Oral squamous cell carcinoma (SCC) is one of the leading causes of cancer mortality worldwide. It is generally thought that adjuvant chemotherapy provides modest prolongation of survival in various carcinoma. Docetaxel (Taxotere, TXT) play a significant role in the treatment of various solid tumors of epithelial origin. CsA (immunosuppressive drug) was widely used as adjunct for the treatment of cancer. Thus, it is important to pursue the apoptosis of IHOK and oral SCC induced by TXT combined with CsA related to the pathogenesis of oral SCC. But TXT combined CsA effect on IHOK and oral SCC remains unclear. After cultured IHOK and HN 22 oral squamous cell carcinoma cell line treated by 10 nM TXT and 1 μM, and caspase inhobitor, respectively, apoptosis index, cytochrome c and caspase-3 -8, -9 mRNA expression by RT-PCR, and procaspase-3 protein amount by immunoslot blotting was prepared. The purpose of this study were to examine the TXT-induced apoptosis pathway via caspase activation by CsA enhancement, and to apply these results to an effective therapeutic treatment plan for oral SCC by TXT combined CsA . 10 nM TXT showed about 60%, 55% celluar apoptosis of IHOK and HN 22, cell line, respectively, while CsA alone did not induce apoptosis in IHOK and HN 22 cell line. 1 μM CsA combined with 10 nM TXT increased apoptosis in IHOK and HN 22 cell line through caspase-3 and cytochrome c mRNA expression, while could not effect on caspase-8 and -9. Caspase inhibitor suppressed apoptosis of IHOK and HN 22 cell line induced by a combination of 1 μM CsA and 10 nM TXT. Immnoslot blotting showed procaspase-3 activation by a combination 1 μM CsA and 10 nM TXT, while caspase inhibitor inhibited activation. It suggested that a combination of CsA and TXT might induce increased apoptosis of IHOK and HN 22 oral squamous cell carcinoma cell line through caspase-3 activation. This treatment with a combination of TXT and CsA may be an effective therapeutic strategy for oral squamous cell carcinoma

사회의 환경변화에 따라 기업 또한 기업 또한 과거 폐쇄적 수직 체계의 position power에서 개방적 수평체계의 communication power로 역할이 변화하고 있다. 기업의 사회적 책임 이행의 대표적인 활동인 사회공헌활동은 지역사회와의 소통 수단 뿐 아니라 새로운 마케팅전략으로 자리매김 되고 있다. 사회공헌활동의 성공요소 중 가장 중요한 것은 구성원의 봉사적 마인드이다. 봉사적 마인드는 이론 뿐 아니라 실천적 행동철학에 기인 한다. 기업이 바라는 인재상과도 밀접한 관계가 있다. 본 논문에서는 기업이 신입사원 채용시 봉사활동 실적을 반영하는데 있어서 표준적인 가이드라인을 연구 제시하고자 한다.

The purpose of this study was to investigate the differences of driving performance and physiological responses between young male and female drivers for unexpected situation uSlllg a graphic vehicle simulator. The participants included 20 college graduat

This study was conducted to determine the influence of culture conditions such as temperature, time, water content, koji-thickness and agitation on the production of organic acid by Rhizopus sp. ZB9 isolated from Korean Nuruk during the preparation of rice koji, which is used in brewing the Korean rice wines, Takju and Yakju. Rice koji was made under different culture conditions, and the acidity of each koji was tested. The temperature range suitable for the production of organic acid was 28～32℃, and 36～48 hours of cultivation at that temperature range seemed to produce the optimum results. The production of organic acid increased in proportion to the increase in water content of steamed rice from 25% to 60%. An increase in koji-thickness induced no adverse effects on the production of organic acid, and agitation-work during cultivation showed very beneficial effects.

본 연구는 조사료원으로 청보리 사일리지 급여시 농후사료 급여수준이 육성기 흑염소의 가소화 영양소 섭취량, 영양소 이용율 및 질소 축적율에 미치는 영향을 조사하였다. 시험구는 4처리구 (볏짚+농후사료 체중의 2.0%, 청보리 사일리지 + 농후사료 체중의 2.0%, 체중의 1.5%, 체중의 1.0%)로 나누어 처리구당 3두씩 라틴방각법으로 시험을 실시하였다. 시험기간 동안의 1일 두당 가소화 조단백질 섭취량은 대조구, 청보리 사일리지에 농후사료를 각각 체중의 2.0과 1.5% 급여구가 농후사료를 1.0% 급여구 보다 유의하게 높았다(p<0.05). 가소화 NFC 섭취량은 청보리 사일리지와 농후사료를 체중의 2.0% 급여구가 가장 높았고, 농후사료를 1.0% 급여구가 가장 낮았다 (p<0.05). 일당 증체량은 청보리 사일리지+농후사료 2.0%, 청보리 사알리지+농후사료 1.5%, 볏짚+농후사료 2.0%, 청보리 사일리지+농후사료 1.0%, 순으로 유의하게 낮아졌다(p< 0.05). 건물소화율은 청보리 사알리지와 농후사료를 1.5% 급여구가 대조구 보다 유의하게 높게 나타났다(p<0.05). 질소축적량은 대조구와 청보리 사일리지에 농후사료를 각각 체중의 2.0과 1.5% 급여구가 농후 사료 1.0% 급여구보다 유의하게 높았다(p<0.05). 이러한 결과를 종합적으로 고려할 때 청보리 사일리지를 조사료원으로 급여시 육성기 흑염소의 생산성과 효율적인 영양소 이용을 위한 농후사료 급여수준은 1.5%가 적정한 것으로 사료된다.

토마토 펄라이트 자루재배에서 기존에 알려진 배액 전극제어법 적용시기를 가능한 앞당기고, 배양액을 절감하기 위해 수행되었다. 실험처리는 정식후 15일차(T-15), 19일차(T-19), 22일차(T-22)에 배액전극제어법을 적용하는 3개 처리와 타이머법 1개 처리를 실시하였다. 기존의 정식후 1개월 이후에 배액전극제어법 적용하는 관행보다 2주 앞당긴 15일차 처리부터 작물이 배액전극제어법에 반응하는 것으로 나타났다. 생장 및 수확량은 배액전극법에서 높았다. 용수이용효율과 비료이용효율은 T-15 처리에서 가장 경제적이었고, 타이머법 처리는 경제성이 낮았다. 따라서 배액전극제어법 처리시기를 빨리 적용할수록 경제성이 높음을 알 수 있었다.

When radiation is irradiated onto biological tissue, the occurrence of biological change has been already demonstrated and the change of blood composition and chromosome abnormality could be suggested as the representative biological markers which can identify the disturbance caused by radiation exposure. Recently, radiation treatment is performed for the treatment of cancer. Since the protection of blood within normal tissue is very important, the development of radioprotective has been made continuously to protect normal tissues. Squalene is a very important precursor in the biosynthesis of cholesterol. It is the hydrocarbon contained in the liver of deep sea sharks and in olive oils, and large quantity of it is contained in skin, abdominal fat tissue, subcutaneous fat tissue, lymphatic gland, pancreas and in heart muscle. Because of 6 double bonds in SQ, it could easily bind with oxygen ions to have the hazardous oxygen removal capacity along with the effects of scar treatment, blood vessel expansion, inhibitory action of arteriosclerosis, and has been reported to have the effects on myocardial infarction and liver disease, treatment for burn. It has been reported to have active effect of fibroblast. Therefore, the current study was conducted to know the change of total protein, albumin, total cholesterol and glucose in serum after the injection of whole body radiation of SQ in mouse.

토마토를 대상으로 암면과 코이어를 사용한 자루재배에서 일사량제어와 배액전극제어법의 급액제어 능력을 실험한 결과, 배지 종류에 관계없이 일사량제어법에 비해 배액전극제어법에서 배지함수량과 배액량이 안정 적이었다. 총수확량과 상품과량은 배액전극제어법에서 많았으며, 동일한 급액제어 처리 안에서는 배지간 차이는 없었다. 당도는 급액제어 방법의 차이보다는 배지의 종류에 영향을 많이 받았다. 배액전극제어법은 펄라이트뿐만 아니라 암면과 코이어배지에서도 범용적으로 일사량제어법에 비해 유리한 것으로 나타났다.

The purpose of this study is to understand factors of risk perception and purchase obstruction by consumer characteristics and purchase experience of clothing in online. The collection of the research materials was progressed by online and offline. Out of 374 usable questionnaires used for examining this study, 278 questionnaires were collected from offline and 107 questionnaires were collected from online. Frequency analysis, factor analysis, reliability analysis, t-test, One-way ANOVA and multiple regression analysis using SPSS WIN 12.0 were conducted. Three factors of perceived risk were extracted: harmonic/image, quality/shopping process, payments. Based on these dimensions, ANOVA was conducted. The results indicated that the more purchasing experience people had, the less the extent of perceived risk they got, and quality/shopping process risk mostly among them. As the factors which obstruct purchasing decision, a security obstruction, a reliability obstruction, a convenient obstruction and an information insufficient obstruction are extracted. Also, the factors have got the result of same aspects as the perceived risk recognized by the Internet shopping experience. Meaningful differences between groups appear at security obstruction, reliability obstruction, and convenient obstruction. Perceived risk almost influenced on purchase obstruction when purchasing clothes in Internet shopping mall. When consumers perceiving harmony/image risk highly make decisions, they usually hesitate or abandon due to reliability obstruction, convenient obstruction. All the factors: including security obstruction, reliability obstruction, convenient obstruction and information insufficient obstruction made consumers perceiving quality/shopping process risk highly obstruct purchase decision.

The object of this study was to investigate the effects of rice particle size on the physicochemical properties of beef-rice porridge. The pH of beef-rice porridge was decreased as compared to that of the control, while the redness of beef porridge increased according to rice particle size. The viscosity of flour in the beef-rice porridge was the highest among three porridges, at 40℃. The protein content of beef-rice porridge was increased 3-fold over that of rice porridges. The total amino acid content of the beef-rice porridge was 3071.2 mg/100 g, and that of rice porridge was 1147.5 mg/100 g. As compared to rice porridge, the maximum amounts of the amino acids Lys and Thr were increased beef-rice porridge. Sensory evaluation results showed that the beef-rice porridge with a particle size half that of rice had the highest scores in color, taste, texture, and overall preference. Based on these results, it is suggested that beef-rice porridge with a particle size half (0.7-2.5 mm) that of rice has optimal quality in terms of both physicochemical and sensory properties.

The aim of this study was to investigate effects of reaching distance on movement time and trunk kinematics in hemiplegic patients. Eight hemiplegic patients participated in this study. The independent variables were side (sound side vs. affected side) and target distance (70%, 90%, 110%, and 130% of upper limb). The dependent variables were movement time measured by pressure switch and trunk kinematics measured by motion analysis device. Two-way analysis of variance with repeated measures was used with Bonferroni post-hoc test. (1) There were significant main effects in side and reaching distance for movement time (p=.01, p=.02). Post-hoc test revealed that there was a significant difference between 110% and 130% of reaching distance (p=.01). (2) There was a significant main effect in side and reaching distance for trunk flexion (p=.01, p=.00). Post-hoc test revealed that there were significant differences in all pair-wise reaching distance comparison. (3) There was a significant side by target distance interaction for trunk rotation (p=.04). There was a significant main effect in target distance (p=.00). Post-hoc test revealed that there were significant differences between 70% and 110%, 70% and 130%, 90% and 110%, 90% and 130% of target distance. It was known that trunk flexion is used more than trunk rotation during reaching task in hemiplegic patients from the findings of this study. It is also recommended that reaching training is performed with limiting trunk movement within 90% of target distance whereas reaching training is performed incorporating with trunk movement beyond 90% of target distance in patients with hemiplegia.

The aim of this study was to investigate the effect of supporting surface instability to trunk and lower extremity muscle activities during bridging exercise combined with core-stabilization exercise. Thirty young healthy adults (15 males and 15 females) voluntarily participated in this study. Each subject was asked to perform bridging exercise combined with core-stabilization exercise on three different supporting surfaces (stable ground surface, the wooden balancing board, and the air cushion). The muscle activities were measured using surface electromyography (EMG) during performing exercise. To test statistical significance, one-way ANOVA with repeated measures was used with the significance level of .05. The findings of this study are summarized as follows. (1) There were significant differences in muscle activities on internal oblique, external oblique, gluteus medius, semitendinosus, biceps femoris, medial gastrocnemius and lateral gastrocnemius during exercise (p<.05). (2) The biceps femoris and lateral gastrocnemius showed significantly higher muscle activity on the wooden balancing board rather than on the ground, and semitendinosus, biceps femoris, medial gastrocnemius and lateral gastrocnemius showed significantly higher muscle activity on the air cushion rather than on the ground (p<.05). Therefore, it is concluded that muscle activities in the trunk and the lower limbs during bridging exercise combined with core-stabilization exercise was affected with instability of supporting surface. Further researches are needed to investigate the long term effect of bridging exercise on muscle activity with patient group.

본 연구에서는 공간 과제 수행 시 21%의 산소 농도와 30%의 고농도 산소 공급이 변연계의 활성화에 어떠한 변화를 유발하는지 관찰하였다. 총 8명의 오른손잡이 남자 대학생을 본 연구의 실험 참여자로 선정하였다. 공간 과제를 수행하는 동안 3T MRI 를 이용하여 뇌기능 영상을 획득하였다. 실험은 21%의 일반 공기 중의 산소 농도와 30%의 고농도 산소를 각각 공급하면서 공간 인지 과제를 수행하는 두 개의 회기로 구성된다. 변연계를 대상이랑(cingulate gyrus), 시상(thalamus), 변연엽(limbic lobe), 시상하부(hypothalamus), 해마(hippocampus), 해마방회(parahippocampa gyrus), 편도(amygdala), 유두체(mammilary body)의 8 개의 영역으로 분리하여 뇌 활성화 영역을 비교하였다. 공간 과제 수행 시 두 가지 산소 농도에 따른 변연계의 활성화 영역은 거의 동일하였다. 그러나 21%의 산소 농도에 비해 30%의 고농도 산소 공급 시 대상이랑(cingulate gyrus)과 시상(thalamus) 영역에서 활성화가 증가하였다. 즉, 30%의 고농도 산소 공급 시 공간 인지 수행 능력의 증가는 공간 인지 처리와 관련이 있는 대뇌 피질 뿐만 아니라 시상(thalamus)과 대상이랑(cingulate gyrus) 같은 피질하 영역에서의 신경 활성화의 증가와도 관련이 있는 것으로 판단된다.

본 연구에서는 공간 및 언어 과제를 수행하게 하면서 뇌 기능 영상을 획득하여, 각 인지 과제 수행에 따른 소뇌 활성화 영역을 알아보고, 소뇌 편측화의 차이를 규명하고자 한다. 8명의 오른손잡이 남자 대학생(평균 21.5±2.3세)과 8명의 오른손잡이 남자 대학생(평균 23.3±0.5세)이 각각 공간 및 언어 과제 실험에 참여하였다. 3T MRI 에서 single-shot EPI 기법을 이용하여 뇌 기능 영상을 획득하였다. 뇌 기능 영상 데이터는 SPM-99 S/W 를 사용하여 분석하였다. 실험은 네 개의 블록으로 구성되며, 각 블록은 통제과제(1분), 인지 과제(1분)을 포함하며, 한 실험당 소요시간은 블록당 2분씩, 총 8분이었다. 감산법을 이용하여 공간 및 언어 과제에 대한 소뇌 활성화 영역을 알아보았고, 소뇌의 활성화 voxel 수를 이용하여 소뇌의 편측화 지수를 계산하였다. 두 인지 과제 수행 시 활성화된 소뇌 영역은 선행 연구와 비교하여 유사한 영역이었다. 두 인지 과제 모두 좌, 우소뇌 반구의 활성화 voxel 수가 비슷하여 소뇌 기능의 편측화가 나타나지 않았다.