마비성 패류독소 중독증(paralytic shellfish poisoning; PSP)은 삭시톡신과 그 유사체로 오염된 패류를 섭취했을 때 발생하며, 저림, 구토 등의 증상에서부터 근육 마비와 심각한 경우 호흡 마비로 이어져 사망에 이를 수 있다. 독 성등가계수(toxic equivalency factors; TEFs)는 다양한 마 비성 패류독소의 독성을 표준화하여 위험성을 평가하는 데 사용된다. 마비성 패류독소를 검출하기 위해 사용되던 마우스 생체 실험(mouse bioassay; MBA)에 대한 윤리적 문제가 제기되면서 고성능액체크로마토그래피와 같은 기 기 분석법으로의 전환이 시도되고 있지만, 유사체들의 적절 한 TEF를 설정하기 위해서는 여전히 동물 모델을 통한 생 체 내 독성 데이터가 필수적이다. 본 연구에서는 동물 수를 줄이면서도 신뢰할 수 있는 경구투여 독성 결과를 얻기 위 해 삼단계 반응표면-경로 (three-level RSP) 설계를 사용했다. 인증 표준 물질을 이용하여 각 독소의 초기 용량과 조정 계 수를 결정하고 시험을 진행했으며, STX.2HCl, NeoSTX, dcSTX, GTX1&4, GTX2&3, dcGTX2&3의 반수치사량 (및 TEF) 값은 각각 451.3 (1.00), 306.5 (1.47), 860.9 (0.52), 644.5 (0.70), 915.3 (0.49), 2409.3 (0.19)로 나타났다. 도출된 TEF 값은 2016년 WHO에서 권고한 TEF 값뿐만아니라, 이 전에 보고된 경구 투여 반수치사량을 기반으로 한 TEF 값 과 강한 상관관계를 보였다. 본 연구는 마비성 패류독소 뿐 만 아니라 신규 미관리 해양생물독소에 대해 적절한 TEF를 설정하는 데 있어 삼단계 반응표면경로 설계를 윤리적 우 려와 신뢰할 수 있는 독성 데이터의 필요성 사이에서 효과 적으로 균형을 맞출 수 있는 방법으로 제안한다.

내시경적 역행성 담췌관조영술 중 선택적 삽관은 유두가 보이지 않는 경우, 특히 게실 내 유두(intradiverticular papilla, IDP) 또는 점막 주름에 의해 유두가 덮여 있을 때 어려울 수 있다. Endoclip을 이용한 삽관술은 유두를 외번시키고 고정하는 데 효과적이며, 단독으로 또는 다른 기구와 함께 사용할 수 있는 안전한 기술이다. 본 증례에서는 endoclip을 사용하여 IDP 2예와 점막 주름에 의해 유두가 덮인 1예에서 성공적으로 유두 삽관을 수행한 경험을 보고한다. 두 증례에서는 endoclip만을 사용하여 보이지 않는 유두를 재위치시켜 삽관에 성공하였고, 한 증례에서는 endoclip을 이용해 여분의 주름을 카테터로 밀어 내어 삽관에 성공하였다. Endoclip을 이용한 유두 삽관술은 다양한 상황에서 단독으로 또는 다른 기구와 함께 적용할 수 있는 유용한 방법으로 평가된다.

PURPOSES : This study aims to evaluate the vertical displacement caused by differential drying shrinkage in concrete pavements within tunnels under various independent variables using structural analysis. METHODS : The behavior of differential drying shrinkage was assessed based on literature reviews of slab thickness and atmospheric humidity. The equivalent linear temperature difference (ELTD) values were analyzed using regression analysis. A three-dimensional solid element model of a two-lane highway tunnel section with six slabs was created using the ABAQUS finite element program by referring to standard drawings. Dowels and tie bars were placed in accordance with the highway standards of the Korean Highway Corporation. RESULTS : The results of a finite element analysis revealed no significant difference in vertical displacement owing to the type of slab base. However, thicker slabs exhibited a smaller vertical displacement. Additional dowels installed at the shoulder of the driving lane did not significantly inhibit vertical displacement. A narrower joint spacing resulted in a smaller vertical displacement. A comparison with field data from Tunnel A showed that the amount of differential drying shrinkage varied with the relative humidity of the atmosphere during different seasons. CONCLUSIONS : Increasing the slab thickness and reducing the joint spacing can improve driving performance by mitigating differential drying shrinkage during dry winter conditions. Future research will involve the creation of indoor test specimens to further analyze the behavior of differential drying shrinkage under varying conditions of relative humidity, slab base moisture, and wind presence.

목적: 본 연구는 실명을 유발하는 3대 주요 안질환의 연도별 유병률 추이를 관찰하고, 이들 질환의 인지율과 치 료율 비교와 관련 요인을 분석하고자 하였다. 방법: 질병관리청 국민건강영양조사 제8기(2019~2021년도) 조사에 참여한 대상자 중 만 40세 이상인 성인들을 대상으로 녹내장, 황반변성, 당뇨병성 망막병증의 유병률, 인지율과 치료율을 연도별로 비교하고 일반적 특성을 분 석하였다. 결과: 3대 주요 안질환의 연도별 추이를 보면 녹내장의 유병률은 매년 일정한 추이를 보이지만 당뇨망막병증의 유병률은 당뇨병 유병율과 함께 해마다 증가하고 있다. 연도별 인지율과 치료율은 다른 질환에 비해 녹내장이 높은 편이었으며, 황반변성의 인지율이 상당히 낮게 나타났다. 녹내장과 황반변성은 나이가 주요한 변수였으며, 황반변 성은 교육수준이 높아질수록 인지율과 치료율이 유의하게 높아지는 것으로 나타났다. 한편 당뇨병성 망막증의 경 우, 알코올 섭취는 인지율과 치료율을 감소시키는 것으로 나타났다. 결론: 본 연구를 통해 3대 주요 안질환의 인지율과 치료율에 대한 차이를 비교할 수 있었으며, 치료율에 미치는 다양한 요인 또한 확인할 수 있었다.

Pathogenic Escherichia coli strains are known to cause edema disease (ED) and postweaning diarrhea (PWD) in piglets. Although the exact mechanisms of pathogenicity that lead to ED-PWD remain to be elucidated, we investigated whether another E. coli adhesin, the plasmid-encoded adhesin involved in diffuse adherence (AIDA) might also be present in ED-PWD-causing E. coli isolates. It was showed that E. coli strains attach to HEp-2 cell assay in three different patterns. Twenty-two isolates were from faeces of preweaned pigs and 36 isolates were from faeces of postweaned pigs. The base sequences for specific oligonucleotide primers of PCR used in this study were constructed based on the regions of conserved sequences between forward (5′-3′) ACAGTATCATATGGAGCCA and reverse (5′-3′) TGTGCGCCAGAACTATTA. Product size was 585 base pairs. A total of 58 AIDA-positive E. coli were used for cell adherence pattern analysis of HEp-2 cell assay. Forty three isolates showed three distinct patterns that were localized adherence (LA), diffuse adherence (DA) and aggregative adherence (AA) patterns respectively. But fifteen isolates were nonadherent. LA (14 isolates) pattern was the most common, followed by DA (13 isolates) and AA (9 isolates) pattern. And three isolates showed a combination of the LA and AA patterns and 4 isolates showed a combination of the DA and AA patterns. Escherichia coli strains that cause nonbloody diarrhea in infants are known to present three distinct patterns of adherence to epithelial cells, namely, localized (LA), diffuse (DA), and aggregative (AA) adherence.

본 논문에서는 조선 후기의 대표적인 전통목구조인 수원 화령전 운한각의 구조성능을 평가하였다. 운한각의 가구구성 방식에 맞추 어 3차원 구조해석 소프트웨어인 midas Gen으로 해석모델을 정교하게 구축하였다. 정적해석으로 주요 구조부재의 안전성과 사용성 을 평가하였고, 고유치해석으로 동적거동특성을 평가하였다. 대부분의 부재가 안전성 및 사용성 기준을 여유 있게 만족하고 있으나, 외목도리에서 휨응력비가 기준을 20.7% 초과하고 있어 이 부재에 대해서는 장기적인 모니터링이 필요하다고 사료된다. 운한각의 고 유주기는 1.079초로 비슷한 규모의 전통목구조보다 약간 긴 편이며, 특히 후면 화방벽의 영향으로 2차모드에서 비틀림이 발생한 것으 로 분석된다.

본 연구의 목적은 뮤지컬 넘버의 샘플링을 통해 재창작 된 현대팝송을 분석하여 그 특징을 알아 보고, 이를 통해 뮤지컬 넘버의 샘플링이 대중음악에 기여하는 효과를 분석함으로써 음악적 창작 및 재현에 새로운 시각을 제공하는 데에 있다. 이를 위해 원작 뮤지컬의 개요 및 넘버 분석을 통해 원곡의 분위기와 쓰임새를 파악한 후, 가사 변형 양상을 통해 샘플링 곡의 메시지를 분석하고, 전체적인 음악 구성의 비교와 편곡 부분을 대조하여 살펴보는 연구 방법을 사용하였다 세 곡의 샘플링 양상을 분석한 결과, 대중음악에서의 뮤지컬 넘버 샘플링은 다섯 가지 유형의 효과를 도출 할 수 있었다. 첫째, 친숙한 멜로디의 사용으로 대중들과의 거리감을 좁힐 수 있는 가능성이 생긴 다. 둘째, 뮤지컬 곡이 가진 서사적 특성을 통해 주제의식을 강화시킬 수 있다. 셋째, 자유로운 가사 변형으로 원곡과 다른 메시지를 부각시킬 수 있다. 넷째, 편곡이나 새로운 가창방식을 통해 새로운 곡으로 재창조하여 신선한 느낌을 자아낼 수 있다. 다섯째, 앞서 나열한 네 가지의 효과를 이용하여 아티스트가 대중에게 전달하고자 하는 메시지를 매우 효과적으로 전달할 수 있다. 본 연구자는 대중음악에서의 뮤지컬 넘버 사용이 전 세계 다양한 청자들의 뮤지컬 진입장벽을 낮출 수 있고, 두 장르간의 융합이 양측의 인지도에 좋은 영향을 줄 수 있을 것이라고 생각하였다. 향 후, 본 연구가 앞으로의 대중음악 재창작에 다양한 관점을 제공하고, 국내 음악 산업 발전에도 기여할 수 있는 양분이 되길 기대한다.

The presence of tetracycline (TC) has been detected in the human living environment, and its complex structure makes it difficult to degrade. The green and efficient utilization of electroactivated persulfate advanced oxidation technology for the degradation of tetracycline remains a challenge. In this study, N-doped reduced graphene oxide (N-rGO) was prepared using a hydrothermal treatment method with urea as the nitrogen source. Four different mass ratios of graphene oxide (GO) to urea were synthesized, and the optimal mass ratio was determined through degradation experiments of tetracycline. The N-rGO/EC/PMS three-dimensional electrocatalytic system was constructed, and the influence of the experimental data on TC degradation, such as initial pH, PMS dosage and voltage, was determined. Characterization analysis using scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and other methods was conducted. The efficient catalytic ability of N-rGO was demonstrated through the generation of hydrogen peroxide ( H2O2) and consumption of peroxymonosulfate (PMS). The superiority of the three-dimensional (3D) electrochemical advanced oxidation process was proposed by combining different systems. Furthermore, the presence of hydroxyl radicals (.OH), persulfate radicals ( SO4 ·−), and singlet oxygen (1O2) was identified using electron spin resonance (ESR) technology. The utilization of N-rGO as a three-dimensional electrode, coupled with the advantages of PMS activation and electrochemical oxidation processes, is a promising method for treating organic pollutants in wastewater.

Background: Sleep accounts for approximately one-third of a person’s lifetime. It is a relaxing activity that relieves mental and physical fatigue. Pillows of different sizes, shapes, and materials have been designed to improve sleep quality by achieving an optimal sleep posture. Objects: This study aimed to determine which pillow provides the most comfortable and supports the head and neck during sleep, which may enhance sleep quality. Methods: Twenty-eight healthy adults (19 males and 9 females) with an average age of 29 years participated in this cross-sectional study. This experiment was conducted while the participants laid down for 5 minutes in four different pillow conditions: (1) no pillow (NP), (2) neck support foam pillow (NSFP), (3) standard microfiber filled pillow (SFP), and (4) hybrid foam pillow (HFP). The head-neck peak pressure, cranio-vertebral angle in supine (CVAs), cranio-horizontal angle in supine (CHAs), chin-sternum distance (CSD), and muscle tone of sternocleidomastoid were analyzed using one-way repeated measures analysis of variance (ANOVA). The significance level was set at p < 0.05. Results: The head-neck peak pressure was the highest in the NSFP condition, followed by the NP, SFP, and HFP conditions. The CVAs, CHAs, and CSD of the SFP were lower than those of the other pillows. Muscle tone was the highest in the NP condition, followed by the of NSFP, HFP, and SFP conditions. The participants subjective comfort level in both the supine and side-lying postures was highest in the HFP condition, followed by the SFP and NSFP conditions. Conclusion: This study can be used to establish the importance of pillow selection for highquality sleep. The results of this study, suggest that a hybrid pillow with a good supportive core and appropriate fluffiness can maintain comfort and correct cervical spine alignment during sleep.

The word Náyún (拏雲) appeared in the Tang Dynasty, which was mostly used to describe people’s lofty aspiration, and then produced the verb-object phrases with structure of “Verb (grasp) + Noun (cloud/fog rain/snow)” such as Náyúnwòwù (拏雲擭霧) and so on. In the process of use, ná yún wò wù have been replaced by same word class morphemes or near-synonymy morphemes, and produced phrases like Náyúntǔwù (拏雲吐霧) as well as Náyúnténgxiāo (拏雲騰霄) that describe high ability or magnificent momentum; these phrases are often used as predicates or objects in sentences. Sháobǔ (杓卜) originally refers to use the Big Dipper for divination, while the latter Sháo (杓) refers to wooden dippers and wine-taking dippers which are similar in shape to the Big Dipper. Because the soothsayers can’t be trusting, Zen-Buddhist takes Sháo (杓) to show that they can’t trust words to soothsayers, but should comprehend Zen by personally feeling and understanding. Driven by the evolution of Chinese disyllabic words and influenced by the flexibility and diversity of Zen language, the verb-object structure phrase Yāliángwéijiàn (壓良爲賤) has changed from a verb-object structure phrase to a verb Yāliáng (壓良) that means pushing someone.

PURPOSES : Pavement surface friction depends significantly on pavement surface texture characteristics. The mean texture depth (MTD), which is an index representing pavement surface texture characteristics, is typically used to predict pavement surface friction. However, the MTD may not be sufficient to represent the texture characteristics to predict friction. To enhance the prediction of pavement surface friction, one must select additional variables that can explain complex pavement surface textures. METHODS : In this study, pavement surface texture characteristics that affect pavement surface friction were analyzed based on the friction mechanism. The wavelength, pavement surface texture shape, and pavement texture depth were hypothesized to significantly affect the surface friction of pavement. To verify this, the effects of the three abovementioned pavement surface texture characteristics on pavement surface friction must be investigated. However, because the surface texture of actual pavements is irregular, examining the individual effects of these characteristics is difficult. To achieve this goal, the selected pavement surface texture characteristics were formed quantitatively, and the irregularities of the actual pavement surface texture were improved by artificially forming the pavement surface texture using threedimensionally printed specimens. To reflect the pavement surface texture characteristics in the specimen, the MTD was set as the pavement surface texture depth, and the exposed aggregate number (EAN) was set as a variable. Additionally, the aggregate shape was controlled to reflect the characteristics of the pavement surface texture of the specimen. Subsequently, a shape index was proposed and implemented in a statistical analysis to investigate its effect on pavement friction. The pavement surface friction was measured via the British pendulum test, which enables measurement to be performed in narrow areas, considering the limited size of the three-dimensionally printed specimens. On wet pavement surfaces, the pavement surface friction reduced significantly because of the water film, which intensified the effect of the pavement surface texture. Therefore, the pavement surface friction was measured under wet conditions. Accordingly, a BPN (wet) prediction model was proposed by statistically analyzing the relationship among the MTD, EAN, aggregate shape, and BPN (wet). RESULTS : Pavement surface friction is affected by adhesion and hysteresis, with hysteresis being the predominant factor under wet conditions. Because hysteresis is caused by the deformation of rubber, pavement surface friction can be secured through the formation of a pavement surface texture that causes rubber deformation. Hysteresis occurs through the function of macro-textures among pavement surface textures, and the effects of macro-texture factors such as the EAN, MTD, and aggregate shape on the BPN (wet) are as follows: 1) The MTD ranges set in this study are 0.8, 1.0, and 1.2, and under the experimental conditions, the BPN (wet) increases linearly with the MTD. 2) An optimum EAN is indicated when the BPN (wet) is the maximum, and the BPN decreases after its maximum value is attained. This may be because when the EAN increases excessively, the space for the rubber to penetrate decreases, thereby reducing the hysteresis. 3) The shape of the aggregate is closely related to the EAN; meanwhile, the maximum value of the pavement surface friction and the optimum EAN change depending on the aggregate shape. This is believed to be due to changes in the rubber penetration volume based on the aggregate shape. Based on the results above, a statistical prediction model for the BPN (wet) is proposed using the MTD, EAN, and shape index as variables. CONCLUSIONS : The EAN, MTD, and aggregate shape are crucial factors in predicting skid resistance. Notably, the EAN and aggregate shape, which are not incorporated into existing pavement surface friction prediction models, affect the pavement surface friction. However, the texture of the specimen created via three-dimensional printing differs significantly from the actual pavement surface texture. Therefore, the pavement surface friction prediction model proposed in this study should be supplemented with comparisons with actual pavement surface data in the future.

Hitherto, 37 species in 10 genera under 4 subfamilies have been known from the Korean Peninsula. In this study, three newly recorded species are reported for the first time from Korea: Conops ceriaeformis ussuriensis Zimina, 1974, Physocephala pielina Chen, 1939, and Myopa picta Panzer, 1797. Morphological diagnoses and illustrations of these species are presented. Additionally, a key to all species of Conopidae from Korea is also provided.

The genus Muscidideicus Becker, 1917 is comprised of only one species, M. praetextatus (Haliday, 1855) reported in west Palearctic region. The adults were typically found on sandy beach within the intertidal zone. In the survey of Korean fauna, authors found three new to science species of this genus on the west sea side of Korean Peninsula and Jeju Island. Descriptions and figures of external features of new to science species and key to species of the world are provided here.

Moth flies (Diptera: Psychodidae) are small fuzzy flies found in diverse habitats from mountains to urban areas, even in your house. Approximately 3,000 species among 6 subfamilies are recorded worldwide. However, in Korea, only 10 species from 3 genera of the subfamily Psychodinae have been recorded, including 8 species from North Korea. A preliminary study on moth flies in Korea was conducted using specimens collected via malaise traps and by hands from various locations in South Korea. As a result, Brunettia lungjingensis, Thornburghiella decoricornis, Philosepedon monstruosus and our friendly but unrecorded, Clogmia albipunctata are newly described in Korea. Brief descriptions, photographs, and illustrations of these four species are provided.

Three species belonging to two families of minute-sized spiders, viz, Theridiosoma fulvum (Araneae: Theridiosomatidae), Microdipoena ogatai and Microdipoena shenyang (Araneae: Mysmenidae), were discovered for the first time in Korea. Previously T. fulvum and M. ogatai were known to distribute only in Japan, M. shenyang only in China. All former records of Microdipoena jobi from Korea are misidentifications of M. shenyang. Detailed descriptions and photographs of three species are provided.

The genus Trixagus Kugelann is one of the most diverse genera in the family Throscidae Laporte, which comprises about 80 species. Only a single species of this genus has been reported in Korea throughout the entire family. In this study, three additional species, Trixagus sp., Trixagus leseigneuri Muona, and Trixagus turgidus Hisamatsu are reported for the first time in Korea. Similar to that of the species illustrated in Kovalev, males of Trixagus leseigneuri Muona and Trixagus turgidus Hisamatsu possess sexual modification on mesotarsus. Trixagus sp. and Trixagus turgidus Hisamatsu exhibit characters that are unusual for this genus, including the unincised eye, a blade-like structure on the protibia, and others. Illustrations of habitus and diagnostic characters of each species are provided.