Background: Limb amputation causes complex physical, psychological, and social problems, yet evidence on International Classification of Functioning, Disability, and Health (ICF)-based multidisciplinary rehabilitation remains limited. Objectives: To report functional and emotional outcomes of an ICF Rehab- Cycle® program in a woman with bilateral transfemoral and transradial amputations. Design: Single-case report (quasi-experimental). Methods: A physiatrist, nurse, physical therapist, occupational therapist, and social worker used the ICF Assessment Sheet, ICF Categorical Profile, ICF Intervention Table, and ICF Evaluation Display over four weeks to set and review goals. Results: Nine of eleven ICF Rehab-Cycle® program targets were achieved. Marked gains were observed in gait and activities of daily living, accompanied by improved emotional well-being through structured psychosocial support. Conclusion: An ICF-guided multidisciplinary approach significantly enhanced physical function, emotional health, and independence after complex limb amputation, underscoring the value of the framework for patient-centered collaborative rehabilitation.

Field drying remains the primary bottleneck to consistent alfalfa haymaking under Korea’s humid, rain-prone summers. This study evaluated how dry matter (DM) yield and tedding frequency shape seasonal drying trajectories and leaf shatter in Cheonan during 2024. The experiment was conducted in May, June, August, September, and October 2024 with three DM yield levels (3, 5, and 7 ton/ha) and three tedding regimes (no tedding, once daily, and twice daily). Favorable May–June weather enabled swaths to reach <20% moisture within 100 h, whereas in September–October, moisture commonly remained ≥50%, indicating conditions unsuitable for dry hay. Yield effects on drying were generally small except in August, when re-wetting events accentuated between-group differences. Tedding effects were season-dependent: treatment differences emerged after rainfall in August and were evident in September, with twice-daily tedding producing the lowest moisture among tedding treatments. Leaf dropout rose with greater tedding frequency and higher DM yield; significant tedding effects were detected in June and September, and twice-daily tedding often exceeded no-tedding for leaf losses, particularly at 7 ton/ha. Collectively, omitting tedding is a viable option for May–June hay (4 days to ~20% moisture), while for post-June harvests, tedding offers limited drying benefits and may elevate leaf shatter; ensiling is therefore recommended when drying conditions are suboptimal.

Between July 2024 and July 2025, we collected spleen samples from 119 wild rodents captured across various zoogeographical regions of Gwangju City, Republic of Korea, to screen for major zoonotic pathogens, including Anaplasma, Babesia, Bartonella, Borrelia, Coxiella, Ehrlichia, and Rickettsia species. Of these, 13 samples (10.92%) tested positive for Bartonella spp. The positive samples were cultured on blood agar, resulting in eight bacterial isolates. Internal transcribed spacer (ITS) gene sequencing and phylogenetic analysis confirmed all Bartonella-positive samples as B. grahamii. Antibiotic susceptibility testing revealed that all B. grahamii isolates exhibited multidrug resistance (MDR) to ciprofloxacin, nalidixic acid, cefoxitin, streptomycin, and tetracycline, and showed intermediate resistance to ampicillin. In contrast, the isolates were susceptible to ceftazidime, cefotaxime, ceftriaxone, imipenem, gentamicin, amikacin, azithromycin, chloramphenicol, and trimethoprim/sulfamethoxazole. These findings provide essential baseline data on the presence and resistance patterns of B. grahamii in wild rodent populations inhabiting peri-urban environments. The detection of MDR Bartonella strains underscores a potential public health concern, particularly regarding zoonotic spillover via ectoparasites such as ticks. Sustained molecular surveillance and antimicrobial resistance monitoring are warranted to mitigate future zoonotic threats.

Myxomatous mitral valve disease (MMVD) is the most prevalent cardiac disease in dogs worldwide. Left atrial enlargement is a prominent feature associated with an increased risk of congestive heart failure in dogs with MMVD. Left atrial anteroposterior diameter (LAD) has been suggested as a supplementary parameter for evaluating LA size in various species. The purpose of our study was to establish a correlation between the left atrial anteroposterior diameter normalized to body weight (LADn) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in dogs with MMVD and to assess the diagnostic potential of LADn for MMVD. We conducted this study on 35 dogs and categorized them into the control and MMVD groups. The control group consisted of 10 dogs, whereas the MMVD group included 25 dogs classified into stages B1, B2, and C according to the American College of Veterinary Internal Medicine (ACVIM) guidelines. LADn was measured using echocardiography, and NT-proBNP levels were assessed using a fluorescent immunoassay. In conclusion, LADn shows promise as a valuable diagnostic marker of MMVD in dogs. The strong positive correlation between LADn and NT-proBNP levels demonstrates the usefulness of LADn as a clinical index for evaluating cardiac function and disease progression in dogs with MMVD.

본 연구는 DNVGL-CG-0127 및 통합공통구조규칙(H-CSR)이 적용된 유한요소해석(FEA)을 통해 검증된, 기존 드라이도킹의 지 속 가능한 대안으로서 안벽 부유식 구조 보수의 타당성을 연구하였다. 정수압 하중을 받는 75K 제품 운반선의 전역 및 국소 거동을 시뮬레이션하여, 보수가 필요한 무시할 수 있는 변위 변화(<1%, 12.3mm~12.4mm)와 von-Mises 응력(26.4MPa, 허용 한계값 188MPa의 14%) 에서, 구조적 무결성을 확인했다. 최적화된 보수 설계는 고강도 해양 등급 강재(예: AH36)와 하위 모델링 기법을 활용하여 Saint-Venant 의 원리와 선형 탄성 가정을 준수하면서 기하학적 불연속점의 응력 집중을 해결하였다. 선급 지침을 준수하면 유체역학적 안정성과 하 중 경로 충실도가 보장되어 선박 운항 중단을 최소화할 수 있습니다. 본 연구 결과는 비용 효율적이고 시간 효율적인 유지보수로의 패 러다임 전환을 보여주며, 기존 방식 대비 가동 중단 시간을 최대 30% 단축합니다. 향후 추진 방향에는 동적 하중 하의 피로 분석, AI 기반 최적화, 그리고 실시간 구조 건전성 모니터링을 위한 디지털 트윈 통합이 포함되며, 이는 해양 탈탄소화 및 운영 민첩성 목표 달 성에 부합한다. 본 연구는 노후화된 선박의 성능 개선을 위한 확장 가능한 프레임워크를 제공하며, 계산 정밀도와 지속가능성에 대한 업계의 요구를 충족한다.

Fabry disease is an X-linked lysosomal storage disorder caused by GLA mutations, leading to a deficiency in α-Galactosidase A activity and subsequent accumulation of globotriaosylceramide (Gb3). This accumulation contributes to progressive multiorgan dysfunction, with cardiovascular complications, particularly endothelial dysfunction and left ventricular hypertrophy being major drivers of disease morbidity and mortality. Although enzyme replacement therapy is currently the standard treatment, its effectiveness is limited in addressing advanced cardiovascular pathology. To better understand Fabry-associated vascular and cardiac phenotypes, an isogenic human induced pluripotent stem cell (hiPSC) model in which GLA was knocked out was developed using CRISPR/ Cas9. GLA-knockout (GLA-KO) hiPSCs were differentiated into endothelial cells (ECs) and cardiomyocytes (CMs) to evaluate disease-relevant phenotypes in vitro . GLA-KO ECs exhibited normal morphology and differentiation capacity but showed markedly impaired tube formation, high expression of inflammatory genes ICAM1, VCAM1, and SELE, and increased mitochondrial and cytoplasmic reactive oxygen species levels. GLA-KO CMs demonstrated enlarged cell size and nuclear translocation of NFATC4, consistent with hypertrophic remodeling. Together, these findings recapitulate key features of Fabry vasculopathy and cardiomyopathy in a genetically defined, human-derived system. This platform enables direct investigation of Gb3-induced oxidative and inflammatory mechanisms and provides a valuable model for the preclinical evaluation of therapeutic strategies targeting the cardiovascular manifestations of Fabry disease.