This study investigated ethopabate (EPB) residues in edible tissues of broiler chickens given in drinking water and established the withdrawal time (WT) of EPB in poultry tissues. Twenty-four healthy Ross broiler chickens were orally administered with EPB at the concentration of 3.8 mg/L for 14 days (EPB-1, n=24) and 15.2 mg/L for 7 days (EPB-2, n=24) through drinking water, respectively. After the drug treatment, tissue samples were collected from six broiler chickens at 0, 1, 3, and 5 days, respectively. EPB residue concentrations in poultry tissues were determined using LC-MS/MS. Correlation coefficient values ranged from 0.9980 to 0.9998, and the limits of detection and quantification (LOQ) were 0.03~0.09 and 0.1~0.3 μg/kg, respectively. Mean recoveries in muscle, liver, kidney and skin/fat tissues were 95.9~109.8, 108.7~115.3, 89.9~96.6 and 86.7~96.8%, respectively, and coefficient of variations were less than 17.11%. At the end of the drug-administration period (0 day), EPB was detected at levels under the LOQ in all tissues from both the EPB-1 and EPB-2 groups. According to the results of EPB residue in Ross broiler tissues, withdrawal periods of both EPB-1 and EPB-2 in poultry tissues were established to 0 day. In conclusion, the developed analytical method is suitable for the detection of EPB in poultry tissues, and the estimated WT of EPB in poultry tissues will contribute to ensuring the safety of Ross broiler chickens.

Background: Pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) offer the immense therapeutic potential in stem cell-based therapy of degenerative disorders. However, clinical trials of human ESCs cause heavy ethical concerns. With the derivation of iPSCs established by reprogramming from adult somatic cells through the transgenic expression of transcription factors, this problems would be able to overcome. In the present study, we tried to differentiate porcine iPSCs (piPSCs) into endothelial cells (ECs) for stem cell-based therapy of vascular diseases. Methods: piPSCs (OSKMNL) were induced to differentiation into ECs in four differentiation media (APEL-2, APEL-2 + 50 ng/mL of VEGF, EBM-2, EBM-2 + 50 ng/ mL of VEGF) on cultured plates coated with matrigel® (1:40 dilution with DMEM/F-12 medium) for 8 days. Differentiation efficiency of these cells were exanimated using qRT-PCR, Immunocytochemistry, Western blotting and FACS. Results: As results, expressions of pluripotency-associated markers (OCT-3/4, SOX2 and NANOG) were higher observed in all porcine differentiated cells derived from piPSCs (OSKMNL) cultured in four differentiation media than piPSCs as the control, whereas endothelial-associated marker (CD-31) in the differentiated cells was not expressed. Conclusions: It can be seen that piPSCs (OSKMNL) were not suitable to differentiate into ECs in the four differentiation media unlike porcine epiblast stem cells (pEpiSCs). Therefore, it would be required to establish a suitable PSCs for differentiating into ECs for the treatment of cardiovascular diseases.

Synced advertising (SA) has grown in popularity due to its ability to facilitate multitasking and personalize ads to the media content users consume. Research on the effects of SA has been limited, but it has been suggested that repetition and personalization with SA will lead to a stronger, lasting impression. However, there are concerns that SA could be perceived as intrusive and lead to privacy issues. This study seeks to explore how the consumer paradox between perceived relevance and privacy concerns may affect the outcome of the advertisements.

This study examines the impact of others' reviews (reviews, product ratings) on consumer responses (helpfulness & buying intention) in an online shopping platform. We propose that review features, such as review message construal and review inconsistency between review message valence and rating, determine review credibility as product-related information, which in turn influences helpfulness of review and buying intention toward the product. Specifically, low- level construal review messages will be perceived as more credible than high-level construal review messages, which affect helpfulness and buying intention. In addition, the effect of review message construal will be moderated by review inconsistency. The effect of the review message construal will be enhanced in the condition of review consistency (positive content-high rating & negative content-low rating), but it will be disappeared or attenuated in the condition of inconsistency (positive content-low rating, negative content-high rating).

본 연구는 아시아의 국제관계가 변화하는 맥락에서 "아시아 나토"의 실 행 가능성과 잠재적 영향을 검토한다. 아시아 버전 나토의 가능성을 분 석하기 위해 세 가지 목표를 추구한다: (1) 나토의 성격을 조사하고 아시 아에서의 잠재적 적용을 검토한다, (2) 세력균형이론과 위협균형이론의 관점에서 나토의 과거 실패를 검토한다, (3) 정치와 군사적 도전을 고려 한 아시아 나토의 실행 가능성을 평가한다. 이 연구는 미국과 일본을 중 심으로 아시아 나토에 대한 관심이 증가한 지정학적 변화를 탐구한다. 현재 미중 균형과 위협 사이의 균형은 양자 및 삼자 동맹을 설정하는 데 이르렀지만 아시아 나토의 가능성은 여전히 쉽지 않다. 그러나 중국이 지역 패권 추구로 인한 압도적인 외부 위협을 초래하면, 아세안 국가들 은 집단 안보 체제에 가입할 수 있다. 본 논문은 특히 이러한 상황에서 한국이 직면할 수 있는 문제점에 대해서도 지적한다.

The Body Appreciation Scale-2 (BAS-2) measures the extent to which individuals feel, accept, and respond to their own bodies in a positive manner. Given the research need to explore positive body image and its associations with various sociocultural factors and related consequences among individuals with various cultural backgrounds, several studies have established the psychometric properties and factor structures of the BAS-2 in different languages and samples with different characteristics. The current study investigated the psychometric properties and measurement invariance of a Korean version of the BAS-2 in an older Korean adult population (599 older Korean adults with the average age of 70 years). Data were collected using both online and offline (paper-based) survey questionnaires. The results of exploratory factor analyses and confirmatory factor analysis evidenced the unidimensional factor structure and measurement invariance of the Korean BAS-2 among older Korean men and women, after dropping item 1. Scalar invariance was supported across gender, and men and women did not significantly differ in observed mean scores of the Korean BAS-2. The results also supported good convergent validity and criterion validity. Incremental validity was demonstrated by predicting self-esteem over and above measures of age, BMI, subjective financial and health status, body esteem, and ageism. High internal reliability and test-retest reliability over a 2-week period were confirmed. Overall, the results of this study support the reliable use of a Korean BAS-2 to measure positive body image among older Koreans after excluding item 1.

According to NSSC Notice No. 2021-10, safety analysis needs to be introduced in the decommissioning plan. Public and occupational dose analyses should be conducted, specifically for unexpected radiological accidents. Herein, based on the risk matrix and analytic hierarchy process, the method of selecting accident scenarios during the decommissioning of nuclear power plants has been proposed. During decommissioning, the generated spent resin exhibits relatively higher activity than other generated wastes. When accidents occur, the release fraction varies depending on the conditioning method of radioactive waste and type of radioactive nuclides or accidents. Occupational dose analyses for 2 (fire and drop) among 11 accident scenarios have been performed. The radiation doses of the additional exposures caused by the fire and drop accidents are 1.67 and 4.77 mSv, respectively.

목적 : 본 연구는 만 50세 이상 성인에서 녹내장, 황반변성, 당뇨병성망막병증의 의사진단여부와 삶의 질의 관 련성을 알아보고자 하였다. 방법 : 국민건강영양조사 제7기(2016~2018) 자료 중 만 50세 이상의 성인으로 녹내장, 황반변성, 당뇨병성망 막병증의 의사진단여부에 따라 현재의 건강상태를 묻는 EQ-5D와의 관계를 분석하였으며, p<0.050인 경우 유의 한 값으로 판단하였다. 결과 : 녹내장, 황반변성, 당뇨병성망막병증에 영향을 주는 요인은 공통적으로 연령이었다. 이들 안질환과 삶의 질의 관계에서 녹내장과 당뇨망막병증은 일상 활동에서의 불편함이 있는 것으로 보였으나 통계적 유의성은 없었 다. 반면 황반변성은 자기관리 능력을 상실시킬 수 있는 위험이 유의하게 큰 것으로 나타났다[Odds ratio: 2.56(95% CI:1.05-6.25)]. 결론 : 본 연구에서 녹내장, 황반변성, 당뇨망막병증과 같은 주요 안질환은 연령과 관련이 있으며, 황반변성은 자기관리능력과 같은 삶의 질을 저하시킨다는 것을 확인하였다

From 2020, Korean Animal and Plant Quarantine Agency has reset the withdrawal time (WT) for veterinary drugs typically used in livestock in preparation for the introduction of positive list system (PLS) program in 2024. This study was conducted to reset the MRL for amprolium (APL) in broiler chickens as a part of PLS program introduction. Forty-eight healthy Ross broiler chickens were orally administered with APL at the concentration of 60 mg/L (APL-1, n=24) for 14 days and 240 mg/L (APL-2, n=24) for 7 days through drinking water, respectively. After the drug treatment, tissue samples were collected from six broiler chickens at 0, 1, 3 and 5 days, respectively. Residual APL concentrations in poultry tissues were determined using LC-MS/MS. Correlation coefficient (0.99 >), the limits quantification (LOQ, 0.3~5.0 μg/kg), recoveries (81.5~112.4%), and coefficient of variations (<15.5%) were satisfied the validation criteria of Korean Ministry of Food and Drug Safety. In APL-1, APL in all tissues except for kidney was detected less than LOQ at 3 days after drug treatment. In APL-2, APL in liver and kidney was detected more than LOQ at 5 days after treatment. According to the European Medicines Agency’s guideline on determination of withdrawal periods, withdrawal periods of APL-1 and APL-2 in poultry tissues were established to 3 and 2 days, respectively. In conclusion, the developed analytical method is sensitive and reliable for detecting APL in poultry tissues. The estimated WT of APL in poultry tissues is longer than the current WT recommendation of 2 days for APL in broiler chickens.

A low- and intermediate-level radioactive waste repository contains different types of radionuclides and organic complexing agents. Their chemical interaction in the repository can result in the formation of radionuclide-ligand complexes, leading to their high transport behaviors in the engineered and natural rock barriers. Furthermore, the release of radionuclides from the repository can pose a significant risk to both human health and the environment. This study explores the impact of different experimental conditions on the transport behaviors of 99Tc, 137Cs, and 238U through three types of barrier samples: concrete, sedimentary rock, and granite. To assess the transport behavior of the samples, the geochemical characteristics were determined using X-ray diffraction (XRD), X-ray fluorescence (XRF), Fouriertransform infrared spectroscopy (FTIR), scanning electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS), and Brunauer-Emmett-Teller (BET) analysis. The adsorption distribution coefficient (Kd) was used as an indicator of transport behavior, and it was determined in batch systems under different conditions such as solution pH (ranging from 7 to 13), temperature (ranging from 10 to 40°C), and with the presence of organic complexing agents such as ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), and isosaccharinic acid (ISA). A support vector machine (SVM) was used to develop a prediction model for the Kd values. It was found that, regardless of the experimental parameters, 99Tc may migrate easily due to its anionic property. Conversely, 137Cs showed low transport behaviors under all tested conditions. The transport behaviors of 238U were impacted by the order of EDTA > NTA> ISA, particularly with the concrete sample. The SVM models can also be used to predict the Kd values of the radionuclides in the event of an accidental release from the repository.

The organic complexing agents such as ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), and isosaccharinic acid (ISA) can enhance the radionuclides’ solubility and have the potential to induce the acceleration of radionuclides’ mobility to a far-field from the radioactive waste repository. Hence, it is essential to evaluate the effect of organic complexing agents on radionuclide solubility through experimental analysis under similar conditions to those at the radioactive waste disposal site. In this study, five radionuclides (cesium, cobalt, strontium, iodine, and uranium) and three organic complexing agents (EDTA, NTA, and ISA) were selected as model substances. To simulate environmental conditions, the groundwater was collected near the repository and applied for solubility experiments. The solubility experiments were carried out under various ranges of pHs (7, 9, 11, and 13), temperatures (10°C, 20°C, and 40°C), and concentrations of organic complexing agents (0, 10-5, 10-4, 10-3, and 10-2 M). Experimental results showed that the presence of organic complexing agents significantly increased the solubility of the radionuclides. Cobalt and strontium had high solubility enhancement factors, even at low concentrations of organic complexing agents. We also developed a support vector machine (SVM) model using some of the experimental data and validated it using the rest of the solubility data. The root mean square error (RMSE) in the training and validation sets was 0.012 and 0.016, respectively. The SVM model allowed us to estimate the solubility value under untested conditions (e.g., pH 12, temperature 30°C, ISA 5×10-4 M). Therefore, our experimental solubility data and the SVM model can be used to predict radionuclide solubility and solubility enhancement by organic complexing agents under various conditions.

In response to a regulatory mandate, all nuclear licensees are obligated to establish an information system that can provide essential information in the event of a radiation emergency by connecting the monitoring data of the Safety Parameter Display System (SPDS) or equivalent system to the Korea Institute of Nuclear Safety (KINS). Responding to this responsibility, the Korea Atomic Energy Research Institute (KAERI) has established the Safety Information Transmission System (SITS), which enables the collection and real-time monitoring of safety information. The KAERI monitors and collects safety information, which includes data from the HANARO Operation Work Station (OWS) and the HANARO & HANARO Fuel Fabrication Plant (HFFP) Radioactivity Monitoring System (RMS), and the Environmental Radiation Monitoring System (ERMS) & meteorological data. Currently, the transmission of this safety information to the AtomCARE server of the KINS takes place via the SITS server located in the Emergency Operations Facility (EOF). However, the multi-path of transmission through SITS has caused problems such as an increase in data transmission interruptions and errors, as well as delays in identifying the cause and implementing system recovery measures. To address these issues, a new VPN is currently being constructed on the servers of nuclear facilities that generate and manage safety information to establish a direct transmission system of safety information from each nuclear facility to the AtomCARE server. The establishment of a direct transmission system that eliminates unnecessary transit steps is expected to result in stable information transmission and minimize the frequency of data transmission interruptions. As of the improvement progress, a security review was conducted in the second and third quarters of 2022 to evaluate the security of newly introduced VPNs to the nuclear facility server, and based on the results of the review, security measures were strengthened. In the fourth quarter of 2022, the development of a direct transmission system for safety information began, and it is scheduled to be completed by the fourth quarter of 2023. The project includes the construction of the transmission system, system inspection, and comprehensive data stability testing. Afterward, the existing SITS located in the EOF will be renamed as the Safety Information Display System (SIDS), and there are plans to remove any unused servers and VPNs.

Decommissioning plan of nuclear facilities require the radiological characterizations and the establishment of a decommissioning process that can ensure the safety and efficiency of the decommissioning workers. By utilizing the rapidly developed ICT technology, we have developed a technology that can acquire, analyze, and deliver information from the decommissioning work area to ensure the safety of decommissioning workers, optimize the decommissioning process, and actively respond to various decommissioning situations. The established a surveillance system that monitors nuclide inventory and radiation dose distribution at dismantling work area in real time and wireless transmits data for evaluation. Developed an evaluation program based on an evaluation model for optimizing the dismantling process by linking real-time measurement information. We developed a technology that can detect the location of dismantling workers in real time using stereovision cameras and artificial intelligence technology. The developed technology can be used for safety evaluation of dismantling workers and process optimization evaluation by linking the radionuclides inventory and dose distribution in dismantling work space of decommissioning nuclear power plant in the future.