Fenbendazole (FBZ) is one of benzimidazole drugs, which is well known for its broad spectrum of anthelmintics. During recent research on FBZ, it is also expected to have anti-inflammatory characteristics. However, the related research on FBZ with its anti-inflammatory effects is still lacking. This study focuses on the effects of FBZ on macrophage cell line of mouse, RAW264.7, and also on the inflammatory condition induced by lipopolysaccharide (LPS). FBZ alone treatment on RAW264.7 cells reduced the metabolic activity on the range of 1-5 μM, but the metabolic activity in the presence of LPS was higher than that of absence of LPS. Given that LPS has the ability to enhance glucose uptake in macrophage and rapid ATP production, there is a possibility that LPS increases the metabolic activity. Whereas TNF-alpha was hardly produced at FBZ 1-5 μM in the presence of LPS, IL-10 was still being produced, suggesting on the possibility of anti-inflammatory effect. Interestingly, despite the decreased survival of cells treated with FBZ, MHC class II and CD86 expression in surviving cells was markedly increased. Further investigation of FBZ is required through in vivo experiments to validate these findings.

The purpose of this paper is to study how the term “Honmono,” used as a form of hate speech, gained public attention following the release of Makoto Shinkai‘s film “Your Name” (2017) and has affected individuals and society. It also considers the film’s implications in 2023 in relation to Shinkai’s subsequent film “Suzume.” In this study, news articles and online community posts from 2017 were collected and analyzed. In addition, data from Naver Datalab, an online service, and a survey conducted during the popularity of “Suzume” (2023) were utilized. The analysis showed that there were limitations in the“three stages leading to hate speech anddiscrimination“model proposed in earlier research. Accordingly, this paper proposes a revised model better suited to the case of “Honmono.”

Endocrine-disrupting chemicals (EDCs), such as perfluorooctanoic acid (PFOA), have been linked to adverse effects on reproductive health. However, the impact of PFOA exposure during the embryonic stage on hypothalamic gonadotropin-releasing hormone (GnRH) neurons, which are central to the regulation of the hypothalamic–pituitary axis, that controls the reproductive system, has not been investigated. In this study, immortalized embryonic mouse hypothalamic cells (mHypoE-N46) were used to evaluate alterations in GnRH expression following PFOA exposure in vitro. In addition, the expression levels of Pnx, Gpr173, BDNF, and Ntrk2—upstream signals known to regulate GnRH expression—were examined. mHypoE-N46 cells were treated with PFOA for 2-24 hours, and gene expression and protein expression levels were evaluated. PFOA significantly altered the gene expression levels of Pnx, Gpr173, BDNF and Ntrk2. GnRH expression was significantly increased at both the mRNA and protein levels. In conclusion, exposure to PFOA may perturb the upstream signaling of GnRH and may directly or indirectly affect the expression of GnRH, suggesting that PFOA may alter the GnRH regulatory network.

This study explores the expressive characteristics of new media fashion collections, which have emerged through the convergence of fashion and digital technologies. As new media develops with the integration of old media, fashion collections are increasingly functioning as media tools to convey identity, narrative, and artistic intent beyond aesthetic presentation. Through a literature review and case analysis of collections from 2000 S/S to 2025 S/S, this study defines the term ‘new media fashion collection’ and investigates its communicative functions. The findings reveal that such collections embody the significance of the expansion of space-time, evolution of expression methods, and decentralization of experience, while diversifying meanings and modes of expression based on new media attributes such as extensibility, integrativeness, and interactivity. More specifically, their expressive characteristics can be understood through four characteristics: the direct representation through borrowing, the diversity of message expression, the immersion through unreality, and the narrative construction via editing. Collectively, these characteristics demonstrate how new media fashion collections emphasize themes by using digital technology to borrow or transform old media content. Digital technologies allow fashion collections to unfold across limitless space-time dimensions, positioning them as versatile communication media and enhancing expressive possibilities. These approaches reflect how fashion collections in the digital era integrate technological elements to enrich communication and viewer engagement. This research contributes to the positioning of fashion collections as a form of media and offers a framework for analyzing their evolving expressions. Further, it highlights the need for continued interdisciplinary research bridging fashion, technology, and media theory.

이 연구는 집단미술치료가 가정폭력피해여성의 정서표현과 대인관계에 미치는 영향을 알아보는데 그 목적이 있다. 이를 위해 A시의 가정폭력피 해시설에 입소한 여성 6명을 대상으로 2024년 5월 14일에서 6월 11일 까지 주 2회, 회당 120분씩 총 8회기의 집단미술치료 프로그램을 실시하 였다. 또한 이들의 변화를 알아보기 위해 정서표현력검사와 대인관계검 사를 사전, 사후로 실시하여 대응표본 t-test로 검증하였다. 검증 결과 집단미술치료가 가정폭력피해여성의 긍정적 정서표현(t =-4.29, p <.01)과 대인관계(t =-6.22, p <.01)에서 유의미한 영향을 미치고 있음을 확인할 수 있었다. 이러한 연구 결과를 토대로 본 연구는 가정폭력피해여성의 효과 적인 의사소통 능력을 향상시켜 가족관계뿐 아니라 대인관계에서도 긍정 적인 관계를 돕기 위한 집단프로그램 개발의 기초 자료로 제시한다는 것 에 의의가 있다. 하지만, 본 연구의 신뢰성 확보를 위해서는 다양한 지역 과 더 많은 대상으로 범위를 확대한 후속 연구와 함께 프로그램의 지속 성의 확인을 위한 추후 검사를 실시할 필요가 있을 것이다.

Despite its historical association with oppression, fear, and marginalized femininity, modern reinterpretations of the figure of the witch position it as a symbolic entity combining historical context and literary imagination. This study analyzes contemporary fashion designs that incorporate witch imagery, focusing on the designs' representational methods and aesthetic characteristics. It includes a literature review examining evolving perceptions of witches across different eras as well as visual and formal analyses of post-2010 fashion collections, using image and text materials from Showstudio.com and other online sources. In various realms of visual culture–including art, film and drama, advertising, product design, and halloween costumes–the image of the witch is no longer confined to traditional iconography. Instead, it is continuously reimagined, taking on expanded and multifaceted meanings that attest to its unique and evolving nature. This study identifies two primary expressive types: direct iconographic appropriation, employing traditional motifs such as pointed hats, black cloaks, and pentacles; and metaphorical suggestion, using dark tones, deconstructed silhouettes, and layered styling to imply the witch's essence. The analyses also highlight three aesthetic characteristics: empowered sensuality, expressed through sheer fabrics and dramatic makeup; supernatural mysticism, combining natural and occult symbols; and uncanny playfulness, which subverts traditional motifs through fantasy and humor. Ultimately, the witch in contemporary fashion serves as both a stylistic code and a visual signifier of cultural narrative and identity. This reimagining has contributed to the development of new aesthetic systems in fashion and broadened the visual culture and design innovation discourse.

Baicalin is known to exhibit neuroprotective effects during brain injury through its antioxidant and anti-inflammatory functions. Moreover, γ-enolase is specifically expressed in nerve cells and exhibits neuroprotective properties. In this study, we investigated whether baicalin regulates γ-enolase expression in an moddle cerebral artery occulsion (MCAO)-induced brain injury model. Adult male rats were intraperitoneally injected with baicalin (100 mg/kg) or phosphate-buffered saline (PBS) immediately after right MCAO surgery. Neurological behavior tests were performed 24 hours after surgery and brain water content was evaluated. Right cortical tissue was collected. Western blot analysis were conducted to elucidate γ-enolase expression in MCAO animals treated with baicalin. In addition, γ-enolase expression was analyzed using immunofluorescence staining. MCAO animals administered PBS displayed severe behavioral impairments and edema, whereas baicalin administration alleviated these disorders, demonstrating the protective effects of baicalin against ischemic damage. Western blot analysis results showed that MCAO-induced damage decreased γ-enolase expression, and baicalin treatment mitigated this reduction. These findings were confirmed through immunofluorescence staining. Since γ-enolase is known to contribute to neuroprotective effects, these results suggest that baicalin alleviates neurobehavioral impairments in stroke animals and exerts neuroprotective effects by attenuating the decline in γ-enolase expression caused by brain injury. In conclusion, we demonstrated that baicalin regulates γ-enolase expression during cerebral ischemic damage.

본 연구는 무용을 기반으로 한 연극과 사진을 활용한 문화예술교육 프 로그램 참여가 성인 발달장애인의 자율성, 자기표현, 사회적 행동에 미치 는 효과를 분석하였다. 이를 위해 G시 인재평생교육진흥원과 A대학교가 협업하여 진행한 장애인 문화예술교육 특화 프로그램에 참여한 성인 발달 장애인 10명을 대상으로 연구를 진행하였다. 연구방법은 양적연구와 수업 관찰 및 면담조사 등의 질적 연구를 병행한 혼합분석방법을 활용하였다. 연구결과, 무용 기반 연극과 사진을 활용한 문화예술 프로그램이 성인 발달장애인의 자율성, 자기표현, 사회적 행동에 긍정적인 효과가 있음을 확인하였다. 구체적인 내용을 살펴보면 첫째, ‘참여 정도’, ‘적극적인 표 현과 반응’, ‘창작 활동의 적극성’이 긍정적으로 변화하며 스스로 결정하 고 행동하는 자율성이 향상되는 모습을 확인하였다. 둘째, ‘표현 거부’와 ‘소극적인 표현’에서 점차 ‘적극적인 표현’, ‘망설임 없는 표현’, ‘자유로운 표 현’ 으로 변화되는 모습을 통해 자기표현이 향상됨을 확인하였다. 셋째, 상대방 행동에 ‘적극적인 반응’과 ‘경청’하는 태도를 보였고, ‘적극적인 팀 활동’, ‘협동 심’, ‘양보’, ‘배려’, ‘자신의 감정 통제’ 등이 긍정적으로 변화하는 모습을 확인하였다. 본 연구의 결과를 기반으로 장애인의 자율성, 자기표현, 사 회적 행동 촉진을 위한 문화예술교육의 방향을 시사점으로 제안하였다.

Italian ryegrass (Lolium multiflorum L.) is an annual forage crop widely cultivated across the globe for its excellent nutritional value and high productivity. Despite its importance, studies on differentially expressed genes (DEGs) involved in its morphogenesis remain limited. In this study, we employed a high-yielding mutant line developed through radiation mutagenesis to identify candidate genes associated with morphogenesis, focusing on Expansins (EXPs), GRFs (Growth regulating factors), GIFs (GRF-interacting factors), and growth hormone-related genes. RT-qPCR primers were designed, and differential gene expression analysis was performed. Gene expression was assessed in the leaves of seedlings at one to three weeks of age, comparing the control cultivar 'Kowinearly' with the mutant line. Expression patterns fell into four distinct categories: (1) genes consistently exhibiting lower expression in the mutant line across all developmental stages; (2) genes showing persistently low expression in the mutant, while the control displayed a sharp increase at early stages followed by a decline; (3) genes with low expression in the control but a marked early-stage increase in the mutant; and (4) genes with decreasing expression over time in the mutant, contrasting with gradually increasing expression in the control. These expression profiles highlight Actin and GRF6 as Group 1 genes, AXR1 (Auxin-resistant protein 1) and EXPB6 (c) as Group 2 genes, PEVMPP1 (Pyrophosphate-energized vacuolar membrane proton pump 1) as a Group 3 gene, and EF1A (Elongation factor 1-alpha) as a Group 4 gene, all of which are key candidate genes for the development of high-yielding Italian ryegrass cultivars.

Growth is a fundamental and vital characteristic of abalone, regulated by both cell number and size, and modulated by growth-related genes. The mollusk-like growth factor (MLGF) is a secreted protein that plays a key role in the growth and development of Pacific abalone. In this study, the growth-specific expression of Hdh-MLGF were analyzed under different conditions commonly encountered by Pacific abalone in aquaculture systems. The expression of Hdh-MLGF varied significantly with growth patterns, showed higher expression in rapid-growing individuals and lower expression in slow-growing abalone. Under starvation conditions, Hdh-MLGF expression was downregulated as the duration of starvation progressed. Under thermal stress, Hdh-MLGF expression increased during the first 12 hours at 25 °C stress. However, at 30 °C, the highest expression was recorded after 6 hours of thermal stress. These results provide valuable insights for future research on this growth factor in abalone and its aquaculture management.

Maca has been reported to alleviate male menopause symptoms in humans and experimental animals; however, its mechanism of action in improving male menopause has not been clearly identified. This study aimed to investigate the mechanism of action of gelatinized maca in improving male menopause by analyzing serum testosterone, testicular androgen receptor (AR) expression, and testicular oxidation-antioxidation balance. Gelatinized maca was administered orally to aged male C57BL/6 mice at three doses (500, 1,000, and 1,500 mg/kg/day) for 28 consecutive days. Serum biochemical analysis showed an increase in serum hydroxysteroid 17-beta-dehydrogenase 13 (HSD17β13) concentration at 1,500 mg/kg/day and a decrease in serum sex hormone-binding globulin (SHBG) concentration at ≥ 1,000 mg/kg/day. Gelatinized maca administration also resulted in the increased expression levels of testicular AR and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) at 1,500 mg/kg/day. Oxidative stress analysis showed an increase in testicular superoxide dismutase and glutathione reductase activities and a decrease in testicular malondialdehyde at 1,500 mg/kg/day. In conclusion, gelatinized maca administration to aged male mice increased HSD17β13, AR and CREB expression, and antioxidant capacity and decreased serum SHBG. The results of the present study suggest that gelatinized maca may be a useful substance that can help alleviate male menopause symptoms.

Sweetpotato (Ipomoea batatas L.) is a globally important food crop susceptible to root-knot nematode (Meloidogyne incognita) infection, which causes significant crop losses. Previous transcriptome and proteome analyses have identified several genes that show differential expression patterns in susceptible and resistant cultivars in response to root-knot nematode (RKN) infection. Among the genes responsive to this process, sporamin (SPO) genes were identified as the most abundant in the transcriptome analysis, and additional changes in the expression of SPO genes that showed specific responses to RKN infection were identified during nematode infection. In this study, we used SPO genes used in previous studies to identify expression patterns under various abiotic stress conditions. The expression of four SPO genes in sweetpotato leaves was investigated under conditions of drought, high salt, and stress-related chemicals treatment. The expression of G13675/TU22356, G34367/TU56356, and G34382/TU56395 increased similarly under dehydration and chemicals treatment conditions. On the other hand, G34367/TU56358 was constantly expressed during the stress treated conditions. This study is expected to be used as basic data on how the gene for the major protein SPO of sweetpotato responds to various abiotic stress conditions as well as nematode infection.