To investigate the effects of coated liposome from Discorea rhizoma extract (DRE) in streptozotocin (STZ)-induced, we evaluated changes in body weight, fasting blood glucose, blood insulin and blood lipid concentrations in mice. Mice were divided into four groups: (DC), diabetic DRE at 10 ㎎/㎏ (DRE-1), diabetic DRE at 50 ㎎/㎏ (DRE-2), and diabetic DRE at 250 ㎎/㎏ (DRE-3). Mice had free access to water and diet (10 weeks). The DC group showed higher blood cholesterol than the DRE-1, DRE-2, DRE-3 groups. In glucose tolerance test, the DRE-1, DRE-2, and DRE-3 groups increased after 30 minutes in decremental glycemic response area under the curve. Fasting blood glucose levels in the DRE groups significantly decreased through 4 weeks. Plasma total cholesterol, triglyceride and LDL-cholesterol concentrations were also lower in the DRE groups. On the other hand, the DRE-1, DRE-2 and DRE-3 groups showed higher HDL-cholesterol and insulin levels than the DC group. Moreover, blood glucose and lipid levels significantly decreased in streptozotocin (STZ)-induced diabetic mice treated with DRE. These results indicate that DRE may reduce elevated blood glucose levels and serum lipid concentrations in hypoglycemic and diabetic mice, suggesting its usefulness as a functional food.

Marine ω-3 fatty fish가 정상인의 공복 혈당 및 기저 인슐린 농도에 미치는 영향을 살펴본 결과는 다음과 같다. Low ω-3 fatty acid군은 3.8g ω-3 fatty acid (EPA 1.0g, DHA 2.8g)를 포함, 약 1, 780kcal/day의 실험식을, high ω-3 fatty acid군은 7.7g ω-3 fatty acid(EPA 2.06g, DHA 5.68g)가 함유된 약 1, 815kcal/day의 실험식을 각각 1주일씩 투여받았으며, 실험 후 체중과 BMI는 두 군 모두에서 약간의 증가를 보였으나, 실험 전, 후의 체중 및 BMI가 모두 정상 범위였다. 공복 혈당농도는 low ω-3 fatty acid군이 실험 전 89.8±7.0mg/dl에서 88.7±8.5mg/dl로, high ω-3 fatty acid군은 91.0±6.6mg/dl에서 89.8±6.7mg/dl로 두 군 모두 약간 감소하였으나, 유의성은 없었으며, 두 군간에 ω-3 fatty acid 투여량에 따른 유의적 차이는 나타나지 않았다. 기저 인슐린 농도는 low ω-3 fatty acid군이 4.02±1.44uU/ml에서 4.54±2.61uU/ml 약 12.9% 정도 증가하고, high ω-3 fatty acid군은 4.97±2.13uU/ml에서 5.19±2.19uU/ml로 약간 증가하였으나, 두 군 모두 유의성은 없었으며, 두 군간에 유의적 차도 존재하지 않았다. 이로 미루어 marine ω-3 fatty acid 투여는 인슐린 비의존형 당뇨병환자에 미치는 영향과는 달리, 정상인에 있어서는 일상적 섭취수준이나 그 보다 비교적 높은 섭취수준에도 glycemic control에 그다지 영향이 미치지 않을 것으로 사료된다.

Background : Insulin-like growth factor 1 (IGF-1) appears to enhance the differentiation of osteoblasts and to activate the mineralization of bone. Hence, the aim of this study was to investigate the effects of ginseng complex on the remodeling of rats tibia. Methods and Results : Ginseng complex significantly increased serum IGF-1 by 58% and 34.5% than the control, respectively. Treatment with α-amylase when manufacturing these extracts remarkably increased the concentration of IGF-1 by 63% and 36% above the control, respectively. This ways that this ginseng complex, especially α-amylase treated extracts, contained a higher level of IGF-1 secretion in the ginseng complex groups. In addition, increases of 8% in femuf length were found after 12 weeks of oral administration with ginseng complex (300mg/kg). Conclusion : These results mean that ginseng complex have beneficial effects on bone effects on bone growth via IGF-1.