New therapeutic measure are needed to improve the outcome for patients with oral squamous cell carcinoma(OSCC) because OSCC continues to portend a relatively unfavorable prognosis. Recently RNA interference(RNAi) has emerged as an effective method to target specific genes for silencing. Although overexpression of urokinase-type plasminogen activator receptor(uPAR) has been implicated in progression and metastasis of OSCC, the transfection effect of RNAi- uPAR on OSCC has been rarely reported. The purpose of this study were to examine the efficient and specific inhibition of uPAR mRNA and protein expression by siRNA targeting of uPAR through RT-PCR and immunoslot blotting, and to study cell proliferation activity, adhesion, invasion and migration in vitro compared to the controls. In MTT assay, siRNA-uPAR transfected cells showed about 70-80% cell proliferation compared to OSCC cell lines after 2 days. In adhesion assay, siRNA-uPAR transfected cells showed about 20-30% adhesion activity compared to OSCC cell lines, but similar features to those of BSA coated wells. In migration assay, siRNA-uPAR transfected cells showed about 60% migration activity compared to OSCC cell lines, but higher 3.5 folds to those of BSA coated wells. In invasion assay, siRNA-uPAR transfected cells showed about 55% invasive activity compared to parental cell lines. mRNA expression of siRNA-uPAR transfected cells showed about 10-15 % compared to parental cell lines by RT-PCR. Protein expression of siRNA-uPAR transfected cells showed about 25% compared to parental cell lines by ELISA assay. It suggested that RNAi-uPAR tranfection might be used as a potent and specific therapeutic tool for the treatment of oral squamous cell carcinoma, especially in inhibiting invasion and metastasis.

Today, there are a multitude of papers being written on films that deal with multicultural society. However, it is difficult to find research on German films that deal with multicultural societies from the educational perspective of cultural exchange. This paper chooses the following four German films and aims to examine them from that perspective – Doris Dörrie’s Kirschblüten, Fatih Akın’s Solino and Gegen die Wand, and Percy Adlon’s Bagdad Café. Kirschblüten is about longings for and communication with other cultures, Solino about cultural differences and ways to overcome them, Gegen die Wand about cultural conflicts and identities, and Bagdad Café about cultural connection and communication. What is of particular importance in handling these movies in the classroom will be to raise and discuss relevant pedagogical questions to encourage the students to contemplate the various aspects of cultural encounters as their own issue. Thus, the ultimate goal of the education should be the learning of the values of coexistence, harmony, and exchange that are required of any multicultural society.

PURPOSES: This paper evaluates, using LS/DYNA-3D software, the vehicle impact performance of flexible barriers made of steel WBeam supported by four different types of post configurations. These types include circular post, H-shape post, C-shape post, and square post. METHODS : The post-soil interaction has been investigated according to different impact angles. For this purpose, energy absorption, maximum displacements of post and rail, and occupant risk index of THIV have been compared each other. The three dimensional soil material model, instead of the conventional spring model based on Winkler and p-y curve, has been used to increase the correctness of computational model. RESULTS: It is noted the crash energy absorption has been increased with respect to the increase of impact angle. CONCLUSIONS : In particular, a post with open section(H-shape, C-shape) shows the greater crash energy absorption capability as compared with a post with closed section under the same level of impact conditions.

The purpose of this study was to identify the effects of two types of stretching extensor carpi radialis on the visual analog scale (VAS), pressure-pain thresholds (PPTs), grip strength (GS), and strength of wrist extensor (SWE) in patients with lateral epicondylalgia. Sixteen patients with lateral epicondylalgia were recruited for this study and randomly assigned to two groups; the conventional stretching group (CS) and the stretching of proximal functional massage group (PFM); the VAS, PPTs, GS, and SWE were measured before and after the intervention. Over a period of stretching exercises were performed for five minutes per day, five days per week. The paired t-test and Wilcoxon signed-rank test were used to determine the statistical differences in the VAS, PPTs, GS, and SWE (pre- and post-test). The Independent t-test and Mann-Whitney U test were used to compare the effects of stretching exercises between the CS and PFM groups. The results of this study demonstrated that in the PFM group, the PPTs, GS, and SWE significantly increased, and the VAS decreased (p<.05). In the CS group, the VAS and GS increased significantly after the three-week intervention (p<.05). Pain was decreased and strength (GS and SWE) was increased in the PFM group, compared to the CS group (p<.05). The findings of this study indicate that PFM technique can be applied for decreasing pain and increasing the GS and SWE in patients with lateral epicondylalgia.

국내 지침에 의하면 성능기준에 적합한 노측용 방호울타리만이 도로 현장에 설치될 수 있다. 그러나 공용중인 고속도로 노측의 상당 구간에는 지침 개정 이전에 설치된 성능이 미흡한 기존 구형 가드레일이 설치되어 있어서 고속도로 운전자의 안전을 위협하고 있다. 구형 가드레일은 전국의 고속도로에 약 2,777km가 설치되어 있으며 일률적으로 동시에 모든 구간의 가드레일을 교체하기란 예산상 어려움이 많아 최소한의 보강을 통해 국내 지침에 만족스럽게 보강개선된 가드레일을 개발하는 것이 본 연구의 목적이다. 본 연구에서는 LS-DYNA 3D를 이용한 충돌시뮬레이션과 실물차량 충돌시험을 통해 철재 노측용 가드레일 보강방안(SB1, 3, 5등급)을 개발하였고 개발된 가드레일 보강개선방안은 차량의 충돌 및 이탈사고의 심각성을 감소시켜 도로의 안전도를 개선, 향상시킬뿐만 아니라 많은 예산절감을 기대할 수 있다.

Fuel test loop is an irradiation test facility which can conduct the irradiation tests of nuclear fuels and materials at HANARO. The FTL simulates the operating conditions of commercial nuclear power plants such as their pressure, temperature, flow and water chemistry to conduct the irradiation and thermo-hydraulic tests. The passivation of the fuel test loop was performed for the main cooling system in the commissioning stage with satisfaction of the operation criterion such as temperature and water chemistry conditions. The experimental results show that the passivation was completed successfully.

현재 진행되고 있는 대부분의 로봇 연구는 특정한 목적을 수행함에 있어서 기능적으로 안정적이고 원활한 움직임을 보이는 것과 더불어 사용자가 원하는 정보를 적절하게 전달하는 것에 초점을 맞춰 진행하고 있다. 본 논문에서는 로봇의 작업수행 상태가 아닌 외부로부터 입력 값이 없는 대기상태의 행동패턴을 제시하여 보다 자연스러운 인간-로봇 상호작용을 제시하고자 하였다. 로봇의 대기상태 행동패턴을 디자인함에 있어서 비디오 판독 방법을 선택하였고, 실제 서비스업에 종사하는 10명의 사람들을 비디오로 녹화하여 사람들과 상호작용이 없는 대기상태의 반복적인 행동패턴을 관찰하였다. 각각의 비디오 데이터로부터 총 21개의 반복적 행동을 기록하였고, 비슷한 항목들을 통합하여 최종적으로 11개의 행동패턴을 추출하였다. 추출된 패턴들 가운데 6개의 대표적인 행동들을 EEEX라는 로봇에 적합하도록 인코딩 작업을 하였고, 이것들이 사람들에게 올바르게 인식되는지를 확인하기 위하여 검증실험을 수행하였다. 사람들은 대부분의 로봇 행동패턴을 실험에서 의도한 바와 같이 인식하였으나 로봇의 하드웨어 특성상 몸과 팔의 움직임에서 약간의 혼동 요소가 있었다. 추후 실험을 통해 EEEX를 대형 마트의 입구에 실제로 배치하여 대기 중에 중립행동을 보일 때와 보이지 않을 때의 손님의 관심도 차이를 조사해보고자 한다.

국내에 설치되고 있는 가드레일의 단부처리시설(end treatments)은 차량의 관통이나 전복을 유발할 수 있는 형상을 하고 있어 사고 시 탑승자가치명상을 입을 가능성이 매우 높다. 실제로 차량이 가드레일의 단부에 충돌하였을 경우, 가드레일이 차량내부를 관통하여 탑승자에게 직접적인 상해를 입히는 경우가 발생되고 있다. 본 연구에서는 미국과 유럽의 성능평가기준(performance evaluation criteria)에 근거하여 국내 실정에 적합한 단부처리시설에 관한 성능평가기준(안)을 제시하였다. 또한 외국의 설치사례 및 연구사례를 조사하여 단부처리시설의 mechanism을 파악하고 국내 도로환경 에 적합한 단부처리시설을 제안하였다. LS-DYNA 프로그램을 이용한 컴퓨터 시뮬레이션을 통해 제안된 단부처 리시설에 대한 성능을 검증한 결과 성능평가기준(안)에 모두 만족한 결과를 보였으며, 개발 단부처리시설에 대한 실물차량 충돌시험을 수행한 결과 성능평가기준(안)의 탑승자 보호성능, 단부처리시설의 거동, 충돌 후 차량의 거동을 모두 만족하였다. 국내 최초로 탑승자의 안전을 고려하여 개발된 단부처리시설이 고속도로나 국도에 설치된다면 단부충돌사고의 심각성을 감소시켜 도로의 안전성을 향상시킬 수 있을 것으로 사료된다.

FTL(Fuel Test Loop) is a facility that confirms performance of nuclear fuel at a similar irradiation condition with that of nuclear power plant. FTL construction work began on August, 2006 and ended on March, 2007. During Construction, ensuring the worker's safety was the top priority and installation of the FTL without hampering the integrity of the HANARO was the next one. The installation works were done successfully overcoming the difficulties such as on the limited space, on the radiation hazard inside the reactor pool, and finally on the shortening of the shut down period of the HANARO. The Commissioning of the FTL is on due to check the function and the performance of the equipment and the overall system as well. The FTL shall start operation with high burn up test fuels in early 2008 if the commissioning and licensing progress on schedule.

600, 700, 800, 900, 1000㎍/50g 무기셀레늄(Na2SeO3)의 배지처리에 의한 노랑느타리버섯 균사배양기간, 균사밀도, 초발이소요일수, 유효경수, 개체중, 유기셀레늄 전이량을 조사한 결과는 다음과 같다. Na2SeO3의 처리에 의한 노랑느타리버섯 균사배양기간은 대조구 22일에 비하여 600~ 1000㎍/50g처리는 3~8일 까지 농도가 진할수록 배양기간이 길어졌다. Na2SeO3의 처리에 의한 노랑느타리버섯 균사밀도는 600~1000㎍/50g처리 까지는 대조구와 동일하게 보통이었다. Na2SeO3의 처리에 의한 노랑느타리버섯 초발이소요일수는 600~1000㎍/50g처리는 대조구 5일에 비해 3~8일 까지 농도가 진할수록 초발이소요일수가 길어졌다. Na2SeO3의 처리에 의한 노랑느타리버섯 유효경수는 600~1000㎍/50g처리는 10~16개로 대조구 18개에 비해 2~8개 까지 농도가 진할수록 유효경수가 적어졌다. Na2SeO3의 처리에 의한 노랑느타리버섯 수량(개체중)은 600~1000㎍/50g 처리는 94~166g/850cc로 대조구 123g/850cc에 비해 5.7~23.5%까지 농도가 높을수록 수량이 감소되었다. Na2SeO3의 처리에 의한 노랑느타리버섯 축적된 유기셀레늄 량은 600~ 1000㎍/50g처리까지 9.1~10.8㎍/g/dry로 농도가 높을수록 대조구 0.05㎍/g/dry에 비해 182~216배까지 축적되었다. 결론적으로 노랑느타리버섯 균사배양기간, 균사밀도, 초발이소요일수, 유효경수, 개체중, 유기셀레늄 전이량은 600~ 1000㎍/50g에서 억제되는 경향이 나타남에 따라 가장 적당한 농도는 600~ 1000㎍/50g보다 낮은 400㎍/50g이라고 본다.

Yeats held a life-long interest in Japanese culture, and employed the images, knowledge and inspiration he gained from Japan in many of his literary works. On the whole, it was the Japanese literary form that was most significant in his development as a writer. It was through the translations of Ezra Pound and Ernest Fenollosa that Yeats became acquainted with Noh, the medieval Japanese drama. It is generally agreed that Yeats’s encounter with Noh marked a turning point in his career as a dramatist. The Noh led him to create “a form of drama, distinguished, indirect and symbolic...an aristocratic form.” In “Note to At the Hawk’s Well,” Yeats writes: I have found my first model—and in literature, if we would not be parvenus, we must have a model—in the ‘Noh’ stage of aristocratic Japan. From this statement, we can see how significant the Noh-form was to Yeats in his development as a playwright. When Yeats was first introduced to Noh, he immediately perceived affinities with Irish legends and beliefs. The Noh was not something completely new or alien to Yeats. It was the discovery of an ideal, an ideal form for him to express his perennial themes of the tension between the physical and spiritual worlds. Yeats’s Noh-inspired plays are often categorized as “dance plays” and we can see that “dance” was an important symbol which Yeats developed through his experience with Noh. Yeats wrote in his “Introduction” to Certain Noble Plays of Japan that it was a Japanese dancer, Ito Michio, who inspired him to write his new play, At the Hawk’s Well (1916). In Noh, the dance which is usually danced by a supernatural figure, is placed at the centre. Here, the supernatural dominates the stage and the action develops toward a moment of enlightenment. Yeats precisely points out this fact and writes that in his new play, instead of “the players working themselves into a violence of passion...the music, beauty of form and voice all come to climax in pantomimic dance.” However, since Yeats intended Cuchulain as the central figure of At the Hawk’s Well, the theatrical effect of the dance had to differ from that of Noh. Another characteristic of this play is that it dramatizes the ‘transformation’ of the Guardian of the Well, the role which Ito Michio played, through spirit possession. This change in personality is conveyed by means of a change in costume(she throws off her cloak to reveal a dress suggesting a hawk). This is a method resembling ‘monogi(物着),’ one of the most important dramatic conventions of Noh. Yeats explores this device again, in The Only Jealousy of Emer(1919), another dance play modeled on Noh, but this time using different masks to show the change in personality. Yeats’s interest in this motif of spirit possession eventually led him to write The Words Upon the Window-Pane(1930), a play where he dramatizes a seancē. Here, the dramatic tension is concentrated mainly on a supernatural manifestation through the ‘protagonist’ who is a professional spiritual medium. In this paper, I have discussed Yeats’s relationship with Noh through a detailed analysis of At the Hawk’s Well. In this play, we can see many aspects of Noh. The simplified stage, the musicians, the mask, the dance, the use of a square blue cloth to represent a well; these are characteristics reminiscent of Noh. However, we must note that this play was not merely an imitation of Noh but a completely new form of creative writing. Richard Taylor indicates the influence of Yoro, a felicitous Waki-noh, or God Play on this play. A comparison of these two plays reveal that Yeats had no intention of following the Noh paradigms faithfully. However, the inspiration he gained from Noh opened a wide range of dramatic experiments enabling him to write a sequence of dance plays. In later plays such as The Words Upon the Window-Pane and Purgatory, Yeats succeeded in achieving a dramatic effect closer to that of Noh.