본 연구는 무늬 식물의 발현 양상을 확인하기 위해 Peperomia 속의 무늬가 없는 P. rotundifolia와 무늬 발생 양상이 서로 다른 P. argyreia, P. obtusifolia ‘Variegata’, P. marmorata ‘Pink Lady’4종을 대상으로 잎의 형태적 특성과 색소 구성 특성을 비교 분석하였다. 연구 결과, P. argyreia은 배경색과 무늬색의 색차(△E)가 크게 나타났지만, 단면 세포에서는 엽 록소가 고르게 분포하고, 색소 구성에서 무늬 유무에 따른 차 이가 없었다. 반면, c ‘Variegata’는 색소 구성에서 배경색과 무늬색 사이에 유의적인 차이를 보였다. 단면 세포에서도 엽 록소 분포의 차이가 뚜렷이 관찰되었다. 붉은 색의 무늬를 가 진 P. marmorata ‘Pink Lady’는 안토시아닌을 포함하고 있 어, 다른 품종들과는 다르게 색소체 생성에 따른 무늬 발현 양 상을 보였다. 결론적으로, P. argyreia는 표피의 공기층에 의 해 무늬가 발현되는 구조적 패턴을 가지며, P. obtusifolia ‘Variegata’와 P. marmorata ‘Pink Lady’는 엽록소와 카르 티노이드, 안토시아닌 등 색소적 특징에 의해 무늬를 발현시 키는 것으로 확인되었다. 이처럼 품종 특이적으로 다른 무늬 발생 양상을 가진 식물은 관상 가치를 유지하기 위한 광환경 이 다르게 요구될 것으로 판단된다.

Nursing research in veterinary hospitals is critical to the work of veterinary nursing and is necessary for continued advancements that promote optimal nursing care. Since the work of veterinary nursing involves animals with whom communication is difficult, the level of work performance can vary greatly depending on the experience, knowledge, and abilities of each animal nurse. In addition, veterinary nursing might establish a successful work environment through collaboration with veterinarians, and smooth work cooperation and communication among hospital members are direct factors in improving the work performance of animal hospitals. Because the work of nursing shows significant differences in performance depending on the individual, much research is being conducted to develop tools to measure work performance in the veterinary nursing field of medical assistants. In the present study, we attempted to develop a work performance measurement tool that is useful and suitable for veterinary nursing using the Delphi method. As a result of this study, an 18-item questionnaire was developed to measure the work performance of veterinary nursing, and these evaluation items were found to have excellent suitability in terms of content and construct validity. The evaluation scale of work performance of animal nurses developed through this study is believed to be useful in evaluating work performance in terms of work performance ability, attitude, and work performance relationship. Additionally, it is considered that the results of this study can be actively used to understand and develop the work relationships of veterinary nursing.

Traditional medicine and herbal remedies are gaining popularity worldwide, comprising a significant portion of healthcare research, advancements, and market demand. Growing scientific evidence supports their substantial efficacy as pharmaceutical ingredients and dietary supplements in preventive healthcare. When developing pharmaceuticals, it is crucial to ensure that ingredients are free from side effects and toxicity in order to prioritize safety. Geckos, known as shou gong, are a diverse group of lizards that are widely utilized for treating various diseases in Korean Medicine. This study was conducted to assess the potential acute toxicity of a water extract Gekko gecko by a single oral dose in Sprague-Dawley rats. Twenty rats of each sex were randomly assigned to four groups (5 rats each). Test articles were administrated once by oral gavage to rats at dose levels of 0, 500, 1,000, or 2,000 mg/kg body weight. Mortality, changes of body weight, and clinical signs of gross observation were monitored for 14 days after dosing. At the end of a 14-day observation period, all animals were sacrificed and complete macroscopic and hematological examinations were performed. There was no dead animal or test article-related effect on clinical signs, body weight, or gross finding. Other specific changes were not found between control and treated groups in hematology. Results showed no adverse effect at a dose of 500, 1,000, or 2,000 mg/kg in rats. The minimal lethal dose was considered to be over 2,000 mg/kg body weight in rats.

Objective: This study aimed to translate and validate the Motivation to Change Lifestyle and Health Behaviors for Dementia Risk Reduction (MCLHB-DRR) scale among middle-aged and older Korean adults. Methods: This study included a sample of Korean adults aged ≥ 50 years recruited from an online panel. Content and construct validity were examined to determine the scale’s validity. Internal consistency and test-retest reliability were examined to determine its reliability. Results: A total of 270 participants completed the questionnaire. Content validity was determined by professors and researchers of occupational therapy. One item was deleted during the content validity assessment. The confirmatory factor analysis results showed a good model fit (χ 2/degree of freedom = 1.845, comparative fit index = 0.939, Tucker-Lewis index = 0.929, root mean square error of approximation = 0.056). Cronbach’s alpha values were 0.821 - 0.900, indicating good internal consistency. The test and retest scores did not differ significantly. Conclusion: The Korean version of the MCLHB-DRR scale has validity and reliability for use among the Korean population, to assess beliefs and attitudes toward lifestyle change to reduce the risk of dementia.

Researchers have examined how individuals' preferred ways of comparing achievements differ according to their mindset. However, studies investigating the concomitant impact of such differences on individuals' happiness are relatively scant. Using a variety of scenarios, the present study examined how fixed-mindset and growth-mindset individuals' different achievement-comparison styles (more than others, less than others, better than before, and worse than before) affected their subjective happiness. A total of 880 participants were recruited. Fixed-mindset individuals felt happy when they felt they achieved more than others and unhappy when they felt the opposite, but were not influenced significantly when their achievement was better or worse than before. Conversely, growth-mindset individuals felt happy when their achievement was better than before but unhappy when it was the opposite, without being influenced significantly by achieving more or less than others. This study examined mindset, achievement comparison, and subjective happiness comprehensively, which, to date, have only been examined independently.

This paper aims to investigate how and to what extent ‘critical’ global citizenship is reflected in middle school English textbooks in Korea. Framed within Freire’s concept of critical literacy, the study is concerned with analyzing the written texts in two English textbooks, with a focus on the issue of representations. Using critical content analysis, the research centers on unpacking how race, racism, or racialization, especially in the United States, is represented, and to what extent these representations may be associated with global citizenship education in English language learning. The major findings indicate a notable absence of sufficient sociohistorical and cultural contexts of race in the United States as presented in the concerned English textbooks. Based on the analysis, this paper calls for an expansion of the dimensions of critical global citizenship in English language learning settings, aiming to provide students with broader opportunities to question colonial discourse and challenge issues related to power and systemic oppression.

Drug-induced liver injury (DILI) is considered to be a significant cause of drug wastage. To mitigate clinical DILI risks, assessing drugs using human liver models is crucial since animal studies may fall short due to species-specific liver pathway variations. Cell-based preclinical hepatotoxicity testing is often pertinent. In the present study, cells from a human liver cancer line (HepG2 and HepaRG) were cultured in both formats of 2D and 3D spheroids to explore their responses to drugs. Liver-specific marker expressions across cell lines and culture formats were also examined to assess disparities in DILI marker expressions. After treating each cell with the drugs, cytotoxicity and liver injury markers aspartate aminotransferase and alanine aminotransferase were increased. In addition, liver specific markers albumin and urea decreased in a drug concentration-dependent manner. These findings were consistent with drug sensitivity. Additionally, mRNA expression levels of cytochrome P450 enzymes (CYPs) involved in hepatocellular drug metabolism were compared following treatment with enzyme inducers. CYP1A2 and CYP2C9 were not epxressed in HepG2 cells. HepaRG cells exhibited significantly increased expression of CYP1A2, 2C9, and 3A4 post-treatment. Notably, enzyme expression was notably higher in 3D cultures than in 2D cultures. Collectively, these findings suggest that HepaRG cells and 3D cultures hold promise for evaluating DILI during early-stage drug development.

Helicobacter pylori are known as a causative agent of gastritis, gastric duodenum and peptic ulcer, and gastric cancer, and multiple drug use is associated with various side effects in patients. The discovery of antibacterial substances against H. pylori from Korean resource plants is an important substitute for antibiotics. 52 species of Korean resource plants were collected and extracted with 50% ethanol, and antibacterial activity against H. pylori was measured using the disk diffusion method. The toxicity of plant extracts to human gastric adenocarcinoma(AGS) cells was measured by MTT assay, and the level of IL-8 secreted when gastric epithelial cells were inoculated with H. pylori was measured. As a result of measuring the antibacterial activity of H. pylori, antibacterial activity was confirmed in 38 plant extracts. The plant species with the strongest antibacterial activity were Chrysanthemum indicum, Rheum rhabarbarum, Patrinia scabiosaefolia and Petasites japonicus. C. indicum was not cytotoxic to H. pyroli-infected AGS cells and showed anti-inflammatory effects. This study's results can be used to develop healthy, functional foods and medical materials.

Ophiopogonin D (OPD) is a steroidal glycoside derived from Ophiopogon japonicus , a traditional Chinese medicine with diverse biological activities, including antithrombosis, anti-inflammation, and antitussive effects. To investigate the cellular effects and mechanisms of OPD on oral squamous cell carcinoma, cell viability was explored, and the effects of OPD on cell cycle regulators, apoptotic marker proteins, and key proteins involved in metastasis and signaling pathways were examined by MTT assay and Western blotting in YD38 cells. OPD strongly inhibited cell proliferation and induced caspase-dependent apoptosis of YD38 cells by suppressing the cell cycle and activating caspase-3 and poly ADP ribose polymerase. Additionally, OPD suppressed the expression of vital proteins regulating metastasis and proliferation within the integrin/matrix metalloproteinases/FAK and AKT/PI3K/mTor pathways. Thus, OPD can be a potential treatment candidate for gingival cancer.

This study aimed to reconfirm the sex change scale and pattern of Tegillarca granosa. Although the sex ratio (female : male, female proportion) of T. granosa was 1:2.32 (30.2%) at the initial stage (2011) of the study, it was 1:0.94 (51.5%) after one year (2012) in the same population. The increase of the female proportion was greater in the 2+ year class (23.0%) when compared to the 1+ year class (19.2%). Overall, sex change ratio of 37.6% was observed in this population of T. granosa. The sex change ratio of the 2+ year class (39.3%) was higher than that of the 1+ year class (35.3%). And sex change ratio in the males (42.2%) was higher than that in the females (26.9%). The female proportion was the opposite of the result from 2006~2007, and one of the causes was presumed to be the difference in cumulative water temperature during the gonadal inactive stage (winter).

As environmental concerns escalate, the increase in recycling of aluminum scrap is notable within the aluminum alloy production sector. Precise control of essential components such as Al, Cu, and Si is crucial in aluminum alloy production. However, recycled metal products comprise various metal components, leading to inherent uncertainty in component concentrations. Thus, meticulous determination of input quantities of recycled metal products is necessary to adjust the composition ratio of components. This study proposes a stable input determination heuristic algorithm considering the uncertainty arising from utilizing recycled metal products. The objective is to minimize total costs while satisfying the desired component ratio in aluminum manufacturing processes. The proposed algorithm is designed to handle increased complexity due to introduced uncertainty. Validation of the proposed heuristic algorithm's effectiveness is conducted by comparing its performance with an algorithm mimicking the input determination method used in the field. The proposed heuristic algorithm demonstrates superior results compared to the field-mimicking algorithm and is anticipated to serve as a useful tool for decision-making in realistic scenarios.

Fluorescent bacteria were isolated from sporocarps that browned into various mushrooms during survey at places of the production in Korea. We examined the pathogenicity, biodiversity, and genetic characteristics of the 19 strains identified as Pseudomonas tolaasii by sequence analysis of 16S rRNA and White Line Assay. The results emphasize the importance of rpoB gene system, fatty acid profiles, specific and sensitive PCR assays, and lipopeptide detection for the identification of P. tolaasii. As a result of these various analyses, 17 strains (CHM03~CHM19) were identified as P. tolaasii. The phylogenetic analysis based on the 16S rRNA gene showed that all strains were clustered closest to P. tolaasii lineage, two strains (CHM01, CHM02) were not identified as P. tolaasii and have completely different genetic characteristics as a result of fatty acids profile, specific and sensitive PCR, lipopetide detection, rpoB sequence and REP-PCR analysis. Pathogenicity tests showed 17 strains produce severe brown discolouration symptoms to button mushrooms and watersoaking of sporophore tissue within three days after inoculation. But two strains did not produce discolouration symptoms. Therefore, these two strains will be further investigated for correct species identification by different biological and molecular characteristics.

Extracellular traps (ETs), primarily composed of DNA and antibacterial peptides, are mainly secreted by neutrophils to inhibit pathogen spread and eliminate microorganisms. Recent reports suggest that microglia can also secrete ETs, and these microglial ETs are associated with various neurological conditions, including nerve injury, tumor microenvironment, and ischemic stroke. However, the components and functions of microglial ETs remain underexplored. Secretagogin (Scgn), a calcium-sensor protein, plays a crucial role in the release of peptide hormones, such as insulin, in endocrine cells; however, its function in immune cells, including microglia, is not well understood. Our study demonstrated that Scgn deficiency can lead to the formation of abnormal ETs. We hypothesized that this may involve the c-Jun N-terminal kinase-myeloperoxidase pathway and autophagy.

This study was conducted to collect the patents of microbiome-based treatment technology for pets. An electronic search for microbiome or probiotics in brain nervous system disease was studied using the WINTELIPS database. Patent Cooperation Treaty of Korea, Japan, the EU, the US, and China that were registered by October 31, 2022 were selected in this study. A total of 206 patents were included for final analysis. Since 2016, patent activity has shown an explosive increase in recent years. China is the leading market in this technology field, and Korea has the second-highest market share. To provide the groundwork for the next research and development, we examined the industrial trend of microbiome for brain nervous system diseases in this study using an analysis of patents that have been applied for and registered up to this point. Looking at the overall patent trends by year in the technology field related to treating of brain and nervous system diseases using the microbiome, there was a tendency to repeat increasing and decreasing trends. However, considering 2021 and 2022, which have undisclosed sections, it can be seen that patent activity has tended to increase explosively in recent years, starting in 2016. If related studies use the patent analysis data constructed in this way strategically, it is expected that it will lead to patent registration and the development of new products, ultimately contributing to the revitalization of the companion animal industry.

This study introduces a novel approach for identifying potential failure risks in missile manufacturing by leveraging Quality Inspection Management (QIM) data to address the challenges presented by a dataset comprising 666 variables and data imbalances. The utilization of the SMOTE for data augmentation and Lasso Regression for dimensionality reduction, followed by the application of a Random Forest model, results in a 99.40% accuracy rate in classifying missiles with a high likelihood of failure. Such measures enable the preemptive identification of missiles at a heightened risk of failure, thereby mitigating the risk of field failures and enhancing missile life. The integration of Lasso Regression and Random Forest is employed to pinpoint critical variables and test items that significantly impact failure, with a particular emphasis on variables related to performance and connection resistance. Moreover, the research highlights the potential for broadening the scope of data-driven decision-making within quality control systems, including the refinement of maintenance strategies and the adjustment of control limits for essential test items.

The issue of marine accidents can be based on the traffic/distribution of vessels in the waterways. These accidents are often associated with human and financial losses and require special attention. Usually, these accidents include collision of two fishing vessels with each other, collision of a fishing vessel with other types of vessels in the course and collision of a fishing vessel with an obstacle in the course (Yancai, et al, 2020). In this article, we first want to deal with analysing the recorded statistical samples in 7 fishing areas in coastal waters of South Korea in 2023, while fuzzy clustering them. Then, according to analysing the sample data and finding the probabilistic structure and the membership of data sets the determined clusters, through Monte Carlo simulation, we will generate similar data in each of the 7 studied regions and model them in unsupervised mode. The generated data by Monte Carlo simulation based on the statistical distribution will able us to study the reality of distribution and possible accident in our target areas and find the model for future demands. We show that how the simulated data reduce the cost of data analysis and deliver us the facts of clusters for fishing vessels collisions. Finally, we reach to the most notified area for preventing the fishing vessels accidents and to make more preparations for reducing the human and costly damages in future activities.

고주파 흡수제(Accusorb MRI)를 이용한 자기공명영상 검사 중 화재가 발생했다. 다행히 환자는 화상을 입지는 않았 지만 스트랩과 4채널 코일의 케이블, Accusorb MRI가 녹아서 탄 흔적이 발견되었다. 자기공명영상 검사에 사용되 는 도구의 안전 지침을 준수해야 하지만 이를 지키지 않으면 화상, 열상, 장비 손상의 위험이 있다. 사고를 방지하기 위해서는 철저한 사전 점검을 해야 하고 모든 기기, 물품들이 자기공명영상 검사 시 사용 가능한 제품인지 확인하고 사용법을 정확하게 숙지하여야 한다.

In recent automated manufacturing systems, compressed air-based pneumatic cylinders have been widely used for basic perpetration including picking up and moving a target object. They are relatively categorized as small machines, but many linear or rotary cylinders play an important role in discrete manufacturing systems. Therefore, sudden operation stop or interruption due to a fault occurrence in pneumatic cylinders leads to a decrease in repair costs and production and even threatens the safety of workers. In this regard, this study proposed a fault detection technique by developing a time-variant deep learning model from multivariate sensor data analysis for estimating a current health state as four levels. In addition, it aims to establish a real-time fault detection system that allows workers to immediately identify and manage the cylinder’s status in either an actual shop floor or a remote management situation. To validate and verify the performance of the proposed system, we collected multivariate sensor signals from a rotary cylinder and it was successful in detecting the health state of the pneumatic cylinder with four severity levels. Furthermore, the optimal sensor location and signal type were analyzed through statistical inferences.

흉골 자기공명영상 검사 시 호흡 등 환자 움직임에 의한 인공물 발생을 최소화하는 것은 어렵다. 하지만 자기공명영 상 검사는 타 영상 검사와 비교해 흉골 병변을 발견하는 데 있어 진단적 가치가 높은 장점이 있다. 따라서 본 연구에 서는 환자의 검사 자세 및 딥러닝 기법을 통해 최적의 검사 방법을 도출하고자 한다. 자세 별 영상 변화를 확인하기 위해 바로 누운 자세, 엎드린 자세, 유방 코일을 사용한 엎드린 자세로 진행하였으며, 고식적 기법의 영상과 Deep Resolve Boost(DRB) 기법을 적용한 영상을 비교 관찰하였다. 모든 대상에게 같은 조건으로 각 영상을 2회씩 획득 한 후 전반적인 영상 품질을 기준으로 정성적으로 평가하였고, DRB의 적용 여부에 따른 신호 대 잡음비의 변화 정도를 정량적으로 평가하여 개선 정도를 산출하였다. 정성적 평가에서 DRB 적용 여부와 무관하게 엎드린 자세, 유방 코일을 사용한 엎드린 자세, 바로 누운 자세 순으로 높은 점수를 얻었으며, DRB를 적용한 영상이 고식적 기법 의 영상보다 높은 점수를 얻었다. 또한 정량적 평가를 통해 유방 코일을 사용한 엎드린 자세, 엎드린 자세, 바로 누운 자세 순으로 높은 개선 정도를 확인하였다. 본 연구를 통해 흉골 검사 시 DRB 기법을 적용하는 것은 영상의 질을 높이는 방법임을 확인하였다. DRB를 적용하지 못하는 환경에서는 될 수 있으면 엎드린 자세를 적용하는 것을 권고하며, DRB를 적용할 수 있는 환경에서는 환자 측 인자를 고려하여 엎드린 자세와 유방 코일을 사용한 엎드린 자세를 모두 적용할 수 있다.