Following the previous study, which investigated the pharmacological properties of the Technekitty injection (Tc-99m), the toxicity of a single intravenous administration of the Technekitty injection (Tc-99m) and the side effects that may occur at the diagnostic dose were confirmed. The Technekitty injection (Tc-99m) was administered intravenously once at a dose of 0, 0.67, 2.0, and 6.0 mCi/kg to 5 male and female rats per group. Mortality, general symptom observation, and weight measurement were performed for 2 weeks, followed by observation of autopsy findings. There were no deaths, and no statistically significant weight change was observed. No abnormal systemic signs related to the Technekitty injection (Tc-99m) were observed. These results confirmed that Technekitty injection (Tc-99m) can be safely administered intravenously at doses up to 6.0 mCi/kg. Additionally, technetium-99m at an average dose of 2 mCi (74 MBq) has been verified as a diagnostic dose without adverse effects, allowing the Technekitty injection (Tc-99m) to be used safely without side effects at this dosage. This study demonstrates that the Technekitty injection (Tc-99m) has a wide safety margin, supporting its potential for clinical application. Moreover, these findings align with the nonclinical safety standards for radiopharmaceuticals, reinforcing its utility in veterinary medicine. The Technekitty injection (Tc-99m) is expected to be applicable for clinical diagnosis as a veterinary drug in Korea.

Thyroid scanning using technetium-99m (99mTc) is the gold standard for diagnosing feline hyperthyroidism. In cats with an overactive thyroid, a thyroid scan is the most appropriate imaging technique to detect and localize any hyperfunctional adenomatous thyroid tissue. In this study, the pharmacological properties of the Technekitty injection (Tc-99m), developed as a diagnostic agent for feline hyperthyroidism using 99mTc as an active ingredient, were tested in FRTL-5 thyroid follicular cell line and ICR mice. The percentage of cell uptake of the Tc-99m in FRTL-5 thyroid cells was 0.182 ± 0.018%, which was about 6 times higher compared to Clone 9 hepatocytes. This uptake decreased by 38.2% due to competitive inhibition by iodine (sodium iodide). In tissue distribution tests by using ICR mice, the highest distribution was observed in the liver, kidneys, spleen, lungs, and femur at 0.083 hours after administration, and this distribution decreased as the compound was excreted through the kidneys, the primary excretory organ. Maximum distribution was confirmed at 1 hour in the small intestine, 6 hours in the large intestine, and 2 hours in the thyroid gland. Additionally, the total amount excreted through urine and feces over 48 hours (2 days) was 78.80% of the injected dose, with 37.70% (47.84% of the total excretion) excreted through urine and 41.10% (52.16% of the total excretion) through feces. In conclusion, the Tc-99m has the same mechanism of action, potency, absorption, distribution, metabolism, and excretion characteristics as 99mTc used for feline hyperthyroidism in the United States, Europe, and other countries, because the Technekitty injection (Tc-99m) contains 99mTc as its sole active ingredient. Based on these results, the Technekitty injection (Tc-99m) is expected to be safely used in the clinical diagnosis of feline hyperthyroidism.

Rare earth elements, which are important components of motors, are in high demand and thus constantly get more expensive. This tendency is driven by the growth of the electric vehicle market, as well as environmental issues associated with rare-earth metal manufacturing. TC 298 of the ISO manages standardization in the areas of rare-earth recycling, measurement, and sustainability. Korea, a resource-poor country, is working on international standardization projects that focus on recycling and encouraging the domestic adoption of international standards. ITU-T has previously issued recommendations regarding the recycling of rare-earth metals from e-waste. ISO TC 298 expands on the previous recommendations and standards for promoting the recycling industry. Recycling-related rare earth standards and drafts covered by ISO TC 298, as well as Korea’s strategies, are reviewed and discussed in this article.

Since the ISO decided to deal with rare-earth elements at the 298th Technical Committee (TC) in 2015, Korea has participated in four plenary meetings and proposed four standards as of June 2019. The status of ISO TC 298, the standards covered by the TC, and the standardization strategies of Korea are summarized. Korean delegations are actively engaged in WG2, which deals with recycling, proposing four standards for fostering the rare-earth recycling industry. However, the participation of domestic experts is still low compared with the increase in the number of working groups and the number of standards in TC 298. The aim of this article is to summarize the current status of ISO international standards related to rare-earth elements, to encourage relevant experts to participate in standardization, and to develop international standards that accurately reflect the realities of the industry.

1990년 이래 미국에서의 특허침해소송 재판지는 인구도 얼마 되지 않는 텍사스동부지역의 연방지방법원에 집중되어 왔었다. 이러한 현상은 연방항소법원이 특허법으로부터 비롯되는 사건에 관한 특별재판적 규정에 회사에 관한 일반재판적 규정도 보충적으로 적용된다고 해석함으로써 원고가 사실상 미국 전역의 연방지방법원에 특허침해 소송을 제기하는 것이 가능하게 된 결과였다. 이러한 해석을 바탕으로 나타난 포럼쇼핑(forum shopping) 현상에 대하여 제동을 건 것이 바로 미국에서 뜨거운 논쟁의 대상이 되었던 TC Heartland 사건의 2017년 5월 연방대법원 판결이었다. 이 판결은 특허침해소송에 관한 특별재판적 규정에 회사에 관한 일반재판적규정이 보충적으로 적용될 수 없다고 판단하였는데, 이로 인하여 텍사스동부지방법원에 특허침해 사건이 몰리는 현상이 완화될 것으로 예상된다. 한편 우리나라에서는 2016년 민사소송법과 법원조직법의 개정으로 특허권에 관한 소송의 관할집중이 이루어졌고, 서울중앙지방법원에는 중복관할이 인정되었다. 비록 서울중앙지방법원으로의 사건이 집중되고 있는 것으로는 보이나, 우리나라의 경우 제반 사정에 비추어 볼 때 미국에서와 같은 포럼쇼핑의 문제는 심각하지 않은 것으로 보인다.

The time-series of Walker circulation index (WCI) in this study shows the strengthening of the Walker circulation in recent years. To further understand the large-scale features related to the WCI strengthening, a difference between the averaged meteorological variables in two time periods 1999-2013 and 1984-1998 is analyzed. The difference in 850 hPa stream flows between the two periods shows that the anomalous easterlies (anomalous trade wind) are dominant due to the strengthening of anomalous anticyclonic circulations at the subtropical Pacific of both hemispheres. The difference between the averaged zonal atmospheric circulations over 5oS-5oN in the two periods confirms that upward flows are strengthened at the tropical western Pacific and downward flows are strengthened at the tropical central and eastern Pacific in recent years. It matches the WCI strengthening in recent years. The time-series of tropical cyclone (TC) genesis frequency from July to September shows that a mean TC genesis frequency from 1999-2013 decreases compared to that of the time period 1984-1998. The monsoon trough in the period 1984-1998 was located in the further east direction and stronger than that in the period 1999-2013. TCs in the recent period that are generated in further west than TCs in the past period moved from the west. Thus, the TC intensity along the coasts in East Asia becomes weaker in recent period. The intensification of Walker circulation in recent years is related to the weaker TC intensity in East Asia through strengthened anomalous anticyclones at the subtropical western Pacific.

New paradigm to the technological advancement and policies for disaster management is required for the fast change of the social framework such as climate change, urbanization, and aging. In these circumstances, enhancing the capacity of disaster management of national has become important issues, which is based on the ISO/TC223(Societal Security) In this research, we analyzed international trend and proposed effective domestic strategy for adapting TC223; 1) establishing a new department for effective corresponding, 2) activating an accreditation related to public and private field.

This article shows various factors that influence the thermal-cycling reliability of semiconductor devices utilizing the lead-on-chip (LOC) die attach technique. This work details how the modification of LOC package design as well as the back-grinding and dicing process of semiconductor wafers affect passivation reliability. This work shows that the design of an adhesion tape rather than a plastic package body can play a more important role in determining the passivation reliability. This is due to the fact that the thermal-expansion coefficient of the tape is larger than that of the plastic package body. Present tests also indicate that the ceramic fillers embedded in the plastic package body for mechanical strengthening are not helpful for the improvement of the passivation reliability. Even though the fillers can reduce the thermal-expansion of the plastic package body, microscopic examinations show that they can cause direct damage to the passivation layer. Furthermore, experimental results also illustrate that sawing-induced chipping resulting from the separation of a semiconductor wafer into individual devices might develop into passivation cracks during thermal-cycling. Thus, the proper design of the adhesion tape and the prevention of the sawing-induced chipping should be considered to enhance the passivation reliability in the semiconductor devices using the LOC die attach technique.

이 연구는 태풍의 온대성 저기압화에 대해 간단히 소개하고 Evans and Hart(2003)와 Hart(2003의 객관적 온대성 저기압화 판별식을 이용하여 최근 온대성 저기압화를 거친 세 태풍(Shanshan, Yaki, Soulik)에 대한 사례분석이 이루어졌다. 500-hPa 고도장분석에서 온대성 저기압화 시작시 세 태풍 모두 중위도 경압지역으로 북상하는 공통된 특성을 보였다. 그러나 연직단면 분석에서는 온대성 저기압화의 시작전 시 태풍 중심부근의 모든 층에서 온난 다습한 특성을 보였다. 온대성 저기압화 이후에는 이 개념모델의 전형적 특성인 태풍의 서쪽영역에 한랭 건조한 특성을 나타내었다. 따라서 Evans and Hart(2003)와 Hart(2003)의 객관적 온대성저기압화의 판별식은 태풍의 온대성저기압화 시작 및 구조변화를 잘 반영하므로 기상청 예보현업에서도 유용하게 사용될 수 있을 것으로 판단된다.

The relationship between electrical properties of superconductor and externally applied magnetic field was studied to develop a magnetic field sensor. The electrical resistance of the superconductor was increased by applying external magnetic field and even after removal of the magnetic field. This behavior was related to the magnetic flux trapped in the superconductor, which penetrated through the material by the external magnetic field. Some portion of the superconductor was changed to a normal state by the trapped magnetic flux. The appearance of the normal state yielded to enhance the electrical resistance.

(001) SrTiO3(STO) 기판위에 고온초전도 YBa2Cu3O7-x(YBCO)박막을 이용한 계단형 모서리 임계접합을 제조하였다. STO (100) 단결정 기판위에 계단형 모서리(step-edge)를 제작하기 위한 이온밀링 마스크로 plasma enhanced chemical vapor deposition방법으로 증착된 diamond-like carbon (DLC) 박막을 사용하였고, oxygen reactive ion etch 방법으로 건식식각하였다. 이렇게 제작된 계단형 모서리 기판위에 c-축 수직한 YBCO 박막과 STO박막을 pulsed laser deposition방법으로 에피텍셜하게 증착하였다. 계단의 상층과 하층에서 모두 임계가 형성되었으며 이 접합의 임계온도는 77 K 이상이었고 16K에서 ICRnproducts가 7.5mV, 77 K에서 0.3mV의 값을 나타내었다. 이들 전류-전압 특성은 two noisy resistively shunted Josephson junction 모델을 잘 만족하였다.

산화물 초전도체에 있어서 고천이 임계온도를 갖는 미소영역을 추출하여 이를 분석하기 위하여 La-Ba-Cu-O 계, Y-Ba-Cu-O 계 및 Bi-Pb-Sr-Ca-Cu-O 계의 초전도체를 고상법 및 nitrate solution method로 제조하였다. 제조된 시료들에 대해서 x선회절분석과 저항을 측정하였다. 이들 시료 중에서 고천이온도를 나타내는 미소부분을 Meissner효과를 이용한 추출법으로 분리 해내고 EDAX로 이를 분석하였으며, 이들 결과를 요약하면 다음과 같다. nitrate solution method를 적용하면 YBCO계에 있어서 비교적 단시간에 치밀한 미세조직을 갖는 천이 온도 90K의 초전도체를 제조할 수 있다. Meissner효과를 이용하여 고천이온도에서 추출해낸 미소영역의 EDAX분석 결과는 고상법을 사용한 YBCO-23S와 nitrate solution method으로 제조한 YBCO-23N 및 YBCO-36N 에서는 초기의 조성과 거의 같았으며, 고천이 온도에서 추출된 미소영역은 조성보다는 산소 결함의 차이에 기인한 것으로 생각된다. 공침법으로 제조한 YBCO-23NA 에서는 과도한 Ba의 조성을 보였으며, 천이온도 100K 인 Bi계에서는 약한 반자성효과 때문에 추출이 불가능하였다.

Technetium has been identified as an element of interest for the safety assessment of a deep geological repository for used nuclear fuel. In this study, the sorption of Tc(IV) onto MX-80 bentonite, illite, and shale in ionic strength (I) 0.1–6 mol·kgw−1 (m) Na-Ca-Cl solutions at pHm = 4–9 and limestone at pHm = 5–9 was studied. Tc(IV) sorption on MX-80 increased with pHm from 4 to 6, reached the maximum at pHm = 6–7, and then gradually decreased with pHm from 7 to 9. Tc(IV) sorption on illite gradually increased with pHm from 4 to 7, and then decreased as pHm increased. The sorption properties of Tc(IV) on shale were quite similar to those on illite. Tc(IV) sorption on limestone slightly increased with pHm from 5 to 6 and then seemed to be constant at pHm = 6–9. Tc(IV) sorption on all four solids was independent of ionic strength (0.1–6 m). The 2 site protolysis non-electrostatic surface complexation and cation exchange model successfully simulated the sorption of Tc(IV) onto MX-80 and illite and the optimized values of surface complexation constants were estimated.

Technetium-99 is identified as an element of interest for the safety assessment of a deep geological repository for used nuclear fuel. The sorption behavior of Tc(IV) onto MX-80 and granite in Ca-Na-Cl solutions of varying ionic strength (0.05–1 mol·kgw−1 (m)) and across a pHm range of 4–9 was studied in this paper. Sorption of Tc(IV) was found to be independent of ionic strength in the range of 0.05 to 1 m for both MX-80 and granite. Sorption of Tc(IV) on MX-80 increased with pHm from 4 to 7 and then decreased with pHm from 8 to 9. Sorption of Tc(IV) on granite gradually increased with pHm from 4 to 8 and then became almost constant or slightly decreased with pHm from 8 to 9. A 2 site protolysis non-electrostatic surface complexation and cation exchange sorption model successfully simulated sorption of Tc(IV) on MX-80 and granite. Optimized values of surface complexation constants (log K0) are proposed.