This study investigated the anti-inflammatory effects of processed (Beopje) curly dock (Rumex crispus L.) in LPS (lipopolysaccharide)-stimulated murine RAW 264.7 cells. The experimental group was classified into five groups : LPS no treatment, CD (curly dock), CD-B (CD processed through Beopje), LPS, LPS+CD-B (LPS+CD processed through Beopje) and LPS+CD (LPS+CD). Treatment of the Raw 264.7 cell lines using LPS led to a significant increase in NO production, pro-inflammatory cytokines (TNF-α, IL-6 and IL-1β), and inflammation related genes (COX-2 and iNOS). Investigation of the inhibitory effects of CD and processed CD on NO production and expression of iNOS and COX-2 was done in LPS-induced RAW 264.7 cells. There was significant inhibition of NO production by LPS+CD and LPS+CD-B in a dose-dependent manner (p<0.05). Particularly, LPS+CD-B exhibited reduced mRNA expression of iNOS and COX-2 and NO production as compared to LPS+CD in Raw 264.7 cell lines (p<0.05). These results may explain some known biological activities of curly dock including the anti-inflammatory effects. CD-B in particular exhibited the highest anti-inflammatory effects of inhibiting production of NO, through the regulation of inflammatory related genes and pro-inflammatory cytokines. These results of Beopje processing might help decrease the anti-biological effects and increase several active substances of curly dock

최근 한국에서 원전해체는 중요한 이슈이다. 원전의 운영 시와 비교해볼 때, 원전 해체 시에는 방사성물질의 방출이 크지 않을 것으로 예상되지만, 주민은 항상 방사선피폭으로부터 보호되어야 한다. 이에 대한 효과적인 관리를 위해, 연간 방출관리치와 방출한도치를 원자력안전위원회 고시 및 일반인 선량한도 기준으로부터 유도하였다. 기체상 유출물에 의한 대기 확산 및 침적 인자는 신고리 발전소 기상탑에서 2008년부터 2010년까지 3년간 수집 된 기상자료를 토대로 XOQDOQ 컴퓨터 코드를 이용해서 평가하였다. 선량평가는 ENDOS-G 컴퓨터 코드를 사용하였다. 이 컴퓨터 코드를 이용하여 기체상 유출물의 연간 방출관리치 및 방출한도치를 평가한 결과, 핵종별로 차이가 있었는데, 이는 연령에 따른 방사선민감도의 차이에 기인한다고 할 수 있다. 본 평가 방법 및 결과는 향후 원전 해체 시 방사성유출물 관리에 중요한 정보를 제공할 수 있을 것으로 판단된다.

We propose a method using QFD for design the hierarchical structure of AHP. This method provides definition for each area of House of Quality and design the hierarchical structure of the bottom-up QFD/AHP in which the upper hierarchy is designed through the classification of common characteristics with a focus on the lower hierarchy. Finally, we apply it to the development of an evaluation index for selecting heavy lifting service providers. This study has significance as the first instance of designing the archical structure of AHP after objectively verifying whether MECE condition, the basic requirement for AHP design, is satisfied.

본 연구는 황태채, 북어채 및 대구채간의 차이를 MS-전자코를 이용하여 분석하였다. 이들 각 시료의 mass spectrum은 뚜렷한 차이를 보였으며 판별함수분석을 통해 휘발성 성분의 패턴을 분석한 결과 황태채와 북어채, 대구채가 구분되었다(r2= 0.7787, F = 185.2). 이러한 결과는 황태채, 북어채 및 대구채를 러시아산만을 선택하여 비교한 결과 그 차이가 더욱 뚜렷이 구분되었다. 결과적으로 전자코를 이용하여 유사 식품 간의 차이를 충분히 구분 가능하였으며 EMA 식품을 선별하는 데에도 도움이 될 것으로 기대된다.

오징어 젓갈과 한치 젓갈의 차이를 질량분석기를 기반으로 한 전자코를 이용하여 분석한 결과 두 시료의 mass spectrum은 뚜렷한 차이를 보였다. 판별함수분석을 통해 휘발성분의 패턴을 분석한 결과 오징어 젓갈과 한치 젓갈이 뚜렷이 구분되었으며 젓갈의 양념을 제거한 후 분석하였을 때 구분이 더 잘되었다. 결과적으로 전자코를 이용하여 유사 식품 간의 차이를 충분히 구분 가능하였으며 이러한 결과는 추후 젓갈뿐 아니라 다양한 방면에 적용 가능할 것으로 보여 EMA 식품을 선별하는 데에도 도움이 될 것으로 기대된다.

The present study aimed to compare and analyze the particulars of and difference in medical expenses and their composition ratio for 2,026 patients hospitalized at 2 types of medical institutions (443 at a clinic and 1,583 at a hospital) in Jeonju-si, Jeollabuk-do under coverage of automobile insurance during 2009. From the analysis, it became evident that there were differences in individual characters of inpatients covered by automobile insurance, and details, composition and composition ratio of medical treatment for them depending on types of medical institutions. There was no difference, however, between the total and average medical expenses per capita even when markup rate was applied to the automobile insurance by types of hospitals. The ratio of radiotherapy and physical therapy in the composition of medical expenses was found to be extraordinarily high in clinics compared to that of hospitals. The composition ratio of the fixed cost including charge for hospitalization also turned out to be fairly high in all medical institutions.

The mu opioid receptor (MOR) has been regarded as the main site of interaction with analgesics in major clinical use, particularly morphine. The repressor element-1 silencing transcription factor (REST) functions as a transcriptional repressor of neuronal genes in non-neuronal cells. However, it is expressed in certain mature neurons, suggesting that it may have complex and novel roles. In addition, the interactions between MOR and REST and their functions remain unclear. In this study, we examined the effects of morphine on the expression of REST mRNA and protein in human neuroblastoma NMB cells to investigate the roles of REST induced by MOR activation in neuronal cells. To determine the effects of morphine on REST expression, we performed RT-PCR, real-time quantitative RT-PCR, western blot analysis and radioligand binding assays in NMB cells. By RTPCR and real-time quantitative RT-PCR, the expression of REST was found to be unchanged by either the MOR agonist morphine or the MOR specific antagonist CTOP. By western blot, morphine was shown to significantly inhibit the expression of REST, but this suppression was completely blocked by treatment with CTOP. In the radioligand binding assay, the overexpression of REST led to an increased opioid ligand binding activity of endogenous MOR in the NMB cells. These results together suggest that morphine inhibits the expression of REST in human neuroblastoma cells through a post-transcriptional regulatory mechanism mediated through MOR.

Purpose – The present study aims to examine the relationship between small enterprise start-up preparatory factors and increases in sales and operating profits, which are business performances utilizing the National Survey of Actual Conditions of Small Enterprises conducted by the Small Enterprise, Market Service. Research design, data, and methodology – Start-up preparatory factors were divided into six types; business type, start-up history, start-up motives, preparatory periods, and start-up funds to figure out the relationship between sales and operating profits with regression analyses. Regression analyses were conducted based on the foregoing with a view to identifying the effects of start-up preparatory factors on business performance. Results – Since start-up preparatory factors generally affect business performance, it was identified that start-up preparatory factors importantly affect operating profits and sales, which are business performances. However, start-up preparatory periods and the implementation of education among preparatory activities were shown to have no effect on business performances, and the effect of the ratio of start-up fund provided by the founder on operating profits was shown to be not significant. Conclusions – The present study comprehensively examined those start-up preparatory factors that have positive effects on business performances after start-up. The present study is meaningful in that it can provide positive implications for efficient start-up of small enterprises hereafter.