This study evaluated the immunogenicity of the Bacillus Calmette-Guérin (BCG) vaccine in a guinea pig model to refine preclinical assessment methods. 24 guinea pigs were divided into four groups for immunohistochemical, histopathological, and molecular analyses, including qRT-PCR and ELISA. The ELISA results revealed significant elevations in interleukin 2 (IL-2), interferon-gamma (IFN- ), and tuberculosis-specific antibodies in vaccinated guinea pigs, particularly γ notable after 6 weeks. Although lung cytokine levels remained unchanged, spleen gene expression showed significant differences in interleukin-17, interleukin-12, interleukin-1β, and C-X-C motif chemokine ligand 10 after 6 weeks. Immunohistochemistry revealed peak IL-2 expression at 8 weeks and significant IFN-γ and TNF-α expression at 6 weeks. This study confirmed the effectiveness of BCG vaccine in guinea pigs, providing crucial insights for future tuberculosis vaccine development and standardizing immune response indicators.

After the permanent shut down of Kori Unit 1, various decommissioning activities will be implemented, including decontamination, segmentation, waste management, and site restoration. During the decommissioning period, waste management is among the most important activities to ensure that the process proceeds smoothly and within the expected timeframe. Furthermore, the radioactive waste generated during the operation should be sent to a disposal facility to complete the decommissioning project. Square and cylindrical concrete re-package drums were generated during the 1980s and 1990s. The square, containing boron concentrates, and cylindrical, containing spent resin, concrete re-package drums have been stored in a radioactive waste storage building. Homogeneous radioactive waste, including boron concentrates, spent resin, and sludge, should be solidified or packaged in high-integrity containers (HICs). This study investigates the sequential segmentation process for the separation of contaminated and non-contaminated regions, the re-packaging process of segmented or crushed cement-solidified boron concentrate, and re-packaging in HICs. The conceptual design evaluates the re-packaging plan for the segmented and crushed cement-solidified waste using HICs, which is acceptable in a disposal facility, and the quantity of generated HICs from the treatment process.

The large rectangular and cylindrical concrete drums are stored in nuclear power plant (NPP) for a long time. At the early stage of NPP operation, the treatment technology of boron concentrates and spent resin was not well developed, when compared to current system. Since the waste acceptance criteria (WAC) of the disposal facility was not established, the boron concentrates and spent resins were packaged in 200 L drum. Some of the 200 L drums, which contain relatively high dose rate radioactive waste, were stored in large concrete drum. The concrete drum offers superior shielding effect and allows reduction of radiation exposure to workers. The WAC requires various characteristics: radiological characteristics, physical characteristics, chemical characteristics, etc. The non-destructive method allows the rapid evaluation and estimation of the concrete structure. Also, it is expected that the large concrete exhibits integrity after the measurements. In this paper, the non-destructive method to understand the large rectangular and cylindrical drum is systematically studied. The advantage and disadvantage of the non-destructive methods were compared in this paper. In addition, the optimized methodology to characterize the radioactive waste containing large rectangular and cylindrical drum will be discussed in this paper.

본 논문에서는 외계 행성에서 주어진 임무를 모두 수행하여 클리어하는 탑 뷰 슈팅 게임을 제안한다. 제안 하는 게임을 진행한 플레이어 45명의 로그 기록과 설문 조사 결과를 분석하여, 몰입감, 플레이 패턴의 다양 성, 접근성을 중심으로 제안하는 게임의 특징을 살펴보고자 한다. 첫째, 제안한 게임은 더 높은 몰입감을 위 해 스토리 애니메이션과 오디오를 제공한다. 실험 결과 시각, 청각적 방면으로 몰입감을 효과적으로 제공하 고 있어 대다수의 플레이어가 스토리 애니메이션을 건너뛰지 않고 끝까지 시청했다. 둘째, 제안하는 게임은 더 다양한 플레이 패턴으로 즐길 수 있다. 실험 결과 수많은 경우의 수가 존재하는 무기와 스킬을 선택할 수 있게 하였기 때문에 대부분의 플레이어가 선택하는 스킬들이 서로 겹치지 않고 다양한 방식으로 게임을 플레이할 수 있다. 플레이 패턴이 다양한 만큼 더 게임을 오랫동안, 더 재미있게 즐길 수 있다. 셋째, 제안한 게임은 맵을 비교적 단순하게 구성하였다. 그런데, 호기심 많은 일부 플레이어들이 미션과 직접 관련이 없는 경로를 찾아서 길을 헤매는 경우가 나타났다. 이로 인해, 플레이어들이 게임을 다시 한번 진행하고자 하는 경향이 나타났다.

시금치의 주요 해충인 흰띠명나방(Spoladea recurvalis) 유충의 살충제 5종에 대한 감수성을 검정하였다. Lufenuron EC, chromafenozide EC, chlorantraniliprole WP, tebufenozide WP, pyridalyl EW는 각각 2(12.5 ppm), 4(12.5 ppm), 8(2.5 ppm), 4(20.0 ppm), 8(12.5 ppm)배 의 희석농도에서 90% 이상의 높은 살충활성을 보였다. 추천농도로 경엽처리 후 7일이 경과된 시금치 잎에 흰띠명나방 유충이 72시간 동안 노출되 었을 경우 chromafenozide EC, chlorantraniliprole WP, tebufenozide WP, pyridalyl EW의 살충률은 각각 98.3%, 100%, 95.0%, 100%로 나타나 높은 잔효성을 보였다. 흰띠명나방에 대한 방제효과를 2개소(화성, 연천)에서 포장검정 결과, 5종의 약제 모두 2개소에서 약제처리 7일 경과 후 90% 이상의 방제효과를 보였으며 2배량에서도 약해가 없어 향후 흰띠명나방 방제약제로 시금치에 활용이 가능할 것으로 판단된다.

Waste containers for packaging, transportation and disposal of NPP (Nuclear Power Plant) decommissioning wastes are being developed. In this study, drop tests were conducted to prove the safety of containers for packaging of the wastes and to verify the reliability of the analysis results by comparing the test and analysis results. The drop height of the waste containers was considered to be 30 mm, which is the maximum lifting speed of a 50 tons crane in the waste treatment facility converted to the drop height. Drop orientation of the containers was considered for bottom-end on drop. The impact acceleration and strain data were obtained to verify the reliability of the analysis results. Before and after the drop tests, measurement of the dose rate and the radiographic testing for concrete wall, and measurement of the wall thickness of steel plate were conducted to evaluate the radiation shielding integrity. Also, measurement of bolt torque, and visual inspection were conducted to evaluate the loss or dispersion of radioactive contents. After the drop tests, the radiation dose rate on the container surface did not increase by more than 20%, and there was no crack in the concrete. In addition, the thickness of the steel plate did not change within the measurement error. Therefore, the radiation shielding integrity of the container was maintained. After the drop tests, the lid bolts were not damaged and there was no loss of pretension in the lid bolts. In addition, there was no loss or dispersion of the contents as a result of visual inspection. In order to prove the reliability of the drop analysis results, safety verifications were performed using the drop test results, and the appropriate conservatism for the analysis results and the validity of the analysis model were confirmed. Therefore, the structural integrity of the waste containers was maintained under the drop test conditions.

This study deals with replacement analysis of deteriorated equipment for improving productivity of production system. Frequent breakdown of the deteriorated equipment causes a situation that reduces productivity such as low product quality, process delay, and repair cost. However, the replacement of new equipment will be required a high initial investment cost, so it is important to analysis the economic feasibility. Therefore, we analyze the effect of the production system due to the aging effect of the equipment and the feasibility of equipment replacement based on the economic analysis. The process flow, working time, logistics movement, etc. are analyzed in order to build the simulation modeling for a ship and land switchboard production system. Using numerical examples, the economic feasibility analysis of equipment replacement through replacement of existing deteriorated equipment and additional arrangement of new facilities is performed.

In this study, the near-complete genome sequence of the novel reassortant H1N2 influenza A virus strain A/swine/Korea/KS60/2016 is reported. Sequences of the hemagglutinin (HA), neuraminidase (NA), and polymerase basic 2 (PB2) genes were analyzed, revealing that the isolates contain segments from previous Korean swine H1N2 strains. Additionally, the remaining genes of this strain originated from human H1N1 strains in 2009.