Background: The Nordic hamstring exercise is a closed-chain exercise that effectively activates all lower extremity muscles, but there is a lack of consideration of ankle joint which affects exercise effectiveness. One of the major advantages of the Nordic exercise have been known as strengthening lower extremity extensors. This manifests the exercise increases activities of the ankle plantar flexors as well as hip extensors. Objectives: To investigated the impacts of changes in ankle position on the lower extremity musculature and subjective difficulties during the Nordic hip extension exercise. Design: Cross-sectional study. Methods: Twenty the healthy male participants participated in this study. Participants perform three variations of the Nordic exercises including three ankle positions. Each Nordic exercise was defined as ankle position (neutral, dorsiflexion and plantar flexion). During the Nordic exercise, erector spine (ES), gluteus maximus (GM), biceps femoris (BF), gastrocnemius (GCM) activities and subjective difficulties (Borg RPE score) were measured. Results: Muscular activities of the biceps femoris and gastrocnemius were significantly different among the three ankle conditions, which showed controversial results (P<.05). The biceps femoris activity was significantly higher with the dorsiflexion condition, compared to the others (P<.05). On the other hand, activity of the gastrocnemius was significantly higher with the plantarflexion position compared to the others (P<.05). Conclusion: Present study suggests the ankle positional changes could affect lower muscular activities during the Nordic exercise. Although it is difficult to affirm the causes due to limited data, selective activation of the biceps femoris might accomplish with ankle dorsi flexion and that of the gastrocnemius might accomplish with the ankle plantarflexion during the Nordic exercises.

The restaurant industry is more engaged in innovation now. Many entrepreneurs realized that the restaurant sector faces major challenging market environments: changing needs of customers, high competition, low barriers to entry, high labor costs, and innovation technology. The market orientation drives business learning about customers. Engaged customers can assist firms to improve performance by getting involved with the firm’s product innovation. Innovation could help restaurants to improve the products and service quality, cut costs, increase sales and profits; it is the basic condition for the survival of restaurant entrepreneurs. However, studies about how the innovation affects restaurant performance were still limited to describe the overview of products innovation process (Ivkov et al., 2016). Resource-based theory takes the internal resources and capabilities of a firm as valuable sources of competitive advantage. How to combine internal resources and quickly respond to market needs to create performance of innovation entrepreneurship that still unclear and worth exploring in depth discussion. Based on the above, This study personal interview with twelve restaurant entrepreneur, government experts and scholars reveal how absorptive capacity could strengthen the link between positional advantage and innovation for entrepreneurship restaurants with the influence of customer engagement. The positional advantages can make enterprise differentiate with their competitors, that including entrepreneurial orientation, human capital and market orientation (Jogaratnam,2017). The experts believe that innovation entrepreneurs need to adopt an open mind, seek new opportunities in the catering market, acquire or develop new technologies and launching new products / services in the market, using high returns and high risk strategies in search of success in market. Training and educating team members are effective way to improve their innovation entrepreneurship.

돼지의 생시체중은 생존율과 폐사율에 밀접한 관련이 있어 양돈산업에서 자돈 관리와 직결된 중요한 경제형질이다. 본 연구는 Genome-Wide Association Study(GWAS) 분석을 통해 순종 랜드레이스의 생 시체중과 관련된 위치상 후보유전자 탐색을 실시하였다. 생시체중의 유의적 관련 분석 결과, genomewide suggestive level에서 유의성 있는 single nucleotide polymorphism(SNP) marker는 3번 염색체 (ASGA0098921, P=2.41×10-5)와 4번 염색체(H3GA0013451, P=2.47×10-5)에서 각각 1개씩 동정되었다. 이들 SNP marker가 위치한 3개의 유전자(LOC110260055, LOC100156472, LOC100157689)들은 순종 랜드레이스 생시체중의 위치상 후보 유전자이며, 이들 유전자 정보를 이용해서 순종 랜드레이스 생시 체중을 선발할 수 있는 기초 연구 자료가 될 것으로 사료된다.

In the swine industry, growth related traits are important economic traits directly linked to profitability. Representative growth traits include daily gain, back fat thickness, and carcass weight. This study was conducted to search for positional candidate genes associated with the carcass weight through a genome-wide association study(GWAS) using suggestive levels of statistical thresholds in pigs. As a result of the genome-wide analysis of the associations with carcass weight, the single nucleotide polymorphism(SNP) markers with suggestive significance were identified in 1 SNP marker on chromosome 2(ALGA0015365) and 1 SNP marker on chromosome 4(ALGA0023678). We could select positional 2 candidate genes, located close to the SNP markers with suggestive significance levels. The SNP markers in adjacent to the 2 genes(LOC100519538, LOC100737583) may provide basic data regarding the marker-assisted selection for the carcass weight trait in pigs.

혈청 내 존재하는 효소 중 Glutamic pyruvic transaminase(GPT)는 근육이나 간세포의 손상에 대한 임상 화학적 지표로 사용 된다. 본 연구는 Landrace와 한국재래돼지의 F2 교잡 축군(N=1,105)에 대해 Porcine SNP 60K beadchip을 사용하여 유전자형 분석을 실시하고, GPT 형질과의 관련성을 검증하기 위해 Genome-Wide Association Study(GWAS)를 수행하였다. F2 교잡축군의 가계구조를 보정한 GWAS를 수행하기 위하여 혼합모형과 회귀분석을 조합한 GRAMMAR방법을 관련성 분석에 사용 하였다. 유의성 있는 SNP 표지들은 Sus scrofa chromosome(SSC) 6, 7, 그리고 13에서 동정되었다. 이들유의성 있는 SNP marker들에 가장 근접한 염색체상 위치의 유전자를 그 유전자의 기능을 고려하여 SSC7에서 2개의 위치후보유전자(BCL11B, AHNAK2)를 선정하였다. Pyrosequencing법을 통하여 이 들유전자 내에 존재하는 4개 SNP 표지들의 유전자형을 분석하여 GPT 형질간의 관련성 분석에 이용하였다. 관련성 분석결과, BCL11B g.267 T>C에서 nominal P=7.23×10-8 과 AHNAK2 g.1439 C>T에서 nominal P=5.64×10-6, g.1736 C>A에서 nominal P=3.51×10-6의 결과를 얻었다. 이 들 중 가장 유의한 결과를 얻은 BCL11B 유전자의 g.267 T>C SNP 표지는 추가 연구를 통하여 혈청 GPT 변이에 영향을 미치는 위치상 후보 유전자 표지로 사용 되어 질 수 있을 것이라 사료되어진다.

While the relationship between market orientation and new product performance has been extensively investigated, the mechanism by which market orientation contributes to new product performance was further studied in a business-to-business context. We developed a set of alternative research models to examine the roles of timing of entry and positional advantage in the market orientation—new product performance relationship. The results showed that industrial firms’ positional advantage is a key step in the process. Market orientation does not directly influence new product performance. Instead, market orientation helps to establish a firms’ positional advantage, which, in turn, positively influences new product performance in the marketplace. Timing of entry, shown to be an outcome of positional advantage, is not a determinant of new product performance in the business-to-business context. The findings revealed that market-oriented firms achieve superior new product performance through thoughtfulness indicated by a well-defined positioning strategy, not rapidity of action.

돼지의 체장, 체폭, 체중 등의 연속적인 변이를 가지는 양적형질에 속하는 형질인 성장형질은 양돈업에 있어서 생산성과 수익성에 직결된 중요한 경제 형질이다. 성장형질로는 일당증체량, 등지방두께, 등심단면적 및 도체품질 등이 있으며, 그중에서 등심단면적과 관련이 있는 후보 유전자를 Genome-wide 수준에서 선발하기 위하여 Illumina 사의 Porcine SNP 60K chip을 이용하여 순종 Landrace 집단(수컷 : 50두, 암컷 : 440두)을 분석하였다. Plink program을 이용하여 filtering 과정을 거쳐 최종적으로 31,960개의 SNP marker를 선별하였으며, Genome-wide 임계수준을 bonferroni correction (i.e.1/31957=3.12×10-5)을 이용해서 결정했을 때, SSC16에서 유의성 있는 4개의 SNP marker들을 발견하였다. 이 중 가장 유의성 있는 SNP marker인 DRGA0016148(P=1.38×10-5)와 근접한 후보유전자로 PDE4D를 선정하였고, PDE4D에서 2개(g.9870 T>C, g3976 C>T)의 SNP를 탐색하였다. 본 연구에서는 Genome-wide association study (GWAS)를 이용하여 등심단면적과 관련성이 있는 SNP를 선발하여, 등심단면적과 후보유전자 PDE4D와의 관련성을 규명하고자 연구를 실시하였으나, PDE4D g.9870 T>C 에서는 Hardy-weinberg equilibrium P-value 0.7581로 음의 상관관계를 나타내었으며, PDE4D g.3976 C>T에서는 모두 호모타입이 확인되었다.

We present results of the VLBA observation toward the radio continuum and water maser emissions in a nearby LINER galaxy NGC 1052. The jet structure observed in 2000 is similar to that in 1998, and the two jet structures in 1998 and 2000 support the sub-luminal motion with apparent velocity of 0.26c. Distribution of water maser spots are located ~0.05 pc shifted to southwest from the component which is supported to be the nucleus, and no rapid positional change of the water maser gas with respect to the central engine is seen from 1995 to 2000. The maser gas is positionally coincident with a plasma torus, and the position of the maser gas relative to the nucleus is stable from 1995 to 2000. The maser gas in NGC 1052 could be explained to be associated with the nuclear circumnuclear torus or disk like the situation found in the nucleus of NGC 4258.

산업 비파괴 분야에서 사용되는 방사선원은 장비의 노후화 및 작업자의 부주의로 인해 선원이 노출되는 사고가 발생되어 왔다. 이에 선원의 위치를 실시간으로 추적할 수 있는 안전관리 시스템의 필요성이 부곽 되고 있다. 이에 본 연구에서는 방사선원의 위치 추적을 위한 line-array 선량계를 구성하는 unit-cell 선량계 단위의 각도의존성을 분석하기 위해 Monte Carlo Simulation을 수행하였다. 그 결과 각 기울기에서 상위 1 0% 수치에 대한 오차율은 0°에서 5.90%, 30°에서 8.08%, 60°에서 20.90%의 오차율을 보였다. 총 흡수선량의 비율은 0°(100%)를 기준으로 30°에서 83.77%, 60°에서 53.36%로 나타났으며 기울기가 증가함에 따라 낮아지는 경향성을 보였다. 모든 기울기에서 최대 수치는 30°의 No. 9에서 나타났으며, No. 10에서는 7.24% 낮아지는 경향성을 보였다. 본 연구 결과 각도의존성은 크게 발생되는 것으로 나타났으며, 이를 낮추기 위해서는 선원과 line-array 선량계의 적정거리는 1 cm 이상의 거리에서 유지해야 하는 것으로 사료된다.

The paper examines the relative contribution that prominence effect and frequency effect make on the phonetic substances in a large-scale corpus of reading-style Standard Korean. Japanese has been reported to have a sentence-final shortening effect in reading style database, probably due to frequency effect with attenuated effect of prosodic prominence. To examine whether the Korean reading style has a similar effect to the Japanese sentence-final shortening, phonetic characteristics of declarative sentence-ending ‘ta’ are examined based on the speech of 10 male and 10 female Korean speakers drawn from a large-scale speech corpus. The result showed that the declarative-ending ‘ta’ is marked by higher F1 as well as longer duration and lower F0 than medial ‘ta,' which served as a reference. The paper ends with the discussion of phonological consequences that these phonetic prominence effects may have in a number of languages.

본 연구에서는 6종류의 종실에서 기름을 착유하여 조지방 함량(crude fat content) 측정 및 총 지방산 조성과 위치별 지방산 조성을 비교 분석 하였으며, triacylglycerol(TAG)의 조성과 tocopherol 함량을 분석하였다. Folch법을 이용하여 분석된 조지방 함량은 들깨 21.64%, 홍화씨 13.85%, 고추씨 9.60%, 석류씨 8.85%, 녹두 2.25%, 결명자 2.00%로 나타났다. 추출된 종실유의 지방산 분

이 논문은 피하산란의 정도가 다를 것으로 예상되는 얼굴의 6개의 부위를 촬영하여 각각의 산란특성을 추출하고 렌더링에 반영하여 얼굴의 사실감 있는 표현이 가능한 방법을 제안한다. 각 부위별 산란이미지는 프로젝터로부터 피부에 입사된 단위광선이 내부 산란을 거쳐 밖으로 드러나는 모양을 여러 노출로 촬영하여 HDR 이미지로 합성하고, 비선형 최소제곱합의 해법 중 Sequential Quadratic Programming을 이용하여 광선의 입사지점을 지나는 단면이 이루는 곡선에 '가우스 함수의 선형결합'을 적합한다. 가우스 함수는 산란곡선을 잘 근사하면서 필터로서 적용이 쉬운 장점을 가진다. 우리는 최소제곱합의 해가 지역 해에 빠지는 않도록 유전알고리듬을 이용해 초기 값을 설정한다. 근사된 식의 각 가우스 항은 얼굴에 입사되는 복사조도를 렌더링한 텍스처에 가우스 필터로 적용되어 피하산란효과를 표현. 이 논문에서는 최대 12회의 가우스 필터링을 효율적으로 처리하기 위해 쿠다의 병렬처리능력를 활용하였다.

The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification of the roles of specific genes and signaling pathways in development. I will talk about positional cloning of two developmental mutants in zebrafish. The first mutant is headless: The vertebrate organizer can induce a complete body axis when transplanted to the ventral side of a host embryo by virtue of its distinct head and trunk inducing properties. Wingless/Wntantagonists secreted by the organizer have been identified as head inducers. Their ectopic expression can promote head formation, whereas ectopic activation of Wnt signalling during early gastrulation blocks head formation. These observations suggest that the ability of head inducers to inhibit Wntsignalling during formation of anterior structures is what distinguishes them from trunk inducers that permit the operation of posteriorizing Wnt signals. I describe the zebrafish headless (hdl) mutant and show that its severe head defects are due to a mutation in T-cell factor-3 (Tcf3), a member of the Tcf/Lef family. Loss of Tcf3 function in the hdl mutant reveals that hdl represses Wnt target genes. I provide genetic evidence that a component of the Wntsignalling pathway is essential in vertebrate head formation and patterning. Second mutant is mind bomb: Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneuralgene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. (중략)

Positional clonging (map-based cloning) of mutations or genetic variations has been served as an invaluable tool to understand in-vivo functions of genes and to identify molecular components underlying phenotypes of interest. Mice homozygous for the cerebellar deficient folia (cdf) mutation are ataxic, with cerebellar hypoplasia and abnormal lobulation of the cerebellum. In the cdf mutant cerebellum approximately 40% of Purkinje cells are ectopically located within the white matter and the inner granule cell layer (IGL). To identify the cdf gene, a high-resolution genetic map for the cdf-gene-encompassing region was constructed using 1997 F2 mice generated from C3H/HeSnJ-cdf/cdf and CAST/Ei intercross. The cdf gene showed complete linkage disequilibrium with three tightly linked markers D6Mit208, D6Mit359, and D6Mit225. A contig using YAC, BAC, and P1 clones was constructed for the cdf critical region to identify the gene. A deletion in the cdf critical region on chromosome 6 that removes approximately 150 kb of DNA selection. cdf mutant mice with the transgenic copy of the identified gene restored the brain abnormalities of the mutant mice. The positional cloning of cdf gene provides a good example showing the identification of a gene could lead to finding a new component of important molecular pathways.