목적 : 본 연구에서는 코로나19 이전과 이후 10대 청소년의 근시 진행 정도를 비교하여 알아보고자 하였다 방법 : 본 연구는 전북 전주시에 있는 안경원을 방문한 코로나 이전과 이후 14~16세 청소년을 대상으로 안질 환이 없고 연1회 이상 방문하여 기록된 안경처방서를 분석하였다. 코로나 이전과 이후 각각 3년간 추적조사한 굴 절이상 변화는 RM(repeated measures of ANOVA))을 사용하여 분석하였다. 결과 : 코로나19 전과 후 안경처방서를 3년간 추적하여 분석한 결과 오른눈이 왼눈보다 근시 변화량이 크게 나 타났다. 연령별 굴절이상도에서 코로나 이전은 14세에서 가장 높게 나타났고, 코로나 이후는 15세에서 가장 높게 나타났다. 근시 진행 속도는 코로나 전후 모두 14세에서 가장 큰 폭으로 증가하였다. 코로나 이전과 이후 연구대 상자의 회차별 등가구면 굴절이상 변화량을 1차년도와 3차년도를 비교한 결과 코로나 이전은 –0.68±0.52 D였으 며, 이후는 –1.01±0.55 D로 코로나 이후 근시가 매우 증가하는 것으로 나타났다. 결론 : 본 연구에서는 코로나 이전보다 이후 10대 청소년의 근시 진행이 빠른 속도로 진행되는 경향을 보였으 며, 이에 대한 다양한 원인을 찾는 지속적인 연구가 필요하다. 추후 청소년의 시력저하 및 근시 진행을 예방하기 위해 국민 안보건 복지 차원에서 계속적이고 추가적인 연구를 시행할 것을 제안한다.

Silene fissipetala Turcz., which is native to Continental China and Taiwan, was newly found in Chungcheongnam-do, Korea. S. fissipetala is similar to the related taxa S. antirrhina L., S. armeria L., and S. koreana Kom. in that it has glutinous zones. However, S. fissipetala is distinguished from the congeneric species by the presence of laciniate at the petals. The species grows on slopes and roadsides, suggesting that it is likely to have been introduced through the installation of green sites and road construction. A precise description, photographs, voucher specimens and a key to related taxa are provided.

목적 : 신체균형 측정기를 이용하여 주시거리와 다양한 시각 상태가 신체 안정성에 미치는 영향을 알아보고자 하였다. 방법 : 대상자는 총 23명(23.92±2.09세)으로 진행하였으며, 시각 조건은 모두 ‘완전교정, 흐림 조건(시력 0.5 logMAR 미만) 그리고 10° 이내의 시야’이다. 신체 안정성 측정은 ‘3D Guidance‘를 사용하였다. 결과 : 완전교정 상태에서는 주시거리 간 통계적으로 유의한 차이는 없었다(p>0.050). 그러나 흐림 조건에서는 주시거리에 따라 측면 및 전·후면 흔들림에서 유의한 차이가 확인되었으며(p=0.004, p=0.027), 시야가 10° 이 내로 제한되었을 때에도 유의한 신체 흔들림이 관찰되었다(p<0.050). 결론 : 주시거리에 따라 신체 안정성의 변화가 나타나며, 특히 흐림과 제한된 시야 상태에서는 주시거리에 따른 차이가 더 유의하였다.

This study (1) explored spatio-temporal population distribution patterns in Jeonju by using emerging hot spot analysis and (2) identified the influential factors to determine the spatio-temporal patterns by using multinomial logit model. The major findings are as follows. First, the results of emerging hot spot analysis indicated that the 100*100m grid in the urban area of Jeonju was found to have a category of hot spots, whereas most of the cold spot series was concentrated in the outskirts of the city. Also, new towns such as Jeonju Eco City, Jeonbuk Innovation City, and Hyocheon District were persistent or intensifying hot spots, Third, the results of multinomial logit model revealed that the factors influencing deterrmining the spatio-temporal patterns were accessibility to schools, hospitals, parks, and walfare services. This study offered a deeper understanding of urbanization and regional changes in Jeonju, and important information for urban planning.

Companies are paying attention to project governance to realize their goal strategies, project success, and project value in a rapid and complex environment due to the development of information technology. This study aims to explore project governance and factors from literature review and practice guides related to project governance and empirically analyze the impact of project governance factors on IT project objective performance. The survey was conducted on project managers, project team members, and project management members with experience in carrying out business IT projects within two years at companies in various industries in Korea. The main conclusion is as follows. Among the project governance factors, disclosure and reporting that uses and reports using appropriate and reliable information about projects related to decision-making activities positively impact the achievement of IT project objectives: business success and stakeholder satisfaction. Among the project governance factors, project sponsorship, a role that effectively connects management and projects, and a project management framework that provides tools, procedures, resources, and techniques for projects positively impact IT project objective performance. This study is of academic and practical significance in that it identifies the definition and factors of project governance through companies in various industries in Korea and the positive impact of project governance factors on IT project objective performance.

Under increased complexity and uncertainty of overseas construction projects, it is important for construction companies to improve their own project risk management capabilities instead of risk-taking strategies to secure competitiveness in the overseas construction market. Although most of the risks occur in project execution stage, many previous studies focused on planning stage including risk identification and analysis among PRM process. Therefore, this study aims to verify the effectiveness of whole PRM process during project execution stage through empirical study on participants of overseas construction projects. As the result it was found that first, the factor directly affects the project success is the execution process of PRM. It implies that appropriate actions such as appointing charged manager for risks, timely implementation of responding plan, continuous risk monitoring and updating established plan are the key for contribution to the project success. Second, the importance of communication in PRM is also found, which is not conducted at a specific but throughout the entire PRM process and need to be managed as essential factor for successful PRM..

In this study, we focus on the improvement of data quality transmitted from a weather buoy that guides a route of ships. The buoy has an Internet-of-Thing (IoT) including sensors to collect meteorological data and the buoy’s status, and it also has a wireless communication device to send them to the central database in a ground control center and ships nearby. The time interval of data collected by the sensor is irregular, and fault data is often detected. Therefore, this study provides a framework to improve data quality using machine learning models. The normal data pattern is trained by machine learning models, and the trained models detect the fault data from the collected data set of the sensor and adjust them. For determining fault data, interquartile range (IQR) removes the value outside the outlier, and an NGBoost algorithm removes the data above the upper bound and below the lower bound. The removed data is interpolated using NGBoost or long-short term memory (LSTM) algorithm. The performance of the suggested process is evaluated by actual weather buoy data from Korea to improve the quality of ‘AIR_TEMPERATURE’ data by using other data from the same buoy. The performance of our proposed framework has been validated through computational experiments based on real-world data, confirming its suitability for practical applications in real- world scenarios.

Background: The potential impact of aqueous extracts from Psidium guajava leaves on the reproductive system of female rabbits was evaluated. Methods: Twenty-eight rabbits, aged five to six months were utilized. Rabbits were divided into four groups and were randomly assigned to receive one of the following oral doses of the guava leaf extracts: 0 (control group), 10, 20, or 30 mg/kg of body weight. After a treatment period of 30 days, blood was collected via jugular venipunture and the serum was extracted for the assessment of serum biochemical traits levels. The females were bred and monitored throughout their pregnancy to ascertain reproductive outcomes. Results: The results indicated that the guava leaf extract significantly increased the body weight of the rabbits during both pre- and post-pregnancy compared to the control group (p < 0.05). The litter size at three weeks post-birth, prolificity rate, FSH, LH, and protein levels were notably higher (p < 0.05) at a dose of 20 mg/kg of body weight. The viability rate three weeks post-birth increased with escalating extract doses, and the highest values were observed at doses of 20 and 30 mg/kg of body weight (p < 0.05). Conclusions: This study demonstrated that, the aqueous extract of guava leaves appears to stimulate the production of FSH, LH and enhance body weight, prolificity, and pregnancy outcomes in mammals. As such, it is suggested that a dose of 20 mg/kg body weight could be beneficial in improving the reproductive performance of female.

The air transport industry is experiencing unprecedented fluctuations in aviation demand through the Covid-19 pandemic, and is more focused than ever on maintaining and generating business profitability. During the pandemic, demand for air cargo has soared, and the conversion business from passenger aircrafts to freighters(P2F) is drawing attention as a new business in the aviation maintenance industry. This study derives important factors to be considered in order to successfully carry out the P2F project through a wide range of cases and related literature, and analyzes the relative importance of each factor using the analytic hierarchy process. Through a survey of 33 aviation maintenance experts with more than 20 years of field experience, the importance of main factors and their sub factors was determined and implications were drawn. As a primary result, in order to succeed in the P2F project, the main factors were identified in the order of skill, finance, and location. The most important sub factors for each main factors were identified in order of securing airframe modification skill, securing infrastructure construction cost, and creating P2F business complex and district. The quantified success factors suggested the critical direction for the successful development of Korea's P2F business, and presented viable and specific business strategies and implementation plans for each factors.

This study was conducted to assess the genetic variability and correlation of phenotypic characteristics in 12 tomato (Solanum lycopersicum L.) genotypes including 11 WorldVeg and one commercial variety (Pusa Ruby) in Terai (plain) region of Nepal in 2021–2022. This experiment was laid out in a randomized complete block design with three replications. The phenotypic traits, including days to 50% flowering, plant vigor and height, fruit number/plant, fruit yield, fruit weight and diameter, fruit firmness and fruit pericarp thickness, and total soluble solids (TSS) content of the fruits, were studied. Analysis of variance revealed significant differences among the genotypes for all the traits except for plant vigor. The genotype of AVTO1705 resulted the highest fruit yield (2.9 kg/plant) than Pusa Ruby, a commercial check (0.5 kg/plant). The phenotypic coefficient of variation (PCV) was higher than the genotypic coefficient of variation (GCV) for all the traits and PCV values were maximum for the number of fruits, fruit yield, and fruit weight. High PCV, GCV, and genetic advance (GA) were observed for yield, fruit weight, and plant height, respectively, indicating the additive gene effect. High heritability for fruit yield/plant and plant height inferred the phenotypic selection for their genetic improvement. Fruit yield was significantly (P<0.05) positively correlated with the fruit number and fruit weight, and direct selection of these traits are reliable for yield improvement in tomato.

Buckwheat (Fagopyrum esculentum), which is a traditional Korean crop, has been known as a health food due to its rich nutrition. This study was conducted to evaluate the change in flavonoid content of flowers and seeds during post-flowering growth of Korean tartary buckwheat variety ‘Hwanggeummiso’, with the aim of providing basic data for the development of functional food and feed additive. Tartary buckwheat took 69 and 99 days from the sowing date to reach the flowering and maturity stages, respectively. As a result of examining the flavonoid components of each part of tartary buckwheat, chlorogenic acid, rutin, and isoquercitrin of flowers increased from the flowering period on 22 May (0 days after flowering) to 42 days after flowering, while quercetin increased until 21 days after flowering and then decreased thereafter. In seeds, chlorogenic acid, rutin, and isoquercitrin were most abundant at the time of seed-bearing on 14 days after flowering, and showed a decreasing tendency thereafter. On the other hand, quercetin showed a tendency to increase until 21 days after flowering and then decrease. Overall, the flavonoid content was higher in flowers than in seeds, with rutin being particularly prominent. Based on this, the possibility as food materials and feed additives was confirmed using buckwheat produced in Korea.

Narcissus (Narcissus spp.) bulbs were used to investigate contagious viral retention in the dormant stage. The amplified polymerase chain reaction (PCR) bands were screened using universal potyvirus primers and sequenced to identify specific viruses. To identify individual viruses, primers for specific viruses were designed, and reverse transcription (RT)-PCR was performed. The PCR fragments were sequenced and compared by phylogenetic analysis. Three potyviruses, cyrtanthus elatus virus A (CyEVA), narcissus yellow stripe virus (NYSV), and narcissus late season yellows virus (NLSYV) were singly or doubly detected in 18 samples from six cultivars of the 38 samples representing eight cultivars that were tested. Based on RT-PCR using specific primers, CyEVA was detected in the split corona daffodil cv. Orangery. NLSYV and NYSV frequently occurred as co-infections with each other in the double daffodil cv. Tahiti, and the N. cyclamineus daffodil cv. Tete-a-tete and cv. Tete Boucle. Results has shown that at least three potyviruses are present in imported Narcissus bulbs.

Extensive research and testing continue to be conducted for the development of vaccines targeting zoonotic diseases such as brucellosis. In this study, the potential of the DapB as a recombinant protein vaccine to effectively combat Brucella abortus 544 infection in BALB/c mice was evaluated. Western blotting assay results showed that recombinant protein DapB reacted with Brucella-positive serum, indicating its potential immunoreactivity. In vivo results showed that the peripheral blood CD4+ and CD8+ T cell population significantly increased in the DapB-immunized mice group after the first, second and third blood collection, compared to the control group that received PBS. Additionally, at the fourth blood collection, an increase in CD4+ T cell activation was observed in three vaccination groups compared to PBS negative control group. These results indicate the potential of DapB in stimulating cellular immunity. Fourteen days after infection, the bacterial load in the spleen was evaluated. The reduction in bacterial replication in the spleen by both DapB and RB51 highlights their protective efficacy against Brucella infection. These findings contribute to the ongoing efforts in developing effective vaccines against brucellosis and provide valuable insights for further research in this field.

Canine parvovirus-2 (CPV-2) has been reported worldwide as a major pathogen associated with acute hemorrhagic enteritis. The disease is a major infectious cause of death, particularly in young dogs. The earliest type of CPV-2 was replaced with three main subspecies, CPV-2a, CPV-2b, and CPV-2c, within a few years. Vaccination is carried out regularly, but the emergence of antigenic variants and the influence of maternal antibodies have limited the efficacy of commercial vaccines. New vaccines, such as the subunit vaccine, have been developed for alternative, safe, and effective vaccination. The baculovirus expression vector system (BEVS) is an excellent eukaryotic expression system with a high-level expression of foreign proteins and the ability of post-translational modification. Therefore, it is used widely to produce recombinant protein and subunit vaccines. In this study, the VP2 protein of CPV-2b cloned in the gateway vector system was generated using a baculovirus expression system in Spodoptera frugiperda (SF9) insect cells. Hemagglutination assay (HA) titers (24) were obtained, and the expression was detected in 6-His tagged VP2 and monoclonal antibody (mAb) against CPV-2 by western blotting. The VP2 protein of CPV-2b expressed in this study may provide a basis for a clinical diagnosis and vaccination applications for CPV-2.

Background: Coating a culture plate with molecules that aid in cell adhesion is a technique widely used to produce animal cell cultures. Extracellular matrix (ECM) is known for its efficiency in promoting adhesion, survival, and proliferation of adherent cells. Gelatin, a cost-effective type of ECM, is widely used in animal cell cultures including feeder-free embryonic stem (ES) cells. However, the optimal concentration of gelatin is a point of debate among researchers, with no studies having established the optimal gelatin concentration. Methods: In this study, we coated plastic plates with gelatin in a concentrationdependent manner and assessed Young’s modulus using atomic force microscopy (AFM) to investigate the microstructure of the surface of each plastic plate. The adhesion, proliferation, and differentiation of the ESCs were compared and analyzed revealing differences in surface microstructure dependent on coating concentration. Results: According to AFM analysis, there was a clear difference in the microstructure of the surface according to the presence or absence of the gelatin coating, and it was confirmed that there was no difference at a concentration of 0.5% or more. ES cell also confirmed the difference in cell adhesion, proliferation, and differentiation according to the presence or absence of gelatin coating, and also it showed no difference over the concentration of 0.5%. Conclusions: The optimum gelatin-coating for the maintenance and differentiation of ES cells is 0.5%, and the gelatin concentration-mediated microenvironment and ES cell signaling are closely correlated.

Background: Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer the immense therapeutic potential in stem cell-based therapy of degenerative disorders. However, clinical trials of human ESCs cause heavy ethical concerns. With the derivation of iPSCs established by reprogramming from adult somatic cells through the transgenic expression of transcription factors, this problems would be able to overcome. In the present study, we tried to differentiate porcine iPSCs (piPSCs) into endothelial cells (ECs) for stem cell-based therapy of vascular diseases. Methods: piPSCs (OSKMNL) were induced to differentiation into ECs in four differentiation media (APEL-2, APEL-2 + 50 ng/mL of VEGF, EBM-2, EBM-2 + 50 ng/ mL of VEGF) on cultured plates coated with matrigel® (1:40 dilution with DMEM/F-12 medium) for 8 days. Differentiation efficiency of these cells were exanimated using qRT-PCR, Immunocytochemistry, Western blotting and FACS. Results: As results, expressions of pluripotency-associated markers (OCT-3/4, SOX2 and NANOG) were higher observed in all porcine differentiated cells derived from piPSCs (OSKMNL) cultured in four differentiation media than piPSCs as the control, whereas endothelial-associated marker (CD-31) in the differentiated cells was not expressed. Conclusions: It can be seen that piPSCs (OSKMNL) were not suitable to differentiate into ECs in the four differentiation media unlike porcine epiblast stem cells (pEpiSCs). Therefore, it would be required to establish a suitable PSCs for differentiating into ECs for the treatment of cardiovascular diseases.

A one-year-old, female, Maltese dog was presented with head tilting, horizontal nystagmus, and tetraparesis. Blindness was first identified, and magnetic resonance imaging (MRI) scanning revealed diffuse lesion which was hyperintense on T2-weighted image over the cerebellum and brainstem. The immunosuppressive therapy had been administered, but the patient had no improvement. Re-performed MRI revealed the progression of the pre-existed inflammatory lesions. Treatment with prednisolone, leflunomide, cyclosporine, and cytosine arabinoside was initiated. However, neurological signs had been progressive, and the patient was euthanized. The histopathological examination revealed the disseminated granulomatous meningoencephalomyelitis (GME). This GME case suggests the importance of initiation of treatment at the appropriate time.

Mucosa-associated lymphoid tissue (MALT) lymphoma (ML) is a type of non-Hodgkin’s lymphoma involving MALT, commonly the stomach or salivary glands, although virtually any mucosal site can be affected. ML originates from B cells in the marginal zone of MALT, and is also called extranodal marginal zone B cell lymphoma. It is a slow-growing cancer that usually responds well to treatment. A 59-year-old female presented with a 1-day history of quadriparesis and dysarthria. Up arrival at the hospital, motor power in the right upper and lower extremities was grade 3/5 according to the Medical Research Council scale, while that in the left leg was 4/5. The patient had been diagnosed with gastric ML 1 year prior, and had received antibiotics during the previous 2 weeks. The emergency magnetic resonance imaging of the brain performed at the time of presentation showed multifocal embolic infarction in the cerebral hemisphere bilaterally, which did not have a cardiac origin. Magnetic resonance angiography revealed no stenotic or occlusive lesions. Secondary prophylaxis with daily administration of 300 mg aspirin was prescribed. The patient was discharged with residual right hemiparesis 2 weeks after the onset of symptoms. Herein, we present a rare case of multifocal cerebral infarction in a gastric ML patient.

Background: The regulation of maternal immunity is critical for the establishment and maintenance of successful pregnancy. Among many cell types regulating the immune system, innate lymphoid cells (ILCs) are known to play an important role in innate immunity. Although some reports show that ILCs are present at the maternalconceptus interface in humans and mice, the expression and function of ILCs in the endometrium have not been studied in pigs. Methods: Thus, we determined the expression, localization, and regulation of ILC markers, CD127 (a common marker for ILCs), BCL11B (a ILC2 marker), and RORC (a ILC3 marker) at the maternal-conceptus interface in pigs. Results: The expression of BCL11B and RORC, but not CD127, in the endometrium changed during pregnancy in a stage-specific manner and the expression of CD127, BCL11B, and RORC was greatest on Day 15 during pregnancy. CD127, BCL11B, and RORC were also expressed in conceptus tissues during early pregnancy and in chorioallantoic tissues during the later stage of pregnancy. BCL11B and RORC proteins were localized to specific cells in endometrial stroma. The expression of CD127 and BCL11B, but not RORC, was increased by the increasing doses of interferon-γ (IFNG) in endometrial explants. Conclusions: These results suggest that ILCs present at the maternal-conceptus interface may play a role in the establishment and maintenance of pregnancy by regulating the innate immunity in pigs.

Currently, the current status of mobile apps in traditional markets is still passive in digitalization, and services provided using mobile apps are limited. This study aims to propose a cloud platform-based mobile platform that can overcome digital transformation, strengthen the competitiveness of traditional markets, and revitalize the local economy by more consumers visiting traditional markets. This study identified the current situation and problems of the market due to its characteristics, and analyzed the impact and opportunities of cloud and mobile technology on the characteristic market. It also implemented a cloud-based smart traditional market mobile platform prototype. The platform combines the advantages of traditional markets with digital benefits to deliver value to all users, social, industrial, I hope it will be of great help on the social side.