This study was investigated twenty two hazardous chemicals compounds for effluents of nine sewage treatment plants (STPs) and one waste water treatment plant (WWTP) in the Nakdong Ri-ver Basin. They are eleven phthalates(DMP, DEP, DIBP, DBP, BEEP, DNPP, DHP, DCP, DEHP, DNOP, Dinonyl phthalate, seven aliphatic hydrocarbons(n-Tridecane, n-Tetradecane, n-Pentadecan-e, n-Hexadecane, n-Heptadecane, n-Octadecane, n-Nonadecane, Isoquinoline, 2-Chloropyridine, 2-N-itrophenol, and Benzophenone. The twenty two compounds were analyzed by gas chromatograp-hy mass spectrometry (GC/MS) with liquid-liquid extraction (LLE). Twenteen of twenty two subs-tances were detected. They were DMP, DEP, DIBP, DBP, DEHP, n-Tetradecane, n-Pentadecane, n-Heptadecane, n-Octadecane, n-Nonadecane, Isoquinoline and Benzophenone. Among these, DEHP, DEP and Benzophenone were most frequently observed. They were obtained as ND~36.881 ㎍/L, ND~0.950 ㎍/L, ND~2.019 ㎍/L, respectively. When the substances were calculated the average concentration at 10 points, the maximum average detection concentration was investigated at the Dalseocheon STP.

상당한 국가예산이 투입되는 공공목적의 치수사업은 그 성공여부가 국가경제 전반에 걸쳐 큰 영향을 미치는 만큼 보다 정확하고 합리적인 경제성분석 결과를 바탕으로 타당성을 판단해야 한다. 그 동안 국내에서는 치수경제성분석 시 2004년의 치수사업 경제성분석 방법 연구에서 수행되어 개발된 다차원 홍수피해산정법(Multi-Dimension Flood Damage Assessment; MD-FDA)을 바탕으로 치수사업의 경제성 및 타당성을 계량적으로 평가하는데 실무에서 널리 사용되고 있으며, 이는 현재 KDI에서 수행하는 예비타당성조사에서도 채택되어 국내 대표적인 홍수피해산정법이라 할 수 있다.<br>이러한 MD-FDA를 적용하기 위해서는 각종 통계자료뿐만 아니라 토지피복도, 행정구역도, 침수구역도와 같은 GIS 공간자료의 수집 및 구축, 그리고 Spatial Analyst, 3D Analyst 기능 등의 공간분석 과정을 필요로 하며, 이와 더불어 자산분석, 홍수피해액 산정, 경제성분석 등에서 수자원 분야 지식뿐만 아니라 경제학적 지식이 다소 요구된다. 이러한 측면에서 치수경제성분석은 수자원 분야에서 다소 낯선 학문으로 취급되어 왔으며, 적용과정 또한 높은 이해도를 바탕으로 수행하기에는 한계가 있었다.<br>이에 본 연구는 통일된 분석체계를 바탕으로 자동화 실용 목적의 치수경제성분석 시스템(EAF)을 개발하였다. 본 시스템은 치수경제성분석 과정에서 요구되는 정확한 위치정보 탐색을 위하여 GIS 기반으로 설계(stand alone)하였으며, 시스템에서 지원하는 주요 기능은 치수경제성분석 시 필요한 공간데이터의 처리(침수구역도 생성 모듈 포함), 자산분석, 침수편입률 산정, 피해액 산정, 경제성분석이다. 본 연구에서 개발한 MD-FDA 기반의 치수경제성분석 시스템은 향후 치수사업의 경제성 및 타당성을 확인하는 의사결정 단계에서 보다 객관적이고 합리적인 분석도구의 역할을 담당할 것으로 기대한다.

In traditional Korean and Chinese medicine, safflower (Carthamus tinctorius L.) for the treatment of centralnervous system-related symptoms such as tremor, seizure, stroke and epilepsy. We investigated the effects of safflower couldinfluence cerebral ischemia-induced neuronal and cognitive impairments. Administration of safflower for 1 day(200㎎/㎏ body weight, p.o.) increased the survival of hippocampal CA1 pyramidal neurons after transient global brainischemia. And neurological functions measured as short term memory. Post-treatment with safflower for 2 times decreasedthe induction/reduction - induced production of neuronal cell loss from global cerebral ischemia. Safflower markedlydecreased neuronal cell death and also caused a decrease in the content of thiobarbituric acid-reacting substances(TBARS) (55.2±9.4µmol mg-¹) and significant improvement of activities of glutathione (GSH) (27.2±5.0µmol mg-¹) inhippocampus. We conclude that treatment with safflower attenuated learning and memory deficits, and neuronal cell lossinduced by global cerebral ischemia. These results suggest that safflower may be a potential candidate for the treatment ofvascular dementia.

Ginsenosides of roots in Panax ginseng were analyzed by metabolic-targeting HPLC using the partial leastsquares discriminant analysis (PLS-DA) and compared depending on sowing methods between direct seeding andtransplanting method. Score plots derived from PLS-DA could identify the sowing method between the direct seeding andtransplanting method in P. ginseng roots. The ginsenoside compounds were assigned as Rg1, Re, Rf, Rg2, Rb1, Rc,Rb2, Rb3, and Rd. Contents of Re, Rf, Rg2, Rb1, Rc, Rb3, and Rd of main roots produced from the transplanting methodwere relatively higher than those of samples produced from direct seeding method. Also, contents of Rg1, Re, Rf, Rg2, Rb1,Rc, Rb2, Rb3, and Rd of lateral roots from the transplanted samples were relatively higher than those of samples producedfrom direct seeding method. Therefore, HPLC with PLS-DA analysis can be a straightforward tool for identificationof ginsenosides in main or lateral roots of P. ginseng obtained from two different seeding methods between directand transplanting methods.

The purpose of this study was to research for anti-oxidation and anti-wrinkle effects of Acar mono Sap (AM). To cosmetic effect of AM, safety effect (MTT assay), anti-wrinkle effect (elastase, MMP-1 inhibition assay) and anti-oxidant effect (DPPH assay) were measured. When water extract of AM was used for cell viability, it was over 100% at 6% (6 ml/100 ml in phosphate buffer) concentration. AM showed 45.7% elastase inhibition and 23.7% MMP-1 inhibition at 50% (50 ml/100 ml in phosphate buffer) concentration so that it had good anti-wrinkle characteristic. And AM showed 68.9% antioxidation capacity at 50% concentration by using a DPPH assay. Consequently, AM can be used as natural materials or additives for human skin owing to their beneficial biologic functions, including the anti-wrinkle effect, for cosmetic compositions.

최근, 프리캐스트를 통한 모듈화에 대한 관심으로 인해 교량 및 빌딩 뿐만 아니라, 원전구조물, LNG 가스탱크, 중소형 강합성 구조물 등 특수구조물에도 프리캐스트 모듈화에 대한 연구가 활발하게 이뤄지고 있다. 본 연구에서는 프리캐스트 제작의 시공 및 작업성, 원활한 자재의 조달할 수 있는 방법으로 페로시멘트 (ferrocement)를 바탕으로 한 스틸메쉬로 보강된 모르타르 프리캐스트 패널을 제작하였다. 모르타르는 고강도 및 고유동성을 지니도록 실리카퓸과 고로슬래그의 배합율에 대한 변수연구를 통해 최적의 배합을 선정하였으며, 1,200×600×150mm의 패널을 제작하여 스틸메쉬로 보강한 모르타르 시편과 일반 철근콘크리트 시편을 보강비 2%와 4%로 각각 제작하였다. 제작된 스틸메쉬로 보강한 모르타르의 프리캐스트 모듈화의 적용 가능성을 판단하기 위하여 기본적인 재료물성실험과 자유건조수축실험을 수행하였으며, 선하중으로 하중을 재하하여 3점 휨 시험으로 스틸메쉬로 보강한 모르타르의 구조성능을 검토하였다. 실험결과를 통해, 스틸메쉬로 보강된 모르타르 프리캐스트 패널은 높은 휨성능 및 연성효과가 있으나, 4%로 보강된 스틸메쉬 모르타르 프리캐스트 패널은 전단보강에 대한 고려가 필요하다고 판단되며, 이에 대한 조치가 이루어진다면 프리캐스트 모듈화 부재로 적용이 가능하다고 판단된다.

Eucommia ulmoides OLIVER (EU) is a traditional Korean herbal used for the treatment of rheumatoid arthritis (RA). In the present study, the molecular pharmacology basis of its anti-inflammatory effect is revealed in this work, EU was studied in lipopolysaccharide (LPS)-activated macrophage cells (RAW 264.7) as an established inflammation model. After activation, nitric oxide (NO) production and iNOS mRNA were measured by using a colorimetric assay (Griess reagent), and reverse transcription polymerase chain reaction (RT-PCR), respectively. The change in the content of PGE2, TNFα, and IL-6 was concurrently monitored by ELISA. In results, we found that in the concentration range without showing cytotoxicity, EU produced a remarkable anti-inflammatory effect and showed a dose-dependent inhibition of LPSinduced NO production. Compared with indomethacin, EU has more potency and a specific action of NO inhibition, PGE2, IL-6, and TNF-α inhibition. These results suggest that EU may be a suitable herbal medicine to yield the greatest anti-inflammatory activity for food additives and medicine.

The bark of the root and stem of Ulmus davidiana var. japonica has been used as a traditional Korean medicine to treat inflammatory disorders. This plant reportedly shows antioxidant, anticancer, and anti-inflammatory effects. In this study, we investigated the protective effects of Ulmus davidiana var. japonica ethanolic extract (UDE) on UVB irradiation-induced wrinkle in hairless mice. We evaluated for their free radical-scavenging activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the anti-elastase activities, and for their anti-matrix metalloproteinase-1 (MMP-1) activity in human skin fibroblast cells. In the wrinkle measurement and image analysis of skin replicas, the results showed that UDE significantly inhibited wrinkle formation caused by chronic UVB irradiation. These results suggest that UDE has anti-wrinkle activity.

Root extract of Lythrum salicaria reported a hepato-protective effect on CCl4-induced liver toxicity of rat was prepared into fractions such as n-hexane up layer (HA), n-hexane down layer (HB), diethyl ether (E), ethylacetate (EA), n-butanol (B) and water (W). Fractions prepared were tested their activities in vitro and in vivo condition. All of the fractions showed effective antioxidant asctivities on DPPH radical and CuSO4-induced oxidation of human low density lipoprotein and E fraction showed the highest inhibitory effect (98.1% at 50 μg/ml) on linoleic acid autoxidation at 40℃, which was more effective than α-tocopherol (82.4%). Five fractions (H = HA plus HB, E, EA, B, and W, 150 mg/kg/day) were fed into Sprague Dawley, male rats for 4 days, which were intoxicated with intra-peritoneal injection of carbon tetrachloride (1 ml/kg in corn oil) at the 4th day and were sacrificed in 24 hrs. Serum tumor necrosis factor-alpha (TNF-α), a proinflammatory cytokine, elevated with CCl4-intoxication in negative control group (83 pg/ml) was significantly decreased in E fraction-supplemented group (18 pg/ml). Cu, Zn-superoxide dismutase (SOD) activity increased in negative control group (0.12 U/mg protein) was decreased in E fraction (0.07 U/mg protein). From the results, it is suggested that ether fraction from root extract of L. salicaria would be a potent antioxidant candidate for ameliorating liver injury induced by chemical intoxicant.

본 연구는 기존에 공학적 분석에 주로 치중하였던 대안수립 방법을 개선하여 경제적 측면에서 최적사업규모를 고려하는 방법을 제시하기 위한 것이다. 이를 위해서 치수사업을 투입과 산출에 의한 생산활동으로 정의하고 투입과 산출조합들을 최적화하는 방식의 대안수립 방안을 제시하였다. 본 논문은 제시된 방법론에 대한 사례연구로서 영산강유역 치수계획을 위한 대안들을 최적사업규모 결정을 통해 수립하였다. 최적사업규모 결정 결과, 최적대안의 순편익이 대안 내의 대규모 단

유역단위의 통합적 치수계획은 고려되는 단위사업의 수가 많고 그 특성도 다양하므로 이들을 조합한 최적의 대안을 수립하기가 쉽지 않다. 최적의 대안수립을 위해서는 홍수피해를 산정하는 것뿐만 아니라 감내할 수 있는 피해의 수준을 결정해야만 한다. 이에 대한 결정은 큰 틀에서 '사회적 합의'라는 방식으로 도출되지만 일차적으로는 기술적으로 가능한 범주에서 경제적 효율성 측면의 분석을 필요로 한다. 본 연구의 목적은 각 단위사업들의 조합이 경제적 효율성을 갖도록

Achyrantes japonica (AJ) has been used to treat edema and arthritis in the traditional Korean medicine. Toelucidate the anti-inflammatory and anti-nociceptive effects of ethanol extract of AJ, the carrageenan-induced pawedema using a plethysmometer and thermal hypersensitivity using the plantar test were measured. Ibuprofen was used asa control drug. Treatment with AJ (200㎎/kg p.o.) significantly reduced paw edema, compared to the carrageenan -treated rats. In the plantar test, the thermal withdrawal latency in AJ - treated group was significantly increased than thecarrageenan - treated group. The results indicate that AJ could have be the anti-inflammatory and anti-nociceptive prop-erties.

본 연구에서는 전국의 30년 이상의 강우관측기록을 보유하고 있는 기상청 산하 56개 강우관측소의 연 최대치 강우자료들로부터 확률분포형에 대하여 모멘트법, 최우추정법, 확률가중모멘트법을 이용하여 모수를 추정하고, 그 모수의 범위와 확률변수의 범위에 대한 적정성을 알아보았다. 적정성이 있는 모수를 대상으로 적합도 검정법인 x-검정, K-S검정, Cramer von Mises (CVM)검정, Probability Plot Correlation Coeffici