This study aimed to develop a solid self-nanoemulsifying drug delivery system (solid-SNEDDS) to enhance the formulation of ketoconazole (KTZ), a BCS Class II drug with poor solubility. Ketoconazole, which is insoluble above pH 3, requires solubilization for effective delivery. This SNEDDS comprises oil, surfactant, and co-surfactant, which spontaneously emulsify in the gastrointestinal tract environment to form nanoemulsions with droplet sizes less than 100 nm. The optimal SNE-vehicle composition of oleic acid, TPGS, and PEG 400 at a 10:80:10 weight ratio was determined based on the smallest droplet size achieved. This composition was used to prepare liquid SNEDDS containing ketoconazole. The droplet size and polydispersity index (PDI) of the resulting liquid SNEDDS were analyzed. Subsequently, solid-SNEDDS was fabricated using a spray-drying method with solidifying carriers such as silicon dioxide, crospovidone, and magnesium alumetasilicate. The physicochemical properties of the solid-SNEDDS were characterized by scanning electron microscopy and powder X-ray diffraction, and its solubility, droplet size, and PDI were evaluated. In particular, the solid-SNEDDS containing ketoconazole and crospovidone in a 2:1 weight ratio exhibited significantly enhanced solubility, highlighting its potential for improved medication adherence and dissolution rates.

This study aims to prepare a colloidal silica-containing powder to enhance the solubility and dissolution rate of rivaroxaban using a self-nanoemulsifying drug delivery system (SNEDDS). We investigate the impact of colloidal silica on a nanoemulsion system for preparing powdered SNEDDS. The liquid SNEDDS comprises 30/20/50 (w/w/w) Peceol/ Cremophor RH40/Tween 80, which results in the formation of the smallest droplets. Three powdered SNEDDS formulations are prepared by suspending the liquid SNEDDS formulation using colloidal silica and spray drying. The powdered SNEDDS prepared with liquid SNEDDS and colloidal silica at a ratio of 1/0.5 (w/w) exhibits the highest water solubility (0.94 ± 0.62 vs. 26.70 ± 1.81 μg/mL) and dissolution rate (38.4 ± 3.6 vs. 85.5 ± 3.4%, 45 min) when compared to the drug alone. Morphologically, the liquid SNEDDS is adsorbed onto colloidal silica and forms smaller particles. In conclusion, an SNEDDS containing rivaroxaban, prepared using colloidal silica, facilitates the creation of a nanoemulsion and enhances the water solubility of rivaroxaban. Accordingly, this technology holds significant potential for commercialization.

PURPOSES : The purpose of this study is to evaluate the effectiveness of self-luminescent road markings using driving simulation. METHODS : In this study, a driving simulation was conducted to evaluate the effectiveness of self-luminescent road markings. The details of this study are as follows. Highway sections were categorized as tunnels, tunnel approaches, bridges, merging areas, mainlines, and curbs. The luminance of the existing road markings was collected through field measurements. The luminance of the self-luminescent road markings was collected through experimental measurements. The luminance of the road markings is converted into a brightness ratio to be applied to the driving simulation. Road facilities at night were visualized during the driving simulation. Driving simulation was tested by 30 participants. Each participant rated the visibility perception of both the road markings ahead of 90 m with a 5-point scale. The log data generated from the driving simulation tests were analyzed. RESULTS : The luminance of the existing road markings and self-luminescent road markings was measured. The luminance of the existing and lab-based road markings was converted into a brightness ratio. The road facilities of highway sections were investigated for driving simulations. The driving simulation was tested by 30 participants. Visibility perception ratings and log data from the driving simulation were analyzed. The average of visibility point increased from 1.01 to 4.63 when self-luminescent road markings were added to the existing road markings. The average speed also increased when self-luminescent road markings were added to existing road markings. CONCLUSIONS : In conclusion, self-luminescent road markings can improve the visibility of road markings and driving speed, particularly in highway sections where driving speed decreases owing to low visibility.

The objective of this study is to assess the impact of spray drying conditions on medium-chain triglyceride (MCT) loading, solubility, and release of an MCT-loaded solid self-emulsifying system in a water-insoluble oily substance. MCT-loaded solid self-emulsifying systems are prepared by spray drying with SDS and calcium silicate. The effects of inlet temperature (60, 80, or 100oC) and feed solution composition (0, 10, 50, 90, or 100% ethanol) on physicochemical properties of MCT-loaded solid self-emulsifying systems are studied. The inlet temperature significantly affects the water solubility of MCT. Moreover, the feed solution composition significantly affects water solubility, release rate, and MCT loading. The MCT-loaded solid self-emulsifying system obtained at 60oC using 90% ethanol feed solution shows the best physicochemical properties among the synthesized products and exhibits better water solubility (4.43 ± 0.44 vs. 0 μg/mL) and release (94.4 ± 1.6 vs. 32.8 ± 7.4%, 60 min) than a commercial product. Furthermore, the MCT-loaded solid self-emulsifying system shows an excellent emulsion droplet size (approximately 230 nm).

In gamma-ray spectrometry for volume samples, the self-attenuation effect should be considered in the case of differences in chemical composition and density between the efficiency calibration source for quantitative analysis of sample and the sample actually measured. In particular, the lower the gamma-ray energy, the greater the gamma-ray attenuation due to the self-attenuation effect of the sample. So, the attenuation effect of low-energy gamma-rays in the sample should be corrected to avoid over- or under-estimation of its radioactivity. One of the most important factors in correcting the self-attenuation effect of the sample is the linear attenuation coefficient for the sample, which can be directly calculated using a collimator. The larger the size of the collimator, the more advantageous it is to calculate the linear attenuation coefficient of the sample, but excessive size may limit the use of the collimator in a typical environmental laboratory due to its heavy weight. Therefore, it is necessary to optimize the collimator size and structure according to the measurement environment and purpose. This study is to optimize a collimator that can determine the effective linear attenuation coefficient of low-energy gamma-rays, and verify its applicability. The overall structure of the designed collimator was optimized for gamma-ray energy of less than 100 keV and cylindrical plastic bottle with diameter of 60 mm and a height of 40 mm. The materials of optimized collimator consisted of tungsten. Acryl and acetal were used to form the housing of the collimator, which fixes the central axis of the bottle, collimator and point-like source. In addition, using the housing, the height of the tungsten is adjusted according to the height of the sample. For applicability evaluation of the optimized collimator, IAEA reference material in solid form were used. The sample was filled in the bottle with heights of 1, 2, 3 and 4 cm respectively. Using the collimator and point-like source of 210Pb (46.5 keV), 241Am (59.5 keV), and 57Co (121.1 keV), the linear attenuation coefficient and the radioactivity for the samples were calculated. As a result, to calculate the linear attenuation coefficient using the optimized collimator, a relatively high sample height is required. However, the optimized collimator can be used to determine the linear attenuation coefficients of low-energy gamma-rays for the self-attenuation correction regardless of the sample height. It is concluded that the optimized collimator can be useful to correct the sample selfattenuation effect.

Decommissioning of a nuclear power plant (NPP) generate large amounts of various types of wastes. In accordance with the Nuclear Safety and Security Commission Notice of Korea (No. 2020- 6), they are classified as High Level Waste (HLW), Intermediate Level Waste (ILW), Low Level Waste (LLW), Very Low Level Waste (VLLW) and Exempt Waste (EW) according to specific activities. More than 90% of the wastes are at exempt level, mostly metal and concrete wastes with low radioactivity, of which the concentrations of nuclides is less than the allowable concentration of self-disposal. The self-disposal or recycling of these wastes is widely used worldwide. More than 10,000 drums, based on 200 L drum, are expected to be produced in the decommissioning process of a unit of nuclear power plant. Due to the limited storage capacity of the intermediate & low level waste disposal facility in Gyeongju, recycling and self-disposal of EW are actively recommended in Korea. A variety of scenarios were proposed for recycling and self-disposal of decommissioning metal/ concrete wastes, and a computational program called REDISA was developed to perform the dose evaluation for each recycling and self-disposal scenario. The REDISA computer program can calculate external and internal exposure doses by simulating the exposure pathways from waste generation, thru transport, processing, manufacture, to the final destination of recycling or self-disposal. In this study, the self-disposal scenario was only considered for the dose evaluation. Many studies have been conducted to evaluate the exposure doses of the radioactive waste disposal sites. However, there have been few researches on dose evaluation for self-disposal landfills. In particular, the dose evaluation is important not only during the operation period, but also for a long period after the facility is closed. To this end, we developed a conceptual model for dose evaluation for post-closure scenarios of the self-disposal landfill of decommissioning metal/concrete wastes with reference to the methodology of IAEA-TECDOC-1380. The model incorporates three exposure pathways, including external exposure from contaminated soil, internal exposure by inhalation, and internal exposure by ingestion of water and food grown in contaminated soil. The duration of the dose evaluation is set to 100,000 years after the closure of landfill facility. Co-60 was selected as dominant nuclide, and dose evaluation was performed based on unit specific activity of 1 Bq/g. Exposure doses shall be verified for their application in accordance with the annual dose limit of 10 Sv/yr for self-disposal. As a result, the post-closure scenario of selfdisposal landfills have shown negligible effects on public health, which means that the exposures doses from transportation and operational processes should be considered more carefully for selfdisposal of decommissioning metal/concrete wastes.

기업 간 경쟁이 치열해지면서 통상적인 방법으로 기업이 경쟁에서 이길 수 없게 됨에 따라서 모든 조직들이 혁신을 간구하게 되었고, 이에 따라서 조직혁신을 증진하는 다양한 노력을 시도하는 가운데, 개인 수준의 행동을 통해 조직혁신을 도모하고자 혁신행동이 등장하게 되었다. 이런 배경 속에서 탄생한 혁신 행동은 꾸준히 주목을 받아왔고, 그와 더불어 혁신행동을 증진하는 방안에 대해서 다양한 연구가 진행되어 오고 있다. 최근 혁신행동에 대한 종합적 문헌연구를 실시한 Kwon & Kim(2020)의 연구에서는 혁신행동의 선행요인으로서 개인특성의 중요성이 매우 낮게 다루어졌다. 이에 본 연구는 개인특성과 혁신행동 간 관계를 다룬 기존 연구를 간략히 살펴보고, 연구의 방향을 설정하였다. 기존 연구에서는 성격과 혁신행동 간 관계에 대해서는 많이 연구되었으나, 이외의 개인특성과 혁신행동 간의 관계를 다룬 연구는 매우 부족한 편이다. 이에 본 연구는 혁신행동 연구 초기에 다루어졌던 개인 특성인 문제해결 방식과 최근 주목받고 있는 개인특성인 핵심자기평가에 주목하게 되었다. 그리고 성격과 같은 개인특성과 혁신행동을 다룬 연구들은 혁신에 대한 성격의 주효과에도 많은 관심을 보였지만, 특성활성화 이론에 입각하여 성격 등의 특성이 혁신행동으로 발현되게 하는 상황요인에도 많은 관심을 보였다. 이러한 기존 연구 흐름에 따라서, 본 연구는 문제해결 스타일이 혁신행동으로 발현되는 과정에서 관련 상황요인으로 상사지원에 주목하고, 문제해결 스타일과 혁신행동 간의 관계에서 상사지원의 조절효과를 살펴보았다. 나아가, 특성활성화이론을 확장하여, 개인특성이 관련 행동으로 발현하는 과정에서 특정 개인이 이 관계를 증폭시킬 수 있는 가능성에 대해서 논의하고, 핵심자기평가가 문제해결 스타일과 혁신행동 간의 관계를 조절하는지 여부를 확인하였다. 이를 실증적으로 분석하기 위해서 중국의 공기업에 근무하는 228명으로부터 설문을 통해 자료를 수집 하였고, 위계적 회귀분석을 통해 가설을 검증하였다. 분석결과, 문제해결 스타일의 두 하위 차원 중에서 직관적 문제해결 스타일만 혁신행동에 유의한 정(+)의 효과를 보였다. 또한 핵심자기평가는 혁신행동에 통계적으로 유의한 정(+)의 효과를 보였지만, 직관적 문제해결 스타일과 혁신행동 그리고 체계적 문제해결 스타일과 혁신행동 간 관계 모두에 대해서 유의한 조절효과를 보이지 않았다. 마지막으로 상사지원인 식은 혁신행동에 대해서 유의한 정(+)의 효과를 보였고, 직관적 문제해결 스타일과 혁신행동 간에 유의한 조절효과를 보인 반면에 체계적 문제해결 스타일과 혁신행동 간 관계에 대해서 유의한 조절효과를 보이지 않았다. 이상의 결과를 놓고, 이론적 그리고 실무적 함의점에 대해서 논의하였다.

In today's affluent food environment, investigating factors that facilitate resistance in the face of barriers to health goals may be vital for achieving successful promotion and regulation of health. This study was implemented to investigate the effect of self-compassion on the evaluation and choice of healthy vs. unhealthy food. In Study 1, participants (N = 101) primed with self-compassion evaluated unhealthy food more negatively than those primed with self-esteem. As predicted, however, there was no difference in attitude toward healthy food between the two priming conditions. In Study 2, participants (N = 54) were asked to choose between healthy and unhealthy food and then their self-compassion was measured. Results show that participants with high self-compassion chose healthy food more often than unhealthy food, while those with low self-compassion chose unhealthy food more than healthy food. The implications of the findings are discussed in terms of health campaign strategies and further research into the relation between self-compassion and health behaviors.

This study investigated the effects of self and peer evaluations and learners’ involvement on the development of assessment criteria in higher education English literature classes. A total of 40 college students participated in the study, extracting five main criteria with 10 sub-standards to assess their group assignments and conduct self- and peer evaluation on their presentations. The results of the learners’ selfand peer assessments were compared with instructor’s assessments and their final grades using one-way ANOVA and correlation analysis. The study also examined the correlation among the assessment criteria to find which factors affected learning outcomes. The study concluded that their participation in the development of assessment criteria positively, affected their critical thinking ability and the selection of subjects for the group presentations. Logicality of writing also affected the outcomes of final assessments. The study concluded that self- and peer assessments can be highly effective in learning processes when learners actively participate in setting the assessment criteria.

4차 산업혁명 도래와 급변하는 환경 여건에 직면해서 현대사회의 조직구성원은 그 어느 때보다 복잡성 과 불확실성에 노출되어 있다. 이러한 예측 불가능한 환경 맥락적 요인들 속에서 독창적 문제발견과 실행적 해결과정을 통해 환경적응력과 생존가능성을 극대화하려는 창의‧혁신‧제고 노력은 개인 발달과 조직 성장 및 국가발전 모두에 필요한 지속발전 가능성과 원천 경쟁력 확보를 위한 핵심자원으로 간주되고 있다(Craft, 2005). 이렇듯 창의성은 인간의 생존과 관련되어 있다. 창의성은 개인이 직면한 문제해결에 도움이 되고 사회 경제 발전에 매우 중요한 자원이다. 이러한 점에서 인간의 삶의 질 향상과 인류 발전은 창의성을 바탕으로 하고 있다고 해도 과언이 아니다(최병연, 2017). 전 세계적으로 창의성이 주요 담론으로 확고히 자리잡으면서 사회 각 분야에서 관심이 더욱 고조되고 있으며 현재 국가사회가 당면중인 문제 해결을 위해 적극 활용돼야 할 도구로 부상하고 있다. 이에 본 연구에서는 직장인 400명을 대상으로 설문을 통해 핵심자기평가가 개인 창의성, 친사회적 발언행동에 어떠한 영향을 미치는지를 파악하고 친사회적 발언행동에 시사점을 제공하기 위해 핵심자기평가와 개인 창의성 관계에서 매개효과를 분석하여 연구 가설을 검증하였으며 분석결과는 다음과 같다. 핵심자기평가는 개인 창의성, 친사회적 발언행동에 모두 긍정적인 영향을 미치는 것으로 나타났다. 또한, 친사회적 발언행동은 개인 창의성에 긍정적인 영향을 미 치는 것으로 나타났으며 핵심자기평가와 개인 창의성 관계에서 매개효과를 나타내었다. 결과적으로 핵심 자기평가가 개인 창의성을 발휘하는데 있어서 중요한 역할이 되며, 친사회적 발언행동이 핵심자기평가와 개인 창의성 관계에서 긍정적인 상호작용을 일으킨다는 점을 본 연구에서 제시하고 있다.

최근 강우 발생빈도의 불규칙한 변화로 홍수 및 가뭄 피해가 증가함에 따라 불규칙한 자연현상의 특 성을 예측하는 확률론적 방안들이 관심을 받고 있다. 본 연구에서는 자연계 현상을 확률론적으로 예측 하는 기법인 플랙탈이론의 허스트지수(Hurst exponent)를 이용한 자기유사성 평가를 전국 64개 기상관 측소의 월강수량 자료를 대상으로 실시하였다. 1986년부터 2015년까지 총 30년 동안의 월강수량을 평 가한 결과 허스트지수는 H=0.97~0.99의 범위로 나타났다. 이는 H>1/2의 양의 상관관계를 보이며, 자 기유사성을 가지는 것으로 평가될 수 있어 기존의 축척된 자료를 통해 향후의 이상강우에 대한 예측이 가능하다는 사실을 보여주는 것으로 나타났다.

Background: Functional capacity evaluations (FCEs) are designed to systematically assess the capacity to perform work-related tasks and to determine worker’s ability to return to the previous job following work-related injuries. These evaluations may be rated either by clinician or worker. There has been a lack of consensus between the two scoring methods. Objects: This study aimed: 1) to confirm if the data are fit to the Rasch rating scale model and 2) to investigate the item-level concordance rate between the ratings of clinician and injured worker of the FCE. Methods: A cross-sectional study was conducted with a sample (n=124) of a rehabilitation program with the Occupational Rehabilitation Data Base for workers with low back pain. The functional capacity evaluation at admission and discharge was administered to clinicians and workers. The data were analyzed using both classical test theory-based Pearson’s r and intra-class coefficient followed by item-level analysis with Rasch rating scale model. Results: All items of the FCE, except sitting items rated by clinician at admission and handling items rated by both clinician and worker throughout admission and discharge, were acceptable fit statistics with minor out of ranges for a misfit criterion. This may indicate that the items of the FCE overall fit to the Rasch rating scale model. Few problematic items responding differently to clinician and worker both at admission and discharge were detected with the differential item functioning analysis despite the excellent concordance rate using the two conventional statistics-sitting and handling items at admission and handling item at discharge. Conclusion: The item-level speculations using Rasch analysis of the FCE demonstrate that the ratings of clinician and self ratings of worker were psychometrically acceptable though there was an apparent discrepancy between the raters both at admission and discharge.

The underlying empirical work aims at examining the consequences of a negative experienced co-creation process. A mediation analysis investigates how and why a negative co-creation experience affects consumers’ product evaluations and reveals that not all production experiences create additional value.