Electricity generation using nuclear power has various advantages, such as carbon reduction, but the treatment of nuclear waste is emerging as a big issue in many countries. The development of technology that can selectively remove radionuclides from liquid radioactive waste is one of the ways to reduce nuclear waste. Here, we assessed a new way of removing radioactive cobalt from a liquid using an aptamer. Aptamers specifically binding cobalt ions were selected through systematic evolution of ligands by exponential enrichment (SELEX). Their binding strength and stability of their complexes with cobalt were analyzed through surface plasmon resonance assay and 2D program Mfold, respectively. The optimal aptamer/bead conjugate conditions for binding cobalt were established using a FA-C1 aptamer with the strongest binding to cobalt. Under these conditions, more than 80% of radioactive cobalt was removed, and more than 99.95% of removed cobalt was recovered. These results proved that radioactive cobalt removal using this aptamer can effectively reduce liquid radioactive waste. This means that the aptamer/bead complex can be utilized to remove various radioactive metal ions.

It is common knowledgement that small sized firms have the strategic flexibility for sustainable management. The synergies with existing businesses to secure new growth engine is pregnant to rise as a strong going_concern. But many barriers are existing in stages and processes such as collection of tacit knowledge, design, research, development, human resource, financing, etc.. In this study, a factory automation system maker with design capability , during several years, has had a strategic flexibility which the firm has researched and developed the medical device which measures sodium(Na) and potassium(K) in human urine as its new growth engine for sustainable management. The company mentioned above has had a successful case. The successful case has story as following: From the product development through the process of convergence to the requirements of the medical field, research and development has been selected via the item Concurrent access and macro-environment (PEST) analysis. Among the elements necessary technology to medical equipment research and development design a mechanism part to take full advantage of the core competencies of the existing business, production was biosensor linear DNA Aptamer and chemiluminescence protocol improved while using outsourcing from abroad through a fairy tale. Digestion process was being tried. By analyzing the existing Lab on a Chip and avoid patentrelated patents embody the development concept was to develop diagnostic kits addition, diagnostic equipment exterior design were commissioned to proceed with the design and external specialist. It was confirmed that external consultant to reinforce the innovation capacity shortage, strategic alliances with various support organizations and other companies are very important.

Avian Influenza (AI) is an avian disease that break out by AI virus (AIV). As Hemagglutinin (HA) that is a main antigen surface protein of influenza virus that causes these influenza infection changes continuously, HA escapes bond of guided antibody by host"s immunity system. Specification region (HA91-261) of HA molecule that reconize receptor (sialic acid) of host cell is well-preserved without changing relatively, but is gotten buried on inside of trimer structure in natural conditions, is reported that development of effective vaccine or cure for HA protein is difficult because is not exposed to immunity system. Aptamer is relatively small strand DNA or RNA, and has high affinity to specific proteins. In this study, new aptamer DNAs were screened which can specifically bind to the receptor binding region of HA H9 protein.