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        검색결과 274

        54.
        2022.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Following the previous study, the toxicity of a single subcutaneous administration of the Thyrokitty injection (I-131) and the side effects that may occur at therapeutic doses were confirmed. The Thyrokitty injection (I-131) was administered subcutaneously once at a dose of 0, 2.0, 6.0, and 18.0 mCi/kg, 5 male and female rats per group, and mortality, general symptom observation, and weight measurement were performed for 2 weeks, followed by observation of autopsy findings. There were no deaths, and no statistically significant weight change was observed. Mild hair loss, fissures, and crusting were observed by general symptom observation, but it was not a toxic change related to the Thyrokitty injection (I-131). Gastric atrophy and a decrease in the size of the spleen were observed by the autopsy. As a results of single subcutaneous administration of the Thyrokitty Injection (I-131) to rats at a maximum dose of 18.0 mCi/kg, a decrease in the size of the spleen and gastric atrophy were observed as the dose of the Thyrokitty Injection (I-131) increased, which may be related to the test substance. No abnormal findings related to the Thyrokitty injection (I-131) were observed. Therefore, the approximate lethal dose of the Thyrokitty injection (I-131) was 18.0 mCi/kg or more. In addition, as reported for the treatment of feline hyperthyroidism with radioiodine (131I), side effects of the Thyrokitty injection (I-131) are expected to be extremely rare. Temporary dysphagia and fever may occur, but it will recover naturally. It should be administered with caution in cats with diseases such as urinary system, cardiovascular system, gastrointestinal system and endocrine system, especially with kidney disease. And it should not be used in cats who are pregnant, lactating, or likely. It is expected that the Thyrokitty injection (I-131) can be used for clinical treatment in Korea as a veterinary drug.
        4,200원
        55.
        2022.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        Radioiodine (131I) has been used for the treatment of feline hyperthyroidism since the 1990s in the USA and Europe, and it is recommended as the most effective treatment for feline hyperthyroidism because it has a high therapeutic effect, small side effects, and does not require anesthesia. In this study, the pharmacological properties of the Thyrokitty injection (I-131), which is being developed as a treatment for feline hyperthyroidism, using radioiodine (131I) as an active ingredient, was tested. The %cell uptake of the Thyrokitty injection (I-131) in FRTL- 5 thyroid cells was 0.410 ± 0.016%, which was about 18 times higher compared to Clone 9 hepatocytes, and it was decreased by 30.7% due to the competitive reaction with iodine (sodium iodide). In addition, the %cell growth of the FRTL-5 thyroid cells was reduced by 25.0% by treatment with the Thyrokitty injection (I-131). As a result of the tissue distribution test, the Thyrokitty injection (I-131) was distributed at the highest concentration at 0.083 hours (5 minutes) after subcutaneous administration to animals in most organs except the stomach, small intestine, large intestine, muscle and thyroid gland, and it was excreted mainly through the kidneys. The stomach and thyroid gland showed a typical distribution pattern observed when radioiodine (131I) was administered. In addition, about 78.45% of the total amount of excretion was excreted within 48 hours, of which more than 85% was excreted in urine. In conclusion, the Thyrokitty injection (I-131) has the same mechanism of action, potency, absorption, distribution, metabolism and excretion characteristics as radioiodine (131I) reported in connection with the treatment of feline hyperthyroidism. In the future, using the results of this study, it is expected that the Thyrokitty (I-131) could be safely used in the clinical treatment of feline hyperthyroidism.
        4,800원
        56.
        2022.12 KCI 등재 구독 인증기관 무료, 개인회원 유료
        PURPOSES : The aim of this study is to evaluate the effects of air voids, binder content, and aggregate gradation on the indirect tensile strength (IDT) and cracking tolerance index (CTindex) of cored asphalt pavements. METHODS : Cored samples were obtained from roads in Incheon city, and several laboratory experiments were performed. First, the cored samples were first to cut into a size appropriate for the IDT test. Subsequently, the air voids of the samples were measured. The damaged sample from the IDT test was loose mixed at 150 ℃ before the binder content was determined, which was conducted via an asphalt extraction test. Finally, the clean aggregates obtained from asphalt extraction process were analyzed in the aggregate gradation test. RESULTS : The result shows that an increase in air voids from 4% to 8% decreases the IDT and cracking tolerance index (CTindex) by 30% and 28%, respectively. Incorporating a binder enhances the ductile behavior of the asphalt mixture, resulting in a higher CTindex. Finally, the contribution of the aggregate grade on the IDT and CTindex is negligible. CONCLUSIONS : The IDT and CTindex are primarily affected by the air voids and binder content. A higher percentage of air voids results in a lower IDT. In addition, a higher amount of binder increases the IDT and CTindex of the cored samples. Meanwhile, the aggregate grade does not affect the IDT.
        4,000원
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