PURPOSES : The purpose of this paper is to evaluate the performance of MAST composite pavement. METHODS : A Testbed with three different sections with varying pavement materials were constructed: Section 1 (MAST(Multi-Layered Asphalt Surface Treatment) Composite Pavement; RCC(Roller Compacted Concrete)+Modified DBST(Double Bituminous Surface Treatment), Section 2 (Aggregate base+Modified DBST), and Section 3 (aggregate base+General DBST). The structural stability and skid resistance were evaluated using LFWD test and sand patch test, respectively. Moreover, laboratory specimens of four different pavement materials (HMA(Hot Mix Asphalt), Gravel base+DBST, RCC+DBST, and RCC+Modified DBST) were fabricated using and the rutting resistance of each pavement type was evaluated using the MMLS3. RESULTS : As a result of the LFWD(Light Falling Weight Deflectometer) test, the elastic modulus of Section 1 was significantly higher compared to the other section with values between 450 MPa to 650 MPa. Meanwhile, the elastic modulus of Section 2 and Section 3 were almost similar from 50 MPa to 150 MPa. Moreover, sand patch test results showed that Section 1 and Section 2 have an excellent surface roughness with values higher than 0.7 mm but Section 3 has a poor surface roughness with MTD(Mean Texture Depth) value of 0.4 mm. Lastly, based on the results of the MMLS3(third scale Model Mobile Load Simulator) test, gravel base+DBST showed the lowest resistance to rutting among the four specimens, and both RCC+modified DBST and RCC+DBST showed good performance up to 600 loading cycles, but the rut depth increased rapidly until 1,000 loading cycles. CONCLUSIONS : MAST composite pavement(RCC+modified DBST) has superior structural stability compared to general DBST pavement (aggregate base+DBST), has excellent skid resistance with values higher than 0.7 mm, and has similar rutting resistance to that of general dense asphalt concrete pavement. Therefore, exhibiting its good performance in both structural and functional aspects, it can be concluded that MAST composite pavement(RCC+modified DBST) can be an effective alternative for pavement material in Southeast Asian developing countries where support for heavy vehicle loads is required and rutting is likely to occur.

A 11-year-old sexually intact female dog was presented because of a misshapen left elbow with a large mass. The masses on the elbow were diagnosed as high-grade canine mast cell tumor (cMCT) based on the cytological examination using fine-needle aspiration. Cytologically, the mass revealed moderate numbers of eosinophils, anisocytosis, anisokaryosis, and aberrant mitotic figures. The degree of cytologic dysplasia is diagnosed as moderate to severe. The blood analysis revealed low hematocrit and electrolytes. After examining the metastasis and surgical scope with radiographs and ultrasound, surgery was performed to removal the mass. Histopathologically, the mass revealed partially cytoplasmic granules, anisokaryosis of the nucleus, and mitotic counts. Scattered inflammatory cells and necrotic tissues were observed in the tumor. In this study, we found high-grade cMCT and treated the patient through a surgical approach.

함정에 있어서 레이더반사면적은 함정의 생존성과 직결되는 요소로써, 이에 대한 감소설계가 필요하다. 함정의 RCS에 영향을 주는 요소로써, 상부구조물, 함포, 레이더 등이 있다. 레이더의 경우 그 형상이 복잡하여 RCS 감소설계가 어려운 실정이다. 본 논문에서는 레이더의 RCS를 줄이기 위한 최신 기법 중의 하나인 폐위형 마스트에 대해 살펴보고 폐위형 마스트에 적용되는 주파수 선택 표면 (Frequency Selected Surface: FSS)의 특성을 파악하였다. FSS의 형상에 따른 가용 가능한 주파수에 대해 일반적인 레이더와 폐위형 마스트의 RCS 비교를 통해 폐위형 마스트의 RCS 감소 성능을 확인하였고, 해석 고각별, 구조물의 경사별 RCS 해석을 통해 특성을 파악하였다. 일반 적인 레이더의 경우 복잡한 형상으로 인하여 높은 RCS 값을 갖는 반면 폐위형 마스트의 경우 단순한 형상으로 인해 낮은 RCS 값을 갖는 것을 확인하였다.

Allergic diseases have increased rapidly over the past decades, affecting an estimated 20~30% of the population in developed countries. In this study, we investigated whether or not a typical costal sand dune plant Carex pumila (CPE) suppresses the activation of mast cells and IgE-mediated allergic response in vitro and in vivo. As the results, the extract of Carex pumila inhibited antigen-stimulated degranulation in RBL-2H3 cells and Bone marrow-derived mast cells (BMMCs), and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. CPE also suppressed the production of pro-inflammatory cytokines, TNF-α and IL-4, in antigen-stimulated mast cells. As its mechanism of action, CPE inhibited the activation of Syk in FcεRI-mediated signalling pathway, and that of LAT, a downstream adaptor molecule of Syk, in a dose-dependent manner. CPE also suppressed the activation of mitogenactivated protein (MAP) kinases, p38, ERK1/2, JNK, and Akt. Altogether, CPE inhibited mast cell activation and IgEmediated allergic response by antigen through suppressing the activation of Syk. These results suggest that CPE may be useful for the treatment of allergic diseases.

일반적으로 액체가스운반선은 인화성 화물이나 독성물질을 운반한다. 이러한 화물들은 폭발, 화재 및 인명손상을 가져올 수 있기 때문에, 액체가스운반선의 거주구역, 서비스 구역 및 통제실은 가스의 유입이 원천적으로 차단되도록 설계한다. 이러한 이유로, IMO IGC 코드의 멤브레인형 LNG선박의 화물탱크에 설치되는 벤트 출구의 높이는 노출갑판상 B/3 또는 6m 중 큰 것 이상으로 하고 작업구역 및 전후부 통행로, 갑판상의 저장탱크 및 화물설계 액위보다 6m 이상 높게 설치하여야 한다라고 규정하고 있다. 또한 LNG 시장이 점진적으로 증가하면서, LNG선박의 크기도 증가해 왔다. 때문에 현 규정에 의하면 LNG선박의 벤트의 높이는 선박 폭(B)에 비례하기 때문에 상당히 높아져야 할 것이며, 이는 높은 벤트 마스트(Mast)로 인하여 작업의 어려움 및 전방 시야를 방해하는 등 항해의 어려움을 초래한다. 본 연구에서는 멤브레인형 LNG선의 Sea-trial시에 측정하였던 데이터 및 CFD유동해석을 통해 LNG선박 화물탱크의 벤트 출구의 높이에 대한 적합성 평가를 수행한다.

본 논문의 1편에서는 레저선박의 실시간 선체구조모니터링시스템을 개발하기 위하여 도파로 어레이격자(AWG, Arrayed Waveguide Grating)와 광섬유 브래그격자센서(FBG, Fiber-optic Bragg Grating)를 이용한 선체구조모니터링시스템의 설계 및 적용 가능성을 검토하였다. 본 연구에서는 레저선박의 구조취약부의 실시간 모니터링을 위하여 광섬유센서 데이터의 측정 및 분석을 고속으로 처리할 수 있도록 시스템을 최적화하였으며, 레저선박의 선체구조안전모니터링을 위하여 레저선박의 선체 주재료인 FRP와 알루미늄 시편을 대상으로 재료 특성에 대한 기 초 데이터베이스를 구축하였다. 30feet 및 60feet급 세일요트의 알루미늄 마스트에 개발된 시스템을 적용하여 하중변화에 따른 변형률 특성 확인 및 레저선박의 선체구조안전성 평가를 위한 기초 연구를 수행하였다.

Ocjective : Sabaeksan has been used for the purpose of prevention and treatment of bronchial asthma and allergic asthma in korea. Methods : To investigate the biological effect of Sabaeksan, the author examined cytotoxicity and inflammatory cytokines secretion with human leukemic mast cell line, HMC-1. HMC-1 was stimulated with phorbol 12-myristate 13-acetate (PMA) and calcium ionophore A23187. Sabaeksan by itself had no effect on viability of HMC-1. Result : The effects of Sabaeksan on the secretion of tumor necrosis factor-alpha (TNF- α) and interleukin (IL)-6 from HMC-1 were evaluated with enzyme-linked immunosorbent assay. Sabaeksan (1 ㎎/㎖) inhibited PMA plus A23187-stimulated TNF-α and IL-6 secretion, by 43.86 ± 5.26%, 56.39 ± 3.65%, respectively. Sabaeksan also inhibited the NF-κB (p50/p65) expression. Conclusion : Taken together, these results suggest that Sabaeksan inhibit the production of inflammatory cytokines in HMC-1 cells through blockade of NF-κB activation.

Adenophorae Radix (AR) has been used as a traditional medicine for various diseases. However, the regulatory mechanisms of AR in allergic inflammation are not yet understood. The present study was conducted to investigate the effect and mechanisms of AR on the mast cell-mediated allergic response. To determine the pharmacological mechanisms of AR in allergic inflammation, we evaluated the effects of AR on the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β and IL-8 as well as the activation of nuclear factor-κB (NF-κB) and caspase-1 in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). Our results demonstrated that AR effectively attenuated the PMACI-induced production of TNF-α, IL-6, IL-1β and IL-8 in stimulated HMC-1. Additionally, we showed that the inhibitory effect of AR on inflammatory cytokines in PMACI-stimulated HMC-1 cells involved the suppression of the activation NF-kB/caspase-1 in PMACI-stimulated HMC-1. Collectively, these findings provide experimental evidence that AR may be a useful candidate for the treatment of allergic inflammation.

정상 발정주기를 보이는 7주령부터 38주령의 생쥐를 대상으로 발정주기에 따른 자궁조직내 비만세포의 분포를 toluidine blue 염색법으로 조사하였다. 비만세포의 밀도는 생쥐의 연령 증가와 더불어 지속적으로 증가하다가, 30주령 이후 감소하는 경향을 보였다. 발정주기별 분포에서는 조사한 모든 연령의 생쥐에서 발정후기에 가장 높은 밀도를 나타내었고, 그 대부분은 자궁근층에서 발견되었다. 10주령의 생쥐를 대상으로 Alcian blue-safranin

Eleutherococcus senticosus Maxim. has been successfully used as an oriental medicine for various diseases including allergic disorders. Histamine is a major factor on various allergic responses and it is reported that histamine was released from mast cells by sensitization of allergens. In this study, ethanol extracts from E. senticosus Maxim. were prepared and the composition was analyzed by high performance liquid chromatography. The eleutheroside B as a primary effective component of E. senticosus was contained approximately 225 mg/kg in root bark extracts. The extracts were found to significantly inhibit compound 48/80-induced histamine release form mast cells in dose dependent manner. However the extracts had low cytotoxicity on the mast cells with MTT assay. These results showed that E. senticosus Maxim. extracts may be the effective materials on inflammatory disorders.

수삼 추출물에서 홍삼특이 사포닌 성분의 함량을 증대시키고자 추출온도 및 시간에 따른 사포닌 성분별 함량 변화를 조사하였다. 수삼을 85℃에서 48시간 추출 시 총 사포닌 함량이 23.5 mg/g(D.W.)로 가장 많았으며, 본 조건에서 추출한 인삼추출물의 항알러지 기능성을 검토하고자 랫트 비만세포에서 compound 48/80로 유도된 히스타민 유리 작용을 억제하는 인삼추출물의 효능을 분석하였다. 인삼추출물의 비만세포에 대한 세포 독성 시험 결과 각 추출물은 수시간 노출시 높은 세포 생존율을 보이고 있었고 비교적 고농도인 0.5 mg/ml 처리군에서도 80% 이상의 세포 생존율을 보였다. 인삼추출물의 히스타민 유리 억제 효과를 조사하기 위해 랫트 비만세포에 대표적인 탈과립 유도제인 compound 48/80을 단독 또는 각 추출물을 동시에 처리한 후 얻어진 상청액의 히스타민의 정량을 실시한 결과 비만세포는 compound 48/80의 처리 조건에서 대조군에 비하여 30% 가량의 히스타민 유리량이 증가하였는데, 인삼추출물 처리 시 히스타민 유리 수준이 정상 수준에 가까이 감소하는 것을 확인하였다. 이는 인삼추출물의 항 알러지 목적으로의 이용 가능성을 제시하고 있다.

The present study was conducted to investigate the anti-allergic reaction with Glycyrrhiza uralensis. We examined cell viability, β-hexosaminidase release, IL-4 and IL-13 mRNA expression from RBL-2H3 cell after pre-treatment with 0, 100, 250, 500, 1000μg/ml of Glycyrrhiza uralensis water extracts. Effects of Glycyrrhiza uralensis on the degranulation and pro-inflammatory cytokines (IL-4 and IL-13) expression were evaluated with β-hexosaminidase assay, and RT-PCR analysis. We observed that Glycyrrhiza uralensis concentrations from 100μg/ml to 1000μg/ml had no effect on cell survival. The release of β-hexosaminidase decreased significantly with all concentrations of Glycyrrhiza uralensis extracts. The expression of the IL-4 and IL-13 mRNA were decreased by Glycyrrhiza uralensis in dose-dependent manner. These results that Glycyrrhiza uralensis has an anti-histamin effects and controls IL-4, IL-13 secretion on allergic reaction.