본 연구의 목적은 알츠하이머질환(Alzheimer’s disease: AD) 동물 모델을 대상으로 트레드밀 운 동(Treadmill exercise: TE)과 환경강화(environmental enrichment: EE) 처치가 인지기능, 근 기능, 및 밀 착연접 단백질 발현에 미치는 영향을 확인하는데 있다. AD 동물 모델을 제작하기 위해 aluminum chloride(AlCl3)를 90일간(40mg/kg/하루) 투여 하였으며 동시에 TE(10-12m/min, 40-60min/day) 혹은 EE에 노출시켰다. 그 결과 AlCl3 투여에 의한 인지기능 저하와 근 기능 감소가 TE와 EE에 의해 완화된 것 으로 나타났다. 또한, TE와 EE는 AD 질환에서 나타나는 β-amyloid(Aβ), alpha-synuclein 및 tumor necrosis factor-α(TNF-α) 단백질의 발현 증가를 감소시킨 것으로 나타났다. 게다가 TE와 EE는 AlCl3 투여에 의해 감소된 밀착연접 단백질(Occludin, Claudin-5 및 ZO-1)의 발현을 통계적으로 유의하게 증가시킨 것으로 나타났다. 마지막으로 Aβ 단백질과 밀착연접 단백질과의 상관분석을 실시한 결과 부적 상 관관계(Occludin: r=-0.853, p=0.001; Claudin-5 : r=-0.352, p=0.915; ZO-1 : r=-0.424, p=0.0390) 로 나타났다. 따라서 이를 종합해 보면 TE 혹은 EE 처치는 AD에 나타나는 병리학적 특징들을 일부 완화 시켜 인지기능과 근 기능을 일부 개선 시킬 수 있는 효과적인 운동 방법이라고 생각된다.

Background: This study investigated quadriceps femoris muscle activity by comparing concentric and eccentric contractions with self-selective squat speed. Objectives: Study participants agreed in advance and included 30 male college students in their 20s without musculoskeletal system disease. Design: A randomized controlled trial. Methods: Participants who participated in this study agreed in advance and recruited 30 male college students in their 20s who had no disease with musculoskeletal system to conduct this study. When squatting at a self-selected speed, the subjects were evaluated using one-way ANOVA to compare concentric and eccentric contraction muscle activity. Results: There were significant differences between the rectus femoris, vastus medialis, and vastus lateralis regarding concentric contractions.contractions. There was a significant difference in vastus medialis but no significant difference between rectus femoris and vastus lateralis for eccentric contractions. Conclusion: During concentric contraction, all muscles and eccentric contractions indicated significant improvement in the vastus medialis. Therefore, to minimize knee joint injury and maximize efficient muscle activity, self-selected slow and moderate speeds based on self-selection speed when performing the sit-down motion during a squat and moderate speed with fast motions when performing the standing motion should be considered as high muscle activities.

Background: The Nordic hamstring exercise is effective as a representative exercise for strengthening eccentric contraction that can activate the hamstring at high levels, improve eccentric contraction strength and ability, and significantly reduce injury rates. Objectives: To investigated a comparison with the lunge exercise to determine the effect of the Nordic hamstring exercise on muscle activity and balance ability in a sample of adult amateurs and football players. Design: Randomized controlled trials. Methods: The subjects of the study were stratified samples of 28 professional and amateur football players and two groups (Nordic hamstring group and lunge group) of 14 people each were studied. Surface electromyography using, was performed to measure the hamstring muscle activity, and the good morning exercise was selected as the measurement exercise. For balance ability, the surface area ellipse and length were measured with BioRescue, while for static balance, the posture of closing the eyes and single-limb standing was measured, and for dynamic balance the one-legged squat was measured. Results: The %MVIC of the semitendinosus and the biceps femoris improved in the Nordic hamstring exercise group and showed statistically significant increase (P<.05). The static and dynamic balance improved in the Nordic hamstring exercise group and showed statistically significant decrease (P<.05). Conclusion: The Nordic hamstring exercise can be useful as an exercise to improve the hamstring muscle activity and balance ability of professional and amateur football players.

Background: Hemiparesis not only affects the affected side but also exerts an impact on the unaffected side. Stroke patients endure muscular weakness attributable to hemiparesis, resulting in asymmetry of muscular strength between the paralyzed and non-paralyzed sides. Objectives: To investigate the correlation between lower limb muscle strength asymmetry and functional factors in patients with stroke. Design: A cross-sectional study. Methods: A total of 58 stroke patients participated in this study. After measuring the muscle strength of both lower limbs using manual muscle testing, the asymmetry was calculated. Functional factors such as berg balance scale (BBS), timed up and go (TUG), 10-metre walk (10MW), and modified barthel index (MBI) were measured. Results: The BBS showed positive correlations with hip, knee, and ankle strength asymmetry (P<.05). The TUG showed negative correlations with hip, knee, and ankle strength asymmetry (P<.05). The 10MW showed negative correlations with hip, knee, and ankle strength asymmetry (P<.05). The MBI showed positive correlations only with hip strength asymmetry (P<.05). Conclusion: We were found that there is a more pronounced lower limb muscle strength asymmetry in the lower extremity of stroke patients, which is associated with BBS, TUG, and 10MW.

본 연구는 EMG(electromyography) 텍스타일 전극 개발을 목적으로 레이어 수의 디자인 및 원단을 다르게 하여 성능 및 신호 획득 안정성을 평가한다. 레이징 및 프레스 공정을 통하여 텍스타일 전극을 제조하며 Layer-0, Layer-1, Layer-2로 레이어 유무 및 수에 따른 결과를 분석했다. 이에 레이어 유무에 따라서는 근활성 측정에 영향을, 수가 많을수록 높은 성능이 나타남을 확인할 수 있었다. Layer-2 구조로 통일하여 5가지의 원단(네오프렌, 스판덱스 쿠션, 폴리에스테르 100%, 나일론 스판덱스, 광목 캔버스)으로 전극을 제조해 실험해 보았다. 성능적인 면에서, 원단의 중 량이 높은 나일론 스판덱스가 높은 성능을 보였으며, 스판쿠션 텍스타일 전극이 근활성도 수득에 높은 안정성을 보 였다. 이에 위 연구는 레이어에 따른 성능 연관성과 전극-피부사이의 닿는 면적 간의 관계 등을 고찰하여 슬리브 전체의 의복압을 늘리는 대신 특정 센서 측정 부위에만 높은 압력을 가함으로 차후 연구에서 레이어의 수 및 물성에 따른 전극의 공학적 설계 가능성을 제시한 의의가 있다.

Background: Choosing to perform squats on an unstable surface potentially offers advantages surpassing those of their stable counterpart. Objectives: The purpose of this study was to compare muscle activation during squats on stable and unstable surfaces and investigate the relationship among thigh muscles. Design: Observational study. Methods: Nineteen adults participated in this study. The stable surface consisted of a flat floor. The unstable surface involved the use of an air cushion. An air cushion was positioned beneath each foot of the study participants. Surface electromyography was employed to measure muscle activation. %MVC was calculated by measuring muscle activation during squat execution and manual muscle testing. Results: The comparison of muscle activation during squats between stable and unstable surfaces revealed a significant difference in the rectus femoris and biceps femoris (P<.05). On stable surfaces, positive correlations were observed in the rectus femoris, vastus lateralis, and vastus medialis (P<.05). On unstable surfaces, positive correlations were found between the rectus femoris and vastus medialis (P<.05). Conclusion: This study observed an increase in muscle activation of the rectus femoris and biceps femoris during squats on an unstable support surface compared to a stable support surface.

Background: As ways to optimize the mobilization of postural stability muscles for sitting up motions, arm reaching motions and head raising motions have important effects. Objectives: This study was conducted to investigate the effects of reaching to sit-up training on the trunk muscle activity, postural ability, and balance ability of patients with hemiplegia due to stroke. Design: Randomized controlled trial. Methods: This study was conducted with 18 stroke patients who met the selection criteria divided into two groups: a study group of 9 patents and a control group of 9 patients. The study group carried out reaching to sit-up training, which can promote trunk muscles and improve control through trunk interactions. The control group received general physical therapy intervention Results: The activity of the trunk muscle was significantly different before and after intervention in study and control group. The functional reaching test showed significant changes in both the study group and the control group. The timed up and go test showed a significant change in the study group. Conclusion: Reaching to sit-up training for 4 weeks showed increases in trunk muscle activity in stroke patients and was effective in improving balance ability.

Background: Proprioception in the ankle joint is important for maintaining balance. There is a correlation between joint position sense (JPS), balance and ankle dorsiflexion range of motion (DF-ROM). Objectives: The purpose of this study was to compare the effects of talocrural joint mobilization (TJM) and muscle energy technique (MET) of plantar flexor muscle (PF) on improving joint position sense (JPS) and static balance. Design: Cross-over randomized trial research. Methods: Sixteen participants (male 10, female 6; 20’s of their age) without ankle instability were recruited. In a randomized, three conditions, no intervention, talocalcaneal mobilization, and PF-MET were all applied to 16 participants. For TJM, the Kaltenborn grade 3 joint gliding method, in which the talus moves posteriorly perpendicular to the tacrocrural joint plane, were used. In the PF-MET, MET method were applied gastrocnemius muscle and soleus muscle with 25% of 1 Repeat Maximum of each muscle. The all participants performed PF-MET and TJM for 18 minutes. DF-ROM measured the weightbearing lunge test. JPS measured using the active joint angle reproduction test. Static balance was measured displacement of center of pressure parameter. Results: PF-MET and TJM had significant differences in DF-ROM and AP displacements. PF-MET significantly increased at 5° and 15° of plantar flexion and 5° of dorsiflexion, and COP velocity significantly decreased in JPS compared to TJM. Conclusion: PF-MET and TJM are effective in increasing DF-ROM. However, PF-MET has a more positive effect on improving JPS and static balance than on talocrural joint mobilization.

Background: A decrease in physical activity has been observed due to the global pandemic, resulting in the onset and progression of musculoskeletal disorders as chronic diseases. Objectives: This study aimed to assess the difference in the degree of contraction of the lower limb muscles between the existing vertical vibration method and a new cross-vibration method. Design: Randomized controlled trial. Methods: The exercise program using whole-body vibration equipment was conducted for 12 sessions, 25 min per session, three times per week for 4 weeks. Results: The changes over time showed a significant difference in cross-alternating vibrations (P<.05), except for the lateral gastrocnemius and tibialis anterior, with no significant difference in sonic vertical vibration (P>.05). The interaction between time and group was significant for all muscles (P<.05), except for the biceps femoris, with differences between before the program and at 2 and 4 weeks after the program revealed in the post-hoc analysis. Conclusion: Future studies should further evaluate the use of CAV exercise devices as auxiliary equipment in exercise by assessing different groups and variations in intensity.

Background: Some patients may not fully recover their daily activity capabilities even after the total hip replacement (THR), and may continue to experience functional limitations for up to a year after the procedure, according to reports. Objectives: The purpose of this study was to examine the effects of machine squat on muscle strength, balance and gait in patients after THR. Design: A randomized controlled trial. Methods: Thirty-three patients after THR were randomly allocated into slide (n=11), reformer (n=11), and control groups (n=11). Each group underwent their respective squat regimens for thirty minutes, seven times a week, for two weeks. Muscle strength changes were assessed using the manual muscle test (MMT), balance was evaluated using the Berg Balance Scale (BBS), and gait analysis was performed using the 10-meter walk test (10MWT). Results: Significant changes in hip flexor and abductor strength were observed in the slide and reformer groups within each group (P<.05). The reformer group showed significant changes in hip extensor strength (P<.05). Significant improvements in BBS were observed in all three groups (P<.05). There were significant changes in 10MWT in the slide and reformer groups (P<.05). A significant difference in hip extensor strength was found between the reformer and control groups after the intervention (P<.0167). Significant differences in BBS were observed between the slide and reformer groups and between the reformer and control groups after the intervention (P<.0167). Conclusion: Our findings suggest that machine squat regimens can be effective for early rehabilitation after THR, improving muscle strength, balance, and gait.

Background: Various functional tests such as upper quarter Y-balance test (UQYBT) are used to evaluate shoulder stability and mobility in clinical or sports fields. Previous studies have been conducted to determine the correlation between the scapular or trunk muscle and UQYBT. However, the correlation between UQYBT and hip flexor, which can be considered as a core muscle, has not been confirmed. Objects: To verify the relationship between the UQYBT and scapular muscle (scapular protractor and lower trapezius [LT]), trunk muscle, and hip flexor strengths in healthy male participants. Methods: A total of 37 healthy male participants were recruited and underwent UQYBT in the push-up posture. The isometric strength of the scapular protractor, LT, trunk flexor and extensor, and hip flexors were measured using a smart KEMA strength sensor (KOREATECH Inc.). Results: The superolateral direction of the UQYBT was moderately to strongly related to trunk extensor (r = 0.443, p < 0.01), scapular protractor (r = 0.412, p < 0.05), LT (r = 0.436, p < 0.01), and both sides of the hip flexors (supporting-side: r = 0.669, p < 0.01; non-supporting- side: r = 0.641, p < 0.01). The inferolateral direction of the UQYBT was moderately related to the scapular protractor (r = 0.429, p < 0.01), LT (r = 0.511, p < 0.01), and both sides of hip flexors (supporting-side: r = 0.481, p < 0.01; non-supporting-side: r = 0.521, p < 0.01). The medial direction of the UQYBT was moderately to strongly related with the scapular protractor (r = 0.522, p < 0.01), LT (r = 0.541, p < 0.01), and both sides of hip flexors (supporting-side: r = 0.605, p < 0.01; non-supporting-side: r = 0.561, p < 0.01). Conclusion: This study showed that the strength of the scapular muscles, trunk muscles, and hip flexor muscles correlated to the UQYBT. Therefore, the strength of not only the scapular and trunk muscles but also the hip flexor muscles should be considered to improve the UQYBT.

Background: In modern society, the use of computers accounts for a large proportion of our daily lives. Although substantial research is being actively conducted on musculoskeletal diseases resulting from computer use, there has been a recent surge in interest in improving the working environment for prevention. Objects: This study aimed to examine the effects of posture correction feedback (PCF) on changes in neck posture and muscle activation during computer typing. Methods: The participants performed a computer typing task in two sessions, each lasting 16 minutes. The participant’s dominant side was photographed and analyzed using ImageJ software to verify neck posture. Surface electromyography (EMG) was used to confirm the participant’s cervical erector spinae (CES) and upper trapezius muscle activities. The EMG signal was analyzed using the percentage of reference voluntary contraction and amplitude probability distribution function (APDF). In the second session, visual and auditory feedback for posture correction was provided if the neck was flexed by more than 15° in the initial position during computer typing. A 20-minute rest period was provided between the two sessions. Results: The neck angle (p = 0.014), CES muscle activity (p = 0.008), and APDF (p = 0.015) showed significant differences depending on the presence of the PCF. Furthermore, significant differences were observed regarding the CES muscle activity (p = 0.001) and APDF (p = 0.002) over time. Conclusion: Our study showed that the feedback system can correct poor posture and reduces unnecessary muscle activation during computer work. The improved neck posture and reduced CES muscle activity observed in this study suggest that neck pain can be prevented. Based on these results, we suggest that the PCF system can be used to prevent neck pain.

Background: The elderly population is increasing rapidly worldwide. Muscle mass, usual walking speed (UWS), knee extension strength (KES), hand grip strength (HGS), peak expiratory flow (PEF), and depression is used for sarcopenia diagnosis. All four of these factors (KES, HGS, PEF, and depression) correlated with UWS and also to muscle mass. But, many studies have suggested that no correlation exists between muscle mass and UWS. Objects: This study aimed: 1) to investigate whether muscle mass reduction affected UWS, as mediated by KES, HGS, PEF and depression, and 2) to explored whether significant changes in these mediators varied by the body segment in which muscle mass evaluated in elderly female aged 65–80 years. Methods: A total of 100 female aged 65–80 years were surveyed. Muscle mass was measured by body segment (upper and lower segment), and KES, HGS, PEF, depression, and UWS were also assessed. Median analyses were progressed in IBM SPSS software (ver. 23.0, IBM Co.) using a downloaded INDIRECT macro. Results: The direct effect of the KES and PEF were significant, and the indirect effect of KES and PEF were not significant. Thus, KES and PEF served as full mediators of the effect of muscle mass on UWS. Regardless of bodily region, KES and PEF combined with muscle mass were significant mediators of UWS, with similar indirect effect sizes. Conclusion: KES and PEF are the only mediators regardless of body part. Therefore, mediating the KES and PEF may prevent sarcopenia progression in elderly female. Also, sarcopenia can be readily assessed by evaluating either the upper or lower body; it is not necessary to measure total muscle mass.

Background: In terms of physical performance, elastic tape (ET) is known to contribute to injury prevention and performance enhancement. Objects: This study aimed to compare and analyze the effect on lower extremity muscle activity of young adult women with and without ET during squats. Methods: In this study, six healthy, young women were recruited as participants in a university laboratory. Participants were allocated to two groups of three after measuring muscle activity in a pre-test, and the experiment was conducted for a total of two weeks (two sessions). First, 10 half squats were taped once in the first week, and 10 half squats were performed without taping in the second week. The other group did this in reverse and measured muscle activity after the squat was over. Results: As a result of this study, there was no significant difference in the quadriceps with or without ET (Z = –0.11, p > 0.05). Similarly, no significant difference was found in hamstring (Z = –0.31, p > 0.05). Conclusion: No beneficial effect was found on changes in muscle activity following ET application during squats. Further studies require randomized controlled trials that increase the number of participants and the intensity of the intervention, and measure pain, function, and performance rather than muscle properties depending on the biomechanical lifting mechanism.

Background: Mobilization movements was applied with different forces and frequencies for different clinicians. Force transmission varies with frequency. Objectives: The purpose of this study was to examine the effects of frequency- specific application of grade III PA movement on muscle tone and muscle activity around the lumbar vertebrae. Design: A one group pretest-posttest design. Methods: Twenty study subjects applied grades III of PA movement exercise of 0.5 Hz and 1 Hz with a force of 13 N around the 1st and 3rd lumbar vertebrae, and muscle tone and muscle activity were measured and compared before and after. Results: This study showed that 0.5 Hz grade III PA activity exerted an effect on the decrease in muscle tone of the 1st and 3rd right and left lumbar muscles. It was found that 0.5 Hz affected the right side of L1 and 1.0 Hz affected the left side of L1 in near-activity when applying the grade III PA movement by frequency. Conclusion: In the future, it will be necessary to investigate the effect of applying frequency according to various grades of PA movement.

Background: The Trunk Stabilization Exercise and Respiratory Muscle Exercise may help address the complex biomechanical and neuromuscular issues that contribute to shoulder joint disorders and can help improve patient outcomes in terms of pain relief, range of motion, and functional ability. Objectives: To investigated the effects of conventional physical therapy, trunk stabilization exercise, and respiratory muscle exercise, on the Range of Motion (ROM), ULF and balance in patients with shoulder joint disorder. Design: A randomized controlled trial. Methods: This study randomly allocated 18 subjects to the control group, 19 to the trunk stabilization exercise group, and 19 to the respiratory muscle exercise group, while all interventions were performed five times a week for four weeks. The result measurement involved the ROM, the upper limb function test (ULT), and balance tests. Results: The respiratory muscles exercise group indicated significant improvement in ROM and balance tests than the trunk stabilization exercise group and control group. Conclusion: The respiratory muscle exercise is a more effective way to improve ROM and balance ability than trunk stabilization exercise for patients with shoulder joint disorder.

The Animal and Plant Quarantine Agency conducts a targeted sampling plan and analysis for veterinary drugs within the country every year. Target compounds included tetrachlorvinphos as an organophosphate, diminazene as an anti-infective medication, ketoprofen as a nonsteroidal anti-inflammatory drug, triclabendazole and clorsulon as flukicides in 2022. These compounds were not included in National Residues Program (NRP), despite their high sales ranking. A total of 94 bovine muscle samples and 20 equine muscle samples were collected from various locations across the country. The analysis of target compounds in muscle was performed using LC-MS/MS coupled with Food code 8.3.1 revised in 2022. A 2 g sample of muscle tissue was extracted using a water: acetonitrile (1:4, v/v) solution, then cleaned up with C18 and hexane saturated with acetonitrile. Compounds were separated with C18 column and mobile phases consisted of 0.1% formic acid in water (A) and 0.1% formic acid in acetonitrile (B). All analytes exhibited good linearity with correlation coefficients (R2) higher than 0.992. The limit of quantification (LOQ) of these compounds ranged from 0.21 to 2.79 μg/kg except for diminazene (3.85~6.86 μg/kg). The average recoveries of these analytes were 89.45~129.13% in muscle at spiked level of 10 or 20 μg/kg. Relative standard deviations (%) (intra-day and inter-day) were lower than 20% for all target compounds, except for diminazene and triclabendazole, whose intra-day RSD % was slightly higher than 20% in equine muscle. Testing confirmed that all 94 bovine and 20 equine muscle samples from 9 provinces were free from residues of veterinary drugs. Monitoring of compounds not included in the NRP should continue to ensure consumer health and food safety.