Background: Stroke patients commonly suffer from balance impairments that limit functional activities, such as walking difficulties. Robot-assisted gait training is gaining attention as an effective rehabilitation strategy for balance and gait in stroke rehabilitation. Objects: The purpose of this study was to investigate the effects of progressive velocity robot-assisted gait training (PRG) on balance and gait abilities in stroke patients. Methods: All subjects were randomly divided into three groups: PRG (n = 12); comfortable speed robot-assisted gait training (CRG) (n = 12); and control group (n = 16). Subjects in PRG and CRG underwent robot-assisted gait training for 30 minutes, three times a week for six weeks. And the control group performed overground gait training using a treadmill at the same frequency and for the same amount of time as the experimental group. All Subjects were assessed for muscle strength, balance, gait and motor function pre- and post-intervention. Results: The study results showed that all subjects showed significant differences in all measurements post-intervention (p < 0.05). Additionally, PRG was found to significantly improve in Medical Research Council (MRC) and Fugl-Meyer Assessment (FMA) compared to CRG, and CRG showed significant differences compared to the control group in MRC, Berg Balance Scale (BBS) and Timed Up and Go test (TUG) (p < 0.05). PRG exhibited significant differences in all areas in the between-group comparison with the control group (p < 0.05). Conclusion: These results suggest that PRG may be effective strategy to improve balance and gait ability for with stroke.

Background: Pulmonary fibrosis (PF) is a progressive lung disease marked by excessive fibrosis and declining respiratory function. While pharmacological treatments help manage symptoms, they offer limited reversal of fibrosis and often have side effects. As a result, interest in rehabilitation approaches such as breathing exercises combined with self-myofascial release (SMR) has increased. These techniques may enhance trunk stability and thoracic flexibility, contributing to improved respiratory function. Objectives: This study investigated the effects of thoracic expansion exercises using SMR techniques on pulmonary function and chest mobility in a patient with PF, and assessed their clinical applicability. Design: Single-subject A-B-A′ design. Methods: A 60s male with idiopathic PF underwent 20 days of intervention. Standard rehabilitation was applied during baseline (A) and follow-up (A′) phases. During the intervention (B), SMR-based breathing exercises were added. Outcomes included Functional Reach Test (FRT), chest expansion, and pulmonary function tests (FVC, FEV₁, PEF, FEV₁/FVC). Data were analyzed using the 2SD band method. Results: FRT improved from 23.4 cm (A) to 31.3 cm (B) and 34.2 cm (A′). Chest expansion increased from 1.7 cm to 2.8 cm, and FVC rose from 1.70 L to 2.08 L before dropping to 0.94 L. FEV₁/FVC improved from 80.8% to 86.7% during intervention but decreased at follow-up. Conclusion: SMR-based thoracic expansion exercises may enhance trunk stability, thoracic mobility, and certain pulmonary function indicators in PF patients. These findings suggest potential clinical benefits, warranting further studies to confirm long-term effectiveness.

본 연구는 DNVGL-CG-0127 및 통합공통구조규칙(H-CSR)이 적용된 유한요소해석(FEA)을 통해 검증된, 기존 드라이도킹의 지 속 가능한 대안으로서 안벽 부유식 구조 보수의 타당성을 연구하였다. 정수압 하중을 받는 75K 제품 운반선의 전역 및 국소 거동을 시뮬레이션하여, 보수가 필요한 무시할 수 있는 변위 변화(<1%, 12.3mm~12.4mm)와 von-Mises 응력(26.4MPa, 허용 한계값 188MPa의 14%) 에서, 구조적 무결성을 확인했다. 최적화된 보수 설계는 고강도 해양 등급 강재(예: AH36)와 하위 모델링 기법을 활용하여 Saint-Venant 의 원리와 선형 탄성 가정을 준수하면서 기하학적 불연속점의 응력 집중을 해결하였다. 선급 지침을 준수하면 유체역학적 안정성과 하 중 경로 충실도가 보장되어 선박 운항 중단을 최소화할 수 있습니다. 본 연구 결과는 비용 효율적이고 시간 효율적인 유지보수로의 패 러다임 전환을 보여주며, 기존 방식 대비 가동 중단 시간을 최대 30% 단축합니다. 향후 추진 방향에는 동적 하중 하의 피로 분석, AI 기반 최적화, 그리고 실시간 구조 건전성 모니터링을 위한 디지털 트윈 통합이 포함되며, 이는 해양 탈탄소화 및 운영 민첩성 목표 달 성에 부합한다. 본 연구는 노후화된 선박의 성능 개선을 위한 확장 가능한 프레임워크를 제공하며, 계산 정밀도와 지속가능성에 대한 업계의 요구를 충족한다.

남방큰무당벌레(신칭)를 한국 미기록종으로 보고한다. 본 종은 국내 Harmornia속의 3종과는 둥글고 볼록한 체형, 앞가슴등판의 갈라진 점 모양, 각 딱지날개에 7개의 검은점이 1-3-2-1 배열로 나타나는 특징으로 쉽게 구별할 수 있다. 본 연구에서는 Harmonia속의 종 검색표, 진단형질과 DNA바코드 정보를 제공하고자 한다.

This case report describes a 40-year-old captive male hippopotamus exhibiting systemic clinical signs, including anorexia and coughing, prior to death. Despite comprehensive medical treatments, the animal died due to age-related immunodepression, which led to severe pneumonia. Necropsy and subsequent histopathological examination revealed severe acute diffuse seropurulent bronchopneumonia, right ventricular hypertrophy, hepatic congestion, and glomerulonephritis. These findings highlight the vulnerability of geriatric large animals to systemic infections and emphasize the need for improved pathological understanding and the development of evidence-based treatment protocols for these less-studied species like the hippopotamus. To enhance disease management and veterinary care for aging zoo animals, future research should prioritize gut microbiome analysis and antimicrobial resistance profiling.

Emerging RNA viruses continue to pose serious threats to animal and human health, necessitating the development of broad-spectrum antiviral agents within a One Health framework. In this study, we evaluated the antiviral potential of Desmodesmus multivariabilis extracts against three representative RNA viruses: influenza A virus (IAV), porcine epidemic diarrhea virus (PEDV), and hepatitis A virus (HAV). Extracts derived from four closely related microalgal isolates were tested using pre- and post-treatment protocols in vitro. Among them, strain ME749 demonstrated the most potent and consistent antiviral activity, with low cytotoxicity and high selectivity index (SI), particularly against IAV (SI = 23.8), followed by PEDV (SI = 10.7) and HAV (SI = 6.2). ME752 also showed moderate antiviral efficacy. RT-qPCR confirmed significant reductions in viral RNA levels for all three viruses, with ME749 achieving up to 3-log₁₀ reduction in IAV and 2.4-log₁₀ reduction in HAV. These results suggest that the antiviral effect may be mediated through mechanisms beyond direct virucidal activity, potentially involving host immune modulation. Although the active compounds remain unidentified, carotenoids are hypothesized as key bioactive components. This study highlights Desmodesmus multivariabilis, particularly ME749, as a promising source of novel, natural antiviral agents with applications in both veterinary and zoonotic disease control. Future studies including metabolomic profiling, mechanism-of-action analyses, and in vivo validation are warranted to further explore its potential in combating current and emerging RNA virus threats.

Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, leading to a deficiency in α-Galactosidase A activity and subsequent accumulation of globotriaosylceramide (Gb3). This accumulation contributes to progressive multiorgan dysfunction, with cardiovascular complications, particularly endothelial dysfunction and left ventricular hypertrophy being major drivers of disease morbidity and mortality. Although enzyme replacement therapy is currently the standard treatment, its effectiveness is limited in addressing advanced cardiovascular pathology. To better understand Fabry-associated vascular and cardiac phenotypes, an isogenic human induced pluripotent stem cell (hiPSC) model in which GLA was knocked out was developed using CRISPR/ Cas9. GLA-knockout (GLA-KO) hiPSCs were differentiated into endothelial cells (ECs) and cardiomyocytes (CMs) to evaluate disease-relevant phenotypes in vitro . GLA-KO ECs exhibited normal morphology and differentiation capacity but showed markedly impaired tube formation, high expression of inflammatory genes ICAM1, VCAM1, and SELE, and increased mitochondrial and cytoplasmic reactive oxygen species levels. GLA-KO CMs demonstrated enlarged cell size and nuclear translocation of NFATC4, consistent with hypertrophic remodeling. Together, these findings recapitulate key features of Fabry vasculopathy and cardiomyopathy in a genetically defined, human-derived system. This platform enables direct investigation of Gb3-induced oxidative and inflammatory mechanisms and provides a valuable model for the preclinical evaluation of therapeutic strategies targeting the cardiovascular manifestations of Fabry disease.

Media art has evolved significantly by integrating diverse technological advancements and expanding its conceptual boundaries. However, there remains a lack of standardized terminology to describe media art practices that explicitly incorporate regional contexts, social dynamics, and local cultural resources. This study aims to resolve this terminological ambiguity by proposing a comprehensive framework for defining and categorizing region-based media art practices. Drawing upon extensive literature review and analysis of both domestic and international case studies, this research identifies and defines key terms such as "region-based media art," "site-specific media art," "cultural archetype-based media art," "socially engaged media art," and "public media art." Each term is systematically outlined with distinct conceptual boundaries and characteristics, while acknowledging the interrelations and potential overlaps among them. This framework seeks to provide a clearer understanding and language for diverse media art practices grounded in place, community, and cultural specificity.

본 연구는 청소년의 친구관계가 공격성을 매개로 하여 현실 비행에 영향을 미치는지를 검증하였다. 이를 위해 2018년도 한국아동·청소년패널조사에 참여한 중학생 2,590명의 자료를 분석하였다. 분석방법으로는 기술통계, 상관분석 및 매개효과분석을 활용하였다. 연구 결과, 기술통계 분석에서 청소년의 친구관계 평균 이 공격성이나 비행의 평균보다 높은 것으로 나타났다. 상관분석 결과, 친구관계, 공격성, 비행 간에는 모두 유의한 정적(+) 상관관계가 있는 것으로 확인되었다. 매개효과분석을 통해 친구관계가 비행에 직접적인 영 향을 미치는 동시에, 공격성이 그 관계를 부분 매개하는 것으로 확인되었다. 이러한 결과를 바탕으로, 본 연구는 청소년의 친구관계를 긍정적으로 형성·유지하면서 공격성과 같은 부정적 정서를 완화할 수 있는 사회복지 실천 프로그램 및 정책 개발의 필요성을 제언하였다.

This study analyzes the terminological system and hierarchical structure of media art field, centering on the concept of 'Playable Art'. It explores how various media art terms that emerged with the development of digital technology are hierarchized and form interrelationships, particularly examining the position of interactivity and playability in contemporary art discourse. The research findings reveal that media art terminology forms a complex hierarchical structure based on technological media, interaction methods, and artistic intentions, with Playable Art functioning as a core concept that redefines the boundaries between games and art within this structure.

This study structurally analyzes the algorithmic filtering process by which generative AI images are either selected or discarded before reaching users, and models this process through a visual similarity–based simulation. Images generated by Stable Diffusion are placed on a two-dimensional grid, and a modified version of Conway’s Game of Life algorithm is applied to update the state of each cell. The survival of each cell is determined based on a hybrid visual similarity metric combining CLIP and LPIPS. To prevent the rigidity of the simulation and sustain emergent dynamics, random image injections are periodically introduced. The simulation results reveal that visually similar images repeatedly form clusters, and a visual order gradually converges toward a structurally stabilized state. This suggests that specific visual orders can emerge solely from algorithmic selection criteria, independent of human interpretation. By shifting focus from semantic or symbolic analysis to the experimental conditions for the existence and persistence of images, this study proposes a new analytical perspective for understanding digital image environments.

대한민국 정부들은 복지국가를 시대적 과제로 천명하고 있음에도, 낮은 복지 지출과 높은 사회적 불안이 라는 현실에 직면해 있다. 본 논문은 이러한 상황을 타개하기 위한 전략으로 복지국가 ‘체제’의 기획을 제안 하며, 그에 필요한 관점과 방향성을 얻기 위해 복지국가이론의 계보를 탐색한다. 먼저, ‘전후 복지국가’의 팽창을 설명하는 이론들을 고찰하고, 복지체제론을 통해 그 성숙과 위기 대응 양상도 살펴본다. 다음으로, 새로운 사회경제적 환경에 조응하여 진행되는 복지국가의 재구조화, 즉 ‘탈(脫) 전후 복지국가’의 등장을 설명하는 현대 이론들을 종합적으로 검토한다. 이렇듯 복지국가이론의 계보를 살피는 것은 현행 제도의 구 조와 작동원리를 이해하고 미래 기획을 위한 아이디어를 얻는 과정이자, 대한민국이 사회권적 기본권이 적 극 구현되는 나라로 나아가는 데에 필요한 지적 토대를 쌓는 일이라고 본 논문은 주장한다.