간행물
International Journal of Oral Biology KCI 등재
- 발행기관 대한구강생물학회
- 자료유형 학술지
- 간기 계간
- ISSN 1226-7155 (Print)2287-6618 (Online)
- 수록기간 1977 ~ 2026
- 주제분류 의약학 > 치의학 의약학 분류의 다른 간행물
- 십진분류KDC 515DDC 610
권호리스트/논문검색
Vol.51 No.2 (2026년 6월) 4건
1.
2026.06
구독 인증기관 무료, 개인회원 유료
Airborne fine particulate matter (FPM) is a major environmental health threat associated with inflammatory responses. Although previous studies have reported FPM-induced inflammation in macrophage cell lines, the effects of FPM on primary bone marrow-derived macrophages (BMMs) and systemic nitric oxide metabolite (NOx) levels have not been fully characterized. This study evaluated whether low-dose FPM exposure induces inflammatory responses in vitro and in vivo . BMMs isolated from ICR mice were treated with FPM (0.0–12.5 μg/mL), and proinflammatory cytokine production was measured by enzyme-linked immunosorbent assay. For in vivo assessment, mice were administered FPM (7.5 mg/kg) by intraperitoneal injection under short-term exposure conditions, and serum NOx levels were quantified using the Griess assay. Exposure to FPM at 6.25 and 12.5 μg/mL significantly increased tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production by BMMs compared with the control group (p < 0.05). In vivo , serum NOx levels were also significantly elevated in FPM-exposed mice compared with the control group (p = 0.026), consistent with results observed in the lipopolysaccharide-treated positive control group (p = 0.004). These findings suggest that low-dose transient FPM exposure activates innate immune cells and induces systemic inflammatory responses, supporting the potential role of FPM in the pathogenesis of inflammatory diseases.
4,000원
2.
2026.06
구독 인증기관 무료, 개인회원 유료
Peri-implantitis leads to bacterial contamination of titanium implant surfaces, potentially impairing the integrity of peri-implant tissues. This study investigated the effects of various decontamination strategies on contaminated titanium surfaces and their impact on gingiva-derived mesenchymal stem cells (GMSCs). Both rough and machined titanium surfaces were contaminated with bacteria and subsequently subjected to various mechanical and chemical decontamination methods. GMSC viability and osteogenic responses were analyzed to characterize cellular behavior on the treated surfaces. Cellular responses varied according to surface morphology. On rough surfaces, cell viability declined over time regardless of bacterial contamination or subsequent decontamination treatments. Conversely, machined surfaces supported increased cell viability in both decontaminated and uncontaminated groups, whereas viability remained unchanged on untreated contaminated surfaces. These findings suggest that effective bacterial decontamination of machined surfaces may promote GMSC proliferation and establish cellular conditions favorable for maintaining peri-implant tissue stability under controlled in vitro conditions. Correlation analyses demonstrated surface-dependent osteogenic responses. On rough surfaces, GMSC viability was positively correlated with calcium deposition. These findings suggest that titanium surface morphology may modulate mineralization-associated responses in GMSCs.
4,000원
3.
2026.06
구독 인증기관 무료, 개인회원 유료
Su Young Oh, Eun-Kyong Kim, Tae-Lyn Kim, So-Young Choi, Han Byeol Shin, Hye-Rin Choi, Heon-Jin Lee, Su-Hyung Hong
Cisplatin-based chemotherapy is an established treatment for head and neck squamous cell carcinoma (HNSCC); however, treatment resistance remains a major challenge. Biomarkers predictive of cisplatin response may improve risk stratification and treatment selection. We retrospectively analyzed data from The Cancer Genome Atlas (TCGA)- HNSC dataset to investigate the association between LIM homeobox 1 (LHX1) expression and clinical outcomes, particularly among cisplatin-treated patients. Kaplan–Meier survival analysis and differential expression analyses were conducted based on disease-specific survival (DSS) status. LHX1 mRNA expression in tumor and non-tumor tissues was also assessed using TCGA-derived transcriptomic data. In addition, LHX1 mRNA and protein levels were examined in cisplatin-sensitive oral squamous cell carcinoma (OSCC) cell lines and their matched cisplatin-resistant counterparts. Functional relevance was evaluated by performing siRNA-mediated LHX1 knockdown followed by cisplatin treatment in resistant OSCC cells. LHX1 mRNA expression was significantly higher in HNSCC tumors compared with non-tumor tissues (p < 0.001). High LHX1 expression was associated with poor survival in the overall cohort and in the cisplatin-treated subgroup (log-rank p < 0.05 for both). In the cisplatin-treated subgroup, LHX1 expression was significantly associated with DSS status (p < 0.05, q < 0.05). LHX1 expression was also upregulated in cisplatin-resistant OSCC cells (p < 0.05), and its knockdown enhanced cisplatin sensitivity in resistant OSCC cells (p < 0.05). LHX1 may be associated with adverse outcomes and cisplatin resistance in HNSCC/OSCC, supporting its potential as a treatment-relevant biomarker.
4,000원
4.
2026.06
구독 인증기관 무료, 개인회원 유료
Enameloid is well conserved within the teeth, scales, and denticles of the fossils of extinct animals, and extant fish taxa, as well as in extant caudate amphibians. However, this tissue persists only during the larval stage in living caudates and is absent postmetamorphosis in amphibians. Little is known regarding the evolutionary fate of enameloid and whether it transitions into enamel or dentin. Here, the upper jaws of Xenopus laevis tadpoles at stages 55, 56, and 57 were examined to analyze: 1) the spatial patterning of tooth germs, 2) histological profiles of mineral deposition and collagen fiber distribution, and 3) the fine structure of enameloid during early odontogenesis using stereomicroscopy, light microscopy, and transmission electron microscopy. Stereomicroscopic observations revealed that tooth germs at the cap and bell stages form in an alternating sequence in stage 57 tadpoles. Von Kossa staining demonstrated mineral deposition within the dental matrix at the bell stage. Furthermore, the enameloid matrix, which is primarily composed of collagen fibers, was clearly distinguished from enamel via picrosirius red staining. In capstage tooth germs, collagen fibers within the amorphous matrix were sparsely distributed and attached to the inner enamel epithelium and dental papilla cells, respectively. Conversely, bell-stage enameloid was densely occupied with collagen fibers and encapsulated by enamel. Overall, these results suggest that X. laevis serves as an ideal experimental model for investigating tooth evolution, comparable to caudate amphibians.
4,000원
