역사적으로 빈곤층을 대상으로 한 반빈곤 정책은 전통적인 빈민 구호 방식에서 인적 자본 형성과 경제 참여를 촉진하는 사회투자 전략으로 전 환되어 왔다. 미국의 개인발달계좌 (Individual Development Accounts, IDAs) 의 경우, 저소득층이 발달적 목표를 위한 자산을 축적하도록 장려 하고, 이를 통해 지속 가능한 경제적 안정을 달성하도록 설계된 대표적 인 자산형성 프로그램이다. 한국에서도 2010년부터 저소득층을 위한 자 산형성지원사업을 도입하였으나 프로그램의 주된 목표는 탈수급을 유도 하는 것이어서, 사회투자 전략에 기반한 장기적인 발달 목표를 지원하는 데는 한계가 있었다. 이에 본 연구는 빈곤층을 위한 자산형성 개념을 재 조명하고, 한국의 자산형성프로그램에 대한 시사점을 찾아보고자, 저소득 층을 위한 개인발달계좌의 원형적 시범 사업인 아메리칸 드림 시범사업 (American Dream Demonstration, ADD) 프로젝트를 주요 사례로 분 석하였다. 이를 위해 David Gil의 정책분석 틀을 적용하였고, ADD의 주 요 쟁점, 가치 전제, 제도적 메커니즘, 주요 성과와 시사점, 상호작용을 제시하였다. 끝으로 한국의 자산형성지원사업이 ADD에 내재된 사회투자 개념을 잘 활용할 수 있도록 정책 대안을 제시하였다.

Acute myocardial infarction (AMI) is considered the major cause of mortality in the world. Tremendous animal studies are performed to develop novel therapeutics, and this study aimed to induce porcine myocardial infarction model by using polyethylene terephthalate (PET). Coronary guidewire was placed in left anterior descending artery (LAD). The balloon angioplasty catheter was inserted at the back of the PET. The balloon catheter was carefully pushed forward, until the balloon marker was located in mid-LAD. Coronary angiography was performed pre- and post-occlusion at 28 days by C-arm. Histologic analysis of heart tissue was performed 28 days after inducing AMI. Thirty three pigs were anesthetized and underwent percutaneous coronary catheterization. All pigs were successfully embolized in mid-LAD by PET. Fifteen pigs died due to ventricular fibrillation during post-anesthetic recovery time, and overall experiment mortality was 45.5%. In 2,3,5- triphenyl tetrazolium chloride staining, gross finding of the ischemic heart lesion showed firm and white area of infarction associated with the apex and left ventricular posterior wall. Infarct on H&E-stained sections demonstrated a region without myocytes and rich with cardiomyocyte with atypical nuclei. Successful induction of AMI by using PET may provide the pathophysiological information of ischemic heart disease and improvement of therapy development for AMI.

This study was performed to evaluate antimicrobial resistance of food-borne pathogens isolated from retail meat in Korea. A total of 157 samples of beef, pork, and chicken were collected and analyzed for E. coli, Salmonella, Campylobacter. Resistances to tetracycline were declined in accord with reduced usage of tetracycline in live stock production. E. coli stains from chicken meat had higher multi-drug resistance ratio than strains from other meat. One extended spectrum beta lactamase (ESBL) producing E. coli and two ESBL producing Salmonella were identified in this study. ESBL producing Salmonella strains were confirmed to carry CTX-M-1 type genes.

This study was performed to evaluate antimicrobial resistance of food-borne pathogens isolated from retail meat in Korea. A total of 157 samples of beef, pork, and chicken were collected and analyzed for E. coli, Salmonella, Campylobacter. Resistances to tetracycline were declined in accord with reduced usage of tetracycline in live stock production. E. coli stains from chicken meat had higher multi-drug resistance ratio than strains from other meat. One extended spectrum beta lactamase (ESBL) producing E. coli and two ESBL producing Salmonella were identified in this study. ESBL producing Salmonella strains were confirmed to carry CTX-M-1 type genes.

The purpose of this study was to comparatively analyze the active stability of shoulder joints according to the frequency of overhead motions, such as serving and spiking, engaged in by female professional volleyball athletes who play different positions, and to provide the results as the basic data for developing exercise programs to prevent shoulder joint injuries. The subjects of this study were 50 Korean female professional volleyball players and positions were as follows: left and right attackers, centers, setters, and liberos. The external rotation and internal rotation muscle strength and muscle strength ratios of the dominant and non-dominant arms of all subjects were measured using Biodex. The results of this study are as follows: Frist, no significant differences were found in the internal and external rotation muscle strength of the dominant and non-dominant arms between positions. Second, for the shoulder joint muscle strength ratio of the dominant arm, by position, the setter showed significantly greater stability compared to the other positions. Third, for the shoulder joint muscle strength ratio of the non-dominant arm, by position, no significant difference in stability between positions was found. Fourth, it was found that the dominant arm had significantly greater instability of the shoulder joint than the non-dominant arm for attackers and centers, but no significant difference was found for setters and liberos. This study comparatively analyzed the muscle strength ratios of the external/internal rotations and dominant/non-dominant arms, which can determine the stability of the shoulder joints between female professional volleyball playing positions that engage in jumps and spikes using only the dominant hand and positions that do not.

The fragile X mental retardation (FMR) syndrome is the largest source of inherited mental retardation. The syndrome is usually caused by the transcriptional silencing of fragile X mental retardation gene (FMR-1). An 18 years old male wascompla띠ing of multiple toαh missing and abnormal facial profùe, of which signs were matemally dominant in his family. In the C)π。gene디c analysis the pa디ent and his parents did not show any discontinuity in the long arm end of X chromosome, but in the PCR produαs targeω19 the CGG repeat sequence in the 5' untranslated region of FMR gene both the patient'’ s and his mother' s gDNAs produced a normal and an extra bands, sized about 400 and 800 bps, respectively, while the his father' s gDNA produced only one normal band, sized about 400 bps. 까1US ， we suppose that the pa디.ent has heterozygotic alleles of FMR gene inherited matemally, and that the patient s FMR gene was in a premutated state relevant to the dentofacial abnormalities.

본 연구의 목적은 금강유역(9,645.5 km2)을 대상으로 극한 기후변화 사상에 따른 수문 및 유황의 변동을 평가하는 것이다. 본 연구에서는 객관적인 극한 기후변화 사상을 평가하기 위해 강우관련 극한지수(STARDEX)를 적용하고, GCM 10개의 RCP 8.5 기후변화 시나리오에 대해 4개의 평 가기간별(Historical: 1975~2005, 2020s: 2011~2040, 2050s: 2041~2070, 2080s: 2071~2100)로 분석하였다. 분석 결과 5개의 습윤 (CESM1-BGC, HadGEM2-ES), 중간(MPI-ESM-MR) 건조(INM-CM4, FGOALS-s2) 극한 기후변화 사상 시나리오를 선정하여 SWAT 모형에 적용하였다. 2080s 기간에서 중간시나리오 대비 2080s의 증발산은 -3.2~+3.1 mm로 변화하였고, 2080s의 총 유출량은 +5.5~+128.4 m3/s 변화하였다. 건조한 시나리오의 경우 2020s 중간시나리오대비 큰 변화를 보였다. 건조한 시나리오에서의 2020s의 증발산량은 -16.8~-13.3 mm 의 변화를 보였고, 총 유출량은 -264.0~132.3 m3/s의 변화를 보였다. 유황 변동의 경우, 2080s 기간의 습윤한 시나리오에서 CFR은 +4.2~+10.5, 2020s 기간의 건조한 시나리오에서는 +1.7~2.6으로 변화 하였다. 극한 기후변화 시나리오를 적용한 금강유역의 수문인자의 변화에 따라 유황분 석을 실시한 결과, INM-CM4는 극한 건조상태를 나타내기에 적절한 시나리오로 나타났고 FGOALS-s2는 유황변동이 큰 가뭄 상태 분석에 적절한 시나리오로 나타났다. HadGEM2-ES는 유황변동이 작게 나타났기 때문에 최대유량 분석 시 활용 가능한 시나리오로 평가되었고, CESM1-BGC 의 경우 유황변동이 큰 것으로 나타나 극한 홍수 분석 시 적용할 수 있는 시나리오로 평가되었다.

본 연구는 다목적함수를 고려한 입자군집최적화(Particle Swarm Optimization, PSO) 알고리즘을 Python으로 개발하고, Soil and Water Assessment Tool (SWAT) 모형에 적용하여 자동보정 알고리즘의 적용 가능성을 평가하였다. SWAT 모형의 유출 해석은 안성천의 공도 수위 관측소 상류유역(364.8 km2)을 대상으로 하였으며, 공도 지점의 2000년부터 2015년까지의 일 유량 자료를 이용하였다. PSO 자동보정은 결정계수 (coefficient of determination, R2), 평균제곱근오차(RMSE), NSE 모형효율계수(Nash-Sutcliffe Efficiency, NSEQ), 특히 중간유출과 기저유출의 보정을 위해 NSEINQ (Inverse Q)를 활용하여 SWAT을 보정하였다. PSO을 통한 SWAT 모형의 자동보정과 수동보정의 유출해석 결과, 각각 R2 는 0.64, 0.55, RMSE는 0.59, 0.58, NSEQ는 0.78, 0.75, NSEINQ는 0.45, 0.09의 상관성 분석결과를 보였다. PSO 자동보정 알고리즘은 수동보정에 비하여 높은 향상을 보였는데 특히 유출의 감수곡선을 개선시켰으며 적절한 매개변수 추가(RCHRG_DP)와 매개변수 범위의 설정으로 수동 보정의 한계를 보완하였다.

본 연구의 목적은 안성천 상류 공도유역(366.5km²)을 대상으로 SWAT 모형을 이용하여 미래 기후변화 평가에 있어, 미래의 토지이용변화를 동시에 고려하면 수문학적 거동에 얼마나 영향을 주는지를 분석하고자 하였다. 미래기후변화 시나리오는 HadGEM3-RA의 RCP 4.5와 8.5 시나리오를 이용하여 2030s (2020-2039)과 2050s (2040-2059) 기간으로 나누어 적용하였으며, 토지이용변화는 도시성장 시나리오에 따른 회귀모형 기반의 CLUE-s 모델을 이용하였다. 기준년(1976-2005) 대비 미래 강수량은 RCP 4.5에서 2030s에 최대 5.7%의 감소, 2050s에는 최대 18.5% 증가하였고, 미래 기온은 2030s RCP 4.5에서 최대 1.8°C, 2050s RCP 8.5에서 최대 2.6°C 증가하였다. 미래 토지이용은 2050년 도시지역이 58.6% (29.0 km²에서 46.0 km²) 증가하는 것으로 예측되었다. SWAT 수문 검보정은 14년(2002-2015) 동안의 공도관측소 일유량 자료를 이용하였으며, 저유량 모델효율의 향상을 위하여 2014-2015년 연속 가뭄년을 대상으로 보정을 실시한 결과, 하천유량(Q)과 1/Q을 대상으로Nash-Sutcliffe 모델효율은 각각 0.86과 0.76이었다. 미래 기후변화 시나리오만을 적용한 결과, 하천유출량이 2030s RCP 4.5에서 최대 24.2% 감소하다가 2050s RCP 4.5에서 최대 10.9% 증가하는 변화를 보여주었다. 한편, 기후변화와 더불어 미래의 토지이용변화를 함께 고려한 경우는 하천유출량이 2030s RCP 4.5에서 최대 14.9% 감소, 2050s RCP 4.5에서 최대 19.5% 증가하는 변화를 보여주어, 미래 기후변화에 따른 유역의 수문평가 시, 도시성장이 기대되는 유역 등 미래의 토지이용변화가 클 가능성이 있는 유역에 대해서는 토지이용변화 요소를 고려할 필요가 있다고 생각된다.

Acinetobacter baumannii is usually considered an opportunistic pathogen that it responsible for a variety of nosocomial infections, such as, pneumonia, tracheobronchitis, meningitis, endocarditis, peritonitis, skin and soft tissue infections, and urinary tract infections. However, over the years, the organism has developed substantial antimicrobial resistance, and thus, the management of infections has become more difficult. The less common infective endocarditis is one of the more serious consequences of nosocomial bacteremia. Here, we report the successful treatment of the first case of multidrug-resistant A. baumannii endocarditis in a 33-year-old patient.

Herb extracts commercially used in Korea were screened for PPAR-γ agonist test and α-glucosidase inhibition assay. Total 16 herb plants had a PPAR-γ agonist activity. Specially, Alisma orientale Juz (108.41%), Ephedra sinica (98.22%), Sasa japonica Makino var. purpurascens Nakai (140.68%), Astragalus membranaceus Bunge (106.79%) and Cnidium officinale Makino (113.00%) showed high PPAR-γ agonist activity rate compared with rosiglitazone's (167.46%). And Cornus officinalis S. et Z. (90.3%), Cinnamomum cassia Blume (89.2%), Psoralea corylifolia L. (89.8%), Paeonia japonica (Makino) Miyabe (92.4%) and Paeonia suffruticosa Andr (93.2%), showed high α-glucosidase inhibition rates. These results support previous reports of the efficacy of Oriental medicinal plants used for diabetes mellitus.

A reproducible transformation system via optimized regeneration media for Korean rice cultivars was established using Agrobacterium tumefeciens LBA4404 (pSBM-PPGN; gusA and bar). Although japonica rice genotypes were easier to produce transgenic plants compared to Tongil type cultivars, transformation efficiencies were not always correlated with regeneration efficiencies of non-transgenic callus on the control medium. Regeneration efficiencies of Donganbyeo, Ilmibyeo, and Manchubyeo were over 50% in non-transgenic control, however, transformation efficiencies were significantly low when only sucrose was added to the media as a carbon source. However, the medium, MSRK5SS-Pr (or MSRK5SM-Pr), that contains 5~textrmmgL-1 kinetin, 0.5~textrmmgL-1 NAA, 2 % sucrose (or maltose), 3% sorbitol, and 500~textrmmgL-1 proline, was the most efficient not only for regeneration of non-transgenic callus but also for regeneration of transgenic callus in the presence of L-phosphinotricin (PPT). Average transformation efficiencies of 16 Korean rice cultivars were significantly enhanced by using the optimized medium from 1.5% to 5.8% in independent callus lines and from 2.9% to 19.4% in tromsgenic plants obained. Approximately 98.9% (876 out of 885) transgenic plants obtained on optimized media showed basta resistance. Stable integration, inheritance and expression of gusA and bar genes were continued by GUS assay and PCR and Southern analysis of the bar gene. With Pst1 digestion of genomic DNA of transgenic plants, one to five copies of T-DNA segment were observed; however, 76% (19 out of 25 transgenic plants) has low copy number of T-DNA. The transformants obtained from one callus line showed the same copy numbers with the same fractionized band patterns.