This study evaluated the immunogenicity of the Bacillus Calmette-Guérin (BCG) vaccine in a guinea pig model to refine preclinical assessment methods. 24 guinea pigs were divided into four groups for immunohistochemical, histopathological, and molecular analyses, including qRT-PCR and ELISA. The ELISA results revealed significant elevations in interleukin 2 (IL-2), interferon-gamma (IFN- ), and tuberculosis-specific antibodies in vaccinated guinea pigs, particularly γ notable after 6 weeks. Although lung cytokine levels remained unchanged, spleen gene expression showed significant differences in interleukin-17, interleukin-12, interleukin-1β, and C-X-C motif chemokine ligand 10 after 6 weeks. Immunohistochemistry revealed peak IL-2 expression at 8 weeks and significant IFN-γ and TNF-α expression at 6 weeks. This study confirmed the effectiveness of BCG vaccine in guinea pigs, providing crucial insights for future tuberculosis vaccine development and standardizing immune response indicators.

최근 딥러닝은 자기공명영상 검사에서의 화질 개선을 위해 다양하게 활용되고 있다. 하지만 다양한 자기공명영상 검사에서 딥러닝이 적용된 기법과 상황에 대한 평가는 부족한 편이다. 이에 본 연구에서는 모션 ACR(American College of Radiology) 팬텀을 활용하여 일반적인 상황과 움직이는 상황에서 T2-PROPELLER(periodically, rotated overlapping parallel lines with enhanced reconstruction, PROPELLER)와 T2-FSE(fast spin echo, FSE) 기법의 화질을 비교 평가해 보고자 하였다. 연구 결과 움직이지 않는 상황에서의 딥러닝 프로세스를 적용하였을 때 유의미한 신호대잡음비와 대조대잡음비의 상승을 보였다. 하지만 팬텀에 움직임을 주는 동적인 상황 에서 딥러닝 프로세스를 적용하였을 때 유의미한 화질 개선을 보이지 않았다. 이러한 결과는 딥러닝 프로세스를 절대 적으로 사용하기보다 다양한 상황에 맞게 선택적으로 적용하는 것이 필요할 것으로 사료된다.

Diatoms, which are reported to have over 18,000 species worldwide and approximately 2,400 species in Korea, can be found in various environments including freshwater, seawater, and wetlands. They are particularly valuable for understanding global environmental changes throughout history due to their ability to maintain their shape for extended periods of time. Instead of collecting floating diatoms using nets, low-layer substrates such as gravel and leaves, as well as sedimentary surface layers, were gathered in order to identify attached diatom species. This is because attached diatoms demonstrate higher species diversity compared to floating diatoms. In this study, seven previously unrecorded diatoms were discovered in various domestic freshwater environments. Two species were found in reservoirs (Eunotia yanomami, Gomphonella pseudookunoi), two in parasitic cones (Eunotia carverenensis, Luticola minor), two in rivers (Cavinula maculata and Prestauroneis integra), and one (Surirella brebissonii var. kuetzingii) in a lagoon. The shapes, structures, and morphological characteristics of each diatom were identified using electron microscopy.

The Korea Forest Service has designated seven alpine tree species—Abies koreana, A. nephrolepis, Juniperus chinensis, Picea jezoensis, Pinus pumila, Taxus cuspidata, and Thuja koraiensis—as threatened with extinction in Korea. In 2023, we conducted a study on the seasonal occurrence of insect pests, focusing mainly on two coleopteran taxa (Cerambycidae and Scolytinae) and two hemipteran taxa (Aphrophoridae and Cicadellidae) in subalpine forests dominated by A. koreana, A. nephrolepis, Picea jezoensis, Thuja koraiensis, and Taxus cuspidata. We utilized three types of traps—Malaise trap, Lindgren funnel trap, and window trap—in eight investigation locations in Korea. In this presentation, we present the study results and discuss the effects of insect pests on alpine coniferous trees in Korea.

Animal experiments have demonstrated the effectiveness of fermented rice germ and soybean extracts in lowering blood alcohol concentration. A compound primarily derived from fermented soybean extract constitutes the principal component of DA-5521, an experimental dietary substance examined in this study. We investigated the possible hangover-alleviating effects of DA-5521 in individuals aged 19 to 50 who had previously experienced hangovers. Moreover, we enrolled 22 participants who met the eligibility criteria and conducted a double-blind, randomized, placebo-controlled crossover trial. Six hours after alcohol consumption, the test group exhibited a statistically significant reduction in blood acetaldehyde concentration compared with the placebo group. Further, our results displayed significantly lower levels in the DA- 5521 group at 0.50 and 0.75 h post-ingestion and substantially lower peak breath alcohol concentration compared to the placebo group. These findings confirm that consumption of DA-5521 can significantly ameliorate hangover symptoms by diminishing blood acetaldehyde concentration and reduce breath alcohol concentration.

Korean historical literatures offer numerous records on astronomical phenomena such as eclipses, comets, and close approaches, etc. Records of close approaches often use specific terms to describe the angular distance, which lack translation into modern numerical values. We study the usage of the five commonly used terms, namely, Entry (入, En), Invasion (犯, In), Occultation (掩, Oc), Eclipse (食, Ec), as well as the unit Chi (尺). Our analysis is based on more than 2,300 records from Goryeo (918–1392 CE) and Joseon (1392–1910 CE) Dynasties. Through statistical analysis, we determine their quantitative definitions. We convert the lunisolar calendar to the Julian and Gregorian date and utilize the modern ephemeris DE431 to calculate the angular distance between celestial bodies. We find that the angular distances of the terms En, In, Oc, and Ec correspond to respectively 1.78◦+2.36 −1.11, 0.89◦+3.54 −0.51, 0.44◦+1.15 −0.31, and 0.29◦+2.61 −0.16 for the Goryeo Dynasty and 1.36◦+1.15 −0.64, 0.51◦+1.11 −0.32, 0.25◦+0.27 −0.17, and 0.21◦+0.25 −0.11 for the Joseon Dynasty. Additionally, we determine the angular size of the unit Chi by using the records from Korean chronicles along with the drawings of comets’ tails in the Daily Log (天變謄錄). We estimate the unit Chi to be 1.11◦+0.46 −0.40 and find that the numerical definition was consistent throughout the two dynasties in Korea. Furthermore, we find that the terms were used to describe the closest approach and that there is no observational bias in the angular distances against the apparent magnitudes of the objects. We show that the terms En, In, Oc, and Ec represent decreasing angular distance in that order and this ordering was consistent in both dynasties.

Background: There is a lack of research on sling neurac exercise interventions for craniovertebral angle (CVA), head rotation angle, range of motion (ROM), and neck postural alignment in adults with forward head posture Objectives: To investigate the Immediate effects of sling neurac exercise on craniosacral angulation, ROM, and neck postural alignment in adults with forward head posture. Design: Quaxi-experimental study. Methods: Fifty young adults in their 20s were divided into a sling neurac exercise group (SNEG) and a control group (CG). SNEG conducted sling neurac exercise intervention for one day, and CG did not implement intervention. Craniosacral angulation, ROM, and postural alignment before and after exercise was evaluated for each group. Results: In the sling neurac exercise group (SNEG), CVA, cranial rotation angle (CRA), ROM, and postural alignment improved significantly after intervention (all P<.01). There were no significant differences in the control group (CG) (all P>.05). After the intervention, there were significant differences between the groups in craniosacral angulation, ROM, and postural alignment (all P<.01). Conclusion: The Sling neurac exercise can significantly improve CVA, CRA, ROM, and postural alignment. Therefore, it is suggested to consider sling neurac exercise as an intervention.

This study aimed to prepare kombucha, a fermented tea beverage, containing Dendropanax morbiferus (DM) leaves and roots, and analyze its antioxidant and intracellular activities. We compared the pH change, total acidity, radical scavenging activity, and oxygen radical absorbance capacity (ORAC) of kombucha fermented with black tea alone and that with added DM leaves or roots during fermentation. Using RAW 264.7, we evaluated the effects of kombucha containing different DM parts on nitric oxide (NO) production and inflammation-related cytokine content in cells. Kombucha containing ethanol extracts of DM leaves (BTK-E-DML) and roots (BTK-E-DMR) showed higher radical scavenging activity and ORAC 3 d after fermentation than that prepared from black tea alone (BTK-Ori). In an in vitro experiment using RAW 264.7, samples were treated with 8 mg/mL kombucha considering cytotoxicity; the lipopolysaccharide (LPS)-induced NO content significantly reduced after BTK-E-DML and BTK-EDMR treatments compared with that after BTK-Ori treatment. Additionally, the levels of interleukin-6 and tumor necrosis factor-alpha, which were LPS-stimulated inflammatory cytokines, significantly decreased in cells treated with BTK-E-DML and BTK-E-DMR 15 d after fermentation compared with those treated with BTK-Ori. In conclusion, these results demonstrate that kombucha fermented with the leaves and roots of DM increases antioxidant activity and can significantly regulate inflammatory responses at the cellular level.