Recently the meaning of the road name address is expended as an information through the revision of the Road Name Address Act. As this revision, the address of things (AoT) become more important indicating the possibility for the expansion to the related business. However, recent study about AoT does not concern how the current priority system works from the first research. In this study, we analyze perception about addressable object between AoT experts and public using AHP analysis. We structured the importance of addressable objects as two categories; urgency and value creation. The necessity in emergency or daily, accessibility and welfare conform the urgency index. Meanwhile, public value creation in public domain or profitability in the business area and economics conform value creation index. We conducted survey for total of 89 of experts and public. The results of this study indicate the relative importance of AoT measured by experts and public. Generally, public tend to concern more about accessibility conforming the urgency index than experts. Moreover, the public WiFi and the sports complex scored the high priority among the remain addressable objects, in respect of the urgency and the value creation. This result could be implemented for the activation of the smart city industry base on the geospatial information including AoT.

Smart City operates with the purpose of solving urban problems. The important thing in smart city operation is that spatial information must be managed at a high level. In addition, it has the characteristics of being managed by one platform. This study presented the core value dimension of smart city based on analysis of various domestic and overseas smart city operation cases. Smart cities are basically operated based on spatial information, and the higher the level of spatial information, the more smart city services can be connected and managed in an integrated manner. The performance dimension of smart city core values presented in the study includes prosperity, personalization, convenience, accuracy, sustainability, safety, environment, integration, etc., and there is a connectivity dimension, a concept that can be managed in an integrated manner. This study will be useful for empirical research on smart city performance dimension design and surveys based on case studies. It will also help field managers who develop, operate, and manage smart cities when quantifying performance dimensions.

Recently, unmanned aerial vehicles (UAV, Drone) are highly regarded for their potential in the agricultural field, and research and development are actively conducted for various purposes. Therefore, in this study, to present a framework for tracking research trends in UAV use in the agricultural field, we secured a keyword search strategy and analyzed social network, a methodology used to analyze recent research trends or technological trends as an analysis model applied. This study consists of three stages. As a first step in data acquisition, search terms and search formulas were developed for experts in accordance with the Keyword Search Strategy. Data collection was conducted based on completed search terms and search expressions. As a second step, frequency analysis was conducted by country, academic field, and journal based on the number of thesis presentations. Finally, social network analysis was performed. The analysis used the open source programming language 'Python'. Thanks to the efficiency and convenience of unmanned aerial vehicles, this field is growing rapidly and China and the United States are leading global research. Korea ranked 18th, and bold investment in this field is needed to advance agriculture. The results of this study's analysis could be used as important information in government policy making.

Recently, with the increase in demand for big data analysis, related techniques and tools are being developed, which makes it possible to utilize data that was difficult to analyze by traditional methods. Topic modeling is a useful technique for deriving topics from a vast amount of text, and is often used in research on trends and predictions of academic research or science and technology. However, the topic derived from the topic modeling is a combination of words presented on the basis of the frequency and probability of simultaneous occurrence, and cannot describe the importance or priority of each word. Therefore, in this study, we applied AHP (Analytic Hierarchy Process) technique to evaluate the priority of the result derived from topic modeling (Topic). In this study, bibliographic data (total of 15,888 articles) of academic researches related to consulting were collected and used in the analysis of this study in order to suggest prioritization method using Topic-Modeling and AHP.

‘Consulting’, which is the main research topic of the knowledge service industry, is a field of study that is essential for the growth and development of companies and proliferation to specialized fields. However, it is difficult to grasp the current status of international research related to consulting, mainly on which topics are being studied, and what are the latest research topics. The purpose of this study is to analyze the research trends of academic research related to ‘consulting’ by applying quantitative analysis such as topic modeling and statistic analysis. In this study, we collected statistical data related to consulting in the Scopus DB of Elsevier, which is a representative academic database, and conducted a quantitative analysis on 15,888 documents. We scientifically analyzed the research trends related to consulting based on the bibliographic data of academic research published all over the world. Specifically, the trends of the number of articles published in the major countries including Korea, the author key word trend, and the research topic trend were compared by country and year. This study is significant in that it presents the result of quantitative analysis based on bibliographic data in the academic DB in order to scientifically analyze the trend of academic research related to consulting. Especially, it is meaningful that the traditional frequency-based quantitative bibliographic analysis method and the text mining (topic modeling) technique are used together and analyzed. The results of this study can be used as a tool to guide the direction of research in consulting field. It is expected that it will help to predict the promising field, changes and trends of consulting industry related research through the trend analysis.

The study aims at quantifying the effect of nano technology in the fields of economics and social aspects by using the methodology of system dynamics. A case study which using selenium oxide nanoparticles as additive agent in order to enhance fuel efficiency was selected as an example of nano technology in economic and societal benefits. Additionally, models for exhaust gas from combustion of fuel (diesel) and related issues are developed to evaluate real-time assessment of the effect of nano technology. It was found that the selenium oxide nanoparticles increase fuel efficiency, and it also affects on the amount of exhaust gas and the respiratory disease related issues. The results of this study which give quantitative value for the effect of nano technology can be used as objective references in development of national policy.

It is difficult to make an accurate estimate of the economic value and effects on societal economy of Nano-technologies. This research measures an economic value of Nano-technologies quantitatively and analyzes its influences on societal economy. This paper chooses some major industries as analysis targets and adapts the DEFRA comparative methodology model which has been developed in the UK and recommended by OECD. For this reason, some industries which are in range of economic value assessment were investigated and related data were collected. Also, the economic value and societal influences of Nano-technologies were calculated, through the procedure of the model. In addition, this study conducts a questionnaire to experts for the validity of measurement results and procedures. This paper suggests a guideline for economic value and effects on societal economy of Nano-technologies assessments through quantitative Defra comparative methodologies.

역학적 경험적 포장 설계법을 도입하려는 현재의 연구추세에 발 맞추어 정확한 응력, 변형률, 변형을 기초로 포장구조체를 해석하기 위한 역학적 접근방법이 필요한 시점이다. 기존의 실험결과에 따르면 연성포장 구조의 기층에 이용되는 자갈과 노상층에 이용되는 노상토등의 포장 하부재료는 반복하중 조건하에서 비선형 회복탄성계수의 특징을 따르는 것으로 나타났다. 이 비선형 거동은 재료의 현재 응력에 의한 회복탄성계수 모델로 나타나질 수 있으며 정확한 해를 구할 수 있는 역학적 방법중의 하나인 유한요소 해석 방법에 적용되어 질 수 있다. 이 연구에서는 비선형 해석기법과 효과적인 해 수렴기법이 구현된 재료 모델 부 프로그램을 범용 유한요소 프로그램의 하나인 아바쿠스에 적용시켰다. 이 수치해석 방법에는 더 정확한 해를 찾기 위한 체눈분할에 의해 만들어진 유한요소 모델이 이용되었다. 이런 일련의 방법들에 의한 포장구조체의 해석결과, 2차원과 3차원 비선형 유한요소 해석의 결과가 큰 차이를 보이는 것으로 나타났다. 또한, 사용된 부 프로그램은 미연방 항공국 공항 시험포장에서 측정되어진 결과 값에 의해 비교 검증되었다.

Considering the great potential of iron chelators at inhibiting the proliferation of tumor cells, in order to determine the molecular and biological basis for the effects of iron chelator in oral cancer, we investigated the effects of iron chelator, desferrioxamine (DFO), on the gene profiling analysis of immortalized human oral keratinocytes (IHOK), and oral cancer cells (HN12), using the cDNA microarray. We identified 46 clones cDNA exhibiting more than 2 fold overexpression in DFO treated IHOK and HN12 cells, and 94 cDNA reveal more than 2 fold down-regulated expression. Examination of gene expression that differs between DFO treated vs. control IHOK and HN12 cells apprear to be related to : cell cycle regulator, cell growth and apoptosis, signal transduction and stress. p21 for cell cell cycle factor was upregualted, and cyclin-cdk gene was decreased expression, so we observed cell cycle arrest in DFO treated IHOK and HN12 cells. In tumor growth, we have identified downregulation of hemidesmosomal protein (bullous pemphigoid antigen 1) and epiregulin expression in DFO treated IHOK and oral cancer cells. Signal transducers including mitogen-activated protein kinase-activated protein kinase 5, serine/thereonine kinase 6 were downregulated with DFO treated cells, suggesting the DFO regulates the p38 MAP kianse pathway in immortalized and maignant oral keratincytes. In conclusion, we have demonstrated the high-throughput utility of cDNA array hybridization in parallel to the gene expression analysis to identify genes that are expressed differentially in DFO treated with immortalized and malignant oral keratinocytes. The differentially expressed genes identified here should be informative in DFO-induced anti-cancer effects.

The purpose of this study was to examine the effects of vi tamin D3 and 1'etinoic acid(RA) on the human mesenchymal stem ce!ls(MSC) g1'owth and osteogenic differentiations. Cell proliferation, mineralization, cell cycle, expression of cell cycle regu l atOJγ proteins and markers fo1' osteogenic differenatiaiton were determined by MTI assay, mineralization assay, flow cytomet1'Y‘ and Western blot analysis, respectively. Cell viability was dec1'ease by each vitamin D3 and RA added to MSC. it was more decrease by vitamin D3 and RA. Mineralized nodule formation revealed similar expression pattern with positive cont rol group at vitamin D3 and RA mixed add to MSC. At vitamin D3 and RA mixed add to MSC after 7 days of incubation was increase G1 s tage. after 21 days of incubation was inhibit cell cycle prog1'ess by inc1'ease of sub-G1 Treatment vitamin D3 to MSC inhibits p53 and p21, but inc1'ease pRb. RA inhibit p53, but increase p21 and pRb, vitamin D3 plus RA group was same as added RA group. so two vitamin was effect to inhibited cell growth each different mechanism. Expression of BMP-2 protein was prominent in osteogonic supplement treated g1'oup of MSC at 2 weeks cultivation days, but vi tamin D3 treatment decreased BMP-2 expression rather than in (+) control group. BSP protein was notably increased in the OS compa red to positive controls at 2 weeks cultivation, but similar to that of vitamin D3 group t1'eatment group and was least expressed in plus RA mixed group, at 3 weeks, BSP expression was similar to 1'esult of 2 weeks Collectively, these results shows that vitamin D3 and RA have diffe1'ential effects on the MSCs g1'owth and differ entia tion 211

We have examined the effect of NO donor, S-nitl‘ oso-N-acetyl-DL-penicillamine(SNAP) on heme oxygenase-1 (HQ-l) ex pression in human oral immortalized & malignant keratinocytes, and investigated in the control of keratinocyte proliferation evidence tha t HO-1 cou ld be involved in a low dose of NO, NO inhibitor, HOinducer, and HO inhibitor medi ated cytoprotect ion against cytotoxi city induced by a high dose of NO Oral keratinocyte growth inhibitory or anti-proliferative effects were exerted by with SNAP and hemin in a dose- and cul tivation time dependent manner The level of HQ-1 protein was increased in all cell types after exposure hernin dose, and the hemin induced HQ-1 protein achieved at higher maximum level by 12 hrs in all kind of cells , The pretreatment of cells with 0, 2 μ M SNAP reduced 1 mM SNAP-induced death in IHOK and HN4 cells , These cytoprotective effects on high dose of NO induced HQ-1 expresion and cell ular toxicity were blocked by low dose of SNAP, HCB, and ZnPP IX supporting the involvement of HQ-1 in high dose NO induced growth arrest or cell death, But these cytoprotection pattern is different from immortalized and malignant keratinocytes , These results indirectly demonstrate that HQ-1 could be involved in cytoprotection by NO priming against high dose NO induced cytotoxicity in immortalized and maigla nt oral keratinocytes, Thus, HQ-1 might be an important cellular target of NO donor, with clinical implications for the pre vention of inJlammatory di seases and anti-tumor immunity

본 연구는 사용자간 게임 아이템 현금거래의 개념과 현금거래의 거래방식, 가치사슬, 이해관계자 그리고 발생 가능한 이슈에 대해 분석하였다. 게임아이템 현금거래는 게임 자체의 비즈니스 모델뿐만 아니라 디지털 콘텐츠의 유통, 사행성 및 작업장 등 민감한 사회적 특성을 보이고 있다. 게임 시장의 지속적인 성장에 따라서 게임 아이템 현금거래의 거래방식과 가치사슬도 변화하고 있으며 기존의 거래방식 및 가시사슬과 다른 현재의 게임아이템의 새로운 개념에 대해 새롭게 분석하였다. 또한 게임아이템 현금거래와 관련하여 계정거래, 캐릭터 선물하기 서비스, 캐릭터 육성하기 서비스, 자금세탁, 아이템 자동 등록기 등의 대한 다양한 이슈를 분석하였다. 이 같은 분석 결과는 게임아이템 현금거래 관련 정책 및 각 이해관계자들의 전략 수립 등에 중요한 현황자료가 될 것이다.

본 연구는 컨버전스 환경변화가 게임 산업에 미치는 영향에 대해 게임의 내용적인 변화와 플랫폼의 변화에 대한 고찰을 시작으로 게임 사용자, 게임 기업, 게임의 유통구조, 게임 산업 전반으로 관점을 확대해 가면서 향후 변화의 방향과 이슈에 대해 분석해 보았다. 보다 체계적인 변화 예측을 위해 시나리오 기법을 통해 IPTV환경 변화가 게임 산업에 미치는 영향 및 예상 변화에 대한 예측 시나리오를 도출하였다. 예측된 시나리오를 통해 게임의 내용적인 변화와 플랫폼의 변화에 대한 양상과 관련된 이슈들을 다각도에서 가시화할 수 있었다. 본 연구를 통해 예측된 게임산업 변화에 대한 현황 진단과 이슈 분석을 바탕으로 컨버전스 환경변화에 따른 게임 기업차원의 전략적 대응방안 모색은 물론 정부 차원에서 인지하고 대비해야할 사항들에 대해서 파악해 볼 수 있는 기회와 관점을 제공하고자 하였다.

PCBs and DDE were determined in the soil samples and the Korean striped field mice, Apodemus agrarius, collected at six localities in Changwon and one locality in Gaduck Island from August 1997 to May 1998. The residual level of PCBs in soils, in which the concentrations of high chlorinated compounds were much higher than those of low chlorinated ones, was highest in the industrial area(IA) in Changwon(60.7 ng/g in average), whereas those of DDE in soils was highest in Gaduck Island(331.9 ng/g in average). However, the levels of each compound detected from soils in the respective remaining places were relatively low. The similar tendency as in the soils was observed in the mice, indicating that the concentration of pollutants in the mice could denote the status of pollution in the terrestrial environment. The composition of PCB congeners in the mice, however, was different from that of soils, but similar to those of other mammals. Moreover, the residual levels of PCBs and DDE in pregnant females from which fetuses were removed were lower than those of males and non-pregnant females. It suggests that these compounds accumulated in pregnant females might have been transferred to the fetuses through placenta as in other mammals. Judging from the above facts, it is suggested that the striped field mouse can be an useful biological index to evaluate the contamination in mammals inhabiting terrestrial environment.