Background: Pulmonary fibrosis (PF) is a progressive lung disease marked by excessive fibrosis and declining respiratory function. While pharmacological treatments help manage symptoms, they offer limited reversal of fibrosis and often have side effects. As a result, interest in rehabilitation approaches such as breathing exercises combined with self-myofascial release (SMR) has increased. These techniques may enhance trunk stability and thoracic flexibility, contributing to improved respiratory function. Objectives: This study investigated the effects of thoracic expansion exercises using SMR techniques on pulmonary function and chest mobility in a patient with PF, and assessed their clinical applicability. Design: Single-subject A-B-A′ design. Methods: A 60s male with idiopathic PF underwent 20 days of intervention. Standard rehabilitation was applied during baseline (A) and follow-up (A′) phases. During the intervention (B), SMR-based breathing exercises were added. Outcomes included Functional Reach Test (FRT), chest expansion, and pulmonary function tests (FVC, FEV₁, PEF, FEV₁/FVC). Data were analyzed using the 2SD band method. Results: FRT improved from 23.4 cm (A) to 31.3 cm (B) and 34.2 cm (A′). Chest expansion increased from 1.7 cm to 2.8 cm, and FVC rose from 1.70 L to 2.08 L before dropping to 0.94 L. FEV₁/FVC improved from 80.8% to 86.7% during intervention but decreased at follow-up. Conclusion: SMR-based thoracic expansion exercises may enhance trunk stability, thoracic mobility, and certain pulmonary function indicators in PF patients. These findings suggest potential clinical benefits, warranting further studies to confirm long-term effectiveness.
남방큰무당벌레(신칭)를 한국 미기록종으로 보고한다. 본 종은 국내 Harmornia속의 3종과는 둥글고 볼록한 체형, 앞가슴등판의 갈라진 점 모양, 각 딱지날개에 7개의 검은점이 1-3-2-1 배열로 나타나는 특징으로 쉽게 구별할 수 있다. 본 연구에서는 Harmonia속의 종 검색표, 진단형질과 DNA바코드 정보를 제공하고자 한다.
Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, leading to a deficiency in α-Galactosidase A activity and subsequent accumulation of globotriaosylceramide (Gb3). This accumulation contributes to progressive multiorgan dysfunction, with cardiovascular complications, particularly endothelial dysfunction and left ventricular hypertrophy being major drivers of disease morbidity and mortality. Although enzyme replacement therapy is currently the standard treatment, its effectiveness is limited in addressing advanced cardiovascular pathology. To better understand Fabry-associated vascular and cardiac phenotypes, an isogenic human induced pluripotent stem cell (hiPSC) model in which GLA was knocked out was developed using CRISPR/ Cas9. GLA-knockout (GLA-KO) hiPSCs were differentiated into endothelial cells (ECs) and cardiomyocytes (CMs) to evaluate disease-relevant phenotypes in vitro . GLA-KO ECs exhibited normal morphology and differentiation capacity but showed markedly impaired tube formation, high expression of inflammatory genes ICAM1, VCAM1, and SELE, and increased mitochondrial and cytoplasmic reactive oxygen species levels. GLA-KO CMs demonstrated enlarged cell size and nuclear translocation of NFATC4, consistent with hypertrophic remodeling. Together, these findings recapitulate key features of Fabry vasculopathy and cardiomyopathy in a genetically defined, human-derived system. This platform enables direct investigation of Gb3-induced oxidative and inflammatory mechanisms and provides a valuable model for the preclinical evaluation of therapeutic strategies targeting the cardiovascular manifestations of Fabry disease.
본 연구는 청소년의 친구관계가 공격성을 매개로 하여 현실 비행에 영향을 미치는지를 검증하였다. 이를 위해 2018년도 한국아동·청소년패널조사에 참여한 중학생 2,590명의 자료를 분석하였다. 분석방법으로는 기술통계, 상관분석 및 매개효과분석을 활용하였다. 연구 결과, 기술통계 분석에서 청소년의 친구관계 평균 이 공격성이나 비행의 평균보다 높은 것으로 나타났다. 상관분석 결과, 친구관계, 공격성, 비행 간에는 모두 유의한 정적(+) 상관관계가 있는 것으로 확인되었다. 매개효과분석을 통해 친구관계가 비행에 직접적인 영 향을 미치는 동시에, 공격성이 그 관계를 부분 매개하는 것으로 확인되었다. 이러한 결과를 바탕으로, 본 연구는 청소년의 친구관계를 긍정적으로 형성·유지하면서 공격성과 같은 부정적 정서를 완화할 수 있는 사회복지 실천 프로그램 및 정책 개발의 필요성을 제언하였다.
대한민국 정부들은 복지국가를 시대적 과제로 천명하고 있음에도, 낮은 복지 지출과 높은 사회적 불안이 라는 현실에 직면해 있다. 본 논문은 이러한 상황을 타개하기 위한 전략으로 복지국가 ‘체제’의 기획을 제안 하며, 그에 필요한 관점과 방향성을 얻기 위해 복지국가이론의 계보를 탐색한다. 먼저, ‘전후 복지국가’의 팽창을 설명하는 이론들을 고찰하고, 복지체제론을 통해 그 성숙과 위기 대응 양상도 살펴본다. 다음으로, 새로운 사회경제적 환경에 조응하여 진행되는 복지국가의 재구조화, 즉 ‘탈(脫) 전후 복지국가’의 등장을 설명하는 현대 이론들을 종합적으로 검토한다. 이렇듯 복지국가이론의 계보를 살피는 것은 현행 제도의 구 조와 작동원리를 이해하고 미래 기획을 위한 아이디어를 얻는 과정이자, 대한민국이 사회권적 기본권이 적 극 구현되는 나라로 나아가는 데에 필요한 지적 토대를 쌓는 일이라고 본 논문은 주장한다.
본 연구는 기업공개(IPO) 과정에서 최고경영자(CEO)의 해외 경험이 IPO의 성공에 미치는 영 향을 탐구하고, CEO가 경험한 국가와 주관사 국적 간 문화적 거리가 이 관계에 미치는 조절효과 를 분석한다. 또한 IPO 기업과 외부 투자자 간의 정보 비대칭성 정도가 CEO 해외 경험의 신호 효 과에 미치는 영향을 살펴본다. 2014년부터 2019년 사이 코스피와 코스닥 시장에 상장한 368개 기업을 대상으로 실증 분석을 진행한 결과, CEO의 해외 경험은 IPO 성공에 긍정적 영향을 미쳤다. 하지만 이러한 긍정적 영향은 CEO가 경험한 국가와 주관사의 국적 간 문화적 거리가 클수록 약화 되었다. 반면 IPO 기업과 외부 투자자 간 정보 비대칭성이 높을수록 CEO의 해외 경험이 IPO 성 공에 미치는 긍정적 효과는 더욱 강화되었다. 본 연구는 도구변수를 사용하여 내생성 문제를 통제 하였으며, 도구변수 사용 시에도 주요 가설은 대체로 지지되었다. 본 연구는 CEO의 해외 경험이 IPO 과정에서 중요한 신호(signal)로 작용할 수 있음을 제시하며, 특히 문화적 거리와 정보 비대 칭성이라는 맥락적 요인이 CEO 특성의 신호 효과를 조절할 수 있음을 밝힘으로써, 기업공개 및 신호 이론 연구에 기여한다. 실무적으로는 IPO를 준비하는 기업들이 해외 경험이 있는 CEO를 선 임하면 도움이 될 수 있음을 시사하고, 주관사를 선택할 때는 문화적으로 유사한 국가의 주관사를 전략적으로 고려할 필요가 있음을 시사한다.
As digital transformation accelerates, platform business has become a core business model in modern society. Platform business has a network effect where the winner takes all. For this reason, it is crucial for a company's pricing policy to attract as many customers as possible in the early stages of business. Telecommunication service companies are experiencing stagnant growth due to the saturation of the smartphone market and intensifying competition in rates, but the burden of maintaining communication networks is increasing due to the rapid increase in traffic caused by domestic and foreign CSPs. This study aims to understand the dynamic characteristics of the telecommunications market by focusing on pricing policy. To this end, we analyzed how ISPs, CSPs, and consumers react to changes in pricing policy based on the prisoner's dilemma theory. The analysis of the dynamic characteristics of the market was conducted through simulation using the Agent-Based Model.
As social media becomes increasingly integrated into daily life, it has reshaped how people communicate and consume advertising. Instagram, a visually-oriented platform, uses advanced targeting and shopping features to deliver personalized advertising, particularly in the fashion retail sector. Grounded in the cognitive-affective-behavioral model and human information processing theory, this study investigates how Instagram’s personalized fashion advertising influences consumer perception and behavior, focusing on recommendation system quality (accuracy, novelty, diversity) and content quality (vividness, diagnosticity). A survey of 403 Korean adults aged 20–69 was conducted to assess causal relationships among these variables. The findings reveal that accuracy and diversity in recommendation systems, along with diagnosticity of content quality, positively influence user satisfaction, which, in turn, influences their click-through and purchase intentions. However, novelty and vividness exhibited no significant effects. Academically, the study contributes to a deeper understanding of the mechanisms underlying personalized advertising on visuallyoriented platforms like Instagram. Practically, it underscores the importance of creating high-quality, personalized content that aligns with user preferences and provides clear product information. Brands can enhance user engagement by designing visually appealing advertisements and optimizing linked web pages to foster emotional bonds with consumers. These strategies can cultivate long-term customer relationships and enhance brand loyalty while maximizing advertising effectiveness on Instagram.
Background: Balance disorder is a prevalent clinical manifestation following stroke, often causing considerable discomfort and gait disability. Various water-based therapeutic approaches have been developed to address balance and gait disorder. Objects: The purpose of this study was to investigate the effects of water-based gait training using auditory stimulation on balance and gait abilities in stroke patients. Methods: All subjects were randomly divided into three groups: water-based gait training using auditory stimulation group (WAG) (n = 24), water-based gait training group (WG) (n = 24), and control group (n = 22). Subjects in WAG and WG underwent water-based gait training for 30 minutes, 3 times a week for 6 weeks. All Subjects were assessed for muscle strength, balance, gait, motor function, and activity of daily living pre- and post-intervention. Results: Results showed that all outcome measures significantly improved post-intervention (p < 0.05). Additionally, WAG was found to significantly improve in Medical Research Council (MRC), Berg Balance Scale (BBS), and Timed Up and Go (TUG) test compared to WG, and WG showed significant differences compared to the control group in MRC and Fugl-Meyer Assessment (FMA) (p < 0.05). WAG exhibited significant differences in all areas except Modified Bathel Index (MBI) in the between-group comparison with the control group (p < 0.05). Conclusion: These results suggest that water-based gait training using auditory stimulation may be effective strategy to improve muscle strength, balance and gait ability for with stroke.