This study aimed to develop a solid self-nanoemulsifying drug delivery system (solid-SNEDDS) to enhance the formulation of ketoconazole (KTZ), a BCS Class II drug with poor solubility. Ketoconazole, which is insoluble above pH 3, requires solubilization for effective delivery. This SNEDDS comprises oil, surfactant, and co-surfactant, which spontaneously emulsify in the gastrointestinal tract environment to form nanoemulsions with droplet sizes less than 100 nm. The optimal SNE-vehicle composition of oleic acid, TPGS, and PEG 400 at a 10:80:10 weight ratio was determined based on the smallest droplet size achieved. This composition was used to prepare liquid SNEDDS containing ketoconazole. The droplet size and polydispersity index (PDI) of the resulting liquid SNEDDS were analyzed. Subsequently, solid-SNEDDS was fabricated using a spray-drying method with solidifying carriers such as silicon dioxide, crospovidone, and magnesium alumetasilicate. The physicochemical properties of the solid-SNEDDS were characterized by scanning electron microscopy and powder X-ray diffraction, and its solubility, droplet size, and PDI were evaluated. In particular, the solid-SNEDDS containing ketoconazole and crospovidone in a 2:1 weight ratio exhibited significantly enhanced solubility, highlighting its potential for improved medication adherence and dissolution rates.

For the selective catalytic reduction of NOx with ammonia (NH3-SCR), a V2O5WO3/TiO2 (VW/nTi) catalyst was prepared using V2O5 and WO3 on a nanodispersed TiO2 (nTi) support by simple impregnation process. The nTi support was dispersed for 0~3 hrs under controlled bead-milling in ethanol. The average particle size (D50) of nTi was reduced from 582 nm to 93 nm depending on the milling time. The NOx activity of these catalysts with maximum temperature shift was influenced by the dispersion of the TiO2. For the V0.5W2/nTi-0h catalyst, prepared with 582 nm nTi-0h before milling, the decomposition temperature with over 94 % NOx conversion had a narrow temperature window, within the range of 365-391 °C. Similarly, the V0.5W2/nTi-2h catalyst, prepared with 107 nm nTi-2h bead-milled for 2hrs, showed a broad temperature window in the range of 358~450 °C. However, the V0.5W2/Ti catalyst (D50 = 2.4 μm, aqueous, without milling) was observed at 325-385 °C. Our results could pave the way for the production of effective NOx decomposition catalysts with a higher temperature range. This approach is also better at facilitating the dispersion on the support material. NH3-TPD, H2-TPR, FT-IR, and XPS were used to investigate the role of nTi in the DeNOx catalyst.

The activity of anaerobic ammonium oxidation (ANAMMOX) immobilized in synthetic media (Poly Ethylene Glycol, PEG) and granular form was evaluated comparatively to investigate the effect of influent nitrogen concentration and exposure of oxygen. In ANAMMOX granule reactor, when concentration of influent total nitrogen increased to 500mg/L, removal efficiency of ammonium, nitrite and nitrate were shown to 90.5±6.5, 96.6±4.9, and 93.2±6.1%, respectively. In the case of the PEG gel, it showed lower nitrogen removal performance, resulting in that the removal efficiency of ammonium, nitrite and nitrate were shown to 83.3±13.0, 96.4±6.1, and 90.3±7.5%, respectively. In second step, when exposed to oxygen, the nitrogen removal performance in the ANAMMOX granule reactor also remained stable, but the activity of PEG gel ANAMMOX was found to be inhibited. Consequently, the PEG gel ANAMMOX was a higher sensitivity than that of granular ANAMMOX with two variables applied in this study.

This study was conducted to evaluate the applicability of a carrier media with natural minerals as packing material in a biofilter to remove odor-causing compounds. The carriers were prepared by mixing powdered zeolite, barley stone, and clay. They have a pellet type with a length of 5m m to 10 mm, 3.2 m2/g of a specific surface area, and 0.04 cm3/g of a pore volume. The adsorption capacity and the biodegradation by biomass formation on the media were experimented with toluene and ammonia as the test compounds. The carrier possessed the ability to adsorb toluene and ammonia. The adsorption capacity of toluene and ammonia at the inlet concentration of 100 ppmv was 58 g/g and 96 g/g, respectively. In the biofilter using the carrier as the packing material, the biofilter performances were different depending on the supply of moisture and liquid-nutrient. The critical loading was found to be 33.13 g/m3/hr for toluene removal and 6.5g /m3/hr for ammonia removal even when no nutrients were supplied. The proposed material has been confirmed to be capable of adsorbing inorganic and organic compounds, and can be effectively applied as packing materials for the biofiltration.

A biofilter filled with sintered glass media and wood bark media were developed and tested. Acetic acid and ammonia added in brewery wastewater were used as an artificial odor source. The Reynolds’ number (NRe) was below 130 in the loading range of 3~5 m3/m2-min, while the pressure drop was less than 6 mmH2O. The average removal efficiency of acetic acid was 87.6% and 71.5% at surface loading rate of 3.1 m3/m2-min and 4.4 m3/m2- min, respectively. The acetic removal capacities were 8.1~14.3 g/m3-min with the mass loading rates of 11.7~22.4 g/m3-min, indicating very high performance. However, the acetic removal capacity was sharply decreased at the mass loading rate of 20 g/m3-min. The average removal rate of ammonia was 38% and 25% at the surface loading rates of 3.1 m3/m2-min and 4.4 m3/m2-min, respectively. The ammonia removal capacity was 0.47~0.88 g/m3-min in the range of 11.7~22.4 g/m3-min mass loading rates. The intensity of complex odor was also decreased based on the findings in the measurement using the direct olfactory method and the GC analysis.

Bloom of small centric diatom Stephanodiscus is quite occasional in winter season in temperate freshwater ecosystems. It often leads to degradation of water quality and affects the quality of supplied drinking water. In a previous study, we have found that naphthoquinone (NQ) 4-6 derivate is an effective tool for efficient mitigation of natural S. hantzschii blooms. In the present research, polylactide (PLA) and agar foam were used as immobilized agent for NQ 4-6 to improve the efficiency of NQ 4-6 compound releasing process for its application under various field conditions. Mesocosm experiments at 10 ton scale suggested that the abundance of S. hantzschii was continuously increased in the control and upon treatment of the mesocosm with immobilized NQ 4-6 from PLA and agar foam. Their algicidal activities were 78.8% and 77.1%, respectively, on S. hantzschii after 10 days. In the mesocosm experiments, the dynamics of biotic (bacteria, HNFs, ciliates, zooplankton) and abiotic (water temperature, dissolved oxygen, pH, conductivity, nutrients) factors remained unaffected. They exhibited similar trends in the control and treatment groups. Therefore, the immobilized NQ 4-6 from PLA and agar foam has potential to be used as an alternative algicidal substance to effectively mitigate natural S. hantzschii blooms under various field conditions. In addition, it not only can be used to control S. hantzschii, but also is an effective technique. The immobilized NQ 4-6 showed stable controlled release in desired system.

담체가 투여된 침지형 막결합 연속회분식 반응기(SMSBR)를 사용한 하수의 고도처리에서 담체가 여과성능과 제 거효율에 미치는 영향을 조사하였다. 담체는 반응기 부피 기준으로 10% 투여하였고, 담체와 분말활성탄을 첨가하지 않은 반 응기, 분말활성탄(10 g/L)만을 첨가한 반응기 및 담체와 분말활성탄을 모두 첨가한 반응기를 대조군으로 하였다. COD, T-N 및 T-P에 대한 제거효율은 담체 및 분말활성탄 첨가 유무에 따라 큰 차이가 없었다. 그러나 담체를 첨가하지 않은 경우 막간 차압(TMP)은 급격히 증가하였으나, 담체를 첨가한 경우에 막간차압은 매우 서서히 증가하였다. 담체를 투여한 SMSBR를 사 용하여 하수를 고도처리 할 때, 91일 이상의 운전기간 동안 막 세정 없이 운전이 가능하였다. 담체만을 투여한 경우, 운전 80 일 경과 이후의 COD, T-N 및 T-P 평균 제거율은 각각 95.0, 69.3% 및 51.4%이었다.

The objective of this study was to investigate the response characteristics and performance of a biofilter in the removal of ammonia, as a malodor compound. A trickle-bed type biofilter was applied for this study, and operated at the ammonia loading rate of 0.97-15.52 g/m3·h. The results of the experiment indicate that the critical loading rate of ammonia to the biofilter was 10.7 g/m3·h and the elimination capacity was 11.6 g/m3·h. The analysis of nitrogen mass balance in the reactor indicates that inlet nitrogen as gas phase was converted through the biofilter into NH4 + (41.5% by mass), NO2 - (43%), and NO3 - (15%) as the available form of nitrogen in the effluent liquid. Free ammonia concentration in the effluent liquid was estimated as being in the range from 0.14 to 2.93 mg/L (average 1.7 mg/L) during the experimental period.

스펀지 형태의 담체가 첨가된 침지형 막결합 연속회분식 생물반응기에서 담체가 제거효율과 여과성능에 미치는 영향을 조사하였다. 담체는 반응기 부피 기준으로 각각 5%, 10% 및 20% 첨가하였고, 담체를 첨가하지 않은 반응기를 대조군으로 하였다. COD, T-N 및 T-P에 대한 제거효율은 담체 첨가 유무에 관계없이 큰 차이가 없었다. 그러나 담체를 첨가한 경우, 첨가하지 않은 경우에 비해 조업시간에 따른 막간차압(TMP)은 매우 서서히 증가하였다. 이러한 결과는 폭기에 의해 상승하는 담체가 막 표면과 충돌하게 되고, 이때 막 표면에 형성된 케이크 층을 제거시키기 때문이다. 결론적으로 담체가 첨가된 막결합형 연속회분식 생물반응기는 담체가 없는 반응기에 비해 여과성능이 크게 개선되어, 폐수처리에 효과적으로 활용될 수 있을 것이다.

갈색날개노린재의 집합페로몬(Methyl-(E,E,Z)-2,4,6-decatrienoate)으로 갈색날 개노린재(Plautia stali)와 뚱보기생파리(Gymnosoma rotundatum)의 발생소장을 조사하고, 페로몬담체별 휘발속도와 유인력을 조사하였다. 2009년에는 경남 사천시의 녹차원에서, 2010년에는 경남 도내 11개 단감원에서 발생소장을 조사하였다. 갈색날개노린재는 2009년, 2010년 조사 결과 7월 셋째주 에 발생 peak를 나타내었다. 뚱보기생파리는 2009년에 5월 말과 10월 중순에 2번 발생 peak를 나타내었고, 2010년에는 8월 말 현재까지 7월 둘째주에 가장 큰 peak 를 나타내었다. 갈색날개노린재 집합페로몬의 담체별 휘발속도 및 유인력을 2010 년 경상대학교 캠퍼스 내에서 실험하였다. Poly-tube, PE-Vial, Rubber septum의 3 가지 담체를 이용하여 휘발속도는 SPME법으로 분석하였고 휘발량에 따른 유인 수는 fish trap을 설치하여 조사하였다. Poly- tube의 페로몬이 가장 빨리 휘발하였 고, rubber septum의 페로몬은 시간이 흐름에 따라 지속적이고 일정하게 감하였 다. Poly-tube 페로몬은 실험시작 4주 후 까지 갈색날개노린재에 대해 지속적인 유 인력을 나타내었고, PE-vial은실험 시작 2주 후까지 유인력을 나타내었다.

Oxidation characteristics of benzene as a VOC were investigated using a fixed bed reactor system over transition metal catalysts. The transition metal catalysts were made by using transition metal nitrate reagent and various support materials such as γ-Al2O3, and TiO2. The parametric tests were conducted at the reaction temperature range of 200～500℃, benzene concentration of 2,000～3,000 ppm with space velocity of 10000 hr-1. The property analyses such as BET, SEM, TGA and the conversions of catalytic oxidation of VOC were examined. The experimental results showed that the BET surface areas of catalyst are 86.4∼167.7m2/g, the pore volumes are 0.049∼0.056cm3/g, and the average pore sizes of catalyst are 27∼44Å, which mean the meso pore. It was also found that the conversion of benzene oxidation reaction at 400∼500℃ with Cu/γ-Al2O3+TiO2 catalyst showed 90∼100%, which indicate that the transition metal catalyst with composite supports is very effective for the oxidation of benzene.

두 가지 다른 기질의 담체를 이용하여 살조세균 Pseudomonas fluorescens HYK0210-SK09의 포집율과 microcosm에서 Stephanodiscus hantzschii의 살조능을 파악하였다. Active carbon polyvinyl alcohol (ACPA)담체가 cellulose sponge (CS)담체보다 SK09를 높게 포집하였다. 이를 이용한 microcosm에서 ACPA담체가 CS담체보다 S. hantzschii의 살조

The purpose of this study is to estimate the performance of various biofilter media using ammonia. The results can be summarized as follows: 1) The removal of ammonia using various biofilter media was performed, and inorganic media was proved to be better than the organic media. 2) From the inorganic media, fibril form was most superior. 3) Because fibril form is expensive, PU was determined to be the optimum biofiler media for ammonia removal.