Productivity of the Giant Magellan Telescope is estimated based on the annual number of papers produced by the currently operating large telescopes such as the telescope at the ESO La Silla observatory, CFHT, AAT, the Magellan telescopes, ESO VLT, Japanese Subaru, the Gemini telescopes, and the Keck telescopes. We find that the amount of papers produced by a large telescope is roughly proportional to the diameter of its primary mirror. With this fact, we estimate the SCI-paper productivity of the Giant Magellan Telescope by extrapolating the productivity of the above-mentioned large telescopes. Moreover, according to the paper written in 2001 by Benn and Sanchez, the amount of highly-cited papers produced by a large telescope is roughly proportional to the light-gathering power of the telescope or the square of the diameter. Hence, we survey the productivity of Nature-class papers of the large telescopes and extrapolate the relationship to estimate the productivity of the Nature-class papers by using the Giant Magellan telescope of a filled aperture 21.4 meters in diameter. We expect that Korean astronomers will be able to produce annually 60 SCI-class papers and 20 Nature-class papers with high scientific impact by using the telescope-time corresponding to the 10% share of the Giant Magellan Telescope.

The purpose of this study was to examine the effects of vi tamin D3 and 1'etinoic acid(RA) on the human mesenchymal stem ce!ls(MSC) g1'owth and osteogenic differentiations. Cell proliferation, mineralization, cell cycle, expression of cell cycle regu l atOJγ proteins and markers fo1' osteogenic differenatiaiton were determined by MTI assay, mineralization assay, flow cytomet1'Y‘ and Western blot analysis, respectively. Cell viability was dec1'ease by each vitamin D3 and RA added to MSC. it was more decrease by vitamin D3 and RA. Mineralized nodule formation revealed similar expression pattern with positive cont rol group at vitamin D3 and RA mixed add to MSC. At vitamin D3 and RA mixed add to MSC after 7 days of incubation was increase G1 s tage. after 21 days of incubation was inhibit cell cycle prog1'ess by inc1'ease of sub-G1 Treatment vitamin D3 to MSC inhibits p53 and p21, but inc1'ease pRb. RA inhibit p53, but increase p21 and pRb, vitamin D3 plus RA group was same as added RA group. so two vitamin was effect to inhibited cell growth each different mechanism. Expression of BMP-2 protein was prominent in osteogonic supplement treated g1'oup of MSC at 2 weeks cultivation days, but vi tamin D3 treatment decreased BMP-2 expression rather than in (+) control group. BSP protein was notably increased in the OS compa red to positive controls at 2 weeks cultivation, but similar to that of vitamin D3 group t1'eatment group and was least expressed in plus RA mixed group, at 3 weeks, BSP expression was similar to 1'esult of 2 weeks Collectively, these results shows that vitamin D3 and RA have diffe1'ential effects on the MSCs g1'owth and differ entia tion 211