Though Farnesiferol C (FC) derived from Ferula asafoetida is known to have antiangiogenic and apoptotic effect in gastric, breast, nonsmall lung cancers, the underlying antitumor mechanism of FC is not fully understood so far. Hence, in the current study, apoptotic mechanism of FC was explored in colon cancers in association with carbon catabolite repression 4-negative on TATA-less 2 (CNOT2)/c-Myc signaling. Herein FC significantly increased cytotoxicity and reduced the number of colonies in HCT116 cells more effectively than in SW480 cells, though FC enhanced sub-G1 cell population in HCT116 and SW480 cells compared to untreated control. Consistently, FC activated the cleavages of Poly ADP-ribose polymerase (PARP) and Bax and attenuated the expression of pro-PARP and Cyclin D1 in HCT116 cells better than SW480 cells. Also, FC significantly reduced the expression of CNOT2 and c-Myc. Also, FC reduced of c-Myc stability in HCT116 cells by cycloheximide assay. Notably, CNOT2 depletion reduced the expression of c-Myc, while c-Myc depletion also attenuated the expression of CNOT2 in HCT116 cells, implying the crosstalk between CNOT2 and c-Myc. Furthermore, overexpression of c-Myc or CNOT2 promoted the expression of pro-PARP in HCT116 cells. Overall, these findings suggest that FC induces apoptosis via inhibition of CNOT2 and c-Myc in colon cancers for a potent anticancer candidate for further agriculture cultivation in Korea.

The present study presents an experiment in which online acronyms, formed from common fixed phrases or formulaic expressions, and in common usage in English medium computer-based communication, were presented to Korean university-level learners placed into either a control group or treatment group which was given instruction into the expansions and meanings of the acronyms. Their knowledge of the target vocabulary was measured using the Vocabulary Knowledge Scale (VKS) test in a pre-, post-, delayed post-test format. The pre-test results showed relatively little awareness or familiarity with the target online acronyms for either group. Repeated measures ANOVA analysis did not show differences between pre-test and immediate post-test scores for the control group, although the delayed post-test did show a significant improvement. The treatment group showed significant and robust gains in both immediate and delayed post-tests. Comparison between the groups wa s done by one-way ANOVA. This showed significant differences in gains between control and treatment groups, with a large effect, suggesting that brief explicit instruction sessions could result in large gains. Implications of the study findings for educators and learners are discussed.

This study explores the seismic performance of steel diaphragm walls in underground structures, a critical aspect of structural engineering. The study focuses on the effects of slab diaphragm flexibility, an often overlooked factor in seismic design. Traditional seismic designs often assume the slab acts as a rigid diaphragm, leading to inaccuracies in predicting how forces are distributed between the slab and walls during an earthquake. To address this, the authors model steel diaphragm walls using equivalent cross-sections and analyze shear forces in both rigid and semi-rigid diaphragm scenarios. Results show that semi-rigid diaphragms reduce the shear forces on the exterior walls while increasing them on the internal core, thereby affecting the overall stiffness of the structure. The study emphasizes the importance of considering diaphragm flexibility in seismic design to achieve more accurate predictions of structural behavior and improve construction efficiency.

A total of 225, 3 weeks old weaned pigs of the Landrace × Yorkshire × Duroc breeds with initial average body weight (BW) of 6.25±0.6 kg were randomly assigned to 3 different treatments based on their BW, with each having 5 replicates. Each replicate contained 15 pigs, resulting in 75 pigs per treatment group. The treatment included a basal diet (CON), CON + allicin and cinnamaldehyde mixture 500 ppm (ALI), CON + Bacillus-based probiotics 500 ppm (PRO) tested for 42 days in a 3-phase feeding program (0–14 as phase 1, days 15–28 as phase 2, and days 29–42 as phase 3). Result shows final BW (6.3%) and average daily gain (9.0%) in the overall phase were higher (p<0.05) in PRO compared with CON. At d 14, the level of Escherichia coli was lower (p<0.05) in ALI (12.0%) and PRO (13.2%) over CON. At days 28 (14.6%) and 42 (12.8%), the level of Escherichia coli was lower (p<0.05) in PRO compared with CON. The level of tumor necrosis factor-α was lower (p<0.05) in PRO over CON (15.0%). Superoxide dismutase (9.2%) and immunoglobulin A (19.4%) were higher (p<0.05) in PRO over CON. We concluded that dietary PRO at 500 ppm showed better performance in piglets by enhancing their growth performance and health.

본 연구에서 Acyrthosiphon (Acyrthosiphon) lactucae를 국내에서 처음으로 보고한다. 이 종의 무시성충에 대한 형태학적 정보, 분포지역, 기주 식물, 한국에 분포하는 Acyrthosiphon 속 종들의 분류키를 제공한다.

With increasing globalization and the urgent need for sustainable energy solutions, electrochemical water splitting has emerged as a crucial technology for clean energy production. In this study, we report the successful synthesis of 0.1 % Fe-doped NiS2 via a one-step hydrothermal method. The incorporation of Fe into the NiS2 matrix significantly enhances its electrochemical performance, as evidenced by a remarkable reduction in overpotential, to 180 mV at a current density of 10 mA cm-2, compared to 250 mV for undoped NiS2. Additionally, the Fe-doped NiS2 exhibits a reduced Tafel slope, high double layer capacitance, and lower charge transfer resistance than undoped NiS2, indicating improved reaction kinetics for oxygen evolution. These improvements are attributed to the enhanced conductivity and catalytic activity imparted by Fe doping, which facilitates more efficient charge transfer and reaction processes at the electrode surface. The results suggest that Fe-doped NiS2 is a highly promising and robust candidate for applications in electrochemical energy conversion. Moreover, the doping strategy employed here offers a valuable approach for tailoring the properties of other metal sulfides and chalcogenides, paving the way for the design of next generation electrocatalysts that can drive large-scale energy conversion processes with minimal energy loss.

Scaling relations are fundamental tools for exploring the morphological properties of galaxies and understanding their formation and evolution. Typically, galaxies follow a scaling relation between mass and size, measured by effective radius. However, a compact class of galaxies exists as outliers from this relation, and the origin of these compact galaxies in the local universe remains unclear. In this study, we investigate the compact dwarf galaxy SDSS J134313.15+364457.5 (J1343+3644), which is the result of a merger. Our analysis reveals that J1343+3644 has a half-light radius of 482 pc, significantly smaller than typical galaxies with the same brightness (Mr = −19.17 mag). With a high star-formation rate (SFR) of 0.87 M⊙ year−1, J1343+3644 is expected to evolve into a compact elliptical galaxy in a few million years. J1343+3644 could, therefore, be a progenitor of a compact elliptical galaxy. The phenomenon happened in early universe, where compact galaxies were common.

Background/Aim: This study investigated the relationship between albumin-bilirubin (ALBI) grade and advanced liver fibrosis in patients with a history of gallstone disease and cholecystectomy, focusing on those diagnosed with metabolic dysfunctionassociated steatohepatitis (MASH) using the acMASH algorithm. Methods: Data from 566 subjects in the National Health and Nutrition Examination Survey 2017-2020 dataset were analyzed. MASH and advanced fibrosis (AF) were determined using acMASH and acFibroMASH algorithms, respectively. Liver stiffness measurement (LSM), ALBI grade, and other fibrosis indices were evaluated. Results: Of 566 subjects, 13 (2.3%) were diagnosed with MASH, and 65 (11.48%) had AF. MASH subjects showed significantly higher LSM values compared to non-MASH subjects (p=0.032). ALBI grade demonstrated weak positive correlations with LSM, FIB- 4, and acFibroMASH in non-MASH subjects. The AUROC for ALBI grade in identifying AF was 0.631 (95% CI 0.590-0.671). Multivariate analysis confirmed ALBI grade as an independent predictor of AF (odds ratio 0.193, 95% CI 0.1025-0.2837, p<0.001). Conclusions: ALBI grade shows potential as a non-invasive marker for advanced liver fibrosis in patients with a history of gallstone disease and cholecystectomy, particularly in those with MASH. Further studies with larger MASH cohorts are needed to validate these findings.

본 연구는 지난 10여년간 고려대학교 및 한국과학기술연구원(KIST)에서 AMS를 이용하여 측정된 우주선유발 동위원소 10 Be의 준비 및 측정 과정을 다룬 보고서이다. 총 2 4세트의 표준물질과 107개의 Blank시료가 분석되었으며, 2017년 이후 표준물질의 측정 재현성이 크게 향상되어 국제적인 주요 실험실의 결과와 비교할 만한 수준의 성과를 보였다. 그러나 Blank 값은 사용된 9 Be 캐리어의 종류 및 석영 추출 과정과 AMS 측정 세팅 등 실험 조건에 따라 영향 을 받는 것으로 나타났으며, 이는 잠재적인 오염원을 체계적으로 추적하고 관리할 필요성을 시사한다. 본 연구는 10 Be Background 값을 줄이는 것이 우주선유발 동위원소 연구의 범위를 넓히는 데 중요한 역할을 함을 강조한다. 낮은 Background 값은 상대적으로 최근에 형성된 지형이나 오랜 시간 매몰되어 방사성 핵종이 상당량 감소한, 저준위 10 Be 지형의 연대측정을 가능하게 한다. 향후 연구에서는 실험 과정을 개선하고 가중평균 계산법 등의 새로운 통계적 방법을 도입하여 측정 오차를 최소화하는 데 중점을 둘 예정이다. 본 연구는 다양한 시간적 및 공간적 규모에서 지구표면과학 연구를 발전시키기 위한 우주선유발 동위원소 분석의 기반을 제공한다.

중국 소수민족의 민속학은 성 역할과 민족 정체성 간의 관계에 대한 귀중한 통찰을 제공한다. 문화 보존과 혁신의 주요 참여자로서, 여성은 사회 변화 속에서도 소수민족 전통의 회복력을 유지하는 데 중요한 역할 을 한다. 본 연구는 소수민족 여성들을 중심으로, 의식, 전통 의복 및 예 술적 표현에서의 상징적 역할을 탐구한다. 역사적 문서 분석과 현장 조 사를 결합하여, 다양한 공동체의 전통 노래, 춤, 구술 역사를 질적 방법 으로 분석한다. 연구 결과에 따르면, 여성은 문화적 관행을 계승할 뿐만 아니라 전통적인 성 역할과 현대적 영향을 통합하여 문화적 적응과 결속 을 이끄는 혁신적인 역할을 수행한다. 이 연구는 소수민족 민속학 형성 에서 여성의 핵심적인 역할을 강조하며, 다양한 사회에서 문화 통합의 역동성에 대한 폭넓은 통찰을 제공한다.

This study explored the development direction of punk fashion through 3D digital fashion design by analyzing the expressive characteristics and inherent meanings of the punk fashion expressed in Vivienne Westwood’s creations. To this end, the concept underlying punk and its expressive characteristics were examined, and the eco-friendly expressive attributes of punk fashion were scrutinized through photos of Vivienne Westwood’s collections. The analysis focused on 10 seasonal collections showcased over the past five years, from the designer’s 2018 S/S to 2022 F/W collections. The results revealed that Westwood’s punk expression was characterized by traditionality, eco-friendliness, playfulness, resistance, and deconstruction. Traditionality appeared in the form of a harmonious redesign of classics to create new works, while eco-friendliness was manifested through the use of slogans and eco-friendly materials and methods. Playfulness conveyed positive messages through comedic situations or characters, and resistance emerged as a means of delivering messages for improving social issues. Finally, the deconstruction of punk was reflected as resistance, boldly destroying fashion structures to express dissatisfaction with society. Punk design in fashion is one of the avenues in which designers effectively express the messages that they want to communicate to society. This study is significant, as it provides foundational data for exploring punk characteristic design strategies to be used in future fashion. The scope of application for 3D virtual clothing programs is expected to expand in the fashion industry, and continuous research on digital fashion design is anticipated.