI Reference disposal System for SNFs). The methods and tools established through this study can be used for the development of a safety case for the KRS+ system as well as for the design modification and the operational safety assessment of the KRS+ system.

In this paper, an approach developed by the Finnish nuclear waste management organization, Posiva, for the construction license of a geological repository was reviewed. Furthermore, a computer program based on the approach was developed. By using the computer program, the lifetime of a copper disposal canister, which was a key engineered barrier of the geological repository, was predicted under the KAERI Underground Research Tunnel (KURT) geologic conditions. The computer program was developed considering the mass transport of corroding agents, such as oxygen and sulfide, through the buffer and backfill. Shortly after the closure of the repository, the corrosion depths of a copper canister due to oxygen in the pores of the buffer and backfill were calculated. Additionally, the long-term corrosion of a copper canister due to sulfide was analyzed in two cases: intact buffer and eroded buffer. Under various conditions of the engineered barrier, the corrosion lifetimes of the copper canister due to sulfide significantly exceeded one million years. Finally, this study shows that it is necessary to carefully characterize the transmissivity of rock and sulfide concentration during site characterization to accurately predict the canister lifetime.

In this paper, an overview of the scoping calculation results is provided with respect to criticality and radiation shielding of two KBS-3V type PWR SNF disposal systems and one NWMO-type CANDU SNF disposal system of the improved KAERI reference disposal system for SNFs (KRS+). The results confirmed that the calculated effective multiplication factors (keff) of each disposal system comply with the design criteria (< 0.95). Based on a sensitivity study, the bounding conditions for criticality assumed a flooded container, actinide-only fuel composition, and a decay time of tens of thousands of years. The necessity of mixed loading for some PWR SNFs with high enrichment and low discharge burnup was identified from the evaluated preliminary possible loading area. Furthermore, the absorbed dose rate in the bentonite region was confirmed to be considerably lower than the design criterion (< 1 Gy‧hr-1). Entire PWR SNFs with various enrichment and discharge burnup can be deposited in the KRS+ system without any shielding issues. The container thickness applied to the current KRS+ design was clarified as sufficient considering the minimum thickness of the container to satisfy the shielding criterion. In conclusion, the current KRS+ design is suitable in terms of nuclear criticality and radiation shielding.

With respect to spent nuclear fuels, disposal containers and bentonite buffer blocks in deep geological disposal systems are the primary engineered barrier elements that are required to isolate radioactive toxicity for a long period of time and delay the leakage of radio nuclides such that they do not affect human and natural environments. Therefore, the thermal stability of the bentonite buffer and structural integrity of the disposal container are essential factors for maintaining the safety of a deep geological disposal system. The most important requirement in the design of such a system involves ensuring that the temperature of the buffer does not exceed 100℃ because of the decay heat emitted from high-level wastes loaded in the disposal container. In addition, the disposal containers should maintain structural integrity under loads, such as hydraulic pressure, at an underground depth of 500 m and swelling pressure of the bentonite buffer. In this study, we analyzed the thermal stability and structural integrity in a deep geological disposal environment of the improved deep geological disposal systems for domestic light-water and heavy-water reactor types of spent nuclear fuels, which were considered to be subject to direct disposal. The results of the thermal stability and structural integrity assessments indicated that the improved disposal systems for each type of spent nuclear fuel satisfied the temperature limit requirement (< 100℃) of the disposal system, and the disposal containers were observed to maintain their integrity with a safety ratio of 2.0 or higher in the environment of deep disposal.