This study evaluated the immunogenicity of the Bacillus Calmette-Guérin (BCG) vaccine in a guinea pig model to refine preclinical assessment methods. 24 guinea pigs were divided into four groups for immunohistochemical, histopathological, and molecular analyses, including qRT-PCR and ELISA. The ELISA results revealed significant elevations in interleukin 2 (IL-2), interferon-gamma (IFN- ), and tuberculosis-specific antibodies in vaccinated guinea pigs, particularly γ notable after 6 weeks. Although lung cytokine levels remained unchanged, spleen gene expression showed significant differences in interleukin-17, interleukin-12, interleukin-1β, and C-X-C motif chemokine ligand 10 after 6 weeks. Immunohistochemistry revealed peak IL-2 expression at 8 weeks and significant IFN-γ and TNF-α expression at 6 weeks. This study confirmed the effectiveness of BCG vaccine in guinea pigs, providing crucial insights for future tuberculosis vaccine development and standardizing immune response indicators.

After the permanent shut down of Kori Unit 1, various decommissioning activities will be implemented, including decontamination, segmentation, waste management, and site restoration. During the decommissioning period, waste management is among the most important activities to ensure that the process proceeds smoothly and within the expected timeframe. Furthermore, the radioactive waste generated during the operation should be sent to a disposal facility to complete the decommissioning project. Square and cylindrical concrete re-package drums were generated during the 1980s and 1990s. The square, containing boron concentrates, and cylindrical, containing spent resin, concrete re-package drums have been stored in a radioactive waste storage building. Homogeneous radioactive waste, including boron concentrates, spent resin, and sludge, should be solidified or packaged in high-integrity containers (HICs). This study investigates the sequential segmentation process for the separation of contaminated and non-contaminated regions, the re-packaging process of segmented or crushed cement-solidified boron concentrate, and re-packaging in HICs. The conceptual design evaluates the re-packaging plan for the segmented and crushed cement-solidified waste using HICs, which is acceptable in a disposal facility, and the quantity of generated HICs from the treatment process.

Valgus Kolbe, 1909 is a small genus of Cetoniinae, with 20 described species worldwide. In Korea, only one species, Valgus koreanus Sawada, have been recorded. Species of this genus have been known that they are commonly associated with termite colonies. They feed on the wall of termite burrows in logs or standing dead trees. In this study, we report a new species of this genus, Valgus gwangneungensis sp. nov.. We provide a key to the species of Valgus, description of the new species and photographs of habitus and male aedeagus.

Subgenus Bothynoptera Schaum, 1863 of the genus Parena is mainly found in Oriental region. Despite this widespread distribution, species of the subgenus Bothynoptera are poorly known in Korea. While a total of 14 species have been recorded worldwide, only 3 species have been recorded in Korea. In this study, as a revisional work of Korean known species, a pictorial key and photographs of habitus and male genitalia for each species are provided, with a newly recorded species in Korea.

Currently, 12 subspecies of Coptolabrus smaragdinus have been recorded in Korea, of which 7 subspecies are listed in South Korea. C. smaragdinus has limited movement due to degenerated hindwings, resulting in high intraspecific diversity due to geographic isolation. Previous studies have been mainly classified based on external characters or genitalia structure, but the differences between subspecies are very ambiguous. In this study, we aimed to more clearly distinguish at the subspecific classification level, by examining the male aedeagal and inflated endophallus. Additionally, we provide photos of adult, endophallus and the process of endophallus inflation.

The genus Bembidion is a prominent terrestrial group found in various regions around the world, encompassing a large number of species. Species of this genus have a reduced apical palpomere, as do all members of the tribe Bembidiini. This study reviews four species belonging to the subgenus Plataphus, which is included within the genus Bembidion. Descriptions and photos of adults are provided.

The continuous use of pesticides with the same mode of action has lead to the development of insecticide resistance in the target pests. Establishing pesticide resistance management methods and effective control strategies for these pests has become an important target. Bemisia tabaci, a representative pest of greenhouse, directly affects the growth of crops at all stages of its development except eggs. It also causes indirect damage by secreting honeydew that eventually promotes sooty mold in leaves and fruits. In this study, eight insecticides with different mechanisms of action (Flonicamid, Fluxametamide, Spinetoram, Cyantraniliprole, Dinotefuran, Pyridaben, Milbemectin and Pyriproxyfen), and registered for use against cucumber B. tabaci were selected and tested for insecticide resistance. The tested populations of B. tabaci were collected from greenhouse cucumber cultivations in 12 domestic regions. The results were presented as RR (Resistance ratios), and CEI (Control efficacy index) values.

본 논문에서는 빙하가 녹아 갈라져서 떠내려 온 새끼 펭귄이 다시 펭귄 무리로 되돌아가기 위 해서 길을 찾아 나서는 퍼즐 어드벤처 게임을 제안한다. 플레이어 40명의 로그 기록과 설문지 를 분석한 결과를 바탕으로 제안하는 게임의 특징을 살펴보고자 한다. 첫째, 제안하는 게임은 새끼 펭귄이 얼음 덩어리를 밀어서 길을 만들어 이동하는 직관적인 규칙을 제공한다. 로그 기 록에서 플레이 평균 시간은 19분이며, 이를 19개의 리스폰 지점으로 나누면, 구간별 플레이 평균시간은 1분이다. 설문에서 게임 목표 명확성은 4.45점, 게임 난이도는 4.16점을 받았다. 둘째, 제안하는 게임은 가마우지가 새끼 펭귄에게 도움말을 제시하는 등 유용한 정보를 친절 하게 제공한다. 전체 플레이 평균 시간은 baseline이 24분이고, kinder UI가 19분이다. kinder UI에서 새끼 펭귄이 얼음 덩어리를 덜 밀고, 게임 재시작을 덜 하고, 더 빨리 상호작 용하여, 문제를 빨리 해결한다. 설문에서 게임 스토리 이해는 4.15점, 유용한 정보는 4.45점을 받았다. 셋째, 제안하는 게임은 남극과 유사한 환경을 제공하여 몰입도를 상승시킨다. baseline에 비해서 kinder UI에서 다양한 게임 오브젝트와 더 적극적으로 상호작용을 시도하 고, 미션 완료 후 더 오랫동안 오로라를 지켜봤다. 설문에서 게임 캐릭터 선호도는 4.56점, 게 임 환경 만족도는 4.22점을 받았다.

본 논문에서는 몬스터에게 붙잡히지 않고 키를 찾아서 연구소를 탈출하는 공포 방탈출 게임을 제안한다. 제 안하는 게임을 진행한30명의 게임 플레이 로그 데이터 분석 결과와 설문조사 결과를 바탕으로, 제안하는 게 임의 특징을 분석한 결과는 다음과 같다. 첫째, 제안하는 게임은 다양한 아이템, 액션, 탈출 경로를 제공한다. 제안하는 게임이 숨을 곳도 많고 다양한 상호작용을 제공한다고 설문에서4점 이상 주었다. 또한, map의 footprint를 분석한 결과, 플레이어는 다양한 경로를 통해 키를 찾아서 탈출하였다. 둘째, 제안하는 게임은 외 관으로 기능을 추론할 수 있는 직관적인 오브젝트를 제공한다. 따라서, 플레이어는 시각적 공간 및 게임 아 이템 용도를 쉽게 파악하여 조작할 수 있다. 설문조사 결과에서, 플레이어는 조작감 관련 항목의 점수를4점 이상을 주었다. 셋째, 제안하는 게임에서 플레이어는 아이템이 충분할 때보다는 부족할 때 더 몰입을 잘 한 다. 게임 플레이 로그 데이터 분석 결과와 설문조사 결과에 따르면, 플레이어는 아이템이 부족할 때 더 크게 공포를 느끼고 상황에 몰입하여, 더 적극적으로 행동하게 되고 더 민감하게 반응한다.