본 연구는 환경교육용 보드게임 개발에 관한 연구다. 이를 위해 문헌 고찰과 전문가 인터뷰를 실시하여 핵심 메커니즘과 용어를 도출하였다. 또한, 타당도와 신뢰도 검증을 위하여 델파이 조사를 진행하였다. 연구 결과 9개 항목에 대하여 합의가 이뤄졌으며, 이를 기반으로 ‘수풀로 메이커’ 프로토타입을 제작하고 플레이테스트 를 진행하였다. 그 결과, 환경에 대한 관심, 생태복원의 개념, 탄소 중립에 대한 이해를 보여, 연구의 초기 목 적을 달성한 것으로 나타났다. 본 연구로 인해 개발된‘수풀로 메이커’는 아동과 청소년의 환경교육 교재의 역할 뿐만 아니라, 환경에 대한 깊이 있는 이해를 견인하고, 더 나아가 실천양식 변화의 잠재성을 키우는 역 할에 기여할 수 있을 것으로 기대한다.

The function of coolant in machining is to reduce the frictional force in the contact area in between the tool and the material, and to increase the precision by cooling the work-piece and the tool, to make the machining surface uniform, and to extend the tool life. However, cutting oil is harmful to the human body because it uses chlorine-based extreme pressure additives to cause environmental pollutants. In this study, the effect of cutting temperature and surface roughness of titanium alloy for medical purpose (Ti-6Al-7Nb) in eco-friendly ADL slot shape machining was investigated using the response surface analysis method. As the design of the experiment, three levels of cutting speed, feed rate, and depth of cut were designed and the experiment was conducted using the central composite planning method. The regression expressions of cutting temperature and surface roughness were respectively obtained as quadratic functions to obtain the minimum value and optimal cutting conditions. The values from this formula and the experimental values were compared. As a result, this study makes and establishes the basis to prevent environmental pollution caused by the use of coolant and to replace it with ADL (Aerosol Dry Lubricant) machining that uses a very small amount of vegetable oil with high pressure.

The purpose of using coolant in machining is both to increase a tool life and also to prevent product deformation and thus, stabilize the surface quality by lubricating and cooling the tool and the machining surface. However, a very small amount of cutting mist should be used because chlorine-based extreme pressure additives are used to generate environmental pollutants in the production process and cause occupational diseases of workers. In this study, medical titanium alloy (Ti-6Al-7Nb) was subjected to a processing experiment by selecting factors and levels affecting cutting power in the processing of the Aerosol Dry Lubrication (ADL) method using vegetable oil. The machining shape was a slot to sufficiently reflect the effect of the cutting depth. As for the measurement of cutting force, the trend of cutting characteristics was identified through complete factor analysis. The factors affecting the cutting force of ADL slot processing were identified using the reaction surface analysis method, and the characteristics of the cutting force according to the change in factor level were analyzed. As the cutting speed increased, the cutting force decreased and then increased again. The cutting force continued to increase as the feed speed increased. The increase in the cutting depth increased the cutting force more significantly than the increase in the cutting speed and the feed speed. Through the reaction surface analysis method, the regression equation for predicting cutting force was identified, and the optimal processing conditions were proposed. The cutting force was predicted from the secondary regression equation and compared with the experimental value.

Store-operated Ca2+ entry (SOCE) represents one of the major Ca2+ entry routes in non-excitable cells. It is involved in a variety of fundamental biological processes and the maintenance of Ca2+ homeostasis. The Ca2+ releaseactivated Ca2+ (CRAC) channel consists of stromal interaction molecule and Orai; however, the role and action of Homer proteins as an adaptor protein to SOCE-mediated Ca2+ signaling through the activation of CRAC channels in non-excitable cells still remain unknown. In the present study, we investigated the role of Homer2 in the process of Ca2+ signaling induced by the interaction between CRACs and Homer2 proteins in non-excitable cells. The response to Ca2+ entry by thapsigargin-mediated Ca2+ store depletion remarkably decreased in pancreatic acinar cells of Homer2–/– mice, as compared to wild-type cells. It also showed critical differences in regulated patterns by the specific blockers of SOCE in pancreatic acinar cells of Homer2–/– mice. The response to Ca2+ entry by the depletion in Ca2+ store markedly increased in the cellular overexpression of Orai1 and STIM1 as compared to the overexpression of Homer2 in cells; however, this response was remarkably inhibited by the overexpression of Orai1, STIM1, and Homer2. These results suggest that Homer2 has a critical role in the regulatory action of SOCE activity and the interactions between CRAC channels.

Under physiological conditions, calcium (Ca2+) regulates essential functions of polarized secretory cells by the stimulation of specific Ca2+ signaling mechanisms, such as increases in intracellular Ca2+ concentration ([Ca2+]i) via the store-operated Ca2+ entry (SOCE) and the receptor-operated Ca2+ entry (ROCE). Homer proteins are scaffold proteins that interact with G protein-coupled receptors, inositol 1,4,5-triphosphate (IP3) receptors, Orai1-stromal interaction molecule 1, and transient receptor potential canonical (TRPC) channels. However, their role in the Ca2+ signaling in exocrine cells remains unknown. In this study, we investigated the role of Homer2 in the Ca2+ signaling and regulatory channels to mediate SOCE and ROCE in pancreatic acinar cells. Deletion of Homer2 (Homer2–/–) markedly increased the expression of TRPC3, TRPC6, and Orai1 in pancreatic acinar cells, whereas these expressions showed no difference in whole brains of wild-type and Homer2–/– mice. Furthermore, the response of Ca2+ entry by carbachol also showed significant changes to the patterns regulated by specific blockers of SOCE and ROCE in pancreatic acinar cells of Homer2–/– mice. Thus, these results suggest that Homer2 plays a critical role in the regulatory action of the [Ca2+]i via SOCE and ROCE in mouse pancreatic acinar cells.

As the number of North Korean refugees increases in South Korean, their acculturation to life in their host country is coming to be an important social issue. This study explores some clothing-related barriers experienced by North Korean refugees and their moderating effects on acculturation to South Korea. Data were collected using a self-administered survey of 163 female and 37 male North Korean refugees in South Korea aged 20 to 69 years. Descriptive analyses, t-tests, ANOVA, Duncan tests, and moderated multiple regression were conducted using SPSS 20.0 and Process Macro v.3.3. The results show that the North Korean refugees who participated in the study had experienced clothing-related barriers regarding fashion terminology and shopping rituals in South Korea. In particular, those in their 60s perceived more clothing-related barriers than those in their 20s and 30s. Next, the clothing-related barriers experienced by North Korean refugees have a negative moderating influence on the relationship between self-esteem and acculturation in South Korea. This study provides a deeper understanding of the relationship between fashion and the acculturation of North Korean refugees to South Korea. The results of the study can be also helpful of government policy makers, practitioners, and academics to develop education programs for North Korean refugees.

As modern industries are highly being developed, it is required that mechanical parts have to be manufactured with a high precision. In order to have precise parts, error-free designs have to be done before manufacturing with accuracy. For this intention being fulfilled, a mechanical analysis is essential for design proof. Nowadays, FEM simulation is a popular tool for verifying a machine design. In this paper, an impeller, being utilized in a compressor or an oil mixer as an actuator, is studied for an evaluation. The purpose of this study is to present a safety of an impeller for a proof of its mechanical stability. A static analysis for stress, strain, and deformation within a regular usage is examined. This simulation test shows 357.26×106 Pa for maximum equivalent stress and 0.207mm for total deformation. A fatigue test is carried to provide durability and its result shows that minimum safety factor is 3.2889, which guarantees that it runs without a fatigue failure in 106 cycles. The natural frequencies for the impeller is ranged from 228.09Hz to 1,253.6Hz for the 1st to the 6th mode. Total deformations at these natural frequencies are shown from 6.84mm to 12.631mm. Furthermore, Campbell diagram reveals that a critical speed is not found throughout regular rotational speeds. From the test results for the analysis, this paper concludes that the suggested impeller is proved for its mechanical safety and good to utilize at industries.

Homer proteins are scaffold proteins that regulate calcium (Ca2+) signaling by modulating the activity of multiple Ca2+ signaling proteins. In our previous report, Homer2 and Homer3 regulated NFATc1 function through its interaction with calcineurin, which then acted to regulate receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis and bone metabolism. However, to date, the role of Homers in osteoclastogenesis remains unknown. In this study, we investigated the roles of Homer2 and Homer3 in aging-dependent bone remodeling. Deletion of Homer2 /Homer3 (Homer2/3 DKO) markedly decreased the bone density of the femur. The decrease in bone density was not seen in mice with Homer2 (Homer2−/−) and Homer3 (Homer3−/−) deletion. Moreover, RANKL treatment of bone marrow-derived monocytes/macrophages in Homer2/3 DKO mice significantly increased the formation of multinucleated cells and resorption areas. Finally, Homer2/3 DKO mice decreased bone density in an aging-dependent manner. These findings suggest a novel potent mode of bone homeostasis regulation through osteoclasts differentiation during aging by Homer proteins, specifically Homer2 and Homer3.

Mechanical components are to be produced with accurate dimensions in order to function properly in assemblies of a machine. Once designs of mechanical components are created, designers examine the designs by adopting many known experimental methods. A primary test method includes stress and strain evaluation of structural parts. In addition, fatigue test and vibration analysis are an important test method for mechanical components. Real experiments at a laboratory are established when products are manufactured. Since design changes should be done before producing the designs in factories, rapid modifications for new designs are required in production industries. FEM simulation is a proper choice for a design evaluation with speed at a detail stage in design process. This research focuses modeling and mechanical simulation of a mechanical component in order to ensure structural safety. In this paper, a universal joint, being used in driving axels of vehicles, is studied as a target component. A design model is created and tested in some ways by using commercial software of FEM. The designed component is being twisted to transmit heavy power and thus, torsional stress should be under strengths of the component’s material. The next is fatigue analysis to convince fatigue cycles to be within the endurance limit of the material. Another test is a vibration analysis for rotational components. This research draws final conclusions from these test analyses and recommends whether the designed model is under safety condition in terms of mechanical structure.

The objectives of this study were to determine in vitro dry matter and energy utilization of hatchery waste products and to confirm whether in vivo energy digestibility of hatchery waste products could be estimated using in vitro data. Two in vitro assays were conducted for infertile eggs, unhatched eggs, culled chicks, and a mixture(20% dried infertile eggs, 20% dried unhatched eggs, and 60% dried culled chicks). In Exp.1, in vitro dry matter disappearance (IVDMD) of hatchery waste products was determined. In Exp.2, in vitro energy disappearance (IVED) was determined using undigested residues from Exp.1. The IVDMD of infertile eggs, unhatched eggs, culled chicks, and the mixture were 81.7, 88.7, 83.9, and 85.4%, respectively. The IVED of the test ingredients were 74.4, 85.1, 77.6, and 79.8%, respectively. Both IVDMD and IVED were greater in unhatched eggs compared with infertile eggs and culled chicks (p<0.05). In vivo energy digestibility was estimated well using prediction equations for hatchery waste products developed in the present study: In vivo energy digestibility(%) = 2.52 × IVDMD (%) – 133.95 with r2 = 0.70 and in vivo energy digestibility(%) = 1.63 × IVED(%) – 50.03 with r2 = 0.67. In conclusion, energy utilization of unhatched eggs was the greatest among test ingredients and energy utilization of hatchery waste products can be estimated using data from in vitro procedures.

This research explored antecedents of stickiness of m-commerce sites, based on the push–pull–mooring (PPM) framework, which was developed to explain what leads people to move from one original location to another. In the current study, the stickiness of m-commerce sites was used as the opposite concept to switching. Therefore, pull effects refer to the positive factors which make consumers stick to an m-commerce site, while push effects refer to the negative factors which make consumers not stick with an m-commerce site. After reviewing the literature, responsiveness, ubiquity, enjoyment, and effectiveness were selected as the pull effects, while privacy concern and efficiency were selected as the push effects. The amount of money spent in specific mobile sites was considered as a mooring effect. According to the results of the structural equation modeling analysis, efficiency actually had a negative impact on stickiness of m-commerce sites. Also, a test of the mooring effect suggested that the negative impact of efficiency on stickiness of m-commerce sites was greater for people who spent more money in their mobile shopping compared to those who spent less. For both the high and low spending groups, responsiveness was the important pull effect as it was the strongest predictor of enjoyment for the low spending group and the strongest predictor of effectiveness for the high spending group (note that enjoyment and effectiveness had the strongest positive impacts on stickiness of m-commerce sites for the low and high spending groups, respectively.). Therefore, the fast response and feedback on m-commerce sites should increase consumers’ stickiness to these sites regardless of the amount consumers spend on these sites. On the other hand, the duration and retention of the low spending group of consumers were influenced by enjoyment the most.

The aim of this study was to investigate the effects of foot position adjuster on body alignment and weight loads in chronic stroke patients. The subjects were 15 chronic stroke patients who were admitted to KHospital in Daegu, South Korea. The study compared the body alignment and weight load changes on flat ground with the foot position adjuster using Foot scan and Dartfish video analysis software. In the results of this study, posterior superior iliac spine (PSIS) alignment decreased significantly after use of the foot position adjuster and center pressure was significantly increased after use of the foot position adjuster. This study suggests that foot position adjuster influences body alignment and weight distribution.

In recent years, advancing technology and growing interest in neuromarketing and neurobranding have led to foundational research that facilitates a better understanding of consumers’ affective responses and unconscious information processing. However, the areas of aesthetics and design have remained largely unaffected by such advances and implications. The purpose of this study is to present a systematic review of the neuroscientific evidence aimed at sensible design for design and marketing researchers interested in exploring neuroaesthetics, an interdisciplinary area by nature. Sciencedirect, EBSCO, and the Google Scholar database were searched in February 2014 to select and review previous studies of aesthetics involving neuroscience. Twenty-eight studies were reviewed and divided into two categories: reward system and emotion. In addition to discussions on previous approaches, future research directions focusing on the process of aesthetic judgments (e.g., design elements, marketing stimuli) are proposed.

A study of oxidation kinetic of Fe-36Ni alloy has been investigated using thermogravimetric apparatus (TGA) in an attempt to define the basic mechanism over a range of temperature of 400 to and finally to fabricate its powder. The oxidation rate was increased with increasing temperature and oxidation behavior of the alloy followed a parabolic rate law at elevated temperature. Temperature dependence of the reaction rate was determined with Arrhenius-type equation and activation energy was calculated to be 106.49 kJ/mol. Based on the kinetic data and micro-structure examination, oxidation mechanism was revealed that iron ions and electrons might migrate outward along grain boundaries and oxygen anion diffused inward through a spinel structure, .

머루(Vitis coignetiae)는 국내에 자생하는 야생종 포도의 한 종류로서, 포도 새눈무늬병에 저항성이다. 내병성 포도 육종에 활용할 유용한 육종소재를 개발하고자 머루의 잎과 과실로부터 cDNA libraray를 제작하였다. 머루의 cDNA library의 총 5,760개의 EST 클론을 분석하여 676개의 contig와 2,306개의 singleton을 분리하여 총 2,982개의 unigene을 분리하였다. NCBI 데이터베이스의 BLAST를 통한 상동성을 검색한 결과, 2,241개의 클론이 기능이 알려진 유전자이었고, 그 중에서 1,442개는 생물학적인 대사에 관여하고 836개는 세포구성물과 관련이 있었다. EST와 contig의 평균 크기는 각각 702bp와 757bp이었다. 포도새눈무늬병균에 감염된 머루 cDNA library로부터 Proline-rich cell wall protein, thaumatin-like protein, class IV chitinase, and pathogenesis-related (PR) protein 10 등의 다양한 방어관련 유전자와 광합성관련유전자 및 수분스트레스 저항성 관련유전자가 많이 검출되었다. 본 연구를 통해 얻어진 머루의 EST 자료는 포도의 새로운 유전자원에 관한 연구 및 내병성 포도 신품종 육종 프로그램에 기본자료로 유용하게 활용될 것이다.

본 논문의 연구목적은 Choroidal neovascularization (맥락막 신생혈관) 모텔에서 HO-1 발현제와 억제재의 영향을 알아보고자 한다. 30마리의 Brown Norway rat을 각각 10마리씩 세 그룹， Hemin treated group, SnPP treated group, Contorl group으 로 나누어서 실험을 진행하였다. Hemin treat group은 10μmol/kg hemin(Frontier Scientific Inc. USA) 을 SnPP treat group은 10 μmol/kg SnPP(Frontier Scientific Inc. USA)을 laser 시술 2 일에서 14 일까지 복강내 주사하였고 Control군은 0.5 mß씩 식 염 수를 주사하였다. 14 일 후 안저사진촬영과 형광안저촬영을 실시하였다. SnPP treated group에서 Hemin treated group보다 더 많은 선생혈관이 생성되었다. Hemin treated group에서는 맥락막 신생혈관 형성의 정도가 정상대조군에 비교하여 저하됨을 알 수 있었다. 본 연구의 결과 HO-1 의 inducer 인 Hemin 이 맥락막의 신생혈관 억제에 영향을 미치는 것으로 보여진다.