목적 : 본 연구는 신체적 활동이 경도인지장애 노인의 실행기능에 미치는 효과의 근거를 제공하고자 한다. 연구방법 : Preferred Reporting Items for Systematic Reviews and Meta-Analysis(PRISMA) guidelines의 보고 지침 체크리스트 항목을 바탕으로 체계적 고찰방법을 사용하였다. 전자 데이터베이스인 PubMed, CINAHLPychINFO, Embase, Cochrane를 사용하여 자료를 수집하고, Cochrane Risk of Bias Tool을 통하여 각 연구의 비뚤림 위험을 평가하였다. 검색어에는 “MCI” OR “mild cognitive impairment” AND “physical activit*” OR “physical performance” OR “physical exercise*”, AND “executive function*”을 사용하여 최종 2005년부터 2017년까지 무작위대조군 연구 11편을 선정하였다. 결과 : 중재는 주로 그룹으로 진행 되었으며 복합적 중재보다는 단일 중재가 많았다. 중재를 진행한 전문가는 피트니스 전문가, 물리치료사, 작업치료사가 많았다. 실행기능을 측정한 도구로는 TMT-A(21.4%)와 TMT-B(17.9%)가 가장 많았으며, 중재로 사용된 신체적 활동으로는 유산소 운동과 (8편, 72.7%) 무산소 운동 (7편, 63.6%)이 많았다. 유산소 및 무산소 운동을 포함한 중재는 실행기능 향상에 유의한 효과가 있었으나, 여가 활동을 제공한 중재는 실행기능에 유의한 변화가 없었다. 결론 : 본 연구를 통해 신체적 활동이 경도인지장애 노인의 실행기능에 효과를 확인할 수 있었다. 작업치료는 경도인지장애노인의 실행기능 향상을 위한 중재로 인지적 접근과 더불어 신체적 활동에 관한 다양한 연구들이 활발하게 이루어 져야 할 것이다.

고치벌과에 속하는 Helconinae아과의 Schizoprymnus terebralis (Snoflák, 1953)을 한국에서 처음으로 보고한다. 본 종의 재기재, 진단, 숙주 정보 그리고 삽화를 제공한다.

Much research has not been conducted on how classroom-based research articles concerning teaching effectiveness in the ESL/EFL classroom have changed over time, in spite of deep interest in the field. Therefore, this study aims to examine the characteristics of research articles on effective teaching in the ESL/EFL classroom, focusing specifically on articles from TESOL Quarterly. For this purpose, this study searched articles using three key terms; effective teaching, ESL/EFL, and activity. Articles which included those terms were investigated, depending on research topic and publication year, and four key facts were found; the importance of teachers’ input (older articles), a focus on group or peer work (newer articles), teachers’ education, and the use of students’ native languages. While students preferred teachers’ reliable and explicit input in the past, modern articles tended to recommend more frequent interactions among peer groups in the English learning classroom. Limited resources in teaching contexts asked for additional qualifications from ESL/EFL teachers, thus emphasizing teacher education as an important factor for effective teaching. Lastly, the use of students’ native language had a positive influence on learning English. The findings of this study suggest some implications for how effective teaching in Korean context could be implemented.

This study explored the effects of note-taking training on Korean college students’ notes during academic English listening tests. A total of 61 college students were randomly assigned to two different groups: Group A that later received training in note-taking strategy and Group B that did not. Group A received note-taking strategy training on three separate times, totaling 60 minutes (30 minutes, 15 minutes, and 15 minutes) that spread out over two months. The two groups took listening tests before and after Group A was trained. The results showed the positive effects of the notetaking training in relation with the groups’ note-taking behaviors. After training, the trained group used more and frequent notes whereas the untrained group’s number of notes decreased. Individual students who drastically increased the number of notes after training (in Test II) showed more systemic framework of notes for Test II than before training (in Test I). The present study is meaningful in that it utilized the different analyzing methods on the quality of notes compared with previous studies.

국산 안개초 ‘Dream Song’ 가을~초겨울 절화 재배시 개화 촉진 및 절화 생산성 향상에 적절한 광원 선발을 위해 전조 광원별 생육 및 개화특성을 조사하였다. 백열등의 광질은 청색, 적색 및 원적외선 파장 모두 높고 고압나트륨등(HPS)은 적색 파장이 약간 높았으며, LED는 청색이 적색 파장보다 높았고 삼파장등은 청색과 적색 파장이 낮게 조사되었다. 주간(13:00)과 야간(전조 1시간 후, 23시)에 측정한 엽록소 형광 반응은 광원별로 차이가 없었다. 백열등과 고압나트륨등이 생육 진전이 빨라 출뢰 및 개화가 촉진되었으며, 화경장과 절화장이 길고 분지수와 개화율이 높아 절화량도 많았다. LED 전조는 개화 촉진 효과는 적었으나 분지수가 향상되었다. 따라서 경영비를 고려한 국산 안개초 ‘Dream Song’ 전조 재배 시 광원은 백열등이 적정하다고 생각된다.

목적 : 안경광학과 학생들의 현장실습 스트레스와 회복탄력성 간의 관련성을 알아보고자 하였다. 방법 : 충남지역에 소재한 안경광학과 학생 59명을 대상으로 설문조사를 시행하였다. 일반적 특성에 따른 회복 탄력성과 현장실습 스트레스에 차이가 있는지 알아보기 위하여 t-test와 one-way ANOVA를 이용하였고, 사후 검증으로는 Scheffe 검증을 실시하였다. Pearson의 상관분석을 이용하여 회복탄력성과 현장실습 스트레스간의 관계를 알아보았고, 회복탄력성이 현장실습 스트레스에 미치는 영향을 파악하기 위해 stepwise 방식에 의한 다중 회귀분석을 실시하였다. 결과 : 회복탄력성은 성별, 현장실습 만족도, 건강상태에 대한 평가, 평소의 대인관계에 따라 유의한 차이를 보였으며, 현장실습 스트레스는 성별, 현장실습 만족도, 건강상태에 대한 평가, 평소의 대인관계에 따라 유의한 차이를 보였다. 현장실습 스트레스는 회복탄력성의 하위요인 중 자기조절능력과 유의한 음의 상관관계를 보였다(r=-0.313, p=0.016). 또한, 회복탄력성 중 자기조절능력(β=-0.313, p=0.016)은 현장실습 스트레스에 통계적으로 유의한 부(-)의 영향을 미치는 것으로 분석되었다. 결론 : 안경광학과 학생의 회복탄력성은 현장실습 스트레스를 감소시키는 중요한 요인이므로, 회복탄력성 증가를 위한 교과과정의 개발 및 적용을 통하여 현장수행능력을 향상시켜야 할 것이다.

The incidence of stomach cancer has been found to be gradually decreasing; however, it remains one of the most frequently occurring malignant cancers in Korea. According to statistics of 2017, stomach cancer is the top cancer in men and the fourth most important cancer in women, necessitating methods for its early detection and treatment. Considerable research in the field of bioinformatics has been conducted in cancer studies, and bioinformatics approaches might help develop methods and models for its early prediction. We aimed to develop a classification method based on deep learning and demonstrate its application to gene expression data obtained from patients with stomach cancer. Data of 60,483 genes from 334 patients with stomach cancer in The Cancer Genome Atlas were evaluated by principal component analysis, heatmaps, and the convolutional neural network (CNN) algorithm. We combined the RNA-seq gene expression data with clinical data, searched candidate genes, and analyzed them using the CNN deep learning algorithm. We performed learning using the sample type and vital status of patients with stomach cancer and verified the results. We obtained an accuracy of 95.96% for sample type and 50.51% for vital status. Despite overfitting owing to the limited number of patients, relatively accurate results for sample type were obtained. This approach can be used to predict the prognosis of stomach cancer, which has many types and underlying causes.

우리나라는 초고령 사회(super-aged society)를 향해 가고 있으며, 이러한 압축적 고령화(compressed aging) 현상은 여러 가지 다양하고 복잡한 노인문제를 야기할 것이다. 본 논문에서는 고령화 시대 노인의 건강 증진과 삶의 질 향상을 목표로 노인 대상 댄스 게임 콘텐츠를 제안한다. 노인 대상 댄스게임을 디자인하기 위해 기존의 운동을 통한 노인 건강 유지 및 활동 개선에 대한 연구, 노인 대상 신체 운동 게임에 대한 연구 성과와 현재 서비스하고 있는 댄스게임을 살펴보았다. 운동은 정신적, 신체적, 사회적으로 건강하고 독립적인 삶의 질을 확보하기 위해 필요한 행동이다. 노화과정에서 나타나는 신체적, 인지적, 정신적 변화를 살펴보고, 이를 바탕으로 댄스의 강도, 빈도, 시간 등을 고려하여 운동 프로그램을 제안할 필요가 있다. 이에 본 연구에서는 손목에 착용할 수 있는 Gear S3와 같은 웨어러블 디바이스를 활용하여 헬스앱과 연동하여 노인이 심박수를 체크하면서 안전하고 즐겁게 운동을 할 수 있는 노인대상 댄스게임을 디자인하고 이를 제안하였다. 제안하는 댄스게임은 운동, 음악, 게임성이 합쳐진 콘텐츠로써 안전하고 지속적으로 노인들이 운동할 수 있도록 유인할 수 있을 것이라 기대한다.

Photosynthetic characteristics and growth responses of Phalaenopsis Queen Beer ‘Mantefon’ orchid were determined in plants exposed to variable carbon dioxide (CO2) concentrations at 2-, 24-, and 36-weeks age (i.e., corresponding to juvenile, young, and mature vegetative growth stages, respectively). Plants were grown at 400 (control), 800, or 1,600 μmol･mol-1 CO2 for 6 hours during the nighttime for 32 weeks. Phalaenopsis ‘Mantefon’ in 2- and 24-week-old plants grown at 1,600 μmol･mol-1 CO2 had increased leaf number and net CO2 uptake compared with the plants grown at 400 μmol･mol-1 CO2. In 36-week-old of Phalaenopsis ‘Mantefon’, leaf number was significantly greater in plant grown at 800 and 1,600 μmol･mol-1 conditions compared with plants grown at 400 μmol･mol-1 CO2. Leaves that emerged after the start of the CO2 treatment were initially longer in the plants grown at 1,600 μmol･mol-1 CO2 than at 400 μmol·mol-1 C O2, but the final leaf length was shortest in the plants grown at 1,600 μmol･mol-1 CO2 condition. Plants showed crassulancean acid metabolism characteristic of nighttime CO2 uptake regardless plant growth stages. We found that growers may be able to promote leaf growth with increasing leaf number and reducing time to leaf initiation in the 36-week-old (i.e., mature stage) plants with 800 – 1,600 μmol·mol-1 CO2 and 2- and 24-week-old (i.e., juvenile and young stages) plants with 1,600 μmol·mol-1 C O2 for Phalaenopsis ‘Mantefon’.

The vehicle routing problem is one of the vibrant research problems for half a century. Many studies have extensively studied the vehicle routing problem in order to deal with practical decision-making issues in logistics. However, developments of new logistics strategies have inevitably required investigations on solution methods for solving the problem because of computational complexity and inherent constraints in the problem. For this reason, this paper suggests a simulated annealing (SA) algorithm for a variant of vehicle routing problem introduced by a previous study. The vehicle routing problem is a multi-depot and multi-trip vehicle routing problem with multiple heterogeneous vehicles restricted by the maximum permitted weight and the number of compartments. The SA algorithm generates an initial solution through a greedy-type algorithm and improves it using an enhanced SA procedure with three local search methods. A series of computational experiments are performed to evaluate the performance of the heuristic and several managerial findings are further discussed through scenario analyses. Experiment results show that the proposed SA algorithm can obtain good solutions within a reasonable computation time and scenario analyses show that a transportation system visiting non-dedicated factories shows better performance in truck management in terms of the numbers of vehicles used and trips for serving customer orders than another system visiting only dedicated factories.

Recently, the importance of on-site detection of pathogens has drawn attention in the field of molecular diagnostics. Unlike in a laboratory environment, on-site detection of pathogens is performed under limited resources. In this study, we tried to optimize the experimental conditions for on-site detection of pathogens using a combination of ultra-fast convection polymerase chain reaction (cPCR), which does not require regular electricity, and nucleic acid lateral flow (NALF) immunoassay. Salmonella species was used as the model pathogen. DNA was amplified within 21 minutes (equivalent to 30 cycles of polymerase chain reaction) using ultra-fast cPCR, and the amplified DNA was detected within approximately 5 minutes using NALF immunoassay with nucleic acid detection (NAD) cassettes. In order to avoid false-positive results with NAD cassettes, we reduced the primer concentration or ultra-fast cPCR run time. For singleplex ultra-fast cPCR, the primer concentration needed to be lowered to 3 μM or the run time needed to be reduced to 14 minutes. For duplex ultra-fast cPCR, 2 μM of each primer set needed to be used or the run time needed to be reduced to 14 minutes. Under the conditions optimized in this study, the combination of ultra-fast cPCR and NALF immunoassay can be applied to on-site detection of pathogens. The combination can be easily applied to the detection of oral pathogens.

Inflammation is an important protective response mechanism that occurs against microbial invasion or injury. However, excessive inflammation may lead to cause of morbidity and mortality in diseases. The activated macrophages plays a vital role in inflammatory response by stimulation of lipopolysaccharide (LPS) and tumor necrosis factor-α (TNF-α). This activation further damages the host by inducing certain pro-inflammatory mediators such as nitric oxide (NO), interleukin-1β (IL-1β), interleukin- 6 (IL-6), TNF-α, inducible nitrous oxide (iNOS) and cyclooxygenase (COX-2). Flavonoids are bioactive compounds with potential effects as anti-cancer, anti-inflammation, anti-viral and anti-bacterial activities. Polymethoxyflavones (PMFs) are unique to citrus plants which are of specific interest owing to their biological effects that includes lipoprotein metabolism and anti-inflammatory activity. Sinensetin is one of the PMFs having five methoxy groups on the basic benzo-γ-pyrone skeleton with a carbonyl group at the C4 position. Sinensetin have been known for exerting various pharmacological activities including anti-angiogenesis, anti-diabetic and anti-inflammatory activities. However, there are no studies focused on the anti-inflammatory effects of sinensetin on skeletal muscle cells. In the present study, we investigated the antiinflammatory effect of flavonoids isolated from Sinensetin on the production of pro-inflammatory mediators mediated by nuclear factor-kappa B (NF-κB) by inhibition of signal transduction in LPS - induced L6 skeletal muscle cells.

In this study, we examined the protective immunity of a combination of seven Brucella abortus recombinant proteins; superoxide dismutase (rSodC), riboflavin synthase subunit beta (rRibH), 50S ribosomal protein (50s rL7/L12), nucleoside diphosphate kinase (rNdk), malate dehydrogenase (rMDH), arginase (rRocF), and elongation factor (rTsf) cloned in a pMal vector system and expressed in DH5α. Mice groups were immunized thrice with a combined subunit vaccine (CSV-7) at 0, 2, and 5 weeks and subsequently challenged with B. abortus at 5 × 104 CFU at 6 weeks. At four weeks post-infection, the mice were sacrificed and the bacterial burden in their spleens was quantified. Results revealed bacterial log reductions of 0.63 and 0.34 in comparison to PBS and maltose-binding protein (MBP), respectively. Cytokine profiling revealed a marked increase in IFN-γ (interferon-gamma), MCP-1 (macrophage chemoattractant protein-1) and IL-6 (interleukin 6) cytokines at 5-weeks post-immunization. On the other hand, only TNF was heightened at 7-weeks post-immunization. In general, this cytokine profile is consistently reflective of a Th1 immune response, which is beneficial for host immunoresistance.

This study was conducted to determine the applicability of the shoot growth model to cut roses grown at high temperatures. Two cultivars of cut roses, ‘Antique Curl’ and ‘Beast’, were cultivated in growth chambers set to night/day temperatures of 24/20°C for the control group and 32/28°C for the treatment group. The shoot growth model, which resulted in high coefficients of determination (R2 = 0.80 and 0.62, respectively, for ‘Antique Curl’ and ‘Beast’), was a good predictor of the decrease in the growth of rose shoots for both treatment groups. Although the model produced good results for both the control and treatment groups of ‘Antique Curl’, the accuracy of the model can be improved by using the modified leaf area at the harvest stage. From these results, the model was confirmed to perform well for predicting a decrease in productiveness and quality in cut roses cultivated during summer under high temperatures.

This study investigated the effects of negotiation in the process of providing written corrective feedback (WCF) by comparing three different patterns: non-negotiation, minimal negotiation, and extended negotiation. The data were collected from three intermediate academic English classes at a university in Korea. Each class was exposed to different degrees of negotiation while they received WCF for two target forms, the past verb forms and the English articles, in their written production (text re-construction tasks). Their accuracy improvement was measured by text-reconstruction writing tasks and error correction tests. The study found that the use of negotiation affected accuracy improvement of the target forms; however, its effectiveness varied depending on the target forms and measurements. For the past tense, negotiation, regardless of its amount, resulted in more accuracy improvement than non-negotiation in both text re-construction tasks and error correction tests. However, for the English articles, negotiation operated differently: extended negotiation significantly brought about more accuracy development in both measurements, but the difference between minimal negotiation and non-negotiation was only observed in the error correction test, not in the text re-construction task.

In March of 2015, severe sooty mold was observed on blueberries cultivated in a farmer’s greenhouses in Goseong-gun, Gyeongsangnam-do, South Korea. Typical symptoms included a black or dark brown, superficial fungal growth on the leaves, stems, and fruit of blueberry plants. The fungal colonies on PDA were flat and black. The conidia were dark green in color, globose to sub-globose in shape and 3-5×3-4 μm in size. The ramoconidia were cylindrical and 18-42×3 μm in size. The conidiophores were dark brown, cylindrical-oblong in shape and 42-138×3-4 μm in size. To confirm the identity of the fungus(F130), the 18S rDNA as well as actin and β-tubulin gene sequences were PCR-amplified and sequenced. The pathogenicity of the isolate was then explored on 2-month-old potted blueberry plants. Based on the mycological characteristics, molecular identification, and pathogenicity on host plants, this fungus was identified as Cladosporium sphaerospermum. This is the first report on sooty mold of blueberry caused by C. sphaerospermum in Korea.

원심 해수냉각 펌프를 분석하기 위하여 다른 운전 유량에 대한 캐비테이션 거동을 조사하였다. 3D 2상 해석은 ANSYS-CFX 상 용코드로 수행되었다. 해석에는 k-ε 난류와 Rayleigh-Plesset cavitation 모델이 사용되었다. 수치 예측에 기초하여 세 가지 토출 유량값에 대 하여 헤드 드롭 특성곡선이 작성되었다. 더 높은 유량에서 임펠러는 버블 캐비테이션에 보다 취약하다. 0.7Q, Q 및 1.3Q(Q: 설계 유량)에서 작동하는 펌프의 3 % 헤드 드롭 위치는 각각 NPSHa 1.21 m, 1.83 m 및 3.45 m에 해당한다. 증기 기포의 볼륨이 예측되고 캐비테이션의 위치는 임펠러 내에서 발생하는 캐비티를 시각화하여 예상하였다. 또한, 압력계수와 날개 부하 분포가 구체적으로 제시되어 캐비테이션이 펌프 운전에 미치는 해로운 영향을 나타냈다. 또한, 압력계수 분포와 날개부하 차트가 구체적으로 제시되어, 펌프 운전에 캐비테이션이 미치는 해로운 영향을 나타냈다.

This study was aimed to determine the effects of hybrid and inoculant on in vitro rumen digestibility and rumen fermentation indices of corn silage. Two corn hybrids(Kwangpyeongok (KW) vs. Pioneer 1543(PI)) were ensiled for 100 days with two inoculants(L. plantarum(LP) vs. L. buchneri(LB)) applied at 1.2 × 105 cfu/g of fresh forage. Silages were incubated in rumen fluid medium at 39℃ for 72 hours. Both of KW and PI had no difference(p>0.05) on in vitro digestibility of dry matter(IVDMD) and neutral detergent fiber(IVNDFD), while application of LB produced higher(p<0.05) IVDMD and IVNDFD than LP. Hybrid and inoculant applications did not affect(p>0.05) total gas volume, ammonia-N, total VFA, and acetate concentrations in the rumen. Applied LB was higher(p<0.05) propionate concentration than LP, while hybrids had no effect(p>0.05). Furthermore, the interaction effect(p<0.05) was occurred in propionate concentration. Butyrate concentration did not affected(p>0.05) by hybrid and inoculant applications, but there was an interaction effect between hybrid and inoculant(p<0.05). Applications of hybrid and inoculant had effects(p<0.05) on iso-butyrate and valerate, without any interaction effects(p>0.05). This study concluded that application of KW and PI has no effects on in vitro rumen digestibility and rumen fermentation indices of corn silage, while application of LB increase the rumen digestibility in both of corn hybrids.

By analyzing the status of Korean tire labeling regulation and comparing the performance indicators of tire labeling in different countries, this paper expounds the serious impact of tire noise on traffic noise pollution, and puts forward that in order to improve the comfort of car ride, control traffic noise pollution and build a green tire industry, the tire labeling system should be improved, and the corresponding requirements for tire rolling noise should be put forward according to the road conditions in Korea.

The study on the tire noise due to the On-Board Sound Intensity test method. The object of this project is to prepare the countermeasure of the noise reduction according to collect tire/road noise data under various influencing factors by using On-Board Sound Intensity test method. To accomplish the object ; A automotive is used as a test platform to test tire/road noise by changing different types of tires and using On-Board Sound Intensity test system. The influence of inflation pressure, road, load, speed and pattern type on tire/road noise is compared and analyzed. At the same time, the mechanism of tire/road noise is analyzed, which provides a experimental basis for tire noise reduction.