PURPOSES : This paper presents a foundational study aimed at strengthening the competitiveness of future overseas construction engineering projects, efficiently guiding investment decisions for the government or private sectors and establishing policy suggestions for areas that need to be supplemented and linked. METHODS : The data envelopment analysis (DEA) model was used to measure the operational efficiency for individual types of work. The DEA model for measuring efficiency uses the representative Charnes, Cooper, and Rhode (CCR) and Banker, Charnes, and Cooper (BCC) models. RESULTS : By using statistics of overseas construction projects and conducting DEA, it was revealed that construction management was most needed in the energy facility sector of overseas construction projects. CONCLUSIONS : Although the capabilities of our country's companies are excellent, it was evident that the energy and industrial facilities sectors, which need to be supplemented to enhance their competitiveness, require policy support that incorporates construction management (CM). Consequently, it was confirmed that the construction management sector needs investment that should continue to be activated in the future. Additional research is needed that considers variables and environments related to overseas construction projects’ on-site conditions. To this end, the government should continue to promote research and government investment linked to CM to make progress in overseas construction sectors.

In recent automated manufacturing systems, compressed air-based pneumatic cylinders have been widely used for basic perpetration including picking up and moving a target object. They are relatively categorized as small machines, but many linear or rotary cylinders play an important role in discrete manufacturing systems. Therefore, sudden operation stop or interruption due to a fault occurrence in pneumatic cylinders leads to a decrease in repair costs and production and even threatens the safety of workers. In this regard, this study proposed a fault detection technique by developing a time-variant deep learning model from multivariate sensor data analysis for estimating a current health state as four levels. In addition, it aims to establish a real-time fault detection system that allows workers to immediately identify and manage the cylinder’s status in either an actual shop floor or a remote management situation. To validate and verify the performance of the proposed system, we collected multivariate sensor signals from a rotary cylinder and it was successful in detecting the health state of the pneumatic cylinder with four severity levels. Furthermore, the optimal sensor location and signal type were analyzed through statistical inferences.

PURPOSES : In this study, the applicability of the water content, suction, and suction stress in a resilient modulus prediction model for a subbase was reviewed. METHODS : To compare the applicability of water content, suction, and suction stress models for resilient modulus prediction, the suction stress was determined based on the soil water characteristic curve. The model parameters for each approach were derived from the measured resilient moduli. Finally, the relationships between the degree of saturation and resilient modulus were analyzed using the calculated model parameters. RESULTS : Prediction models of the resilient modulus based on water content and suction demonstrated high correlation with measured values, but overestimated the resilient modulus at saturation levels beyond the laboratory testing range. In contrast, the model accounting for suction stress effectively reduced this overestimation, likely owing to a decrease in suction stress as the suction increased. CONCLUSIONS : Based on the above results, the resilient modulus of subbase materials could be estimated through the change in the degree of saturation and the stress-dependent resilient modulus model using the suction stress proposed in this study.

PURPOSES : In this study, an empirical approach was established to estimate the parameters of the resilient modulus based on various geotechnical properties of subgrade soils. METHODS : Multiple regression analyses were performed to analyze the relationship between resilient modulus (k1) and deformation. The most important factors are the #200 sieve passing ratio, moisture content, and dry unit weight of the soil. The applicability of this approach was verified using selected field data and the literature. RESULTS : The correlation between the results predicted using the prediction equation of the model constant (k1) and the actual k1-value was high. The applicability of the prediction equation was considered high owing to its high suitability with the existing data. The range of values obtained using the constant prediction equation of the proposed model was also judged to be reasonable. In the comparison of the CBR value of the subgrade material of the actual design section and the predicted elastic modulus (k1), almost no relationship was observed between the CBR and the model coefficient (k1). Thus, the estimation of the elastic modulus through CBR is likely to contain errors. CONCLUSIONS : Based on these results, the parameters of the universal model can be predicted using the stress-dependent modulus model proposed in this study.

PURPOSES : In this study, the wetting band depths of road slopes estimated using numerical analyses and one-dimensional empirical equations were evaluated. METHODS : The one-dimensional empirical equations used in this study to estimate the wetting band depth were the Pradel and Raad equation, based on modifying the Green and Ampt equation, Lumb's equation, and Sun equation. The numerical analysis of a finite load slope model was carried out using the Seep/w program (2D). In particular, the effect of the initial suction, which indicated the effect of the antecedent rainfall based on the soil–water characteristic curve, was examined as one condition. The results of the wetting band depths obtained using the empirical equations were evaluated and compared with those of the numerical analysis. RESULTS : The wetting band depths obtained using one-dimensional empirical equations were greater than those from the analytical results. In the case of empirical equations, the estimated results obtained for the wetting band depth might be misleading because it has the limitation of being expressed using a one-dimensional equation with an error, owing to several assumptions for the water infiltration phenomenon. It was also found that the accuracy of the wetting band depth was closely related to the results of the soil–water characteristic curve. CONCLUSIONS : Because the wetting band depths obtained using the empirical equation may lead to overestimation, the slope stability could be evaluated as low; however, there was an advantage in terms of inducing conservative design of the road slope. In addition, it was confirmed that the estimated value of the wetting band depth obtained using the Pradel and Raad equation varied with the suction and volumetric function ratios, and further attention should be paid to these two variables.

Nasopalatine duct cyst is a developmental non-odontogenic cyst caused by the entrapment of remnants during embryologic fusion. Only a few cases have reported the intraluminal amorphous calcification in these cysts. This case showed a well-demarcated, unilocular lesion containing calcifications, which were later turned out to be cartilage graft at previous surgery. We report here this case to emphasize the need for thorough medical history taking.

Aloin [1,8-Dihydroxy-10-(β-D-glucopyranosyl)-3- (hydroxymethyl)-9(10H)-anthracenone]은 알로에에서 추출한 천연 안트라퀴논이다. 다양한 유형의 인간 암세포에서 항산화, 항암 효과가 있는 것으로 밝혀졌지만 인간 대장암 세포 HT-29에서 aloin의 항암 효과는 밝혀지지 않았다. 본 연구에서는 aloin이 인간 대장암 HT-29 세포에서 세포 사멸 작용을 발휘할 수 있는 메커니즘을 조사하였다. Aloin 이 세포 생존율에 영향을 미치는지 알아보기 위해 대장암 세포 HT-29, 흑색종 세포 A375SM, 위암 세포 AGS를 aloin(0, 100, 200, 300 및 400 μM)으로 처리하였을 때, HT- 29에서는 농도 의존적으로 세포 생존율을 감소시켰고, A375SM과 AGS 세포에서는 암세포 생존율의 감소가 보이지 않았다. 이러한 HT-29에서의 세포 생존율 감소가 세포자멸사로 인한 감소인지 확인하기 위해 DAPI stain과 flow cytometry를 실시한 결과 apoptotic body가 유의적으로 증가하고 세포 자멸사가 증가한 것을 확인할 수 있었다. 이와 같은 결과를 바탕으로 aloin이 대장암 세포 HT- 29에서 세포 사멸 관련 단백질 발현 양상에 미치는 영향을 확인하기 위해 western blotting을 실시하였다. Aloin은 Bax, PARP의 분절을 농도 의존적으로 증가시켰고, caspase- 3, -8을 활성화시켰지만, Bcl-2는 대조군에 비해 변화가 없었다. Aloin에 의해 유도된 세포자멸사 기전을 확인하기 위해 MAPK pathway 중 p-p38과 p-ERK의 발현을 확인한 결과, p-p38을 up-regulation시키고 p-ERK의 downregulation을 유도했다. 따라서, aloin은 인간 대장암에서 암 세포 성장 억제 효과 및 암세포 사멸 유도로 암예방 약제로서의 개발 가능성이 있다고 사료된다.

Intravascular papillary endothelial hyperplasia (IPEH) is an unusual reactive benign lesion of vascular origin caused by endothelial cell proliferation, which rarely occurs in oral cavity. IPEH appears in various forms because it has non-specific clinical presentation, so it can be misdiagnosed as a malignant lesion.Therefore, it is important to make a differential diagnosis by understanding the characteristics of this lesion.We report a case of IPEH in a 22-year-old Korean female patient, discussing about differential diagnosis and treatment. This report presents review of literature and describes a case of IPEH.

우르솔릭산은 항암, 항산화, 항염증 작용과 같은 다양한 효과를 지니고 있다. 본 연구에서는 우르솔릭산이 인간 흑색종 암세포인 A375SM과 A375P 세포에 항암효과가 있는지 확인하였다. 두 세포의 생존율은 MTT assay를 통하여 확인하였으며 증식률은 Wound healing assay로 확인하 였다. 두 세포의 apoptotic body와 apoptosis 비율의 확인을 위한 DAPI 염색과 유세포 분석을 진행하였다. 그리고 웨스턴 블로팅을 통하여 흑색종 세포의 우르솔릭산의 농도에 따른 apoptosis 단백질의 유도를 조사하였다. 우르솔 릭산의 처리 농도에 따라 흑색종 세포의 생존율 감소와 증식률 감소를 확인하였다. DAPI 염색을 통하여 우르솔 릭산의 농도가 증가함에 따라 흑색종 세포의 염색체 응축 이 농도 의존적으로 증가하였고, 유세포 분석을 통하여 우르솔릭산에 대하여 농도 의존적으로 흑색종 세포의 apoptosis 비율의 증가를 확인하였다. 그리고 웨스턴 블로팅을 통해 흑색종 세포 A375SM과 A375P의 우르솔릭산 12 μM 농도에서 cleaved-PARP와 Bax의 증가와 Bcl-2의 감소를 확 인하였다. 본 연구는 우르솔릭산의 농도를 0 에서 20 μM 수준의 저농도에서 진행하였으며, 물질 처리 후 24 시간 뒤 결과를 가지고 분석하였다. 본 연구의 결과로 보아 우르솔릭산은 흑색종 세포 A375SM과 A375P에서 apoptosis 관련 단백질들의 조절을 통해 항암효과를 일으키는 것으로 사료된다.

PURPOSES : This study compares the results of field-monitored unsaturated hydraulic data to verify the wetting path estimation method using the drying path on roadside soil slope. METHODS: A method proposed by Fredlund was used to estimate the wetting curves of soil water characteristic curves. Wetting curves were estimated from the drying curve acquired mainly from laboratory testing, and the estimated wetting curve was applied to the infiltration analysis to verify the estimation method. The infiltration analysis results obtained from the drying, wetting, and estimated wetting curves were compared to the field-monitored data at the same location. RESULTS : The volumetric water contents measured at 40 cm were closest to analysis results obtained from the wetting curve, whereas the volumetric water content measured at 80 cm were closest to the analysis results obtained from the drying curve. The results of the estimated wetting curves were between the results of the drying and wetting curves. The measured suction results were within the drying and wetting curves, and the estimated wetting curves were within the drying and wetting curves. Additionally, the safety factor obtained from applying the drying curves was carefully calculated, and the factor of safety of the estimated wetting curves was close to the results of the wetting curves. CONCLUSIONS : Applying a drying curve to calculate the slope stability during the rainy season will cause an overestimation of the factor of safety at roadside soil slopes. However, if the proposed estimation method of the wetting curve can be applied to the numerical analysis, the stability of the road slope can be reasonably estimated.

흰점박이꽃무지 성충 및 유충을 대상으로 실내조건(26±1℃, 70%RH)에서 광조건 L:D=16:08, L:D=12: 12, L:D=0:24의조건에서 조사하였으며, 성충 산란수는 성충 우화 후 2주부터 6주까지 5회, 유충은 5주간 5회 유충무게를 측정하여광조건에 따른 산란수와 유충무게 변화에 대한 비교를 하였다. 그 결과 L:D=16:8, 12:12, 0:24의 처리구의 산란수는각각 55.2±2.6, 66.8±11.1, 49.6±5.54개이었다. 처리구 L:D=12:12에서 가장 많은 수의 산란수를 보였으며, L:D=16:8과0:24의 처리구에서는 산란수의 차이는 크게 나타나지 않았다. 유충의 경우 L:D=16:8, 12:12, 0:24의 처리구에서5주 후 유충 1마리의 평균무게는 각각 2.62±0.09g, 2.70±0.05g, 2.57±0.06g이었으며, 처리구별 유충의 무게변화에큰 차이를 나타내지 않았다. 이번 실험 결과 흰점박이꽃무지 성충의 산란과 유충의 성장에는 광조건이 큰 영향을주지 않는 것으로 나타났으나, 광조건 L:D=12:12처리구에서 산란수와 유충의 성장이 가장 양호하게 나타났다.

The Gyeong-Ju earthquake in the magnitude of 5.8 on the Richter scaleoccurred in September 12, 2016. Because there are many nuclear power plants (NPP) near the epicenter of the Gyeong-Ju earthquake, the seismic stability of nuclear power plants is becoming a social problem. In order to evaluate the safety of seismically isolated NPP, the seismic response of a NPP subjected to the Gyeong-Ju earthquake was compared with those of 30 sets of artificial earthquakes corresponding to the nuclear standard design spectrum (NSDS). A 2-node model and a simple beam-stick model were used for the seismic analysis of seismically isolated NPP structures. Using 2-node model, the effect of internal temperature rise, decrease of shear stiffness, increase of lateral displacement and decrease of vertical stiffness according to nonlinear behavior of lead-rubber bearing (LRB) were evaluated. The displacement response, the acceleration response, and the shear force response of the seismically isolated nuclear containment structure were evaluated using the simple beam-stick model. It can be observed that the seismic responses of the isolated nuclear structure subjected to Gyeong-Ju earthquake is significantly less than those to the artificial earthquakes corresponding to NSDS.

PURPOSES : Road subsidence occurs owing to road cavities, which cause many social and environmental problems, especially in cities. Recently, road cavities were detected by various ground radars and repair works were carried out against the detected cavities. The condition assessments related to the road cavities are necessary to understand the potential risk of the cavities. Therefore, in this study, a numerical study was performed to assess the various conditions of road cavities. METHODS : The numerical method adopted in this study is the discrete element approach, and it is suitable for analyzing the condition because it can consider the movement of the soil particles in the surrounded cavity areas. In addition, the triaxial test was modeled and performed under various cavity conditions inside the specimens. RESULTS: The conditions of different cavity locations and shapes were analyzed to identify the effect of cavity state. Three general cases of particle size distributions were formulated to identify the effect of surrounding ground conditions. As a result, the degree of decrement and volumetric strain were varied depending on the locations and shapes of the cavity. Only minor changes were observed when the particle size distributions were altered. CONCLUSIONS: The strength reduction was higher when the cavity formed was larger and located in the upper zone. Similar to the cavity shape, strength reduction and volume deformation are more influenced by the width than the length of the cavities. There is an influence from ground conditions such as the particle size distribution, especially on the wide cavity.

The Eradi Quake System (EQS) is a seismic isolation bearing system designed to minimize forces and displacements experienced by structures subjected to ground motion. The EQS dissipates seismic energy through friction of Poly Tetra Fluoro Ethylene (PTFE) disk pad. In general, a force-displacement relationship of EQS has post yield stiffness hardening during large inelastic displacement. In this study, seismic responses of seismically isolated nuclear power plant (NPP) subjected to design basis earthquake (DBE) and beyond design basis earthquakes (150% DBE and 167% DBE) are compared considering the post yield stiffness hardening effect of EQS. From the results, it can be observed that if the post-yield stiffness hardening effect of EQS is increased, the displacement response of EQS is reduced, and the acceleration and shear responses of containment structures of NPP is increased.

본 연구는 인체 유방암세포 SK-BR-3, MDA-MB-231과 위암세포 AGS를 대상으로 국화과 식물 중 흰민들레(Taraxacum coreanum, TC), 고들빼기(Youngia sonchifolia, YS), 씀바귀(Ixeris dentate, ID) 추출물에 의한 증식 억제효과를 비교 한 후, 가장 억제효율이 높은 추출물을 선택하여 apoptosis 유도 효과를 조사하였다. 암세포의 증식 억제효과는 TC 추출물에 의한 영향은 약한 반면, YS와 ID 추출물에 의한 영향은 농도 의존적으로 증가하는 것을 확인하였다. 세 가지 추출물 중 가장 효과가 뛰어난 ID 추출물을 이용하여 추가적으로 농도 설정을 진행한 다음 이후 실험을 진행하였다. ID 추출물에 의한 apoptosis 양성세포를 확인하기 위해 DAPI assay를 진행한 결과, ID 추출물을 처치한 군에서 apoptotic body와 세포질 응축을 확인하였다. MTT assay와 DAPI staining의 결과를 바탕으로 ID 추출물이 SK-BR-3, MDA-MB-231, AGS 세포에서 apoptosis와 관련한 단백질 발현 양상에 미치는 영향을 확인하기 위해 western blot을 실시하였다. ID 추출물에 의해 SK-BR-3, MDA-MB-231, AGS 세포에서 pro-apoptosis인 Bax 단백질 발현은 농도 의존적으로 증가하였고, antiapoptosis인 Bcl-2 단백질 발현은 SK-BR-3 세포에서는 발현의 변화가 거의 없었지만, MDA-MB-231과 AGS 세포에서는 감소하였다. 세포사멸의 주요임상지표인 Bax/Bcl-2 ratio는 MDA-MB-231세포에서 가장 유의적으로 증가하였다. 또한, 손상된 DNA를 복구하는 단백질인 PARP의 발현은 감소하면서, cleaved-PARP이 증가하였다. 이러한 결과들을 종합하였을 때, YS와 ID 추출물은 TC 추출물에 비해 암세포의 생존을 효과적으로 억제하였고, 특히 ID 추출물은 낮은 농도에서도 암세포의 생존 억제효과가 우수한 것을 확인하였다. 또한, ID 추출물에 의한 유방암세포 SK-BR-3, MDA-MB-231와 위암세포 AGS의 생존율 억제는 apoptosis 유도를 통해 이루어 지는 것으로 사료되며,그 중 유방암세포 MDA-MB-231에서 apoptosis 유도 효과가 뛰어난 것을 미루어 보아, 유방암의 종류와 그 특징에 따른 차이를 보이지만 ID는 향후 유방암 예방 및 치료제로 개발 가능성을 제시하며, 추후 지속적인 연구를 통하여 in vivo에서의 ID 추출물의 항암효과에 대해 심도 있는 연구가 이루어 져야 할 것으로 사료된다.

A number of plating companies have been exposed to the risk of fire due to unexpected temperature increasing of water in a plating bath. Since the companies are not able to forecast the unexpected temperature increasing of water and most of raw materials in the plating process have low ignition temperature, it is easy to be exposed to the risk of fire. Thus, the companies have to notice the changes immediately to prevent the risk of fire from plating process. Due to this reason, an agile and systematic temperature monitoring system is required for the plating companies. Unfortunately, in case of small size companies, it is hard to purchase a systematic solution and be offered consulting from one of the risk management consulting companies due to an expensive cost. In addition, most of the companies have insufficient research and development (R&D) experts to autonomously develop the risk management solution. In this article, we developed a real time remote temperature monitoring system which is easy to operate with a lower cost. The system is constructed by using Raspberry Pi single board computer and Android application to release an economic issue for the small sized plating manufacturing companies. The derived system is able to monitor the temperature continuously with tracking the temperature in the batch in a short time and transmit a push-alarm to a target-device located in a remoted area when the temperature exceeds a certain hazardous-temperature level. Therefore, the target small plating company achieves a risk management system with a small cost.

본 연구는 Sprague-Dawley 계통의 4주령 랫드에서 MSG의 반복경구투여 독성평가와 행동실험을 통해 어린랫드의 인지능력과 불안감에 미치는 영향을 평가하기 위해서 시행하였다. 시험군은 MSG 대신 distilled water를 투여한 대조군(Control, n = 4), MSG를 3 g/kg을 투여한 군(Low, n =4), MSG를 5 g/kg을 투여한 군(High, n = 4)으로 나누어 4주 동안 주5회 경구투여를 하였다. MSG의 안정성을 확인하기 위해 다음과 같은 관찰 및 검사를 하였다. 검사항목으로는 체중의 변화, 임상증상, 행동실험인 T-maze, Elevatedplus-maze와 혈액학적 검사, 혈청생화학적 검사, 병리조직 학적 검사를 관찰한 결과 모든 투여군 및 대조군에서 특이할 만한 임상증상과 체중변화는 관찰되지 않았으며, 폐사 및 빈사 동물은 시험 전 기간을 통하여 발견되지 않았다. 행동실험인 T-maze 결과 MSG 고용량 투여군에서 움직이는 횟수가 감소하다 증가하는 양상을 보였고, Elevatedplus-maze 실험에서는 MSG 고용량 투여군의 Open arm의 출입빈도가 증가하는 등 유의적인 변화가 나타났다. 혈액학적 검사 및 혈청생화학적 검사에서는 대조군과 비교 시 유의적인 변화가 관찰되었지만 그 수치가 정상범위 안에 포함되기 때문에 이상을 나타내지 않았다. 병리조직검사 또한 약간의 염증발생 소견이 나왔지만 정상범위 안에 포함되기 때문에 이상을 나타내지 않았다고 판단했다. 따라서, 어린랫드를 이용한 MSG의 반복투여 독성시험 결과 특이할만한 신체적인 변화는 나타나지 않았으나 고용량의 MSG 투여는 어린랫드에서 인지능력의 저하 및 행동의 불 안을 유발할 가능성이 있다고 사료된다.

이 연구는 2006년 5월부터 2010년 11월까지 제주도와 부속도서인 가파도에 서식하는 쇠살모사의 먹이원과 지역에 따른 먹이이용의 차이를 밝혀 먹이원의 차이가 쇠살모사의 생활사에 어떠한 영향을 미치는지 밝히기 위하여 이루어졌다. 연구결과, 제주도 개체군에서 확인된 먹이원은 왕지네(Scolopendra subspinipes mutilans), 제주도롱뇽(Hynobius quelpaertensis), 청개구리(Hyla japonica), 맹꽁이(Kaloula borealis), 북방산개구리(Rana dybowskii), 참개구리(Rana nigromaculata), 도마뱀(Scincella vandenburghi), 대륙유혈목이(Amphiesma vibakari), 작은땃쥐(Crosidura shantungensis), 한라산뒤쥐(Sorex caecutiens hallamontanus), 제주등줄쥐(Apodemus chejuensis) 등으로 양서류나 파충류 및 소형포유류를 주로 포식하는 것으로 나타났다. 이중 양서류가 55.2%로 가장 높은 빈도를 보였고, 포유류 20.7%, 지네 13.8%, 파충류 10.3% 순이었다. 이와 달리 가파도 개체군에서는 지네와 도마뱀만을 먹는 것으로 나타났다. 지네나 도마뱀은 작은 크기라 1회 포식으로 얻을 수 있는 영양분이 떨어지기 때문에 제주도 개체군에 비해 생장이나 생식에 불리하게 작용할 것이다. 가파도 개체군의 경우 이용할 수 있는 먹이원의 종류는 비교적 다양함에도 불구하고 도마뱀과 지네만을 주로 포식하는 것은 다른 먹이원의 밀도가 낮아 이를 찾기 위한 노력에 소비되는 에너지를 최소화하기 위해 질은 낮지만 쉽게 구할 수 있는 먹이를 선택하는 것이라 판단된다. 뱀은 머리의 크기가 클수록 큰 먹이를 선택하는 경향이 있는데, 제주도 개체군에서도 쇠살모사의 머리의 크기와 먹이의 직경 사이에 양의 상관관계를 보였다. 제주도 개체군은 수컷이 암컷보다 머리가 크며, 이러한 결과는 먹이의 선택에도 영향을 미칠 것이라 판단된다. 반면, 지네와 도마뱀만을 포식하는 가파도 개체군에서는 머리 크기와 먹이 크기 간에 유의한 차이는 없는 것으로 나타났다. 이러한 결과는 같은 종이라도 서식장소에 따라 이용가능한 먹이원을 선택하여 각기 다른 방향으로 환경에 적응하면서 개체군을 유지하는 데 유리한 방향으로 성장해간다는 것을 직접적으로 보여주는 매우 의미 있는 자료라 판단된다.