This study was conducted to reset the withdrawal time (WT) for amoxicillin (AMX) in pigs as a part of positive list system (PLS) program introduction. Forty-two healthy pigs were orally administered with AMX at doses of 10 mg/kg body weight (BW) (AMX-1, n=20) and 20 mg/kg BW (AMX-2, n=20), twice daily for 5 days, respectively. After the treatment, tissue samples were collected from four pigs at 1, 3, 5, 7 and 14 days post-administration, respectively. Based on a previously established analysis method, residual AMX concentrations in pig tissues were determined using LC-MS/MS. In both AMX-1 and AMX-2 groups, AMX levels in all tissues except fat was below the limit of quantification (LOQ) at one day after the final administration. According to the European Medicines Agency’s guideline on determination of withdrawal periods, the withdrawal periods for AMX-1 and AMX-2 in fat tissue were established as 0 and 2 days, respectively. In conclusion, the estimated WT of AMX in edible tissues of pigs is shorter than the current WT recommendation of 5 days for AMX.
인도 연극의 선구자인 비제이 텐둘카르는 인도 연극을 전통적 뿌리에서 현대적이고 혼종적인 형태로 탈바꿈시키는 데 중추적인 역할을 하였다. 본 논문은 텐 둘카르의 작품이 어떻게 토착 문화 요소와 서구 모더니즘의 영향을 결합하며 인도 연 극의 진화를 반영하는지를 탐구한다. 산스크리트 희곡과 마하바라타, 라마야나와 같은 서사에 뿌리를 둔 전통 인도 연극은 도덕적 이분법과 사회 규범에 중점을 두었다. 그 러나 탈식민 시대의 인도 영어 연극, 특히 텐둘카르의 작품은 도시 중산층이 직면한 현대 사회 정치적 문제들을 다루는 방향으로 전환되었다. 텐둘카르의 정숙! 재판이 진행 중이다는 가부장제, 성 역할, 사회적 위선과 같은 주제를 조명하며 그 전환을 대표하는 사례 연구로 제시된다. 이 희곡은 모의 재판이라는 개념을 통해 사회적 불의 와 여성 억압을 비판하며, 현대 인도 사회의 보다 넓은 투쟁을 상징한다. 텐둘카르의 인도주의적 접근은 기존의 규범에 도전하며 진정성, 성실성, 새로운 도덕 질서를 옹호 한다. 그의 심리적, 실존적, 여성주의적 문제에 대한 집중은 현대 삶의 분열성을 부각 시킨다. 본 논문은 텐둘카르만의 독특한 시각을 분석함으로써, 인도 연극이 사회 비판 과 문화적 혼종성의 장으로 진화한 과정을 보여준다.
Galaxy evolution studies require the measurement of the physical properties of galaxies at different redshifts. In this work, we build supervised machine learning models to predict the redshift and physical properties (gas-phase metallicity, stellar mass, and star formation rate) of star-forming galaxies from the broad-band and medium-band photometry covering optical to near-infrared wavelengths, and present an evaluation of the model performance. Using 55 magnitudes and colors as input features, the optimized model can predict the galaxy redshift with an accuracy of σ(Δz/1+z) = 0.008 for a redshift range of z < 0.4. The gas-phase metallicity [12 + log(O/H)], stellar mass [log(Mstar)], and star formation rate [log(SFR)] can be predicted with the accuracies of σNMAD = 0.081, 0.068, and 0.19 dex, respectively. When magnitude errors are included, the scatter in the predicted values increases, and the range of predicted values decreases, leading to biased predictions. Near-infrared magnitudes and colors (H, K, and H −K), along with optical colors in the blue wavelengths (m425–m450), are found to play important roles in the parameter prediction. Additionally, the number of input features is critical for ensuring good performance of the machine learning model. These results align with the underlying scaling relations between physical parameters for star-forming galaxies, demonstrating the potential of using medium-band surveys to study galaxy scaling relations with large sample of galaxies.
The present study investigates the impact of freeze–thaw deterioration on the electrical properties and electric-heating capabilities of cement mortar incorporating with carbon nanotubes (CNT) and carbon fibers (CF). Mortar samples, containing 0.5 wt.% CNT and 0.1 wt.% CF relative to the mass of cement, were prepared and subjected to freeze–thaw tests for up to 300 cycles. The electrical properties and electric-heating capability were evaluated every 30 freeze–thaw cycles, and the physicochemical characteristics of the samples were analyzed using X-ray diffraction and mercury intrusion porosimetry. The results indicate a decline in both electrical conductivity and heat-generation capability as the freeze–thaw cycles progress. Furthermore, changes in the pore structure of the mortar samples during the freeze–thaw cycles contributed to damage in the conductive network formed by CNT and CF, resulting in decreased electrical conductivity and heat-generation capabilities of the mortar samples.
This study evaluated the efficacy of a wild boar repellent (Repellent A) consisting of tannins and plant oils (castor oil, garlic oil, and cinnamon oil). Sixty farmed wild boars (4-8 months old) were divided into three groups: the normal control group (NC, n=20), the experimental group (EP, n=20), and the comparative experimental group (C-EP, n=20), which used Repellent B consisting of guaiacol, eugenol, menthol, thymol, and indole. EP and C-EP were equipped with four repellents per feeder, while no repellents were installed in the NC feeder. The feed intake and the number of feeding approaches were measured for one week in all groups. The number of approach of wild boars in feeders was monitored daily using a CCTV camera. The daily feed intake per farmed wild boar in EP and C-EP was significantly decreased compared to NC (p<0.05), and EP was significantly decreased compared to C-EP (p<0.05). In the average number of daily approaches, EP and C-EP were significantly decreased compared to NC (p<0.05), and EP was significantly decreased compared to C-EP (p<0.05). In conclusion, Product A has been confirmed to have excellent repellent effects on wild boars, and it could be used to prevent wild boars from approaching pig farms.
This study evaluated the immunogenicity of the Bacillus Calmette-Guérin (BCG) vaccine in a guinea pig model to refine preclinical assessment methods. 24 guinea pigs were divided into four groups for immunohistochemical, histopathological, and molecular analyses, including qRT-PCR and ELISA. The ELISA results revealed significant elevations in interleukin 2 (IL-2), interferon-gamma (IFN- ), and tuberculosis-specific antibodies in vaccinated guinea pigs, particularly γ notable after 6 weeks. Although lung cytokine levels remained unchanged, spleen gene expression showed significant differences in interleukin-17, interleukin-12, interleukin-1β, and C-X-C motif chemokine ligand 10 after 6 weeks. Immunohistochemistry revealed peak IL-2 expression at 8 weeks and significant IFN-γ and TNF-α expression at 6 weeks. This study confirmed the effectiveness of BCG vaccine in guinea pigs, providing crucial insights for future tuberculosis vaccine development and standardizing immune response indicators.
We report a new route of akaganéite (β-FeOOH) formation and maghemite (γ-Fe2O3) formation. Akaganéite can be produced by stirring Fe2+ at room temperature for a day under mild conditions. We used FeCl2 ·4H2O as the precursor and mixed it with the Na-rich particle from the oxidation debris solution. The role of the concentration ratio between graphene oxide (GO) and NaOH was addressed to generate oxidation debris (OD) on the surface. In particular, the characterization of OD by transmission electron microscope (TEM) imaging provides clear evidence for the crystal formation of Na-rich particle under electron beam irradiation. For the base treatment process, increasing the concentration of a NaOH in Na-rich solution contributed primarily to the formation of γ-Fe2O3. The characterization by scanning electron microscope (SEM) and TEM showed that the morphology was changed from needle-like to small-oval form. In addition, β-FeOOH can be effectively produced directly using GO combined with FeCl2 ·4H2O at room temperature. More specifically, the role of parent material (Hummer's GO and Brodie's GO) was discussed, and the crystal transformation was identified. Our results concluded that β-FeOOH can be formed in basic and acidic conditions.
From 2020, Korean Animal and Plant Quarantine Agency has reset the withdrawal time (WT) for veterinary drugs typically used in livestock in preparation for the introduction of positive list system (PLS) program in 2024. This study was conducted to reset the MRL for tiamulin (TML) in broiler chickens as a part of PLS program introduction. Forty-eight healthy Ross broiler chickens were orally administered with TML at the concentration of 25 g/L (TML-1, n=24) and 50 g/L (TML-2, n=24) for 5 days through drinking water, respectively. After the drug treatment, tissue samples were collected from six broiler chickens at 1, 2, 3 and 5 days, respectively. According to the previously established analysis method, residual TML concentrations in poultry tissues were determined using LC-MS/MS. In TML-1, TML in all tissues was detected less than LOQ at 2 days after drug treatment. In TML-2, TML in liver and kidney was detected more than LOQ at 2 days after treatment. According to the European Medicines Agency’s guideline on determination of withdrawal periods, withdrawal periods of TML-1 and TML-2 in poultry tissues were established to 0 and 2 days, respectively. In conclusion, the estimated WT of TML in poultry tissues is shorter than the current WT recommendation of 5 days for TML in broiler chickens.
Metal-free N–S- and N–P-doped nanocarbon (SCNP and PCNP) electrocatalysts prepared through sustainable microwaveassisted synthesis using hemigraphis alternata plant leaves. The prepared heteroatom-doped nanocarbon materials are active catalysts for the two-electron oxygen reduction reaction (ORR) to produce 65–70% of hydrogen peroxide. As evidenced from the XPS, most proportion of the doped heteroatoms contain the oxygen functional groups in the nanocarbons. These attributes are the critical factors to see the selective two-electron transfer ORR for the PCNP and SCNP. This approach shed light on the critical role of dual heteroatoms doping and the oxygen functionalities in nanocarbon towards the selectivity of ORR. We believe that this method would allow the preparation of heteroatom that contains oxygen functionalities. Our work paves a sustainable way of preparation of nanocarbon based ORR catalysts that are only selective for two-electron transfer process.
Aqueous Zn-ion batteries (ZIBs) are very attractive owing to their high safety and low cost. Among various cathode materials, organic materials-based electrodes incorporating various redox functional groups have gained significant attention in the field of ZIBs due to their benefits of a tunable structural design, facility, eco-friendly, and possibility of multivalent energy storage. Herein, we demonstrate the nanostructured organic active materials deposited onto the CNT networks (HyPT@ CNT) for flexible ZIBs. This HyPT nanorods were obtained reassemblying the herringbone structured 3,4,9,10-tetracarboxylic dianhydride through a hydrothermal process in the presence of acid. These HyPT@CNT hybrids were electronically conductive and redox active, as well as could be fabricated into a flexible electrode achieving flexibility from mechanical integrity of robust networked structure. The as-fabricated flexible ZIBs delivered the high capacity of 100 Ah g− 1 at a current density of 0.1 A g− 1 and long-term cycling performance exceeding 5000 cycles. Consequently, these electrochemical performances are associated with the redox reactivity of carbonyl groups as verified by spectroscopic and electrochemical characterizations and the hybridization of HyPT nanorods with CNT networks.
In this research, in order to increase the oxidation resistance of graphite, kaolin and alumina powder with different ratios (26A-74S, 49A-51S, 72A-28S) and slurry method were used to create an aluminosilicate coating on the graphite substrate. In order to reduce the difference in the coefficients of thermal expansion of graphite with aluminosilicate coating, aluminum metaphosphate coating as an interlayer was prepared on the surface of graphite by cathodic electrochemical treatment. The isothermal oxidation test of the samples was carried out in air at a temperature of 1250 °C for 1, 3 and 5 h. The microstructure, chemical composition, and phase components of the coating were, respectively, analyzed by scanning electron microscope equipped with an energy-dispersive spectrometer and X-ray diffraction. The results indicated that, by increasing the withdrawal speed of the samples in slurry method, the amount of changes in the weight of the samples has increased and therefore had a direct effect on oxidation. In addition, it was approved that, at high-temperature oxidation, AlPO4 glass phase forms on aluminum metaphosphate interlayer which retards graphite oxidation. Along with aluminum metaphosphate, aluminosilicate coating also produces a glass phase which fills and seals the voids on the surface which prevents the oxygen to reach the surface of graphite. The created double-layer coating including an interlayer of aluminum metaphosphate + slurry coating prepared with the ratio of 26A-74S as the optimal coating in this research was able to increase the oxidation resistance of graphite by 73% at a temperature of 1250 °C.
This study was conducted to reset the maximum residue limit (MRL) for didecyldimethylammonium chloride (DDAC) in broiler chickens. The disinfectant containing DDAC (10%, w/w) was diluted 160 times and evenly sprayed on the bodies of twenty-four broiler chickens at a rate of 15 mL per day per bird for 7 days. After the disinfectant treatment, tissue samples were collected from six broiler chickens at 0.25, 1, 3 and 5 days, respectively. Residual DDAC concentrations in poultry tissues were determined using LC-MS/MS. Correlation coefficient (0.99 >), the limits quantification (LOQ, 2.0~10.0 μg/kg), recoveries (86.9~118.6%), and coefficient of variations (<19.98%) were satisfied the validation criteria of Korean Ministry of Food and Drug Safety. In all tissues except for liver, DDAC was detected more than LOQ at 5 days after the disinfectant treatment. In liver tissues, DDAC was detected more than LOQ at 3 days after treatment. According to the European Medicines Agency’s guideline on determination of withdrawal periods, withdrawal period of DDAC in poultry tissues was established to 26 days. In conclusion, the developed analytical method is sensitive and reliable for detecting DDAC in poultry tissues. When DDAC disinfectant is sprayed on a poultry house in the presence of broiler chickens, it is necessary to keep the disinfectant from contacting the body of the livestock.