본 연구는 운전 중 외부 소음으로 유발된 스트레스를 줄이기 위한 방법으로 심박변화율의 상관관계 분석의 선행연구와 음원의 주파수에서 운전자로 하여금 안정상태를 유발하는 음악과 소음 발생 시 심전도의 변화가 있는 지의 여부를 규명하기 위한 목적이다. 매년 자동차의 증가로 인하여 운전자 및 동승자가 외부 소음으로부터 스트레스가 증가하는 추세이다. 자동차 운전 시 외부 소음에 의한 스트레스는 불안, 면역약화, 우울, 심장 질환 등 여러 가지 질병을 일으키고 있다. 따라서 외부 소음으로부터 스트레스를 줄이기 위한 자동차 시뮬레이터를 실시하여 여러 가지 청각 자극을 주어 운전자가 반응하는 연구를 진행하였다. RM-ANOVA (Repeated Measures-ANOVA) 통계분석 결과, 집단별 유의차가 인정되었다(ρ<0.05). 사후 검정을 통해 어떤 요인 간의 차이가 발생하는지를 알아보았다. 사후검정 결과는 요인1(안정) 과 요인2(시뮬레이션운전), 요인1(안정)과 요인3(운전+경찰사이렌), 요인1(안정)과 요인4(운전+경찰사이렌+음악)에서 유의한 차이를 발견할 수 있었다. 또한, 교감신경계 활성도가 가장 높은 집단은 운전+경찰사이렌+음악을 실시한 요인 4이며, 다음으로 운전+경찰사이렌인 요인 3이며, 다음으로 운전을 실시한 요인 2, 마지막으로 안정기 순으로 나타났다. 결론적으로 운전 중 경찰 사이렌 소리를 들려주어도 심전도의 변화는 유의차가 인정되지 않았다. 또한, 사이렌 소리에 안정된 주파수의 음악을 들려주어도 심전도의 변화에 차이가 발생하지 않았다(ρ<0.01). 향후 연구에서는 운전 중 심전 도의 안정을 찾을 수 있는 여러 가지 음악을 들려주어서 심전도가 안정화되는 음악을 찾는 연구방법이 선행되어야 할 것이다.

본 연구는 지진에 저항하는 부재인 비보강 조적벽체로 구성된 건물의 내진성능평가에 활용되는 비선형 정적해석을 위한 비보강 조적벽체의 해석모델을 수립하고자 하였다. 본 연구의 해석모델은 비보강 조적벽체의 휨거동을 모사하기 위한 파이버 요소와 비보강 조적벽체의 전단에 대한 응답을 예측하기 위한 전단스프링 요소로 구성된다. 본 논문은 먼저 제안하고 있는 모델의 형상에 대해서 설명하고, 기존에 행해진 조적조 프리즘의 실험결과로부터 얻은 응력-변형률 곡선을 근거로 파이버와 전단스프링 요소의 물성치에 대한 결정 방법을 설명한다. 제시하고 있는 모델은 비선형 정적 해석결과와 다른 연구자들에 의해 수행된 실험결과를 비교하여 타당성을 검증한다. 해당 모델은 최대강도, 초기강성, 그리고 이들로부터 얻어지는 비보강 조적벽체의 하중-변위 곡선을 적절하게 모사하고 있다. 또한, 해석모델이 비보강 조적벽체의 파괴모드를 예측할 수 있는 것으로 나타난다.

The Hippo pathway was originally discovered in Drosophila by genetic screening and it has been shown to be conserved in various organisms including human. Until now, the essential roles of Hippo pathway in regulating cell proliferation, apoptosis, tumorigenesis, and organ size control is extensively studied. Currently, Mats1/2 (Mob1a/1b), one of the important components in Hippo pathway, mutant mice were generated which has abnormal phenotype such as resistance to apoptosis and spontaneous tumorigenesis. Of note, Mats1/2 mutant mice also showed dental malocclusion. Therefore, in this study, we have evaluated the bone phenotype of Mats1/2 mutant mice. Although the mRNA expressions of Mats1 or Mats2 were observed in both osteoclastogenesis and osteoblastogenesis, the increase of Mats1 level was most prominent during osteoblastogenesis. The RANKL-induced osteoclast differentiation from bone marrow-derived macrophages (BMMs) was unaltered upon Mats1/2 mutation; however, the osteoblast differentiation using calvarial pre-osteoblasts was significantly reduced in Mats1/2 mutant mice compare to that of wild type mice. In accordance with in vitro results, Mats1/2 mutant mice showed decreased bone volume as well as increased trabecular separation in μCT analyses. These results may provide novel prospect of the probable linkage between Hippo pathway and bone homeostasis.

The increase of feral cat population due to man-made activities, such as cat-mom activities, has become a social problem, although cats have lived with humans for a long time worldwide. Nevertheless, in Seoul City, the effectiveness of Trap-Neuter-Return (TNR) management plan has not been evaluated yet. In this study, we calculated the population size of feral cats in Seoul City, which is useful information for feral cat management. Seoul City was divided into 196 areas based on 2012 TNR density data. In each group, 3 areas were selected for a total of 9 areas. Out of those, 6 areas (3 apartment and 3 non-apartment areas) that could be clearly separated by mountains, rivers or roads based on Seoul City Geographical Information System (GIS) were finally selected and they were representative of the two different residential styles (44.21% apartment area and 55.79% non-apartment area). Population size of feral cats was estimated from 3 on-site surveys over 3 days. The results of the survey showed that the population of feral cats in Seoul City ranged between 209,772 and 272,816. Results of this study will be used to develop a policy to control and manage the population of feral cats.

This study investigates the microstructure and wear properties of cermet (ceramic + metal) coating materials manufactured using high velocity oxygen fuel (HVOF) process. Three types of HVOF coating layers are formed by depositing WC-12Co, WC-20Cr-7Ni, and Cr3C2-20NiCr (wt.%) powders on S45C steel substrate. The porosities of the coating layers are 1 ± 0.5% for all three specimens. Microstructural analysis confirms the formation of second carbide phases of W2C, Co6W6C, and Cr7C3 owing to decarburizing of WC phases on WC-based coating layers. In the case of WC-12Co coating, which has a high ratio of W2C phase with high brittleness, the interface property between the carbide and the metal binder slightly decreases. In the Cr3C2-20CrNi coating layer, decarburizing almost does not occur, but fine cavities exist between the splats. The wear loss occurs in the descending order of Cr3C2-20NiCr, WC-12Co, and WC-20Cr-7Ni, where WC-20Cr-7Ni achieves the highest wear resistance property. It can be inferred that the ratio of the carbide and the binding properties between carbide–binder and binder–binder in a cermet coating material manufactured with HVOF as the primary factors determine the wear properties of the cermet coating material.

현재 국내 용기포장재 안전성 평가를 위한 용출시험에서 액체 시뮬란트를 사용하는 경우 실제와 다른 이행량 결과를 나타내는 상황과 고온가열 및 건조식품용 포장재, 그리고 종이·판지의 경우 액체 시뮬란트를 사용할 수 없는 문제점들을 감안한다면 유럽연합과 같이 고체건조 시뮬란트의 도입이 필수불가결해 보인다. Tenax®를 건조식품용 시뮬란트로 사용하여 얻어진 실험 결과치가 실제 식품에서보다 높을 경우 Tenax®에 대한 기준치를 설정하여 안전성 평가 여부를 판단할 수 있을 것이라는 전제가 성립한다. 지금까지 많은 연구결과들이 이러한 전제를 입증하고 있다. 그러나, 아직까지도 Tenax®를 이용한 실험 방법이 완전하게 틀을 잡고 있지 못하다고 판단된다. 이는 Tenax®로 포집되어 측정되는 물질의 물리화학적 특성들이 매우 다양할 수 있는데, 이를 포장재로부터 또는 이행된 식품으로부터 추출분석하기 위한 용매, 추출방법, 추출시간, 오염표준물질들의 종류에 따른 추출 및 분석 방법, Tenax®의 상태에 따른 분석 재현성 등에 대한 자료들이 부족한 것이 사실이다. 국내에서 유통되는 다양한 식품종류를 감안한다면 Tenax®를 국내 식품포장재의 안전성 평가를 위한 고체건조 시뮬란트로 공식적으로 도입하기 위해서는 추가 연구들이 필요할 것으로 판단된다.

Oral adenosquamous carcinoma (ASC) is a rare and aggressive type of squamous cell carcinoma (SCC). It is characterized by a squamous component originating at the mucosa and a deep glandular component. ASC may be misdiagnosed as SCC by superficial incisional biopsy including only the squamous component. ASC has a worse prognosis than general variants of SCC, so accurate diagnosis is essential for patient survival. We present a case report of a large ASC arising in the buccal mucosa, first mistaken as general SCC.

연료 전지 구동 시 전기화학적 활성은 촉매와 연료, 전해질이 만나는 삼상계면에서 일어나며 연료전지의 성능은 이 삼상계면의 수에 영향을 받는다. 인산이 도핑된 Polybenzimidazole (PA-doped PBI)을 기반으로 한 고온 고분자 전해질막 연료전지 (HT-PEMFC)의 경우 막 내의 인산이 전해질의 역할을 하며 삼상계면 및 연료전지의 성능에 영향을 끼친다. PBI 막 내의 인산은 고분자 합성 용매인 폴리인산의 가수분해에 의해 생성된다. 본 연구에서는 Sol-Gel 법(Direct casting 법)으로 제조된 PA-doped PBI 막의 가수분해 조건을 달리하여 이에 따른 연료전지의 성능을 비교하여 보았다.

고온형 고분자 전해질 막 연료전지 (HT-PEMFC)는 100°C 이하의 저온 고분자전해질 운영 시스템에 비해 개선된 전극 반응 동역학, 뛰어난 물 및 열 관리, 연료 불순물에 대한 내성 및 폐열 이용과 같은 많은 이점을 제공한다. 그러나 HT-PEMFC는 구동 중 발생하는 물의 증발과 함께 분리막 내 인산이 증발하여 성능이 낮아진다는 단점이 있다. 때문에 본 연구에서는 이러한 인산의 유출에 대한 핫 프레스 유무, 전극 GDL 종류, 분리막 가수분해 조건, 셀 성능에 따른 영향을 인산의 비색정량을 통해 분석하였다. 그 결과 인산의 유출량은 주로 셀성능에 영향을 받으며 GDL이 치밀할수록 억제됨을 확인하였다.

This study develops an empirical prediction equation of spectral acceleration responses of earthquakes which can induce structural damages. Ground motion records representing hazards of low-to-moderate seismic regions were selected and organized with several influential factors affecting the response spectra. The empirical equation and estimator coefficients for acceleration response spectra were then proposed using a robust nonlinear optimization coupled with a regression analysis. For analytical verification of the prediction equation, response spectra used for low-to-moderate seismic regions were estimated and the predicted results were comparatively evaluated with measured response spectra. As a result, the predicted shapes of response spectra can simulate the graphical shapes of measured data with high accuracy and most of predicted results are distributed inside range of correlation of variation (COV) of 30% from perfectly correlated lines.

미국의 내진설계기준인 ASCE/SEI 7-10은 구조물 붕괴성능에 대한 불확실성을 고려하지 않는 등재해도 기반 내진설계의 문제점을 해결하기 위해 위험도 기반 내진설계 개념을 도입하였다. 하지만 현행 국내 내진설계기준의 경우 한반도 내에서 발생한 큰 규모의 지진기록과 구조물의 붕괴성능과 관련된 연구의 부족으로 위험도 기반 내진설계 개념을 반영하지 않고 있 다. 본 연구에서는 철골 보통중심가새골조를 표본건물로 선정하여 위험도 기반 내진성능평가를 수행하였다. 건물이 위치한 지역, 높이, 지반조건을 변수로 바탕으로 표본건물에 대한 붕괴성능 평가를 수행하였으며, 국내 지진기록의 특성을 반영할 수 있는 경험적 스펙트럴 형상 예측 모델을 활용하여 지진재해도 곡선을 작성하였다. 이를 활용하여 국내 주요 도시에 위치 한 철골 보통중심가새골조의 붕괴확률을 위험도 적분 개념에 따라 평가하였다. 국내 주요 도시에 위치한 철골 보통중심가새 골조의 붕괴확률을 평가한 결과, 현행 건축구조기준에 따라 설계된 표본건물은 본 연구에서 고려한 해석 변수에 따라 붕괴 확률에 상당한 차이를 보였다. 특히 국내 건축구조기준의 경우 철골 보통중심가새골조에 대한 높이제한이 없어 일부 고층 표본건물에서 목표 위험도인 50년간 1%의 붕괴확률을 초과하는 것으로 평가되었다.

In this study, we investigated the effect of bisphosphonate on the osteoblastic differentiation of human dental stem cells (hDPSCs). In the first experiment, we evaluated the effect of bisphosphonate on the differentiation of hDPSCs into osteoblasts by alkaline phosphatase staining after culturing hDPSCs. As a result, on day 13, the osteogenic differentiation of hDPSC was suppressed at 5 μM in clodronate and 2 μM in zolendronate. In NBP, osteogenic differentiation is more suppressed. In second experiment, cytotoxicity and proliferation test, the cell proliferation (examined by MTT assay) was more suppressed as the concentrations of zolendronate were larger than those of alendronate and clodronate. Western blotting, a third experiment, was found that AKT phosphorylation was inhibited in cell signaling proteins involved in cell proliferation inhibition and death by bisphosphonate concentration. In human dental stem cells, bisphosphonates inhibit osteoblast differentiation, and this phenomenon is clearly observed in NBPs (zolendronate), and it has been found that it is related to AKT phosphorylation of cell signaling proteins.

Connective tissue growth factor (CTGF, CCN2) is one of the multi-functional secreted proteins which belong to CCN family of cysteine-rich growth factors. CTGF is known to have pivotal roles in embryonic endochondral ossification but its role in relevance to periodontitis is never been determined. To identify new molecular mediators associated with periodontitis-induced bone resorption, we have analyzed publicly available GEO database and found the markedly augmented CTGF mRNA expression in periodontitis gingival tissues. The existence of CTGF significantly enhanced mature osteoclasts survival which accompanied by reduction in TUNEL-positive nuclei and PARP cleavage. These results may provide another line of evidence the CTGF mediated prolonged osteoclast survival and subsequent increased bone resorption in the periodontitis patients.

The purpose of this study is to consider the relation between the deciding factors of local identity and local image improvement. To achieve this purpose, the deciding factors of local identity have been set as the following four: historical identity, cultural identity, (nature) scenery identity, and industrial identity. The writer has established a model to represent the relation between these factors and the local image improvement, namely 'Visitor Satisfaction' and 'Revisit Intentions', and framed a hypothesis for empirical verification. The study results are as follows: First, the deciding factors of local identity which this study addressed are empirically proven to have a significant effect on the visitor satisfaction and the intention to revisit in which is it likely that the greater the impact of the deciding factors, the higher the visitor satisfaction and revisit intentions would be. Second, the deciding factors of local identity, it appears that the 'historical identity' factor had the largest impact on the visitor satisfaction, and the 'cultural identity' factor had the largest impact on the revisit intentions. Therefore, of the four deciding factors, the 'historical identity' should be considered the highest priority to increase the visitor satisfaction, and the 'cultural identity' should be considered the highest priority to increase the revisit intentions. Third, based on the verification of the relation between the visitor satisfaction and revisit intentions, it can be presumed that the greater the visitor satisfaction, the higher the revisit intentions would be.

This study was conducted to develop a dummy in an environment similar to the human body, to prepare a standard for evaluation and to present the process of the production in order to evaluate the performance of the robot that can detect the persons needing rescue in a confined space, who are difficult for fire-fighting officials to rescue in case of fire and disaster. As a result, a standard for evaluation was developed and standardized into four parts ‘Normal,’ ‘Risk Stage 1,’ ‘Risk Stage 2’ and ‘Risk Stage 3’based on the number of breath cycles, carbon dioxide concentration, core temperature and criteria for hearing to recognize the voice. In addition, in order to produce a dummy, fever, breathing capacity and voice output function were compared and analyzed. This study has significance that it built up basic data of the method of producing the actual dummy, by presenting characteristics and controlling methods using the waterproof insulation heating coil for the function, solenoid valve for the consecutive output of breathing capacity and USB program sound board for voice output.

This study investigates important parameters used to determine an effective peak ground acceleration (EPGA) based on the characteristics of response spectra of historical earthquakes occurred at Korean peninsula. EPGAs are very important since they are implemented in the Korean Building Code for the seismic design of new structures. Recently, the Gyeongju earthquakes with the largest magnitude in earthquakes measured at Korea took place and resulted in non-structural and structural damage, which their EPGAs should need to be evaluated. This paper first describes the basic concepts on EPGAs and the EPGAs of the Gyeongju earthquakes are then evaluated and compared according to epicentral distances, site classes and directions of seismic waves. The EPGAs are dependant on normalizing factors and ranges of period on response spectrum constructed with the Gyeongju earthquake records. Using the normalizing factors and the ranges of period determined based on the characteristics of domestic response spectra, this paper draw a conclusion that the EPGAs are estimated to be about 30 % of the measured peak ground accelerations (PGA).

We developed an Al sputtering process by varying the plasma power, process temperature, and film thickness. We observed an increase of hillock distribution and average diameter with increasing plasma power, process temperature, and film thickness. Since the roughness of a film increases with the increase of the distribution and average size of hillocks, the control of hillock formation is a key factor in the reduction of Al corrosion. We observed the lowest hillock formation at 30 W and 100 oC. This growth characteristic of sputtered Al thin films will be useful for the reduction of Al corrosion in the future of the electronic packaging field.