This study was conducted to evaluate effects of indoor horticultural therapy program based on ‘relaxation - cognitive behavior - social support’ strategy on quality of life, stress and serotonin of woman cancer patients. Subjects were 18 female cancer patients. Experimental group of 9 members received a horticultural therapy program and control group of 9 members did not receive a horticultural therapy program. The horticultural therapy program was conducted, for 90 minutes per session, once a week, total 8 times. And this study was performed from 9. Nov. to 28. Dec. in 2015. As a results, horticultural therapy program made significant improvement in emotional condition among sub-category of quality of life, nervousness, depression and frustration among sub-category of stress. Also the program decreased the total stress score with significant increased level of serotonin comparing to control group. This result means that depression mood in cancer patients was improved. In summary, horticultural therapy program focused on indoor activities based on ‘Relaxation-social support-cognitive behavioral’ strategy could be utilized as supporting program for psychological health for cancer survivors.