본 연구는 표면 반응 분석법을 이용하여 곤드레 데치기 최적 공정 조건을 확립하고 각각의 공정으로부터 생산된 곤드레 추출물로부터 총 페놀 화합물, 플라보노이드의 함량, DPPH 라디칼 소거능 을 분석하였다. 최적 공정 확립을 위한 데치기 공정 범위로 온도는 70℃ - 99℃, 시간은 70 - 170 sec. 로 하였다. 데치기 공정 후 총 페놀 함량의 범위는 13.00 - 35.48 mg/g 이고 최대 예측 총 페놀함량은 35.48 mg/g, 총 페놀 함량의 경향을 보면 데치기 온도에 따라 급격히 감소하다가 증가하는 것으로 보 여 지므로 온도에 의해 더 많은 영향을 받는 것으로 나타난다. 플라보노이드의 함량의 범위는 2.31 - 8.38 mg/g 이고 최대 예측 플라보노이드 함량은 8.38 mg/g 이었다. 플라보노이드 함량의 경향을 보면 데치기 시간에 따라 서서히 증가하다가 급격히 감소하는 것으로 보여 지므로 시간에 의해 더 많은 영향 을 받는 것으로 나타났다. DPPH 라디칼 소거능의 범위는 42.10 - 67.14%이고 최대 예측 DPPH 라디 칼 소거능은 67.14%로 측정 되었다. DPPH의 경향을 보면 데치기 온도에 따라 증가하다가 급격히 감소 하는 것으로 보여 지므로 온도에 의해 더 많은 영향을 받는 것으로 나타난다. 따라서 데치기 공정 최적 조건은 온도 85℃와 시간 150 sec. 로 결정되었다.

OBJECTIVES : The objective of this study is to analyze the nonlinear behavior of block pavements using multi-load level falling weight deflectometer (FWD) deflections. METHODS: Recently, block pavements are employed not only in sidewalks, but also in roadways. For the application of block pavements in roadways, the structural capacities of subbase and subgrade are important factors that support the carry traffic load. Multi-load level FWD testing was conducted on block pavements to analyze their nonlinear behavior. The deflection ratio due to the increase in load was analyzed to estimate the nonlinearity of block pavements. Finite element method with nonlinear soil model was applied to simulate the actual nonlinear behavior of the block pavement under different levels of load. RESULTS: The results of the FWD testing show that the center deflections in block pavements are approximately ten times greater than that in asphalt pavements. The deflection ratios of the block pavement due to the increase in the load range from 1.2 to 1.5, indicating that the deflection increased by 20~50%. The material coefficients of the nonlinear soil model were determined by comparing the measured deflections with the predicted deflections using the finite element method. CONCLUSIONS: In this study, the nonlinear behavior of block pavements was reviewed using multi-load level FWD testing. The deflection ratio proposed in this study can estimate the nonlinearity of block pavements. The use of nonlinear soil model in subbase and subgrade increases the accuracy of predicting deflections in finite element method.

A nineteen years old male patient showed a cystic lesion in left maxillary canine to premolar area (#23-#25). This lesion was asymptomatic, and found during his routine radiological check in local clinic. In the radiological observation the cystic lesion showed round radiolucent image containing many calcified bodies which were usually small but irregular in shape, expanding tumorously and resulted in the displacement of canine and second premolar in the absence of first premolar. The lesion was surgically enucleated, and a cystic fibrous tissue containing abnormal teeth was removed and examined pathologically. With the histological observation of tumorous odontogenic epithelium including many ghost cells, which were closely associated with abortive teeth, the lesion was finally diagnosed as CCOT associated with complex odontoma. The ghost cells of CCOT was strongly positive for β-catenin, GADD45, and LC3, and slightly positive for MMP-9, while they were rarely positive for BCL2, Wnt1, HSP-70, and p38. Therefore, it was presumed that the ghost cells of CCOT might undergo dormant cell state through altered cytodifferentiation stimulated by severe growth arrest, DNA damage signaling, and abundant autophage formation.

Tri-isotropic (TRISO) coatings on zirconia surrogate beads are deposited using a fluidized-bed vapor deposition (FB-CVD) method. The silicon carbide layer is particularly important among the coated layers because it acts as a miniature pressure vessel and a diffusion barrier to gaseous and metallic fission products in the TRISO-coated particles. In this study, we obtain a nearly stoichiometric composition in the SiC layer coated at 1400oC, 1500oC, and 1400oC with 20 vol.% methyltrichlorosilane (MTS), However, the composition of the SiC layer coated at 1300-1350oC shows a difference from the stoichiometric ratio (1:1). The density decreases remarkably with decreasing SiC deposition temperature because of the nanosized pores. The high density of the SiC layer (≥ 3.19 g/cm2) easily obtained at 1500oC and 1400oC with 20 vol.% MTS did not change at an annealing temperature of 1900°C, simulating the reactor operating temperature. The evaluation of the mechanical properties is limited because of the inaccurate values of hardness and Young’s modulus measured by the nano-indentation method.

PURPOSES : The objective of this study is to evaluate the effect of size and depth of cavities on the pavement failure using the full-scale accelerated pavement testing. METHODS: A full-scale testbed was constructed by installing the artificial cavities at a depth of 0.3 m and 0.7 m from the pavement surface for accelerated pavement testing. The cavities were made of ice with a dimension of 0.5 m*0.5 m*0.3 m, and the thickness of asphalt and base layer were 0.2 m and 0.3 m, respectively. The ground penetrating radar and endoscope testing were conducted to determine the shape and location of cavities. The falling weight deflectometer testing was also performed on the cavity and intact sections to estimate the difference of structural capacity between the two sections. A wheel loading of 80 kN was applied on the pavement section with a speed of 10 km/h in accelerated pavement testing. The permanent deformation was measured periodically at a given number of repetitions. The correlation between the depth and size of cavities and pavement failure was investigated using the accelerated pavement testing results. RESULTS : It is found from FWD testing that the center deflection of cavity section is 10% greater than that of the intact section, indicating the 25% reduction of modulus in subbase layer due to the occurrence of the cavity. The measured permanent deformation of the intact section is approximately 10 mm at 90,000 load repetitions. However, for a cavity section of 0.7 m depth, a permanent deformation of 30 mm was measured at 90,000 load repetitions, which is three times greater than that of the intact section. At cavity section of 0.3 m, the permanent deformation reached up to approximately 90 mm and an elliptical hole occurred at pavement surface after testing. CONCLUSIONS : This study is aimed at determining the pavement failure mechanism due to the occurrence of cavities under the pavement using accelerated pavement testing. In the future, the accelerated pavement testing will be conducted at a pavement section with different depths and sizes of cavities. Test results will be utilized to establish the criteria of risk in road collapse based on the various conditions.

PURPOSES : Road subsidence occurs owing to road cavities, which cause many social and environmental problems, especially in cities. Recently, road cavities were detected by various ground radars and repair works were carried out against the detected cavities. The condition assessments related to the road cavities are necessary to understand the potential risk of the cavities. Therefore, in this study, a numerical study was performed to assess the various conditions of road cavities. METHODS : The numerical method adopted in this study is the discrete element approach, and it is suitable for analyzing the condition because it can consider the movement of the soil particles in the surrounded cavity areas. In addition, the triaxial test was modeled and performed under various cavity conditions inside the specimens. RESULTS: The conditions of different cavity locations and shapes were analyzed to identify the effect of cavity state. Three general cases of particle size distributions were formulated to identify the effect of surrounding ground conditions. As a result, the degree of decrement and volumetric strain were varied depending on the locations and shapes of the cavity. Only minor changes were observed when the particle size distributions were altered. CONCLUSIONS: The strength reduction was higher when the cavity formed was larger and located in the upper zone. Similar to the cavity shape, strength reduction and volume deformation are more influenced by the width than the length of the cavities. There is an influence from ground conditions such as the particle size distribution, especially on the wide cavity.

To prepare Mn4+-activated K2TiF6 phosphor, a precipitation method without using hydrofluoric acid (HF) was designed. In the synthetic reaction, to prevent the decomposition of K2MnF6, which is used as a source of Mn4+ activator, NH5F2 solution was adopted in place of the HF solution. Single phase K2TiF6:Mn4+ phosphors were successfully synthesized through the designed reaction at room temperature. To acquire high luminance of the phosphor, the reaction conditions such as the type and concentration of the reactants were optimized. Also, the optimum content of Mn4+ activator was evaluator based on the emission intensity. Photoluminescence properties such as excitation and emission spectrum, decay curve, and temperature dependence of PL intensity were investigated. In order to examine the applicability of this material to a white LED, the electroluminescence property of a pc-WLED fabricated by combining the K2TiF6:Mn4+ phosphor with a 450 nm blue-LED chip was measured.

황색 육아종성 췌장염은 드문 사례로서 저자들은 췌장의 고형 종양이 의심되어 수술 후 조직검사로 진단된 황색 육아 종성 췌장염(xanthogranulomatous pancreatitis)의 1예를 경 험 했기에 문헌 고찰과 함께 보고한다.

이 연구는 집중인성교육 프로그램의 Ⅰ·Ⅱ·Ⅲ 과정에 대한 프로그램의 운영, 교육내용, 교육강사 운용 등을 중심으로 문제점을 검토하고 개선방안을 제시하는 것을 목표로하였다. 이를 위하여 2015년 4월 현재 집중인성교육을 시행하고 있는 4개 교도소의 프로그램내용과 강사구성 등을 분석하였다. 연구를 진행하는 과정에서 수형자의 인성교육을 통해 재범억제는 물론 건전한 사회복귀를 추구하는 집중인성교육 프로그램에서 몇 가지 문제점을 확인하고, 개선방안을 제시하였다. 먼저, 프로그램의 운영과 관련하여, ① 프로그램의 연속성 확보를 위한 제도개선, ② 수용자의 자발적 참여를 유도하는 인센티브 개발, ③ 교육프로그램의 목적 명확화, ④ 프로그램에 대한 평가와 피드백을 통한 한국형 인성교육 프로그램 모델 개발 등이 그것이다. 다음으로, 집중인성교육 프로그램 내용과 관련하여, ① 단순 강의식 교육을 탈피하여 흥미와 참여를 유발할 수 있는 각종 교육기법의 활용, ② 시설 밖 프로그램의 활용 및 교류방안 모색, ③ 주도적 학습 프로그램의 일부 운영, ④ 죄종별 차별화된 인성교육 프로그램의 개발 등이 그것이다. 끝으로, 집중인성교육 교육강사 운용과 관련하여, ① 강사 관련 예산의 확보, ② 지역사회 전문가 집단 인력풀의 확보, ③ 내부강사의 재교육 및 위탁교육 내지 전종직원의 채용 등을 제안하였다.

췌장 신경내분비종양은 다양한 임상 양상과 예후를 보이는 암종으로 기본적으로 근치적 절제술이 우선시되나, 진행성 또는 전이성 종양의 경우 내과적 약물 치료, 색전술, 국소소작 치료, 동위원소 방사선표적치료 등의 다양한 추가 치료가 필 요하다. WHO 2010 grade 1/2의 췌장 신경내분비종양은 5FU, streptozocin, doxorubicin, etoposide, dacarbazine (DTIC), temozolomide 등의 다양한 항암제치료를 사용할 수 있지만, 항암화학요법은 반응 기간이 짧고 다양한 부작용이 발생하는 문제점이 있기 때문에, 최근 everolimus와 sunitinib 등의 분자 표적치료제가 개발되어 사용되고 있다. 또한 과거에는 호르 몬 과분비 증상 조절을 위해 사용되었던 소마토스타틴 유도 체가 항종양 효과를 보이는 것으로 증명되어, 추후 신경내분 비종양의 일차 치료제로 효과가 기대되고 있다. Grade 3의 췌장 신경내분비암종의 경우는 etoposide/cisplatin 항암화학요법이 주로 사용되고, 그 외 oxalipatin/capecitabine, temozolo-mide 등의 다양한 약물 치료가 시도되고 있다.

올해 7월, 미국 나이언틱사가 출시한 증강현실 (Augmented Reality, 이하 AR) 게임 ‘포켓몬 고’의 인기로 AR 기술을 접목한 게임에 대한 관 심도 폭증했다. 게임 유저가 AR 기기를 통해, 마 치 현실에 정말 살고 있는 듯이, 디지털 객체들을 시야에 구현하기 위한 과정에서, 현실 정보가 수집, 교환, 재가공 되는 모습을 실시간으로 체험하며 게임을 즐기는 것이 기존 VR 게임과 다른 점이다. 하지만 증강현실 게임과 관련된 법적 문제 분석 및 이에 대한 대비 규제책 마련은 현재로선 다소 부족한 편이다. AR 게임이 게임 콘텐츠의 지적재산권 외에, 기존의 가상 게임 구현 및 게임 유저의 플레이 과정에선 직접적으로 쓰이지 않았던 지리적 정보⋅게임 유저의 개인 정보와 같은, 이미 존재하는 현실의 데이터를 수집⋅가공⋅이용⋅배포하기 때문이다. AR 게임 관련, 이미 발생했거나 발생이 예상되는 문제들은 모두 유저들이 직접 현실에서 AR 게임의 기술과 게임 시스템을 구현하는 과정에서 문제가 발생한다. 이를 가상 공간에서 빚어진 문제로 볼지, 현실 공간에서 빚어진 문제로 다룰지에 대해 복잡한 논의가 대두될 수도 있다. 현재 가상 공간과 현실 공간을 규제하는데 우선적으로 적용하는 법리가 암묵적으로 고정 분류 되어있는 바, 앞으로는 기존의 게임 형태 혹은 공 간의 현실성을 초월해, 발생한 결과 자체의 현실적 구현 정도에 따라, 그에 맞는 법이나 규제를 적 용해야할 것으로 여겨진다. 그리고 이러한 복합적인 고려과정은 종국적으로는 규제 판단 및 적용 과정을 단순화시켜, 유저가 다양한 상황에도 직접 손쉽게 일괄적으로 사안을 해결할 수 있는 단순화된 보호 체계를 마련하는 경향이 대두되는데도 기여할 것으로 여겨진다.

PURPOSES: The objective of this study was to determine the relationship between the dielectric characteristics of asphalt mixtures and the air voids present in them using ground penetrating radar (GPR) testing. METHODS : To measure the dielectric properties of the asphalt mixtures, the reflection coefficient method and the approach based on the actual thickness of the asphalt layer were used. An air-couple-type GPR antenna with a center frequency of 1 GHz was used to measure the time for reflection from the asphalt/base layer interface. A piece of aluminum foil was placed at the interface to be able to determine the reflection time of the GPR signal with accuracy. An asphalt pavement testbed was constructed, and asphalt mixtures with different compaction numbers were tested. After the GPR tests, the asphalt samples were cored and their thicknesses and number of air voids were measured in the laboratory. RESULTS: It was found the dielectric constant of asphalt mixtures tends to decrease with an increase in the number of air voids. The dielectric constant values estimated from the reflection coefficient method exhibited a slight correlation to the number of air voids. However, the dielectric constant values measured using the approach based on the actual asphalt layer thickness were closely related to the asphalt mixture density. Based on these results, a regression equation to determine the number of air voids in asphalt mixtures using the GPR test method was proposed. CONCLUSIONS: It was concluded that the number of air voids in an asphalt mixture can be calculated based on the dielectric constant of the mixture as determined by GPR testing. It was also found that the number of air voids was exponentially related to the dielectric constant, with the coefficient of determination, R2, being 0.74. These results suggest that the dielectric constant as determined by GPR testing can be used to improve the construction quality and maintenance of asphalt pavements.