자유주의 페미니즘의 선구적 사상가로 불리는 존 스튜어트 밀은 여성 의 종속 현상은 여성에 대한 사회적 억압과 잘못된 교육 때문이라고 보 았다. 여성과 남성은 자라나는 환경이 다르기 때문에 능력에도 차이가 나타나므로 여성에게도 많은 선택의 자유와 남성과 동등한 기회가 주어 진다면 여성도 자신의 잠재적인 능력을 발휘할 수 있다고 보았다. 밀은 말과 행동 사이에 아무런 갈등을 보이지 않는 사상가로서 여성의 지위 향상을 위한 노력을 자신의 저서와 실제 정치를 통해서 전개 시켜 나간 최초의 정치가이기도 하다. 이러한 밀의 주장은 여성만을 위한 것이 아 니라 인류 전체의 발전을 위해서도 필요한 것이다. 그러나 밀의 주장은 선택된 소수의 여성들에게 선거권을 주고 소수의 여성들에 대한 교육의 확대에 관심을 두었기 때문에 중산층 여성을 중심으로 한 엘리트주의라 는 비판을 받기도 한다. 하지만 19세기 서구의 시대적 상황을 고려할 때 밀의 주장은 매우 혁신적인 주장이었고 여성문제에 대한 가장 근본적인 문제를 다루었다는 측면에서 현재의 양성평등 실현에도 지대한 영향을 미쳤다고 평가할 수 있다.

Repetitive or excessive exposure to ultraviolet (UV) radiation causes oxidative stress-mediated skin photoaging through the overproduction of reactive oxygen species. Actinidia polygama is known as a medical plant used in oriental medicine for treating several diseases such as abdominal pain, stroke and rheumatoid arthritis. Recently, it was reported that A. polygama extract had anti-wrinkle and skin hydrating properties in ultraviolet B (UVB)-exposed hairless mice. However, the molecular biological mechanism of this extract on alleviating skin photoaging is still unknown. Therefore, we investigated the anti-photoaging effects of PB203, which is the powder of A. polygama extract, in the in vivo and in vitro photoaging models. First, PB203 showed 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging activities due to the presence of anti-oxidant components including flavonoids and polyphenols. In UVB-irradiated hairless mice, oral administration of PB203 (100 mg/ kg) significantly improved wrinkle formation, skin dehydration, elasticity and skin barrier function by decreasing the levels of matrix metalloproteinases (MMPs) and increasing those of collagen I, filaggrin, involucrin and loricrin. Especially, the reduced production of p-p38, p-c-Jun and p-c-Fos by PB203 reversed the elevated levels of MMPs mediated by UVB exposure, resulting in the upregulation of collagen I expression. Consistent with these animal data, PB203 remarkably enhanced the mRNA expression of collagen I, filaggrin, involucrin and loricrin, while suppressed that of MMPs in UVB-irradiated HaCaT cells. And PB203 increased the wound recovery rate of cells by promoting their proliferation and migration. Moreover, PB203 significantly recovered the activity of superoxide dismutase inhibited by UVB in both mice and cells. In conclusion, PB203, which protects skin from UVB-induced photodamage by exerting antioxidant properties, can be considered to have sufficient potential as a functional ingredient or therapeutic agent improving skin photoaging and related skin symptoms.

본 연구는 유학(儒學)의 핵심을 덕(德)으로 상정하여,『논어(論語)』의 덕(德) 과 연관한 도(道)⋅인(仁)⋅예(藝)와의 용례 분석에 기초하여 덕교육적 의미를 탐구하고자 하였다. 이는 도덕적 실천과 윤리적 가치의 다원성 및 사회공동체 의 역사문화적 배경 등을 견지하는 현대 덕 윤리학의 관점을 지지하는 연장 선상에서, 전통 교육이 표방하는 덕교육적 의미를 강조하고 지금의 교육을 성 찰하기 위한 것이다. 일반적으로 도(道)는 자연에 관한 이치를 표방하는 반면, 덕(德)은 인간을 주체로 하여 주로 논의되고 있다. 그러나 공부를 하여 도를 이해하고 실행하 여 실제로 내 마음에 얻은 것을 덕이라고 하듯이, 공공(公共)의 가치와 지향점 을 체득하게 된다면 바로 도를 깨우친 덕인(德人)이 된다. 따라서 도는 덕에 의해 보다 구체화 된다. 인(仁)은 덕목 중의 하나로서 위계구조상 덕의 하위 범주에 해당하며, 덕의 속성과 특징으로도 논의된다. 그러나 『논어』의 핵심을 인으로 상정하고, 인을 구체적인 인간과 인간다움을 기반으로 이해하자면, 인은 모든 덕의 기초이자 본질적인 요소가 된다. 예(藝)는 예술이나 문예 등의 의미로 이해할 수 있지만, 인을 중심으로 하 여 구체적인 실천 덕목을 이행하고 실현함으로써 덕을 함양하고자 하는 도덕 군자를 주체로 하자면, 예(藝)는 군자가 탐구하는 유학의 학문으로서, 도덕적 실천을 중심으로 하는 덕교육적 교과 영역이나 교과 내용이다. 『논어』의 덕은 구체적인 실천 덕목과 확연히 차별화되어 진술되고 있지 않 고 있으며, 덕과 덕목 간의 위계구조 역시 명확하지 않다. 따라서 『논어』의 덕은 인(仁)을 중심으로 하여 실천 주체와 대상 또는 덕목 간의 관계성 측면 에서 중층구조를 띄고 있으며, 도(道)를 이해하고 깨우침으로써 공공(公共)의 가치와 선(善)을 지향하고 언행일치를 도모하는 등 일상생활에서의 지속적인 이행과 함양을 촉구한다.

This study aimed to identify prognostic factors and describe the treatment outcomes of multidrug therapy in dogs with meningoencephalomyelitis of unknown etiology (MUE). A total of 23 dogs diagnosed with MUE were treated with prednisolone in combination with cyclosporine, cytosine arabinoside (CA), leflunomide, and mycophenolate mofetil. Based on the survival time, these dogs were divided into two groups: group A (n = 10), surviving for < 100 days, and group B (n = 13), surviving for > 100 days. Signalment, seizure activity, cerebrospinal fluid (CSF) analysis results, and magnetic resonance (MR) imaging findings were reviewed. Survival studies were conducted to investigate the association of each prognostic factor and treatment with the clinical outcome. There were no significant differences in age, sex, body weight, occurrence of seizures, cell number and protein concentration in the CSF, or location of lesions between groups A and B. Abnormal MR features were more frequently observed in group A than in group B. It was identified that the longest median survival time was administration of multi-drug therapy including CA. In conclusion, abnormal MR features were associated with poor prognosis in dogs with MUE and CA-based multi-drug therapy could be considered the most effective treatment of MUE.

Global concerns have grown regarding emerging infectious diseases (EIDs) caused by previously unknown pathogens. Considering that strengthening surveillance capacity for unknown diseases is one of the core capacities for preparedness and early response to EIDs, identifying areas with poor capacity could be beneficial to prioritize regions for the improvement of surveillance. In this regard, we aimed to develop prediction models to identify high risk areas for low surveillance capacity for unknown diseases in a global scale. Unexplained death events reported between 2015 and 2019 were collected from two internet-based surveillance systems, ProMED-mail and Global Public Health Intelligence Network. From the reports, the number of reported unexplained deaths at the first report and the time gap between death and report were extracted as measures for sensitivity and timeliness of surveillance capacity, respectively. Using geographical locations of the reports and published global scale spatial data, including demographic, socioeconomic, public health and geographical variables, we fitted two boosted regression tree models to predict regions with the low sensitivity and timeliness. The performance of prediction model for the low sensitivity showed moderate validity, but in terms of the model for timeliness, the performance was unreliable. Therefore, we provided predicted risk only for low sensitivity. The mean predicted risks of low sensitivity were, respectively, 45.2%, 37.4%, 12.5%, and 3.0% in low-income, lower middle-income, upper middle-income, and high-income countries. Enhancing surveillance capacity in low-income countries is highly required, given the predicted low level of sensitivity despite the importance of early response.

지난 20여 년간의 자본과 노동의 세계화로 인해 다양한 문화권의 유입 과 동질적 국민국가의 분화, 즉 다문화사회가 지구적 현상이 되어가고 있다. 다문화사회의 다양한 구성원들 간의 갈등을 완화하고자 사회통합 정책을 전개하는데, 이는 차별적 배제, 상호문화주의, 다문화주의, 동화 주의로 유형화될 수 있다. 이 중 다문화주의가 다문화사회의 규범으로 인식되었다. 그러나 다문화주의의 규범성에도 불구하고, 다문화주의는 소 수자 집단의 문화권을 결핍으로 전제하고 이들을 관리와 통제의 대상으 로 보며 주류 문화권의 지배를 지속시킨다는 점에서 비판을 받고 있다. 필자는 다문화사회의 공존을 위해서 나와 타자화시켜 온 문화권의 사람 들이 동등한 구성원이라는 공감과 연대가 절대적으로 필요함을 주장한 다. 나아가, 국민국가 체제의 안과 밖 경계에서 자유로워진다면, 다양한 문화권의 공존이 보다 안정적이고 성공적일 수 있다. 이런 맥락에서, 필 자는 다문화사회의 규범으로 새로운 민주주의 담론의 하나인 탈경계의 인민, 즉 다중에 대한 논의를 전개한다. 다중은 전 세계적으로 네트워크 되어 있으나 단일한 동일성으로 환원될 수 없고 다양성과 개별적 독특성 을 갖는 능동적 주체이다. 경계의 인민으로부터 탈중심, 탈경계의 다중으 로의 전환은 다문화사회에 대한 문제 인식과 함께 다문화주의 담론의 확 장을 위한 기회를 갖기 위함이고, 보다 근본적으로는 근대 국가의 배타 적 보편성에 대한 문제제기이다.

Following the previous study, the toxicity of a single subcutaneous administration of the Thyrokitty injection (I-131) and the side effects that may occur at therapeutic doses were confirmed. The Thyrokitty injection (I-131) was administered subcutaneously once at a dose of 0, 2.0, 6.0, and 18.0 mCi/kg, 5 male and female rats per group, and mortality, general symptom observation, and weight measurement were performed for 2 weeks, followed by observation of autopsy findings. There were no deaths, and no statistically significant weight change was observed. Mild hair loss, fissures, and crusting were observed by general symptom observation, but it was not a toxic change related to the Thyrokitty injection (I-131). Gastric atrophy and a decrease in the size of the spleen were observed by the autopsy. As a results of single subcutaneous administration of the Thyrokitty Injection (I-131) to rats at a maximum dose of 18.0 mCi/kg, a decrease in the size of the spleen and gastric atrophy were observed as the dose of the Thyrokitty Injection (I-131) increased, which may be related to the test substance. No abnormal findings related to the Thyrokitty injection (I-131) were observed. Therefore, the approximate lethal dose of the Thyrokitty injection (I-131) was 18.0 mCi/kg or more. In addition, as reported for the treatment of feline hyperthyroidism with radioiodine (131I), side effects of the Thyrokitty injection (I-131) are expected to be extremely rare. Temporary dysphagia and fever may occur, but it will recover naturally. It should be administered with caution in cats with diseases such as urinary system, cardiovascular system, gastrointestinal system and endocrine system, especially with kidney disease. And it should not be used in cats who are pregnant, lactating, or likely. It is expected that the Thyrokitty injection (I-131) can be used for clinical treatment in Korea as a veterinary drug.

『대육임필법부(大六壬畢法賦)』는 남송의 능복지(凌福之)가 저술한 육임 고 전이다. 이 고전에는 고시⋅관직과 관련된 이론이 수 곳에 산재(散在)되어 있 어서 일목요연하게 정리되어 있지도 않거니와, 고시⋅관직론을 관통하는 사 상이 앞선 육임의 선행 연구에서 규명되어 있지도 않다. 이러하므로 본고에서 는 『대육임필법부』에 흩어져 있는 고시⋅관직론을 취합(聚合)해서 그 이론을 분석하는 방법으로 『대육임필법부』의 고시⋅관직론을 관통하는 사상을 연구 하였고 그 결과는 다음과 같다. 첫째, 동양의 음양오행사상이다. 음양사상과 관련된 것에는 육양격, 오행과 관련된 사상에는 관성(官星)이 있다. 과전(課傳)의 육양(六陽)이 양을 가리키므 로 음양사상과 관련이 있고, 일간의 관성은 오행의 생극(生剋)에서 비롯되었 으므로 오행사상과 관련이 있다. 둘째, 동양의 천문사상이다. 하늘의 적도를 따라 남북에 있는 별들을 28개 구획으로 구분한 것이 28수이고 이 28수는 12 지에 배속되어 있다. 丑에 배속되어 있는 두(斗)와 未에 배속되어 있는 귀(鬼) 가 일간 및 연명(年命)에서 서로 가(加)하면 고시에 합격한다는 ‘두귀상가격(斗 鬼相加格)’, 일덕귀인이 亥에 가하면 고위직 관리가 된다는 ‘덕입천문격(天門格)’은 모두 동양의 천문사상에서 비롯된 것이다. 또한 12천장의 수장(首 將)으로서 나머지 11천장을 부리는 천을귀인이 자미원에서 천황대제를 보좌 하는 ‘천일(天一)’을 뜻하고, 12천장의 주작이 천을귀인의 명령을 따르므로, 천 을귀인 및 주작과 관련된 여러 격(格)들은 동양의 천문사상에서 비롯된 것이 라고 할 수 있다.

2000년부터 시작된 6·25 전사자 유해발굴사업은 전쟁 기간 동안 수 습되지 못한 전사자 13만여 분을 찾아 국가와 가족의 품으로 모신다는 데 목적을 두고 추진 중이다. 2005년부터 국방부 유해발굴감식단(이하 국유단)을 출범하여 유전자 채취와 신원확인센터 설치 등 체계적 및 전문적으로 추진하고 있는 영구적인 국가정책 사업이다. 아울러 2018 년 4·27 판문점 선언과 9.19 남북군사합의에 의해서 오랜 숙원 사업으 로 제기됐던 비무장지역(DMZ) 내 유해발굴이 가능해졌다. 오랜 기간 접근하지 못했던 DMZ 내에서 남북유해발굴 공동합의는 접경지역과 한 반도에서의 군사적 긴장완화에 대한 남북한의 의지를 잘 반영한 것이 다. 기대했던 북한의 약속 이행은 없었지만 국방부는 2019년 4월 1일 부터 2021년 6월 24일까지 약 2년 반 동안 “9·19 남북군사합의”에 명 시된 남북공동유해발굴의 사전준비 차원에서 화살머리고지 일대 남쪽 지역에서 유해발굴을 꾸준히 진행했다. 특히 DMZ 내 화살머리고지 유 해발굴을 통해 9명의 국군전사자의 신원을 확인하여 유해봉환 및 안장 식을 거행했다. 이런 맥락에서 이 논문은 6·25 전사자 유해발굴사업의 의미와 중요성, 체계 수립을 위해서 “활동이론”(Activity theory)을 근 간으로 세부적으로 분석했다. 이를 기반으로 이 논문에서는 한반도의 지속 가능한 평화와 유지와 인도주의 차원에서의 최초의 DMZ 내 남북 공동유해발굴사업의 추진 배경과 성과, 그리고 의의를 중심으로 유해발 굴사업의 중요성과 함의에 대해 고찰했다.

Radioiodine (131I) has been used for the treatment of feline hyperthyroidism since the 1990s in the USA and Europe, and it is recommended as the most effective treatment for feline hyperthyroidism because it has a high therapeutic effect, small side effects, and does not require anesthesia. In this study, the pharmacological properties of the Thyrokitty injection (I-131), which is being developed as a treatment for feline hyperthyroidism, using radioiodine (131I) as an active ingredient, was tested. The %cell uptake of the Thyrokitty injection (I-131) in FRTL- 5 thyroid cells was 0.410 ± 0.016%, which was about 18 times higher compared to Clone 9 hepatocytes, and it was decreased by 30.7% due to the competitive reaction with iodine (sodium iodide). In addition, the %cell growth of the FRTL-5 thyroid cells was reduced by 25.0% by treatment with the Thyrokitty injection (I-131). As a result of the tissue distribution test, the Thyrokitty injection (I-131) was distributed at the highest concentration at 0.083 hours (5 minutes) after subcutaneous administration to animals in most organs except the stomach, small intestine, large intestine, muscle and thyroid gland, and it was excreted mainly through the kidneys. The stomach and thyroid gland showed a typical distribution pattern observed when radioiodine (131I) was administered. In addition, about 78.45% of the total amount of excretion was excreted within 48 hours, of which more than 85% was excreted in urine. In conclusion, the Thyrokitty injection (I-131) has the same mechanism of action, potency, absorption, distribution, metabolism and excretion characteristics as radioiodine (131I) reported in connection with the treatment of feline hyperthyroidism. In the future, using the results of this study, it is expected that the Thyrokitty (I-131) could be safely used in the clinical treatment of feline hyperthyroidism.

The objective of this study was the acoustic analysis of vocalizations of domestic dogs when they want to play with humans. Using a digital camcorder and microphone, we recorded and acoustically analyzed the vocalizations of six 7-month-old dogs (beagle) when they wanted to play with humans. The vocalizations were classified into five types, namely, barking (type Ⅰ, type Ⅱ), whining (type Ⅰ, type Ⅱ), and howling, based on the shapes of waveforms and spectrograms. There was a significant difference in the fundamental frequency (p<0.01), intensity (p<0.0001), 1st formant (p<0.001), 2nd formant (p<0.0001), 3rd formant (p<0.001), and 4th formant (p<0.05) among the vocalizations, whereas the duration was not different (p<0.05). Whining type I showed high values in the fundamental frequency and 3rd formant, while whining type II showed high values in the fundamental frequency and 1st, 2nd, and 4th formant. Further, bark types I and II showed high intensity values, with bark type II having a high value in the 1st formant. Finally, whining showed high values in the 4th formant only and significantly lower values in the 1st and 2nd formants than other vocalizations. Domestic dogs mainly exhibited barking and whining with differences in characteristics of fundamental frequency, intensity, and formant dispersion when they wanted to play with humans during the experiment. Accordingly, we suggest that vocalization could be a useful method for identifying dogs’ intentions or emotional state in a non-invasive manner.

Sirtuin 1 (SIRT1), the most conserved nicotinamide adenine dinucleotide-dependent protein deacetylase, is involved in the regulation of energy metabolism, genomic stability, and development. SIRT1 knockout (SIRT1) mice exhibit decreased energy expenditure and hypersensitivity to a high-fat diet (HFD). SIRT1 deficiency in the testis has also been shown to cause male infertility in animal models. Therefore, the present study was conducted to examine the alteration of the testicular function of SIRT1 mice on HFD. Six-week-old mice were fed ad libitum as wild type (WT) and SIRT1 male mice with either a control diet or with HFD for 32 weeks and then were sacrificed. The levels of biomarkers for hepatotoxicity, sex hormones, and cytokines were analyzed in the serum and blood-testis barrier, and the sperm morphology was examined in the testis and epididymal spermatozoa. Interestingly, an enlargement of seminal vesicles was observed in the SIRT1 mice fed with HFD. A significantly higher level of hepatotoxicity was also seen in these mice. The concentration of serum testosterone increased in HFD-fed SIRT1 mice compared to the controls. The levels of interleukin-1β and TNF-α increased in both HFD-fed WT and SIRT1 mice. In RT-PCR, the m RNA expression of tight junction protein 2 and claudin 3 significantly decreased in HFD-fed SIRT1 compared to those of the controls. Degenerative spermatocytes and spermatids were detected in the HFD-fed SIRT1 mice testicular section. Sperm motility decreased in WT and SIRT1 with HFD feeding, and sperm concentration decreased significantly in WT-HFD and SIRT1 mice with or without HFD feeding. Taken together, HFD can alter energy and steroid metabolism in SIRT1-deficient mice, which can lead to imbalances in motility and production of sperm and testosterone that can result in male reproductive disorders.

The present trial verified the effects of spraying microbial agents on odor reduction in commercial pig farms of different operating sizes and barn types. Farms without microbial agent spraying and those sprayed with microbial agents at two different intervals were compared. The treatments included spraying of water alone every day or a mixture of water plus microbial agent at 24 and 72 h intervals. The experimental farms were divided according to size into 1,000-, 3,000-, and 5,000-head farms and according to barn type into gestation, farrowing, nursery, and grower-finisher farms. To compare odor concentration within each housing barn, ammonia and hydrogen sulfide gas levels were measured. The average concentrations of ammonia (p<0.01) and hydrogen sulfide (p<0.05) gas were the lowest in all types of farms sprayed with the microbial agent at a 24 h interval. In farms sprayed with the microbial agent at a 24 h interval, the decrease in ammonia concentration according to barn type was in the following order: farrowing (p<0.01) (11.0 to 1.8 ppm), nursery (p<0.05) (17.0 to 9.2 ppm), grower-finisher (15.3 to 8.8 ppm), and gestation (9.7 to 6.4 ppm) farms. Moreover, spraying the microbial agent at a 24 h interval significantly (p<0.01) decreased ammonia concentration from 19.9 to 10.4 ppm, from 11.1 to 4.1 ppm, and from 8.8 to 5.1 ppm in 5,000-, 3,000-, and 1,000-head farms, respectively. Overall, spraying microbial agents every day may be the most effective method to reduce odor in commercial pig farms.

성명학은 ‘성씨와 이름관련 종합학문’으로 아주 넓게도 보나, ‘운명과 연관 된 작명학’으로 아주 좁게도 보면서 점술로 취급되기도 한다. 그러나 1990년 대부터 선행연구가 증가하면서 학술적 요건을 갖추어 가고 있으므로 이를 중 심으로 성명학의 학문적 정체성을 검토했다. 성명학 관련 연구는 10,321건으로 상당히 많지만, 최협의성명학의 학술과 학 위논문은 82건으로 많지 않다. 명칭은 성명학이지만 ‘운명연관 해명이 포함된 작명학’으로 범위를 좁히고 있기 때문에 학문적 영역이 상당히 좁고, 학술연구 분야분류에도 없는 무적 학문이다. 가르치는 교수나 대학(원)도 거의 없이 석사 와 박사만 배출되고 있어서 성명학의 향후 발전을 기대하기 힘들다. 이 같은 상황에서 논하기도 쉽지 않지만, 성명학 발전을 위한 학문적 정체 성 정립은 필수적이다. 이에 분석한 내용을 중심으로 제언하면, 첫째 성명학 은 운명론을 벗어나야 한다. 둘째 성명학의 범위 확대로 학문적 영역이 확보 되어야 한다. 셋째, 성명학의 학술연구분야분류가 필요하다. 넷째, 성명학 전 문가를 양성하는 대학(원) 교육이 시급하다.

This study aimed to investigate the impacts of extreme weather on the dry matter yield (DMY) of silage maize in South Korea. The maize data (n=3,041) were collected from various reports of the new variety of adaptability experiments by the Rural Development Administration (1978-2017). Eight weather variables were collected: mean temperature, low temperature, high temperature, maximum precipitation, accumulated precipitation, maximum wind speed, mean wind speed, and sunshine duration. These variables were calculated based on ten days within seeding to harvesting period. The box plot detected an outlier to distinguish extreme weather from normal weather. The difference in DMY between extreme and normal weather was determined using a t-test with a 5% significance level. As a result, outliers of high-extreme precipitation were observed in July and August. Low-extreme mean temperature was remarkable in middle May, middle June, and late July. Moreover, the difference in DMY between extreme and normal weather was greatest (5,597.76 kg/ha) during the maximum precipitation in early July. This indicates that the impact of heavy rainfall during the Korean monsoon season was fatal to the DMY of silage maize. However, in this study, the frequency of extreme weather was too low and should not be generalize. Thus, in the future, we plan to compare DMY with statistical simulations based on extreme distributions.

Iron deficiency is known to be a common nutritional disorder in many countries, especially among children, women of childbearing age and pregnant women. SUNACTIVE Fe-P80 is a new type of iron supplement that applies nanotechnlateology for the purpose of overcoming the disadvantages of food supplements. This study was conducted to investigate the potential adverse effects of a 28-day repeated oral dose of SUNACTIVE Fe-P80 in rats. SUNACTIVE Fe-P80 was administered once daily by gavage to Sprague-Dawley rats for 28 days at doses of 0, 500, 1,000, and 2,000 mg/kg/day. Additional recovery groups from the control and highdose groups were observed for a 14-day recovery period. At the scheduled termination, the animals were sacrificed, their organs weighed, and blood samples collected. There were no treatment-related effects in the context of clinical signs, body weight, food intake, ophthalmoscopy, urinalysis, necropsy findings, organ weights, and hematologic, serum biochemical and histopathological parameters at any dose tested. Under the present experimental conditions, the no-observed-adverse-effect level of SUNACTIVE Fe-P80 was ≥ 2,000 mg/kg/day in both the sexes, and no target organs were identified. Thus, the results suggest that SUNACTIVE Fe-P80 is relatively safe, as no treatment-related adverse effects were observed following a 28-day repeated oral dose experiment.

This study was conducted to evaluate the effects of ImmunoSEB as an immune-booster additive on the performance of broiler chicks. A total of 1150 broiler chickens were randomly allotted to three treatments on the basis of body weight (10 pens per treatment with 40 broilers in each pen): the control (CON), CON + ImmunoSEB 0.025% in feed (SEB25), and CON + ImmunoSEB 0.050% in feed (SEB50). The experiment was conducted for d 42 in three phases (phase 1, d 0–14; phase 2, d 15–28; and phase 3, d 29–42). There were significant differences in the average daily gain (ADG) and feed intake. The ADG at d 14 in the SEB50 treatment was greater than that in the CON treatment. The overall ADG in the SEB50 treatment was greater than that in the CON treatment. During d 0–14, the feed intake of chickens in the SEB50 treatment increased compared to that in the CON treatment. The crude protein and lysine digestibility improved in the SEB25 and SEB50 treatments compared to those in the CON treatment at d 28. Superoxide dismutase concentration significantly increased in the SEB50 treatment compared to that in the CON treatment. The interleukin-1β and tumor necrosis factor-α concentrations were higher in the cecum of chickens in the CON treatment than in the SEB25 and SEB50 treatments. A lower population of E. coli was detected in the ileum and cecum of broilers fed the SEB50 diet compared to those of broilers fed the CON diet. The overall result showed the beneficial effects of using ImmunoSEB at a dose of 0.050% in broiler chickens.

이 연구에서는 대학 통일교육의 활성화와 20대의 통일에 대한 관심을 증진시키기 위한 대학 통일교육의 변화 방향을 민주시민교육과 결합 방 안을 중심으로 모색한다. 현재 20대 대학생 집단은 과거의 20대와 비교 할 때 북한에 대한 인식은 부정적으로 변했으며, 통일로 인한 경제적 어 려움과 사회문제의 증가 등에 대해 민감하게 받아들이는 태도에서 이전 세대보다 다소 개인주의와 실리주의가 강화된 것으로 파악된다. 이 세대 는 과거와 같은 내용과 방식의 통일교육은 수용하지 않는 반면, 표현의 가치를 중요하게 생각하는 세대이기에 이들 특성에 맞는 교육방안을 민 주시민교육과의 연계를 통해 제시한다. 제도적 차원에서 정부 정책의지 를 전제로 대학 통일교육의 강화를 위한 지속가능한 제도적 개선 방안을 제시하고, 다섯 가지 방향의 전환을 제시한다.

Over the past decade, platelet-rich plasma (PRP) and platelet derivatives have been widely investigated in the field of regenerative medicine due to their high concentrations of platelet- related growth factors, cytokines, and other proteins. Recently, many clinical studies have suggested their regenerative therapeutic efficacy in treating several disorders in medical field. However, their therapeutic applications are not well characterized in veterinary medicine as in human and experimental animals. This article reviews functional roles of platelets, scientific concepts, and clinical use of PRP and platelet derivatives in veterinary medicine. It also presents guidelines for veterinary applications of PRP in the future.

The ambiguity of complex regional pain syndrome (CRPS) posed a challenge to many medical researchers in the early days after its discovery and continues to do so till date. The establishment of the Budapest Criteria of the International Association for the Study of Pain resolved certain queries on CRPS. Many aspects of CRPS, such as pathophysiology and etiology, remain unknown. Therefore, of these aspects, we focused on the genetic basis of CRPS. In this qualitative review, we summarized the recent findings on the genetic association of CRPS and analyzed the roles of genes identified in each study and limitations of the studies. In particular, we confirmed the reliability of each study by comparing the following research, which used the following control groups or the same candidate genes. Notably, specific phenotypes of CRPS with dystonia indicate a significant association with human leukocyte antigen (HLA)-DQ8. Further, HLA-DQ8, which is associated with aberrant CD4+ T-cell reaction, could be associated with CRPS etiology since an increased CD4+ T-cell population was reported in CRPS patients. In addition, matrix metalloproteinase (MMP)-9 found in genome-wide expression profiling is noteworthy since MMP-9 is associated with neuro-inflammatory reactions. Despite these suggestions on the genetic aspects of CRPS, the pathophysiology and etiology of CRPS may be polygenic and multifactorial, influenced by multiple genes and other factors. Further, some studies have suggested that CRPS phenotypes have different etiologies. Thus, further studies with the precise classification of CRPS on a unified basis and with a significant number of case groups are required