세계 4대 실명질환 중 하나인 연령관련 황반변성(Age-related Macular Degeneration, ARMD)에 관한 실험 모델 논문을 검토하면서, ARMD 예방과 치료를 위해 앞으로 나아가야 할 방향을 제시하고자 한다. ARMD 관련 한 전반적인 논문을 세포실험(in vitro)과 동물실험(in vivo)으로 나누어서 점검하고, 현재 진행하고 있는 연구와 한계점에 대해서 살펴보았다. ARMD 발병기전을 연구하고 이를 치료하기 위한 다양한 연구가 진행중이지만, 현재 까지 ARMD를 치료할 수 있는 명확한 치료제는 존재하지 않는다. ARMD 발병기전에 대한 지속적인 연구가 필요 하고, ARMD 치료와 예방을 위해 활용할 수 있는 천연물 후보물질 발굴이 필요하다고 사료된다.

Islanders have tried to find out real alternatives on how to keep sustainable Haenyeo communities through both developing traditional school system at community level (Hansupul Haenyeos School) and advanced school system at university level ( an educational certificate program for Interpreter of Haenyeos Culture and an advanced certificate program for Hanyeos Culture). In oder to share their wisdom of ordinary democratic life style around Bultuk, We created Global Peace Bultuk Assembly for younger generation to succeed in their tradition in July of 2010. It' s a time for us to find out Integrating Policy of the Sustainability of Jeju Haenyeo (Jamnyeo, Jamsu) Community facing their extinction into Jeju Village Conservation Model of Marine Resources Needed.

We developed an age-based spawner-recruit model incorporating environmental variables to forecast stock biomass and recruits of pelagic fish in this study. We applied the model to the Tsushima stock of jack mackerel, which is shared by Korea and Japan. The stock biomass of jack mackerel (Trachurus japonicus) around Korean waters ranged from 141 thousand metric tons (mt) and 728 thousand mt and recruits ranged from 27 thousand mt to 283 thousand mt. We hind-casted the stock biomass to evaluate the model performance and robustness for the period of 1987~2009. It was found that the model has been useful to forecast stock biomass and recruits for the period of the lifespan of fish species. The model is also capable of forecasting the long-term period, assuming a certain climatic regime.

Alzheimer’s disease (AD) is a fatal disorder wherein patients suffer from sensory, motor, and cognitive loss. Currently, the identification and validation of biomarkers for diagnosing AD and other forms of dementia are increasingly important. Olfactory dysfunction is present in patients diagnosed with Alzheimer’s disease or idiopathic Parkinson's disease. Alzheimer’s patients show neuropathological changes in areas of the brain central to the olfactory processing center, suggesting the theoretical importance and potential diagnostic utility of investigating functional changes in olfaction in these patients. However, the usefulness of olfactory screens to serve as informative indicators of Alzheimer’s is precluded by the lack of knowledge regarding neural and molecular mechanisms underlying olfactory dysfunction onto Alzheimer's diseases. To test these ultimate questions, we used molecular and electrophysiological recording techniques to find out the difference of olfactory responses and AD related protein expression patterns by using fly model, Drosophila melanogaster that over-expresses the human β -amyloid, tau protein. We postulated that such flies would present with progressive olfactory impairments compared with age-matched wild type control flies. In this study, our hypothesis is that there is a correlation between olfactory deficits and the spatial expression pattern of β-amyloid and tau protein deposition. Therefore, we demonstrate a specific concentration of lesions in central olfactory structures such as antenna and Maxillary palps. Our study indicates that deficits on olfactory identification may occur in AD, which will be valuable as an indicator of neuropathogenesis.

Basic creep in concrete at an early age plays an important role in the mechancal properties of young concrete and many researches on this field have been carried out. According to recent some studies, however, it is the conclusion that for some cases the basic creep measured from the sealed concrete specimen shows inaccurate results. More specifically, for high-strength concrete (HSC), the incorrectness is more apparent due to autogenous shrinkage occurred at an early age. This paper shows the results obtained from experimental study to evaluate the effect of autogenous shrinkage on basic creep. In this study, four different mixture proportions of which primany test variable is water-cement ratio (w/c) were placed and autogenous shrinkage and basic creep tests on the specimen were performed with age and various loading levels. From this research, it was found that the differences between apparent creep and real creep were remarkable in HSC at an early age. Therefore, it is recommended to modify existing basic creep model equation by considering autogenous shrinkage.

The system life-time are determined by the damage accumulate additively, called to failure, exceeding random thresholds, the system fails. Failures occur according to a non-homogeneous Poisson process with mean-value function ∫ λ(x)ax, where λ(l) is failure rate. Thus, our overall aim is to obtain properties of the survival function of system from models for the stochastic mechanism leading to failure. In this paper, the basic composition Formular is used in deriving many of the results.

In this study, to estimate the corrosion initiation time of reinforced concrete structures subjected to chlorine environments, a 2-parameter model for the age factor of concrete diffusion coefficients is proposed and its applicability is discussed.

According to diverse studies in population migration, there has been a strong age-dependent population distribution in Korea. It is shown that a particular age-group tends to reside in a particular locale or community and the effect possesses usually statistical significance. We quantitatively address this issue: how certain division of age group resides in different region of the country, and investigate possible cause of this migration pattern for different age groups. In this study, population migration trend at age groups of 20s, 30s, 40s and 50s has been analyzed incorporating a spatial econometrics model that accounts for diverse statistical pitfalls such as spatial autocorrelation and spatial dependency. We found that migration trend for different age group corresponds to regional characteristics differently. The study concludes with some policy implications and suggests a need of further study.